A Blog Around The Clock

Who Dares Sings, And Who Sings Wins: Bold Birds Get The Girl:

Humans often choose partners based on behavioural keys that are displayed during social interactions. The way we behave in different social contexts can reflect personality traits or temperament that may inspire long-term love. Behavioural norms that we perceive as sexually attractive are not culturally or evolutionarily arbitrary.

Disproving Conventional Wisdom On Diversity Of Marine Fossils And Extinction Rates:

It took a decade of painstaking study, the cooperation of hundreds of researchers, and a database of more than 200,000 fossil records, but John Alroy thinks he’s disproved much of the conventional wisdom about the diversity of marine fossils and extinction rates.

New Mode Of Gene Regulation Discovered In Mammals:

Researchers at the University of California, Santa Cruz, have discovered a type of gene regulation never before observed in mammals — a “ribozyme” that controls the activity of an important family of genes in several different species.

RNA Emerges From DNA’s Shadow:

RNA, the transporter of genetic information within the cell, has emerged from the shadow of DNA to become one of the hottest research areas of molecular biology, with implications for many diseases as well as understanding of evolution. But the field is complex, requiring access to the latest equipment and techniques of imaging, gene expression analysis and bioinformatics, as well as cross-pollination between multiple scientific disciplines.

Biodiversity Defensing Against Climate Change:

Climate change is happening, and we must develop ways for all life to be able to cope, environmental advocates urge. WWF Vietnam Programme is looking at this through the development of resilient multifunctional landscapes that also work as forest corridors, assisting with species dispersal and adaptation, by changes in land-use practices.

Will Our Future Brains Be Smaller?:

The speed at which we react to threatening situations can have life or death implications. In the more primitive past, it could have meant escaping a wild animal; today it might mean swerving to avoid a head-on car crash. It has been thought for some years that mammals have two decision-making systems in their brains which operate at different speeds to cope with different situations. New research from the University of Bristol supports this theory and has shown that the evolutionary pressures arising from the older, faster, but less accurate, part of the brain may have shaped the more recent development of the slower-acting but more precise cortex, found in humans and higher animals.

I was busy, so I did not have time to take a look until now at what is new this week in PLoS Genetics, Computational Biology, Pathogens and Neglected Tropical Diseases. Go take a look at these papers and others:
Evolution of Evolvability in Gene Regulatory Networks:

A cell receives signals both from its internal and external environment and responds by changing the expression of genes. In this manner the cell adjusts to heat, osmotic pressures and other circumstances during its lifetime. Over long timescales, the network of interacting genes and its regulatory actions also undergo evolutionary adaptation. Yet how do such networks evolve and become adapted?
In this paper we describe the study of a simple model of gene regulatory networks, focusing solely on evolutionary adaptation. We let a population of individuals evolve, while the external environment changes through time. To ensure evolution is the only source of adaptation, we do not provide the individuals with a sensor to the environment. We show that the interplay between the long-term process of evolution and short-term gene regulation dynamics leads to a striking increase in the efficiency of creating well-adapted offspring. Beneficial mutations become more frequent, nevertheless robustness to the majority of mutations is maintained. Thus we demonstrate a clear example of the evolution of evolvability.

Domestic Pigs Have Low Susceptibility to H5N1 Highly Pathogenic Avian Influenza Viruses:

Highly pathogenic avian influenza A viruses of H5N1 subtype have spread through Eurasia and Africa with continuing cases of human infection, suggesting the potential to become a pandemic influenza virus. Pigs which are susceptible to infection with both human and avian influenza A viruses are one of the natural hosts where a pandemic virus could be produced. In this study, we characterized in a pig model the infection caused by four H5N1 virus strains isolated from humans, poultry and wild birds. We demonstrated that exposure of pigs through the nose with H5N1 viruses or consumption of meat from infected chickens resulted in infection with mild weight loss. In contrast to mouse and ferret animal models where some of viruses were highly pathogenic and replicated in multiple organs, replication of H5N1 viruses in pigs was restricted to the respiratory tract, mainly to the lungs, and tonsils. Mild to moderate bronchiolitis and pneumonia were observed in the lungs of infected animals. Our results demonstrated that domestic pigs had low susceptibility to infection and disease with highly pathogenic H5N1 influenza A viruses.

Zebrafish Whole-Adult-Organism Chemogenomics for Large-Scale Predictive and Discovery Chemical Biology:

To understand chemical-induced biological responses/effects, it is important to have large-scale and rapid capacity to investigate gene expression changes caused by chemical compounds at genome-wide scale in an adult vertebrate model; this capability is essential for drug development and toxicology. Small aquarium fish with vast genomic resources, such as zebrafish, will probably be the only vertebrate models that allow for cost-effective, large-scale, genome-wide determination of gene expression net changes in the entire adult organism in response to a chemical compound. Presently, such a whole adult organism approach is only feasible in invertebrate models such as the worm and fly, and not in rodent models, hence the usefulness of such an approach has not been demonstrated in a vertebrate. By using two classes of chemicals with wide implications to human health, we showed that capturing net changes of gene expression at a genome-wide scale in an entire adult zebrafish is useful for predicting toxicity and chemical classes, for discovering biomarkers and major signaling pathways, as well as for inferring human health risk and new biological insights. Our study provides a new approach for genome-wide investigation of chemical-induced biological responses/effects in a whole adult vertebrate that can benefit the drug discovery process and chemical toxicity testing for environmental health risk inference.

Unraveling Protein Networks with Power Graph Analysis:

Networks play a crucial role in biology and are often used as a way to represent experimental results. Yet, their analysis and representation is still an open problem. Recent experimental and computational progress yields networks of increased size and complexity. There are, for example, small- and large-scale interaction networks, regulatory networks, genetic networks, protein-ligand interaction networks, and homology networks analyzed and published regularly. A common way to access the information in a network is though direct visualization, but this fails as it often just results in “fur balls” from which little insight can be gathered. On the other hand, clustering techniques manage to avoid the problems caused by the large number of nodes and even larger number of edges by coarse-graining the networks and thus abstracting details. But these also fail, since, in fact, much of the biology lies in the details. This work presents a novel methodology for analyzing and representing networks. Power Graphs are a lossless representation of networks, which reduces network complexity by explicitly representing re-occurring network motifs. Moreover, power graphs can be clearly visualized: they compress up to 90% of the edges in biological networks and are applicable to all types of networks such as protein interaction, regulatory networks, or homology networks.

Children Are Naturally Prone To Be Empathic And Moral:

Children between the ages of seven and 12 appear to be naturally inclined to feel empathy for others in pain, according to researchers at the University of Chicago, who used functional Magnetic Resonance Imaging (fMRI) scans to study responses in children.

Scientists Identify Genetic Basis For The Black Sheep Of The Family:

Coat color of wild and domestic animals is a critical trait that has significant biological and economic impact. Researchers have now identified the genetic basis for black coat color, and white, in a breed of domestic sheep.

Insect Warning Colors Aid Cancer And Tropical Disease Drug Discovery:

Brightly colored beetles or butterfly larvae nibbling on a plant may signal the presence of chemical compounds active against cancer cell lines and tropical parasitic diseases, according to researchers at Smithsonian’s Tropical Research Institute in Panama. Such clues could speed drug discovery and provide insight into the ecological relationships between tropical-forest plants and insects that feed on them.

Molecular Motor Works By Detecting Minute Changes In Force:

Researchers at the University of Pennsylvania School of Medicine discovered that the activity of a specific family of nanometer-sized molecular motors called myosin-I is regulated by force. The motor puts tension on cellular springs that allow vibrations to be detected within the body. This finely tuned regulation has important implications for understanding a wide variety of basic cellular processes, including hearing and balance and glucose uptake in response to insulin. The findings appear in the most recent issue of Science.

Weight Gain In Adolescent Girls: Role Of Internet, Alcohol And Sleep:

Girls moving through adolescence may experience unhealthy levels of weight gain, but the reasons for this are not always clear. In fact, many potential causes of weight gain are easily overlooked. A new study analyzes the effect of Internet usage, sleep, and alcohol and coffee consumption on weight gain in adolescent girls.

Verbally Aggressive Mothers Direct Their Children’s Behavior:

A new study reveals that verbally aggressive (VA) mothers tend to control their children’s choice of activities as well as use physical negative touch, along with directives, when trying to alter their child’s actions.

Report Calls For Expansion Of Professional Science Master’s Degree Programs:

Policymakers, universities, and employers should work together to speed the development of professionally oriented master’s degree programs in the natural sciences, says a new report from the National Research Council. Graduates of these programs — which build both scientific knowledge and practical workplace skills — can make a strong contribution to the nation’s competitiveness, said the committee that wrote the report.

Decadent, Convenient Banana Dessert Débuted At Food Expo:

Who doesn’t like a banana split? Fresh fruit, three flavors of ice cream and chocolate syrup. Yum. That vision was the subjective basis for a new product developed by a team of Virginia Tech students – frozen bite-sized slices of banana filled with creamy chocolate, vanilla, or strawberry non-fat frozen yogurt and enrobed in dark chocolate. Called “Banana Splitters,” the new confection is packaged as nine individual pieces – three of each flavor – in a sleeve, six sleeves in a package to be available next to the ice cream and other frozen goodies. And, get this, an entire sleeve is a serving.

Superfast Vocal Muscles In Songbirds: Hundred Times Faster Than Blink Of An Eye:

Certain songbirds can contract their vocal muscles 100 times faster than humans can blink an eye — placing the birds with a handful of animals that have evolved superfast muscles, University of Utah researchers found.

Reducing Global Warming And Working For Common Good: What Inspires Collective Cooperation?:

No one enjoys paying taxes. Even so, we need taxes if we want our streets clean, a proper public health care system, an educated population or the maintenance of Earth’s climate within habitable boundaries. This is what scientists commonly refer as public goods — benefits that everyone receives whether or not they contribute to them. The missing link between paying and benefiting from a public good creates an obvious dilemma and temptation to cheat (not to cooperate): Why shouldn’t I let the others pay for it?

Avatars As Communicators Of Emotions:

Current interactive systems enable users to communicate with computers in many ways, but not taking into account emotional communication. A PhD thesis presented at the University of the Basque Country puts forward the use of avatars or virtual Internet personages as an efficient form of non-verbal communication, principally focusing on emotional aspects.

Why Musicians Make Us Weep And Computers Don’t:

Music can soothe the savage breast much better if played by musicians rather than clever computers, according to a new University of Sussex-led study.

Scientists Generally Happy With Their Media Interaction:

Scientists and journalists get along much better than the anecdotal ‘horror stories’ would lead us to believe, according to new research published today in the journal Science, which has found that 57% of researchers were ‘mostly pleased’ with their media interaction, while only 6% percent were ‘mostly dissatisfied’.

Learning To Talk To Teens About Sex — While At Work:

Sex is one of the most difficult topics a parent can bring up with an adolescent, but a new study finds that parents who are taught specific communication skills can more readily tackle these conversations and sustain them over time.

Gender, Time Of Day Affect Response To Vaccination:

A new study reveals that men, but not women, vaccinated in the morning produced a better peak antibody response to both hepatitis A and the influenza strain. ———- Men vaccinated in the morning showed the strongest immune response. Almost twice as many men showed a twofold increase in antibody response when vaccinated in the morning as opposed to the afternoon.

Do We Think That Machines Can Think?:

When our PC goes on strike again we tend to curse it as if it was a human. The question of why and under what circumstances we attribute human-like properties to machines and how such processes manifest on a cortical level was investigated in a project led by Dr. Sören Krach and Prof. Tilo Kircher from the RWTH Aachen University (Clinic for Psychiatry and Psychotherapy) in cooperation with the Department of “Social Robotics” (Bielefeld University) and the Neuroimage Nord (Hamburg).

Surveying German Subs Sunk Off North Carolina During World War II:

NOAA will lead a research expedition July 7-26 to study the wrecks of three German submarines sunk by U.S. forces in 1942 off the coast of North Carolina during the Battle of the Atlantic.

Popular Fish, Tilapia, Contains Potentially Dangerous Fatty Acid Combination:

Farm-raised tilapia, one of the most highly consumed fish in America, has very low levels of beneficial omega-3 fatty acids and, perhaps worse, very high levels of omega-6 fatty acids, according to new research from Wake Forest University School of Medicine.

Scientists Integrate Data In Three Dimensions To Study Climate Effects On Young Fish:

From the surface, the two areas of ocean off the coasts of northern New Jersey and Long Island, New York look the same. But to NOAA scientists, the four-square-mile patches could not be more different as they view real-time underwater images and environmental data to try to figure out what lives there and how climate change is affecting marine life, especially very young fish.

Revolutionary Chefs? Not Likely, Shows Physics Research:

However much the likes of Jamie Oliver or Gordon Ramsay might want to shake up our diets, culinary evolution dictates that our cultural cuisines remain little changed as generations move on, shows new research.

Big Brains Arose Twice In Higher Primates:

After taking a fresh look at an old fossil, John Flynn, Frick Curator of Paleontology at the American Museum of Natural History, and colleagues determined that the brains of the ancestors of modern Neotropical primates were as small as those of their early fossil simian counterparts in the Old World. This means one of the hallmarks of primate biology, increased brain size, arose independently in isolated groups–the platyrrhines of the Americas and the catarrhines of Africa and Eurasia.

Fossil Feathers Preserve Evidence Of Color, Say Scientists:

The traces of organic material found in fossil feathers are remnants of pigments that once gave birds their color, according to Yale scientists whose paper in Biology Letters opens up the potential to depict the original coloration of fossilized birds and their ancestors, the dinosaurs.

New Coral Reefs Teeming With Marine Life Discovered In Brazil:

Scientists have announced the discovery of reef structures they believe doubles the size of the Southern Atlantic Ocean’s largest and richest reef system, the Abrolhos Bank, off the southern coast of Brazil’s Bahia state. The newly discovered area is also far more abundant in marine life than the previously known Abrolhos reef system, one of the world’s most unique and important reefs.

Half Of US Coral Reefs In ‘Poor’ Or ‘Fair’ Condition, NOAA Report States:

Nearly half of U.S. coral reef ecosystems are considered to be in “poor” or “fair” condition according to a new NOAA analysis of the health of coral reefs under U.S. jurisdiction.

Male Cyclists Risk Sexual Problems If They Don’t Choose The Right Bike:

Men who take up cycling in an effort to stay fit, do their bit for the environment or avoid spiralling motoring costs, could be harming their health if they don’t choose the right bicycle. That’s the stark warning from consultant urological surgeon Mr Vinod Nargund from St Bartholomew’s and Homerton Hospitals, London.

Sex Really Does Get Better With Age (Just Ask A 70 Year Old):

An increasing number of 70 year olds are having good sex and more often, and women in this age group are particularly satisfied with their sex lives, according to a study published on the British Medical Journal website.

Some Plants Can Adapt To Widespread Climate Change:

While many plant species move to a new location or go extinct as a result of climate change, grasslands clinging to a steep, rocky dale-side in Northern England seem to defy the odds and adapt to long-term changes in temperature and rainfall, according to a new study by scientists from Syracuse University and the University of Sheffield (United Kingdom) published online in the July 7 issue of the Early Edition of the Proceedings of the National Academy of Sciences (PNAS).

Seasonal Programmed Brain Cell Death Foiled In Living Birds:

Neurons in brains of one songbird species equipped with a built-in suicide program that kicks in at the end of the breeding season have been kept alive for seven days in live birds by researchers trying to understand the role that steroid hormones play in the growth and maintenance of the neural song system.

Flatfish Fossils Fill In Evolutionary Missing Link:

Hidden away in museums for more that 100 years, some recently rediscovered flatfish fossils have filled a puzzling gap in the story of evolution and answered a question that initially stumped even Charles Darwin.

There are 57 new articles in PLoS ONE this week, and it is hard to choose which ones to highlight!
Superfast Vocal Muscles Control Song Production in Songbirds:

Birdsong is a widely used model for vocal learning and human speech, which exhibits high temporal and acoustic diversity. Rapid acoustic modulations are thought to arise from the vocal organ, the syrinx, by passive interactions between the two independent sound generators or intrinsic nonlinear dynamics of sound generating structures. Additionally, direct neuromuscular control could produce such rapid and precisely timed acoustic features if syringeal muscles exhibit rare superfast muscle contractile kinetics. However, no direct evidence exists that avian vocal muscles can produce modulations at such high rates. Here, we show that 1) syringeal muscles are active in phase with sound modulations during song over 200 Hz, 2) direct stimulation of the muscles in situ produces sound modulations at the frequency observed during singing, and that 3) syringeal muscles produce mechanical work at the required frequencies and up to 250 Hz in vitro. The twitch kinematics of these so-called superfast muscles are the fastest measured in any vertebrate muscle. Superfast vocal muscles enable birds to directly control the generation of many observed rapid acoustic changes and to actuate the millisecond precision of neural activity into precise temporal vocal control. Furthermore, birds now join the list of vertebrate classes in which superfast muscle kinetics evolved independently for acoustic communication.

Birds Reveal their Personality when Singing:

Individual differences in social behaviour may have consequences for mate choice and sexual signalling, because partners should develop preferences for personalities that maximize reproductive output. Here we propose that behavioural traits involved in sexual advertisement may serve as good indicators of personality, which is fundamental for sexual selection to operate on temperament. Bird song has a prominent and well-established role in sexual selection, and it displays considerable variation among individuals with a potentially strong personality component. Therefore, we predicted that features of song would correlate with estimates of personality. In a field study of free-living male collared flycatchers, Ficedula albicollis, we characterised personality based on the exploration of an altered breeding environment, and based on the risk taken when a potential predator was approaching during a simulated territorial interaction. We found that explorative and risk-taker individuals consistently sang at lower song posts than shy individuals in the presence of a human observer. Moreover, males from lower posts established pair-bonds relatively faster than males from higher posts. Our results may demonstrate that risk taking during singing correlates with risk taking during aggression and with exploration, thus personality may be manifested in different contexts involving sexual advertisement. These findings are in accordance with the hypothesis that the male’s balance between investment in reproduction and risk taking is reflected in sexual displays, and it may be important information for choosy females that seek partners with personality traits enhancing breeding success.

Can Machines Think? Interaction and Perspective Taking with Robots Investigated via fMRI:

When our PC goes on strike again we tend to curse it as if it were a human being. Why and under which circumstances do we attribute human-like properties to machines? Although humans increasingly interact directly with machines it remains unclear whether humans implicitly attribute intentions to them and, if so, whether such interactions resemble human-human interactions on a neural level. In social cognitive neuroscience the ability to attribute intentions and desires to others is being referred to as having a Theory of Mind (ToM). With the present study we investigated whether an increase of human-likeness of interaction partners modulates the participants’ ToM associated cortical activity. By means of functional magnetic resonance imaging (subjects n = 20) we investigated cortical activity modulation during highly interactive human-robot game. Increasing degrees of human-likeness for the game partner were introduced by means of a computer partner, a functional robot, an anthropomorphic robot and a human partner. The classical iterated prisoner’s dilemma game was applied as experimental task which allowed for an implicit detection of ToM associated cortical activity. During the experiment participants always played against a random sequence unknowingly to them. Irrespective of the surmised interaction partners’ responses participants indicated having experienced more fun and competition in the interaction with increasing human-like features of their partners. Parametric modulation of the functional imaging data revealed a highly significant linear increase of cortical activity in the medial frontal cortex as well as in the right temporo-parietal junction in correspondence with the increase of human-likeness of the interaction partner (computer<functional robot<anthropomorphic robot<human). Both regions correlating with the degree of human-likeness, the medial frontal cortex and the right temporo-parietal junction, have been associated with Theory-of-Mind. The results demonstrate that the tendency to build a model of another's mind linearly increases with its perceived human-likeness. Moreover, the present data provides first evidence of a contribution of higher human cognitive functions such as ToM in direct interactions with artificial robots. Our results shed light on the long-lasting psychological and philosophical debate regarding human-machine interaction and the question of what makes humans being perceived as human.

Soldier-Specific Modification of the Mandibular Motor Neurons in Termites:

Social insects exhibit a variety of caste-specific behavioral tendencies that constitute the basis of division of labor within the colony. In termites, the soldier caste display distinctive defense behaviors, such as aggressively attacking enemies with well-developed mandibles, while the other castes retreat into the colony without exhibiting any aggressive response. It is thus likely that some form of soldier-specific neuronal modification exists in termites. In this study, the authors compared the brain (cerebral ganglion) and the suboesophageal ganglion (SOG) of soldiers and pseudergates (workers) in the damp-wood termite, Hodotermopsis sjostedti. The size of the SOG was significantly larger in soldiers than in pseudergates, but no difference in brain size was apparent between castes. Furthermore, mandibular nerves were thicker in soldiers than in pseudergates. Retrograde staining revealed that the somata sizes of the mandibular motor neurons (MdMNs) in soldiers were more than twice as large as those of pseudergates. The enlargement of MdMNs was also observed in individuals treated with a juvenile hormone analogue (JHA), indicating that MdMNs become enlarged in response to juvenile hormone (JH) action during soldier differentiation. This enlargement is likely to have two functions: a behavioral function in which soldier termites will be able to defend more effectively through relatively faster and stronger mandibular movements, and a developmental function that associates with the development of soldier-specific mandibular muscle morphogenesis in termite head. The soldier-specific enlargement of mandibular motor neurons was observed in all examined species in five termite families that have different mechanisms of defense, suggesting that such neuronal modification was already present in the common ancestor of termites and is significant for soldier function.

Lateral Transfer of a Lectin-Like Antifreeze Protein Gene in Fishes:

Fishes living in icy seawater are usually protected from freezing by endogenous antifreeze proteins (AFPs) that bind to ice crystals and stop them from growing. The scattered distribution of five highly diverse AFP types across phylogenetically disparate fish species is puzzling. The appearance of radically different AFPs in closely related species has been attributed to the rapid, independent evolution of these proteins in response to natural selection caused by sea level glaciations within the last 20 million years. In at least one instance the same type of simple repetitive AFP has independently originated in two distant species by convergent evolution. But, the isolated occurrence of three very similar type II AFPs in three distantly related species (herring, smelt and sea raven) cannot be explained by this mechanism. These globular, lectin-like AFPs have a unique disulfide-bonding pattern, and share up to 85% identity in their amino acid sequences, with regions of even higher identity in their genes. A thorough search of current databases failed to find a homolog in any other species with greater than 40% amino acid sequence identity. Consistent with this result, genomic Southern blots showed the lectin-like AFP gene was absent from all other fish species tested. The remarkable conservation of both intron and exon sequences, the lack of correlation between evolutionary distance and mutation rate, and the pattern of silent vs non-silent codon changes make it unlikely that the gene for this AFP pre-existed but was lost from most branches of the teleost radiation. We propose instead that lateral gene transfer has resulted in the occurrence of the type II AFPs in herring, smelt and sea raven and allowed these species to survive in an otherwise lethal niche.

Hedonic Taste in Drosophila Revealed by Olfactory Receptors Expressed in Taste Neurons:

Taste and olfaction are each tuned to a unique set of chemicals in the outside world, and their corresponding sensory spaces are mapped in different areas in the brain. This dichotomy matches categories of receptors detecting molecules either in the gaseous or in the liquid phase in terrestrial animals. However, in Drosophila olfactory and gustatory neurons express receptors which belong to the same family of 7-transmembrane domain proteins. Striking overlaps exist in their sequence structure and in their expression pattern, suggesting that there might be some functional commonalities between them. In this work, we tested the assumption that Drosophila olfactory receptor proteins are compatible with taste neurons by ectopically expressing an olfactory receptor (OR22a and OR83b) for which ligands are known. Using electrophysiological recordings, we show that the transformed taste neurons are excited by odor ligands as by their cognate tastants. The wiring of these neurons to the brain seems unchanged and no additional connections to the antennal lobe were detected. The odor ligands detected by the olfactory receptor acquire a new hedonic value, inducing appetitive or aversive behaviors depending on the categories of taste neurons in which they are expressed i.e. sugar- or bitter-sensing cells expressing either Gr5a or Gr66a receptors. Taste neurons expressing ectopic olfactory receptors can sense odors at close range either in the aerial phase or by contact, in a lipophilic phase. The responses of the transformed taste neurons to the odorant are similar to those obtained with tastants. The hedonic value attributed to tastants is directly linked to the taste neurons in which their receptors are expressed.

Effects of Unexpected Chords and of Performer’s Expression on Brain Responses and Electrodermal Activity:

There is lack of neuroscientific studies investigating music processing with naturalistic stimuli, and brain responses to real music are, thus, largely unknown. This study investigates event-related brain potentials (ERPs), skin conductance responses (SCRs) and heart rate (HR) elicited by unexpected chords of piano sonatas as they were originally arranged by composers, and as they were played by professional pianists. From the musical excerpts played by the pianists (with emotional expression), we also created versions without variations in tempo and loudness (without musical expression) to investigate effects of musical expression on ERPs and SCRs. Compared to expected chords, unexpected chords elicited an early right anterior negativity (ERAN, reflecting music-syntactic processing) and an N5 (reflecting processing of meaning information) in the ERPs, as well as clear changes in the SCRs (reflecting that unexpected chords also elicited emotional responses). The ERAN was not influenced by emotional expression, whereas N5 potentials elicited by chords in general (regardless of their chord function) differed between the expressive and the non-expressive condition. These results show that the neural mechanisms of music-syntactic processing operate independently of the emotional qualities of a stimulus, justifying the use of stimuli without emotional expression to investigate the cognitive processing of musical structure. Moreover, the data indicate that musical expression affects the neural mechanisms underlying the processing of musical meaning. Our data are the first to reveal influences of musical performance on ERPs and SCRs, and to show physiological responses to unexpected chords in naturalistic music.

Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy:

Epidemiological studies suggest that complex mental activity may reduce the risk for dementia, however an underlying mechanism remains unclear. Our objective was to determine whether individual differences in lifespan complex mental activity are linked to altered rates of hippocampal atrophy independent of global measures of neurodegeneration. Thirty seven healthy older individuals had their complex mental activity levels estimated using the Lifetime of Experiences Questionnaire (LEQ) and completed serial MRI investigations at baseline and three years follow-up. Hippocampal volume and semi-automatic quantitation of whole brain volume (WBV) and white matter hyperintensities (WMHs) were compared at both time points. Higher LEQ scores were correlated with hippocampal volume independent of covariates at the three year follow-up stage (r = 0.43, p = 0.012). Moreover, those with higher LEQ scores experienced less hippocampal atrophy over the follow-up period (r = 0.41, p = 0.02). High LEQ individuals had less than half the hippocampal volume decline of low LEQ individuals in a multivariate analysis (F = 4.47, p = 0.042). No parallel changes were found in measures of WBV and WMHs. High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy. This finding could not be explained by general differences in intracranial volume, larger hippocampi at baseline, presence of hypertensive disease, gender or low mood. Our results suggest that neuroprotection in medial temporal lobe may be one mechanism underlying the link between mental activity and lower rates of dementia observed in population-based studies. Additional studies are required to further explore this novel finding.

Waist Circumference and Body Mass Index as Predictors of Health Care Costs:

In the present study we analyze the relationship between body mass index (BMI) and waist circumference (WC) and future health care costs. On the basis of the relation between these anthropometric measures and mortality, we hypothesized that for all levels of BMI increased WC implies added future health care costs (Hypothesis 1) and for given levels of WC increased BMI entails reduced future health care costs (Hypothesis 2). We furthermore assessed whether a combination of the two measures predicts health care costs better than either individual measure. Data were obtained from the Danish prospective cohort study Diet, Cancer and Health. The population includes 15,334 men and 16,506 women 50 to 64 years old recruited in 1996 to 1997. The relationship between future health care costs and BMI and WC in combination was analyzed by use of categorized and continuous analyses. The analysis confirms Hypothesis 1, reflecting that an increased level of abdominal fat for a given BMI gives higher health care costs. Hypothesis 2, that BMI had a protective effect for a given WC, was only confirmed in the continuous analysis and for a subgroup of women (BMI<30 kg/m2 and WC <88 cm). The relative magnitude of the estimates supports that the regressions including WC as an explanatory factor provide the best fit to the data. The study showed that WC for given levels of BMI predicts increased health costs, whereas BMI for given WC did not predict health costs except for a lower cost in non-obese women with normal WC. Combining WC and BMI does not give a better prediction of costs than WC alone.

A Molecular Study of Microbe Transfer between Distant Environments:

Environments and their organic content are generally not static and isolated, but in a constant state of exchange and interaction with each other. Through physical or biological processes, organisms, especially microbes, may be transferred between environments whose characteristics may be quite different. The transferred microbes may not survive in their new environment, but their DNA will be deposited. In this study, we compare two environmental sequencing projects to find molecular evidence of transfer of microbes over vast geographical distances. By studying synonymous nucleotide composition, oligomer frequency and orthology between predicted genes in metagenomics data from two environments, terrestrial and aquatic, and by correlating with phylogenetic mappings, we find that both environments are likely to contain trace amounts of microbes which have been far removed from their original habitat. We also suggest a bias in direction from soil to sea, which is consistent with the cycles of planetary wind and water. Our findings support the Baas-Becking hypothesis formulated in 1934, which states that due to dispersion and population sizes, microbes are likely to be found in widely disparate environments. Furthermore, the availability of genetic material from distant environments is a possible font of novel gene functions for lateral gene transfer.

Phase Locking Induces Scale-Free Topologies in Networks of Coupled Oscillators:

An initial unsynchronized ensemble of networking phase oscillators is further subjected to a growing process where a set of forcing oscillators, each one of them following the dynamics of a frequency pacemaker, are added to the pristine graph. Linking rules based on dynamical criteria are followed in the attachment process to force phase locking of the network with the external pacemaker. We show that the eventual locking occurs in correspondence to the arousal of a scale-free degree distribution in the original graph.

Professional and Home-Made Face Masks Reduce Exposure to Respiratory Infections among the General Population:

Governments are preparing for a potential influenza pandemic. Therefore they need data to assess the possible impact of interventions. Face-masks worn by the general population could be an accessible and affordable intervention, if effective when worn under routine circumstances. We assessed transmission reduction potential provided by personal respirators, surgical masks and home-made masks when worn during a variety of activities by healthy volunteers and a simulated patient. All types of masks reduced aerosol exposure, relatively stable over time, unaffected by duration of wear or type of activity, but with a high degree of individual variation. Personal respirators were more efficient than surgical masks, which were more efficient than home-made masks. Regardless of mask type, children were less well protected. Outward protection (mask wearing by a mechanical head) was less effective than inward protection (mask wearing by healthy volunteers). Any type of general mask use is likely to decrease viral exposure and infection risk on a population level, in spite of imperfect fit and imperfect adherence, personal respirators providing most protection. Masks worn by patients may not offer as great a degree of protection against aerosol transmission.

A Visual Metaphor Describing Neural Dynamics in Schizophrenia:

In many scientific disciplines the use of a metaphor as an heuristic aid is not uncommon. A well known example in somatic medicine is the ‘defense army metaphor’ used to characterize the immune system. In fact, probably a large part of the everyday work of doctors consists of ‘translating’ scientific and clinical information (i.e. causes of disease, percentage of succes versus risk of side-effects) into information tailored to the needs and capacities of the individual patient. The ability to do so in an effective way is at least partly what makes a clinician a good communicator. Schizophrenia is a severe psychiatric disorder which affects approximately 1% of the population. Over the last two decades a large amount of molecular-biological, imaging and genetic data have been accumulated regarding the biological underpinnings of schizophrenia. However, it remains difficult to understand how the characteristic symptoms of schizophrenia such as hallucinations and delusions are related to disturbances on the molecular-biological level. In general, psychiatry seems to lack a conceptual framework with sufficient explanatory power to link the mental- and molecular-biological domains.
Here, we present an essay-like study in which we propose to use visualized concepts stemming from the theory on dynamical complex systems as a ‘visual metaphor’ to bridge the mental- and molecular-biological domains in schizophrenia. We first describe a computer model of neural information processing; we show how the information processing in this model can be visualized, using concepts from the theory on complex systems. We then describe two computer models which have been used to investigate the primary theory on schizophrenia, the neurodevelopmental model, and show how disturbed information processing in these two computer models can be presented in terms of the visual metaphor previously described. Finally, we describe the effects of dopamine neuromodulation, of which disturbances have been frequently described in schizophrenia, in terms of the same visualized metaphor. The conceptual framework and metaphor described offers a heuristic tool to understand the relationship between the mental- and molecular-biological domains in an intuitive way. The concepts we present may serve to facilitate communication between researchers, clinicians and patients.

Rare Microorganism That Produces Hydrogen May Be Key To Tomorrow’s Hydrogen Economy:

An ancient organism from the pit of a collapsed volcano may hold the key to tomorrow’s hydrogen economy. Scientists from across the world have formed a team to unlock the process refined by a billions-year old archaea. The U.S. Department of Energy Joint Genome Institute will expedite the research by sequencing the hydrogen-producing organism for comparative genomics.

Are Hands-free Cellphones Really Safer?:

Since April 1 when Nova Scotia outlawed the use of hand-held cellphones while driving, sales of hands-free devices have gone through the roof. It seems everyone’s driving–even walking–with tiny electronic devices tucked into their ears.

Good Golf Players See The Hole As Larger Than Poor Players:

Golfers who play well are more likely to see the hole as larger than their poor-playing counterparts, according to a Purdue University researcher.

Baby’s Smile Is A Natural High:

The baby’s smile that gladdens a mother’s heart also lights up the reward centers of her brain, said Baylor College of Medicine researchers in a report that recently appeared in the journal Pediatrics.

Children Born From Frozen Embryos Weigh More And Do Better Than Those Born After Fresh Transfer:

Children born after a frozen, thawed embryo has been replaced in the womb have higher birth weight than those born where fresh embryos were used, Danish scientists reported to the 24th annual conference of the European Society of Human Reproduction and Embryology July 8th. The mothers had longer pregnancies, and the children did not show an increased risk of congenital malformations, said Dr. Anja Pinborg, from the Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Crawling The Internet To Track Infectious Disease Outbreaks:

Could Internet discussion forums, listservs, and online news outlets be an informative source of information on disease outbreaks? A team of researchers from Children’s Hospital Boston and Harvard Medical School thinks so, and it has launched a real-time, automated data-gathering system called HealthMap to gather, organize and disseminate this online intelligence.

Early-life Nutrition May Be Associated With Adult Intellectual Functioning:

Adults who had improved nutrition in early childhood may score better on intellectual tests, regardless of the number of years they attended school, according to a new article.

Creating A New Approach To Archiving Human Genetic Information:

A genome sequence is a long sequence written in a four letter code–3 billion letters in the case of a human genome. But what is the meaning–how is the code deciphered? Traditionally this is left to professional annotators who use information from a number of sources (for instance, knowledge about similar genes in other organisms) to work out where a gene starts, stops, and what it does. Even the “gold standard” of professional annotation is an exceptionally slow process. However, new technology may provide a faster solution.

Why Mosquitoes Select Certain Outdoor Water Containers For Laying Eggs And Avoid Others:

North Carolina State University scientists have figured out one reason why pregnant yellow fever mosquitoes (Aedes aegypti), one of the most important disease transmitters worldwide, choose to lay their eggs in certain outdoor water containers while eschewing others. In a paper published in Proceedings of the National Academy of Sciences, the NC State researchers show that certain chemicals emanating from bacteria in water containers stimulate the female mosquitoes to lay their eggs. The female mosquitoes sense these chemical cues and decide that the water container is a preferable environment for their larvae to develop.

Can You Hear Me Now? Primitive Single-Celled Microbe Expert In Cellular Communication Networks:

When it comes to cellular communication networks, a primitive single-celled microbe that answers to the name of Monosiga brevicollis has a leg up on animals composed of billions of cells. It commands a signaling network more elaborate and diverse than found in any multicellular organism higher up on the evolutionary tree, researchers at the Salk Institute for Biological Studies have discovered.

Study Shows Rise In Cornwall’s Dolphin, Whale, And Porpoise Deaths:

Four weeks since the shocking incident that led to the death of 26 dolphins near Falmouth, research sheds new light on the extent of the problems facing Cornwall’s marine mammals.

A Gene Wiki for Community Annotation of Gene Function:

Gene portals (e.g., Entrez Gene [1] and Ensembl [2]) and model organism databases (e.g., Mouse Genome Database [3], Rat Genome Database [4], FlyBase [5]) are popular and useful tools for researching gene annotation and enforcing data standards. These databases provide a large volume and diversity of information on each gene, including protein and transcript sequences, genome location, genomic structure, aliases, links to literature, and gene function. These sites are considered to be the definitive sources for these types of gene annotation. However, by their very nature as authoritative annotation sources, the data displayed on these sites must be subjected to a high degree of oversight by expert curators. In short, the data model used by gene portals and model organism databases focuses on large contributions from a relatively small number of contributors.

Surveillance Sans Frontieres: Internet-Based Emerging Infectious Disease Intelligence and the HealthMap Project:

* Valuable information about infectious diseases is found in Web-accessible information sources such as discussion forums, mailing lists, government Web sites, and news outlets.
* Web-based electronic information sources can play an important role in early event detection and support situational awareness by providing current, highly local information about outbreaks, even from areas relatively invisible to traditional global public health efforts.
* While these sources are potentially useful, information overload and difficulties in distinguishing “signal from noise” pose substantial barriers to fully utilizing this information.
* HealthMap is a freely accessible, automated real-time system that monitors, organizes, integrates, filters, visualizes, and disseminates online information about emerging diseases.
* The goal of HealthMap is to deliver real-time intelligence on a broad range of emerging infectious diseases for a diverse audience, from public health officials to international travelers.
* Ultimately, the use of news media and other nontraditional sources of surveillance data can facilitate early outbreak detection, increase public awareness of disease outbreaks prior to their formal recognition, and provide an integrated and contextualized view of global health information.