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Unusual Ultrasonic Vocalization Patterns In Mice May Be Useful For Modeling Autism:

Scientists have found novel patterns of ultrasonic vocalizations in a genetic mouse model of autism, adding a unique element to the available mouse behaviors that capture components of the human disease, and representing a new step towards identifying causes and better treatments.

New Concepts In Contraception:

Latest research into dual-purpose contraceptives and non-hormonal contraception will be presented August 27 at a major scientific conference in Melbourne.

Heart Attack Prevention: Potential New Use For Viagra?:

A basic science breakthrough by Queen’s researchers into regulating a single enzyme may lead to new drug therapies that will help prevent heart attacks and strokes.

Over 10 Million Americans Are Taking Opioids Each Week, Study Finds:

Researchers from Boston University’s Slone Epidemiology Center have found that in a given week, over 10 million Americans are taking opioids, and more than 4 million are taking them regularly (at least five days per week, for at least four weeks).

How The Brain Compensates For Vision Loss Shows Much More Versatility Than Previously Recognized:

Previous research has found that when vision is lost, a person’s senses of touch and hearing become enhanced. But exactly how this happens has been unclear.

Genetic Underpinnings Of Sheep Traits May Yield Clues To Greater Productivity:

Keeping America’s sheep healthy and productive while expanding the market for wool and lamb is the goal of Agricultural Research Service (ARS) scientists who are matching the animals’ physical traits to the genes that underpin their expression.

Consumption Of Nuts, Corn Or Popcorn Not Associated With Increased Risk Of Diverticulosis In Men:

Contrary to a common recommendation to avoid eating popcorn, nuts and corn to prevent diverticular complications, a large prospective study of men indicates that the consumption of these foods does not increase the risk of diverticulosis or diverticular complications, according to a new study.

Jamaican Lizards’ Shows Of Strength Mark Territory At Dawn, Dusk:

What does Jack LaLanne have in common with a Jamaican lizard? Like the ageless fitness guru, the lizards greet each new day with vigorous push-ups. That’s according to a new study showing that male Anolis lizards engage in impressive displays of reptilian strength — push-ups, head bobs, and threatening extension of a colorful neck flap called a dewlap — to defend their territory at dawn and dusk.

Student-designed Device To Help Poor East Africans Coax Oil From Coconuts:

A team of Brigham Young University student engineers designed an innovative and cost-effective apparatus that enables poor East African women to turn abundant coconuts into valuable coconut oil.

Protection Zones In The Wrong Place To Prevent Coral Reef Collapse:

Conservation zones are in the wrong place to protect vulnerable coral reefs from the effects of global warming, an international team of scientists warn.

Profiling Protective Proteins In Dairy Cows:

Agricultural Research Service (ARS) molecular biologist John Lippolis is delving into the dynamics of the dairy cow immune system. His work is resulting in the first close-up look at how immune system proteins help protect the cows, and how bacterial proteins fight back.

Facades: A Source Of Water Pollution:

For many years, fingers have been pointed at agriculture whenever pesticides are detected in rivers and streams. Studies carried out by Eawag and Empa now show that built-up areas also account for a considerable proportion of such inputs. For example, substances can be leached out of facade renders and paints by rainwater and enter the environment, where they may have toxic effects on organisms. In cooperation with manufacturers, cantonal authorities and other partners, the researchers have studied these leaching processes and are currently discussing ways of tackling the problem.

Proteins Have Controlled Motions, Researcher Shows:

Iowa State University researcher Robert Jernigan believes that his research shows proteins have controlled motions. Most biochemists traditionally believe proteins have many random, uncontrolled movements. Research conducted by Jernigan, director of the L.H. Baker Center for Bioinformatics and Biological Statistics together with Guang Song, an assistant professor in computer science and graduate student Lei Yang, over a 10-year period shows that not only are protein motions more restricted, but also that these restricted, controlled motions are part of the function of the proteins.</

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There are 13 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. Here are my own picks for the week – you go and look for your own favourites:
Observing Virtual Arms that You Imagine Are Yours Increases the Galvanic Skin Response to an Unexpected Threat:

Multi-modal visuo-tactile stimulation of the type performed in the rubber hand illusion can induce the brain to temporarily incorporate external objects into the body image. In this study we show that audio-visual stimulation combined with mental imagery more rapidly elicits an elevated physiological response (skin conductance) after an unexpected threat to a virtual limb, compared to audio-visual stimulation alone. Two groups of subjects seated in front of a monitor watched a first-person perspective view of slow movements of two virtual arms intercepting virtual balls rolling towards the viewer. One group was instructed to simply observe the movements of the two virtual arms, while the other group was instructed to observe the virtual arms and imagine that the arms were their own. After 84 seconds the right virtual arm was unexpectedly “stabbed” by a knife and began “bleeding”. This aversive stimulus caused both groups to show a significant increase in skin conductance. In addition, the observation-with-imagery group showed a significantly higher skin conductance (p<0.05) than the observation-only group over a 2-second period shortly after the aversive stimulus onset. No corresponding change was found in subjects' heart rates. Our results suggest that simple visual input combined with mental imagery may induce the brain to measurably temporarily incorporate external objects into its body image.

Distributed Dendritic Processing Facilitates Object Detection: A Computational Analysis on the Visual System of the Fly:

Detecting objects is an important task when moving through a natural environment. Flies, for example, may land on salient objects or may avoid collisions with them. The neuronal ensemble of Figure Detection cells (FD-cells) in the visual system of the fly is likely to be involved in controlling these behaviours, as these cells are more sensitive to objects than to extended background structures. Until now the computations in the presynaptic neuronal network of FD-cells and, in particular, the functional significance of the experimentally established distributed dendritic processing of excitatory and inhibitory inputs is not understood. We use model simulations to analyse the neuronal computations responsible for the preference of FD-cells for small objects. We employed a new modelling approach which allowed us to account for the spatial spread of electrical signals in the dendrites while avoiding detailed compartmental modelling. The models are based on available physiological and anatomical data. Three models were tested each implementing an inhibitory neural circuit, but differing by the spatial arrangement of the inhibitory interaction. Parameter optimisation with an evolutionary algorithm revealed that only distributed dendritic processing satisfies the constraints arising from electrophysiological experiments. In contrast to a direct dendro-dendritic inhibition of the FD-cell (Direct Distributed Inhibition model), an inhibition of its presynaptic retinotopic elements (Indirect Distributed Inhibition model) requires smaller changes in input resistance in the inhibited neurons during visual stimulation. Distributed dendritic inhibition of retinotopic elements as implemented in our Indirect Distributed Inhibition model is the most plausible wiring scheme for the neuronal circuit of FD-cells. This microcircuit is computationally similar to lateral inhibition between the retinotopic elements. Hence, distributed inhibition might be an alternative explanation of perceptual phenomena currently explained by lateral inhibition networks.

Exploring The Function Of Sleep:

Is sleep essential? Ask that question to a sleep-deprived new parent or a student who has just pulled an “all-nighter,” and the answer will be a grouchy, “Of course!” But to a sleep scientist, the question of what constitutes sleep is so complex that scientists are still trying to define the essential function of something we do every night. A study published this week in PLoS Biology by Chiara Cirelli and Giulio Tononi addresses this pressing question.

‘Perfect Pitch’ In Humans Far More Prevalent Than Expected:

Researchers at the University of Rochester’s Eastman School of Music and Department of Brain and Cognitive Sciences have developed a unique test for perfect pitch, and have found surprising results.

Undergrads’ Amazon Trip Yields A Treasure Trove Of Diversity:

A group of Yale undergraduates have discovered dozens of potentially beneficial bioactive microorganisms within plants they collected in the Amazon rain forest, including several so genetically distinct that they may be the first members of new taxonomical genera.

Looking Beyond The Drug Receptor For Clues To Drug Effectiveness:

Antipsychotic drugs that are widely used to treat schizophrenia and other problems may not work as scientists have assumed, according to findings from Duke University Medical Center researchers that could lead to changes in how these drugs are developed and prescribed.

Consumers Can Predict Inflation As Well As Professional Economists:

When it comes to predicting the rate of inflation, professional economists might tell consumers, “Your guess is as good as mine.” Research by a Kansas State University professor shows that household surveys predict the inflation rate fairly accurately and as well as professional economists. The pros employ statistics like the unemployment rate, money supply growth and exchange rate changes. Consumers participating in surveys are more likely to think about how much they spent at the grocery store that week.

Is Extinction Or Diversity On The Rise? Study Of Islands Reveals Surprising Results:

It’s no secret that humans are having a huge impact on the life cycles of plants and animals. UC Santa Barbara’s Steven D. Gaines and fellow researcher Dov Sax decided to test that theory by studying the world’s far-flung islands.

How Does Bluetongue Virus Survive Through The Winter?:

Bluetongue virus – which infects livestock – reached Northern Europe for the first time. Some people thought that the outbreak would be limited to that particular year, as winter was expected to kill off the midges that host and spread the disease, bringing the threat of infection to an end. In actuality, the disease escalated in the following year, spreading to the UK. So, how did the virus survive the winter?

Fishing Technology Letting Turtles Off The Hook:

Alternative fishing technology has been shown to save turtles while not affecting fish catches, according to a report released by WWF and the Inter-American Tropical Tuna Commission (IATTC).

Men Defy Stereotypes In Defining Masculinity:

Contrary to stereotypes about sexual performance and masculinity, men interviewed in a large international study reported that being seen as honorable, self-reliant and respected was more important to their idea of masculinity than being seen as attractive, sexually active or successful with women.

Secret Of Newborn’s First Words Revealed:

A new study could explain why “daddy” and “mommy” are often a baby’s first words – the human brain may be hard-wired to recognize certain repetition patterns.

Why Do Eyelids Sag With Age? Mystery Is Solved:

Many theories have sought to explain what causes the baggy lower eyelids that come with aging, but UCLA researchers have now found that fat expansion in the eye socket is the primary culprit.

Java Gives Caffeine-naive A Boost, Too:

New research from the University of Alberta in Edmonton, Canada, shows that–for women–the caffeine advantage is indeed everything it’s cracked up to be. Females who don’t drink coffee can get just as much of a caffeine boost as those who sip it regularly, according to a study in the latest edition of Nutrition Research.

Trouble Quitting? New Smoking Study May Reveal Why:

A new study from researchers at the University of Pittsburgh and Carnegie Mellon University sheds light on why smokers’ intentions to quit “cold turkey” often fizzle out within days or even hours.

Small Scattered Fragments Do Not a Dwarf Make: Biological and Archaeological Data Indicate that Prehistoric Inhabitants of Palau Were Normal Sized:

Current archaeological evidence from Palau in western Micronesia indicates that the archipelago was settled around 3000-3300 BP by normal sized populations; contrary to recent claims, they did not succumb to insular dwarfism. Previous and ongoing archaeological research of both human burial and occupation sites throughout the Palauan archipelago during the last 50 years has produced a robust data set to test hypotheses regarding initial colonization and subsequent adaptations over the past three millennia. Close examination of human burials at the early (ca. 3000 BP) and stratified site of Chelechol ra Orrak indicates that these were normal sized individuals. This is contrary to the recent claim of contemporaneous “small-bodied” individuals found at two cave sites by Berger et al. (2008). As we argue, their analyses are flawed on a number of different analytical levels. First, their sample size is too small and fragmentary to adequately address the variation inherent in modern humans within and outside of Palau. Second, the size and stature of all other prehistoric (both older and contemporaneous) skeletal assemblages found in Palau fall within the normal parameters of modern human variation in the region, indicating this was not a case of insular dwarfism or a separate migratory group. Third, measurements taken on several skeletal elements by Berger et al. may appear to be from smaller-bodied individuals, but the sizes of these people compares well with samples from Chelechol ra Orrak. Last, archaeological, linguistic, and historical evidence demonstrates a great deal of cultural continuity in Palau through time as expected if the same population was inhabiting the archipelago. Prehistoric Palauan populations were normal sized and exhibit traits that fall within the normal variation for Homo sapiens–they do not support the claims by Berger et al. (2008) that there were smaller-bodied populations living in Palau or that insular dwarfism took place such as may be the case for Homo floresiensis.

The Neural Correlates of Desire:

In an event-related fMRI study, we scanned eighteen normal human subjects while they viewed three categories of pictures (events, objects and persons) which they classified according to desirability (desirable, indifferent or undesirable). Each category produced activity in a distinct part of the visual brain, thus reflecting its functional specialization. We used conjunction analysis to learn whether there is a brain area which is always active when a desirable picture is viewed, regardless of the category to which it belongs. The conjunction analysis of the contrast desirable > undesirable revealed activity in the superior orbito-frontal cortex. This activity bore a positive linear relationship to the declared level of desirability. The conjunction analysis of desirable > indifferent revealed activity in the mid-cingulate cortex and in the anterior cingulate cortex. In the former, activity was greater for desirable and undesirable stimuli than for stimuli classed as indifferent. Other conjunction analyses produced no significant effects. These results show that categorizing any stimulus according to its desirability activates three different brain areas: the superior orbito-frontal, the mid-cingulate, and the anterior cingulate cortices.

Climate Warming, Marine Protected Areas and the Ocean-Scale Integrity of Coral Reef Ecosystems:

Coral reefs have emerged as one of the ecosystems most vulnerable to climate variation and change. While the contribution of a warming climate to the loss of live coral cover has been well documented across large spatial and temporal scales, the associated effects on fish have not. Here, we respond to recent and repeated calls to assess the importance of local management in conserving coral reefs in the context of global climate change. Such information is important, as coral reef fish assemblages are the most species dense vertebrate communities on earth, contributing critical ecosystem functions and providing crucial ecosystem services to human societies in tropical countries. Our assessment of the impacts of the 1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites and 26 degrees of latitude in the Indian Ocean. Using Bayesian meta-analysis we show that changes in the size structure, diversity and trophic composition of the reef fish community have followed coral declines. Although the ocean scale integrity of these coral reef ecosystems has been lost, it is positive to see the effects are spatially variable at multiple scales, with impacts and vulnerability affected by geography but not management regime. Existing no-take marine protected areas still support high biomass of fish, however they had no positive affect on the ecosystem response to large-scale disturbance. This suggests a need for future conservation and management efforts to identify and protect regional refugia, which should be integrated into existing management frameworks and combined with policies to improve system-wide resilience to climate variation and change.

Bi-Directional Sexual Dimorphisms of the Song Control Nucleus HVC in a Songbird with Unison Song:

Sexually dimorphic anatomy of brain areas is thought to be causally linked to sex differences in behaviour and cognitive functions. The sex with the regional size advantage (male or female) differs between brain areas and species. Among adult songbirds, males have larger brain areas such as the HVC (proper name) and RA (robust nucleus of the arcopallium) that control the production of learned songs. Forest weavers (Ploceus bicolor) mated pairs sing a unison duet in which male and female mates learn to produce identical songs. We show with histological techniques that the volume and neuron numbers of HVC and RA were ≥1.5 times larger in males than in females despite their identical songs. In contrast, using in-situ hybridizations, females have much higher (30-70%) expression levels of mRNA of a number of synapse-related proteins in HVC and/or RA than their male counterparts. Male-typical and female-typical sexual differentiation appears to act on different aspects of the phenotypes within the same brain areas, leading females and males to produce the same behaviour using different cellular mechanisms.

Evaluation of Two Methods to Estimate and Monitor Bird Populations:

Effective management depends upon accurately estimating trends in abundance of bird populations over time, and in some cases estimating abundance. Two population estimation methods, double observer (DO) and double sampling (DS), have been advocated for avian population studies and the relative merits and short-comings of these methods remain an area of debate. We used simulations to evaluate the performances of these two population estimation methods under a range of realistic scenarios. For three hypothetical populations with different levels of clustering, we generated DO and DS population size estimates for a range of detection probabilities and survey proportions. Population estimates for both methods were centered on the true population size for all levels of population clustering and survey proportions when detection probabilities were greater than 20%. The DO method underestimated the population at detection probabilities less than 30% whereas the DS method remained essentially unbiased. The coverage probability of 95% confidence intervals for population estimates was slightly less than the nominal level for the DS method but was substantially below the nominal level for the DO method at high detection probabilities. Differences in observer detection probabilities did not affect the accuracy and precision of population estimates of the DO method. Population estimates for the DS method remained unbiased as the proportion of units intensively surveyed changed, but the variance of the estimates decreased with increasing proportion intensively surveyed. The DO and DS methods can be applied in many different settings and our evaluations provide important information on the performance of these two methods that can assist researchers in selecting the method most appropriate for their particular needs.

Random Drift versus Selection in Academic Vocabulary: An Evolutionary Analysis of Published Keywords:

The evolution of vocabulary in academic publishing is characterized via keyword frequencies recorded in the ISI Web of Science citations database. In four distinct case-studies, evolutionary analysis of keyword frequency change through time is compared to a model of random copying used as the null hypothesis, such that selection may be identified against it. The case studies from the physical sciences indicate greater selection in keyword choice than in the social sciences. Similar evolutionary analyses can be applied to a wide range of phenomena; wherever the popularity of multiple items through time has been recorded, as with web searches, or sales of popular music and books, for example.

Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism:

BTBR T+ tf/J (BTBR) is an inbred mouse strain that displays social abnormalities and repetitive behaviors analogous to the first and third diagnostic symptoms of autism. Here we investigate ultrasonic vocalizations in BTBR, to address the second diagnostic symptom of autism, communication deficits. As compared to the commonly used C57BL/6J (B6) strain, BTBR pups called more loudly and more frequently when separated from their mothers and siblings. Detailed analysis of ten categories of calls revealed an unusual pattern in BTBR as compared to B6. BTBR emitted high levels of harmonics, two-syllable, and composite calls, but minimal numbers of chevron-shaped syllables, upward, downward, and short calls. Because body weights were higher in BTBR than B6 pups, one possible explanation was that larger thoracic size was responsible for the louder calls and different distribution of syllable categories. To test this possibility, we recorded separation calls from FVB/NJ, a strain with body weights similar to BTBR, and 129X1/SvJ, a strain with body weights similar to B6. BTBR remained the outlier on number of calls, displaying low numbers of complex, upward, chevron, short, and frequency steps calls, along with high harmonics and composites. Further, developmental milestones and growth rates were accelerated in BTBR, indicating an unusual neurodevelopmental trajectory. Overall, our findings demonstrate strain-specific patterns of ultrasonic calls that may represent different lexicons, or innate variations in complex vocal repertoires, in genetically distinct strains of mice. Particularly intriguing is the unusual pattern of vocalizations and the more frequent, loud harmonics evident in the BTBR mouse model of autism that may resemble the atypical vocalizations seen in some autistic infants.

Genetic Architecture of Hybrid Male Sterility in Drosophila: Analysis of Intraspecies Variation for Interspecies Isolation:

The genetic basis of postzygotic isolation is a central puzzle in evolutionary biology. Evolutionary forces causing hybrid sterility or inviability act on the responsible genes while they still are polymorphic, thus we have to study these traits as they arise, before isolation is complete. Isofemale strains of D. mojavensis vary significantly in their production of sterile F1 sons when females are crossed to D. arizonae males. We took advantage of the intraspecific polymorphism, in a novel design, to perform quantitative trait locus (QTL) mapping analyses directly on F1 hybrid male sterility itself. We found that the genetic architecture of the polymorphism for hybrid male sterility (HMS) in the F1 is complex, involving multiple QTL, epistasis, and cytoplasmic effects. The role of extensive intraspecific polymorphism, multiple QTL, and epistatic interactions in HMS in this young species pair shows that HMS is arising as a complex trait in this system. Directional selection alone would be unlikely to maintain polymorphism at multiple loci, thus we hypothesize that directional selection is unlikely to be the only evolutionary force influencing postzygotic isolation.

Gender Differences in the Risk of HIV Infection among Persons Reporting Abstinence, Monogamy, and Multiple Sexual Partners in Northern Tanzania:

Monogamy, together with abstinence, partner reduction, and condom use, is widely advocated as a key behavioral strategy to prevent HIV infection in sub-Saharan Africa. We examined the association between the number of sexual partners and the risk of HIV seropositivity among men and women presenting for HIV voluntary counseling and testing (VCT) in northern Tanzania. Clients presenting for HIV VCT at a community-based AIDS service organization in Moshi, Tanzania were surveyed between November 2003 and December 2007. Data on sociodemographic characteristics, reasons for testing, sexual behaviors, and symptoms were collected. Men and women were categorized by number of lifetime sexual partners, and rates of seropositivity were reported by category. Factors associated with HIV seropositivity among monogamous males and females were identified by a multivariate logistic regression model. Of 6,549 clients, 3,607 (55%) were female, and the median age was 30 years (IQR 24-40). 939 (25%) females and 293 (10%) males (p<0.0001) were HIV seropositive. Among 1,244 (34%) monogamous females and 423 (14%) monogamous males, the risk of HIV infection was 19% and 4%, respectively (p<0.0001). The risk increased monotonically with additional partners up to 45% (p<0.001) and 15% (p<0.001) for women and men, respectively with 5 or more partners. In multivariate analysis, HIV seropositivity among monogamous women was most strongly associated with age (p<0.0001), lower education (p<0.004), and reporting a partner with other partners (p = 0.015). Only age was a significant risk factor for monogamous men (p = 0.0004). Among women presenting for VCT, the number of partners is strongly associated with rates of seropositivity; however, even women reporting lifetime monogamy have a high risk for HIV infection. Partner reduction should be coupled with efforts to place tools in the hands of sexually active women to reduce their risk of contracting HIV.

Cells In Eye Could Help Control Sleep:

A set of nerve cells in the eye control our levels of sleepiness according to the brightness of our surroundings, Oxford University researchers have discovered. The cells directly regulate the activity of sleep centres in the brain, providing a new target for the development of drugs to control sleep and alertness.

New Evidence Debunks ‘Stupid’ Neanderthal Myth:

Research by UK and American scientists has struck another blow to the theory that Neanderthals (Homo neanderthalensis) became extinct because they were less intelligent than our ancestors (Homo sapiens). The research team has shown that early stone tool technologies developed by our species, Homo sapiens, were no more efficient than those used by Neanderthals.

Monkeys Enjoy Giving To Others, Study Finds:

Researchers at the Yerkes National Primate Research Center, Emory University, have shown capuchin monkeys, just like humans, find giving to be a satisfying experience. This finding comes on the coattails of a recent imaging study in humans that documented activity in reward centers of the brain after humans gave to charity.

Polar Bears Found Swimming Miles From Alaskan Coast:

An aerial survey by government scientists in Alaska’s Chukchi Sea has recently found at least nine polar bears swimming in open water – with one at least 60 miles from shore – raising concern among wildlife experts about their survival.

Even Seaweeds Get Sunburned:

It is red, it burns and itches: a sunburn on our skin. However, too much sun is not only bad for humans. Many plants react sensitively to an increased dose of ultraviolet radiation, too. Yet they are dependent on sunlight. With the help of pigments absorbing solar energy and light, plants produce their vitally important building blocks by means of photosynthesis.

There are 12 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. Here are my own picks for the week – you go and look for your own favourites:
Individual Differences in the Amount and Timing of Salivary Melatonin Secretion:

The aim of this study was to examine individual differences in a large sample of complete melatonin profiles not suppressed by light and search for possible associations between the amount and timing of melatonin secretion and a multitude of lifestyle variables. The melatonin profiles were derived from saliva samples collected every 30 minutes in dim light from 85 healthy women and 85 healthy men aged 18-45 years. There was a large individual variability in the amount of melatonin secreted with peak values ranging from 2 to 84 pg/ml. The onset of melatonin secretion ranged from 18:13 to 00:26 hours. The use of hormonal birth control, reduced levels of employment, a smaller number of days on a fixed sleep schedule, increased day length and lower weight were associated with an increased amplitude of melatonin secretion. The use of hormonal birth control, contact lenses, a younger age, and lower ratings of mania and paranoia were associated with a longer duration of melatonin secretion. An earlier occurrence of the onset of melatonin secretion was associated with an earlier wake time, more morningness and the absence of a bed partner. Lifestyle and behavioral variables were only able to explain about 15% of the individual variability in the amount of melatonin secretion, which is likely because of a substantial genetic influence on the levels of melatonin secretion.

Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota:

The human gastrointestinal tract is inhabited by a very diverse symbiotic microbiota, the composition of which depends on host genetics and the environment. Several studies suggested that the host genetics may influence the composition of gut microbiota but no genes involved in host control were proposed. We investigated the effects of the wild type and mutated alleles of the gene, which encodes the protein called pyrin, one of the regulators of innate immunity, on the composition of gut commensal bacteria. Mutations in MEFV lead to the autoinflammatory disorder, familial Mediterranean fever (FMF, MIM249100), which is characterized by recurrent self-resolving attacks of fever and polyserositis, with no clinical signs of disease in remission. A total of 19 FMF patients and eight healthy individuals were genotyped for mutations in the MEFV gene and gut bacterial diversity was assessed by sequencing 16S rRNA gene libraries and FISH analysis. These analyses demonstrated significant changes in bacterial community structure in FMF characterized by depletion of total numbers of bacteria, loss of diversity, and major shifts in bacterial populations within the Bacteroidetes, Firmicutes and Proteobacteria phyla in attack. In remission with no clinical signs of disease, bacterial diversity values were comparable with control but still, the bacterial composition was substantially deviant from the norm. Discriminant function analyses of gut bacterial diversity revealed highly specific, well-separated and distinct grouping, which depended on the allele carrier status of the host. This is the first report that clearly establishes the link between the host genotype and the corresponding shifts in the gut microbiota (the latter confirmed by two independent techniques). It suggests that the host genetics is a key factor in host-microbe interaction determining a specific profile of commensal microbiota in the human gut.

How ‘Secondary’ Sex Characters Can Drive The Origin Of Species:

The ostentatious, sometimes bizarre qualities that improve a creature’s chances of finding a mate may also drive the reproductive separation of populations and the evolution of new species, say two Indiana University Bloomington biologists.

Elephant Legs Are Much Bendier Than Shakespeare Thought:

Throughout history, elephants have been thought of as ‘different’. Shakespeare, and even Aristotle, described them as walking on inflexible column-like legs. And this myth persists even today. Which made John Hutchinson from The Royal Veterinary College, London, want to find out more about elephants and the way they move. Are they really that different from other, more fleet-footed species? Are their legs as rigid and ‘columnar’ as people had thought?

Life Isn’t 2-D, So Why Should Our Encyclopedias Be?:

Biologists and biochemists are now able to access 3D images of biomacromolecules underlying biological functions and disease. Rather than relying on text to provide the understanding of biomacromolecule structures, a collaborative website called Proteopedia now provides a new resource by linking written information and three-dimensional structural information.

Why Wind Turbines Can Mean Death For Bats:

Power-generating wind turbines have long been recognized as a potentially life-threatening hazard for birds. But at most wind facilities, bats actually die in much greater numbers. Now, researchers reporting in Current Biology, a Cell Press journal, on August 26th think they know why.

Animals Adapt Their Vocal Signals To Social Situations:

A special August issue of the Journal of Comparative Psychology, published by the American Psychological Association, presents a host of studies that investigate the way that animals adapt their calls, chirps, barks and whistles to their social situation.

Tiny Cellular Antennae Trigger Neural Stem Cells:

Yale University scientists today reported evidence suggesting that the tiny cilia found on brain cells of mammals, thought to be vestiges of a primeval past, actually play a critical role in relaying molecular signals that spur creation of neurons in an area of the brain involved in mood, learning and memory.

Picking Out Specific Sounds In A Complex Scene: Researchers Study ‘Cocktail Party Effect’, Measure Auditory Dynamics Of Selective Attention:

Call it the cocktail party effect: how an individual can participate in a one-on-one conversation within a cluster of people, switch to another, pick up important comments while tuning out others, change topics and return to the first conversation.

Starting Kindergarten Later Gives Students Only A Fleeting Edge, Study Finds:

New research challenges a growing trend toward holding kids out of kindergarten until they’re older, arguing that academic advantages are short-lived and come at the expense of delaying entry into the workforce and other costs.

Part Of The In-group? A Surprising New Strategy Helps Reduce Unhealthy Behaviors:

Public health campaigns intended to reduce unhealthy behaviors like binge drinking and eating junk food often focus on the risks of those behaviors. But a new study in the Journal of Consumer Research suggests a relatively simple but surprisingly effective strategy to improve consumer health.

79 Million US Adults Have Medical Bill Problems Or Are Paying Off Medical Debt:

The proportion of working-age Americans who have medical bill problems or who are paying off medical debt climbed from 34 percent to 41 percent between 2005 and 2007, bringing the total to 72 million, according to recent survey findings from The Commonwealth Fund. In addition, 7 million adults age 65 and over also had problems paying medical bills, for a total of 79 million adults with medical bill problems or medical debt.

Foul Owls Use Feces To Show They Are In Fine Feather:

Some years ago, within the Department of Conservation Biology of the Estación Biológica de Doñana (EBD-Consejo Superior de Investigaciones Científicas; Seville, Spain), a recently established group (colloquially named the Night Ecology Group) started to explore the possibility of visual communication in crepuscular and nocturnal birds.

Exploding Chromosomes Fuel Research About Evolution Of Genetic Storage:

Human cells somehow squeeze two meters of double-stranded DNA into the space of a typical chromosome, a package 10,000 times smaller than the volume of genetic material it contains.

Fish Cancer Gene Linked To Pigment Pattern That Attracts Mates:

Though skin cancer is deadly to male fish, it also has one perk: The black melanoma splotches arise from attractive natural markings that lure female mates. A new study published in the Proceedings of the National Academy of Sciences this week shows that the melanoma gene can be conserved in swordtail fish because of its beneficial role in sexual selection.

Addiction Treatment Proves Successful In Animal Weight Loss Study:

Vigabatrin, a medication proposed as a potential treatment for drug addiction by scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, also leads to rapid weight loss and reduced food intake according to a new animal study from the same research group.

Insomnia: Changing Your Bedtime Habits Could Help:

Many people sleep better when they are on holiday and wish that they could sleep as well all the time. But according to the German Institute for Quality and Efficiency in Health Care (IQWiG), it is not only being free of daily worries that can make a difference to sleep. Good bedtime habits can help people to sleep well all year round. Medication provides short-term relief at best.

Snacks In Small Packages May Lead To Overeating:

Tempting treats are being offered in small package sizes these days, presumably to help consumers reduce portion sizes. Yet new research found that people actually consume more high-calorie snacks when they are in small packages than large ones. And smaller packages make people more likely to give in to temptation in the first place.

With Skate Eyes, Scientists Peer Into Human Disease:

Paradoxically, the photoreceptor cells in our retinas release more of their neurotransmitter, glutamate, in the dark, when there is nothing to see, than they do in the light. This is doubly surprising since although glutamate is a major signaling molecule in the retina and throughout the central nervous system, it is also a potent cytotoxin that, in large doses, can kill nearby cells.

New Algorithm Significantly Boosts Routing Efficiency Of Networks:

A time-and-money-saving question shared by commuters in their cars and networks sharing ever-changing Internet resources is: “What’s the best way to get from here to there?”

New And Improved Test For West Nile Virus In Horses:

A new test for West Nile virus in horses that could be modified for use on humans and wildlife may help track the spread of the disease, according to an article in the September issue of the Journal of Medical Microbiology.

Insomnia: Changing Your Bedtime Habits Could Help:

Many people sleep better when they are on holiday and wish that they could sleep as well all the time. But according to the German Institute for Quality and Efficiency in Health Care (IQWiG), it is not only being free of daily worries that can make a difference to sleep. Good bedtime habits can help people to sleep well all year round. Medication provides short-term relief at best.

Hormone Replacement Therapy Improves Sleep, Sexuality And Joint Pain In Older Women:

One of the world’s longest and largest trials of hormone replacement therapy (HRT) has found that post-menopausal women on HRT gain significant improvements in quality of life.

Is It Possible To Teach Experience? European Researchers Say Yes:

Business veterans claim you cannot teach ‘experience’, but European researchers say you can. The team developed software that helps players acquire real-life skills and realistic experiences through game playing. But this game is no executive toy.

Genome Of Simplest Animal Reveals Ancient Lineage, Confounding Array Of Complex Capabilities:

As Aesop said, appearances are deceiving–even in life’s tiniest critters. From first detection in the 1880s, clinging to the sides of an aquarium, to its recent characterization by the U.S. Department of Energy Joint Genome Institute (DOE JGI), a simple and primitive animal, Trichoplax adhaerens, appears to harbor a far more complex suite of capabilities than meets the eye.

Genes And Nutrition Influence Caste In Unusual Species Of Harvester Ant:

Researchers trying to determine whether nature or nurture determines an ant’s status in the colony have found a surprising answer. Both.