This is the third of three parts of the lecture on physiology and the end of the course. Please fact-check, make it better.
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This is the third of three parts of the lecture on physiology and the end of the course. Please fact-check, make it better.
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Posted in Basic Biology, BIO101, Physiology, Science Education
This is the second of three parts of a lecture on this topic. Please fact-check, make it better.
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Posted in Basic Biology, BIO101, Physiology, Science Education
This is the first of three parts of a lecture on this topic. Please fact-check, make it better.
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Posted in Basic Biology, BIO101, Physiology, Science Education
In this lecture, as well as in the previous two, I tackle areas of Biology where I am really weak: origin of life, diversity of life, and taxonomy/systematics. The course is (somewhat intentionally) anthropo- and mammalo-centric, for adult non-science majors, but they do have to give talks about the biology of a plant and an animal later in the course. These are also areas where there has been a lot of change recently (often not yet incorporated into textbooks), and I am unlikely to be up-to-date, so please help me bring these lectures up to standards….
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Posted in Basic Biology, BIO101, Evolution, Science Education
In this lecture, as well as in the previous one and the next one, I tackle areas of Biology where I am really weak: origin of life, diversity of life, and taxonomy/systematics. These are also areas where there has been a lot of change recently (often not yet incorporated into textbooks), and I am unlikely to be up-to-date, so please help me bring these lectures up to standards….
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Posted in Basic Biology, BIO101, Evolution, Science Education
Today, and in the following two lectures, I tackle areas of Biology where I am really weak: origin of life, diversity of life, and taxonomy/systematics. These are also areas where there has been a lot of change recently (often not yet incorporated into textbooks), and I am unlikely to be up-to-date, so please help me bring these lectures up to standards….
Follow me under the fold:
Posted in Basic Biology, BIO101, Evolution, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we try to cover the vast field of ecology in just an hour, thus just a very basic survey of key terms and principles. Again, I do a lot of drawing on the whiteboard in this lecture, but have not reproduce any of that here.
See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101 – Cell-Cell Interactions
BIO101 – Cell Division and DNA Replication
BIO101 – From Two Cells To Many: Cell Differentiation and Embryonic Development
BIO101 – From Genes To Traits: How Genotype Affects Phenotype
BIO101 – From Genes To Species: A Primer on Evolution
BIO101 – What Creatures Do: Animal Behavior
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Posted in Basic Biology, BIO101, Ecology, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we discuss animal behavior. Note that I tend to do a lot of drawing on the whiteboard in this lecture, which is not seen in these notes. I also show a lot of short YouTube videos that show examples of strange animal behaviors.
See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101 – Cell-Cell Interactions
BIO101 – Cell Division and DNA Replication
BIO101 – From Two Cells To Many: Cell Differentiation and Embryonic Development
BIO101 – From Genes To Traits: How Genotype Affects Phenotype
BIO101 – From Genes To Species: A Primer on Evolution
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Posted in Animal Behavior, Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we introduce the concept of evolution, mainly via natural selection (sexual selection will come later in the course, and neutral selection etc. are too much for this level). Note that I tend to do a lot of drawing on the whiteboard in this lecture, which is not seen in these notes.
See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101 – Cell-Cell Interactions
BIO101 – Cell Division and DNA Replication
BIO101 – From Two Cells To Many: Cell Differentiation and Embryonic Development
BIO101 – From Genes To Traits: How Genotype Affects Phenotype
Follow me under the fold:
Posted in Basic Biology, BIO101, Evolution, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, I tackle the important but difficult task of explaining why “gene for” idea is wrong and how to think in a more sophisticated manner about the way genes affect phenotype.
See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101 – Cell-Cell Interactions
BIO101 – Cell Division and DNA Replication
BIO101 – From Two Cells To Many: Cell Differentiation and Embryonic Development
Follow me under the fold:
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we continue with the cell biology portion of the course – covering the way cells communicate with each other, something that will come up over and over again for the rest of the course. See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101 – Cell-Cell Interactions
BIO101 – Cell Division and DNA Replication
Follow me under the fold:
Continue reading
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we continue with the cell biology portion of the course – covering the way cells communicate with each other, something that will come up over and over again for the rest of the course. See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
BIO101: – Cell-Cell Interactions
Follow me under the fold:
Continue reading
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we continue with the cell biology portion of the course – covering the way cells communicate with each other, something that will come up over and over again for the rest of the course. See the previous lectures:
BIO101 – Biology and the Scientific Method
BIO101 – Cell Structure
BIO101 – Protein Synthesis: Transcription and Translation
Follow me under the fold:
Continue reading
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we continue with the cell – the basic processes of DNA transcription, RNA translation, and protein synthesis. See the previous lectures:
Biology and the Scientific Method
BIO101 – Cell Structure
Follow me under the fold:
Continue reading
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we continue into biology proper – the basic structure of a (mainly animal) cell. See the previous lectures:
Biology and the Scientific Method.
Follow me under the fold:
Continue reading
Posted in Basic Biology, BIO101, Science Education
As you may know, I have been teaching BIO101 (and also the BIO102 Lab) to non-traditional students in an adult education program for about twelve years now. Every now and then I muse about it publicly on the blog (see this, this, this, this, this, this and this for a few short posts about various aspects of it – from the use of videos, to the use of a classroom blog, to the importance of Open Access so students can read primary literature). The quality of students in this program has steadily risen over the years, but I am still highly constrained with time: I have eight 4-hour meetings with the students over eight weeks. In this period I have to teach them all of biology they need for their non-science majors, plus leave enough time for each student to give a presentation (on the science of their favourite plant and animal) and for two exams. Thus I have to strip the lectures to the bare bones, and hope that those bare bones are what non-science majors really need to know: concepts rather than factoids, relationship with the rest of their lives rather than relationship with the other sciences. Thus I follow my lectures with videos and classroom discussions, and their homework consists of finding cool biology videos or articles and posting the links on the classroom blog for all to see. A couple of times I used malaria as a thread that connected all the topics – from cell biology to ecology to physiology to evolution. I think that worked well but it is hard to do. They also write a final paper on some aspect of physiology.
Another new development is that the administration has realized that most of the faculty have been with the school for many years. We are experienced, and apparently we know what we are doing. Thus they recently gave us much more freedom to design our own syllabus instead of following a pre-defined one, as long as the ultimate goals of the class remain the same. I am not exactly sure when am I teaching the BIO101 lectures again (late Fall, Spring?) but I want to start rethinking my class early. I am also worried that, since I am not actively doing research in the lab and thus not following the literature as closely, that some of the things I teach are now out-dated. Not that anyone can possibly keep up with all the advances in all the areas of Biology which is so huge, but at least big updates that affect teaching of introductory courses are stuff I need to know.
I need to catch up and upgrade my lecture notes. And what better way than crowdsource! So, over the new few weeks, I will re-post my old lecture notes (note that they are just intros – discussions and videos etc. follow them in the classroom) and will ask you to fact-check me. If I got something wrong or something is out of date, let me know (but don’t push just your own preferred hypothesis if a question is not yet settled – give me the entire controversy explanation instead). If something is glaringly missing, let me know. If something can be said in a nicer language – edit my sentences. If you are aware of cool images, articles, blog-posts, videos, podcasts, visualizations, animations, games, etc. that can be used to explain these basic concepts, let me know. And at the end, once we do this with all the lectures, let’s discuss the overall syllabus – is there a better way to organize all this material for such a fast-paced class.
Today, we start with the very beginning – the introductory lecture on Biology and the Scientific Method. Follow me under the fold:
Posted in Basic Biology, BIO101, Philosophy, Science Education
Last week, my SciBling Jason Goldman interviewed me for his blog. The questions were not so much about blogging, journalism, Open Access and PLoS (except a little bit at the end) but more about science – how I got into it, what are my grad school experiences, what I think about doing research on animals, and such stuff. Jason posted the interview here, on his blog, on Friday, and he also let me repost it here on my blog as well, under the fold:
Reposted, as I needed to add a few of the most recent posts to the list – see under the fold:
Comments Off on Best Biology posts on A Blog Around The Clock
Posted in Basic Biology, Blogging
Now that this blog has won the ResearchBlogging.org Award in the Biology category, people are coming here and looking for biology posts. And on a blog with almost 10,000 posts, they may not be easy to find. So, I put together a collection of posts that I think are decent under the fold. Different lengths, styles, topics, reading-levels – hopefully something for everyone:
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Posted in Basic Biology, Blogging, Housekeeping
Last night, braving horrible traffic on the way there, and snow on the way back, I made my way to the N.C. Museum of Natural Sciences for the Darwin Day shark lecture co-organized by NESCent and the sneak preview of the Megalodon exhibit which officially opens today.
I have to say that the trip was very much worth making – the exhibit is excellent! I like the way the exhibit is making good use of the space – so many exhibits feel cluttered and an all-out assault on all of one’s senses. Upon entering the room, it looks quite sparse. Yet, once I started going around I saw how much it actually covers, how well organized the exhibit layout is, how much information (including a lot of new-to-me information) is included and presented so very clearly and tastefully, and how much it has something for everyone independent of age, background or interest. And of course – the fossils! Absolutely amazing and stunning fossils! From the magnificent Megalodon jaws, to some of the strangest teeth arrangements one has ever seen in any jaw of any animal.
Then, exhausted and a little faintly from the lack of food yesterday (yes, it was a busy day), I entered the lecture hall afraid I’d fall asleep or pass out in the middle of the talk. I need not have worried – Adam Summers is an amazing speaker. I was able not just to pay attention throughout, I was excited throughout the talk. For a jaded biologist and blogger, when many public lectures tend to present stuff already well known to me, it was refreshing to keep learning new stuff every couple of minutes or so. And not just new factoids, but new questions and new ways of thinking about them – why are sharks larger than bony fish, why sharks have no bone, how do sharks swim, how do sharks and bony fish manage to swim very fast, etc. Questions I never asked myself before.
There were things in there that are outside my realm of expertise, for which I am essentially a layman: engineering principles, a formula I am unfamiliar with, a couple of graphs….yet all of that was made very clear on an intuitive level. How? Because Adam is really good at using analogies (“think of this as…”) and metaphors (snuck into the description without any warning). Be it water-filters, armor, stacks of coins, or houses made of sponges, it all becomes vivid and immediately makes sense.
It is also obvious that a lot of research went into this, yet very few actual data were shown – only the key data that are essential to make the point. This is a public lecture – there is no need to drown the audience in gazillions of graphs and discussions of statistics. The slides, including the images and brief video clips were both beautiful and essential for grasping the point he is making. And then there was quite a lot of humor, mainly of the self-deprecating kind making fun of himself and his students in the context of scientist stereotypes – how they look, talk, think and behave.
All in all – well done. Who ever said that scientists don’t know how to communicate to lay audience, eh?
The list is now final. Here are the top 13:
#13 Deep-sea corals
#12: Yeti Crab
#11 Venus’s Flower Basket
#10: Echinothuriid Sea Urchins
#9: Bathynomus, the GIANT ISOPOD!!!!
#8 Red Lure Jellyfish
#7 Predatory Tunicates
#6: Giant Sea Spiders
#5 Barreleye Fish
#4 Gold-Footed or Scaly Foot Snail
#3 Flesh Eating Sponges
#2: Bone-Devouring Zombie Worms from Hell
#1 Vampire Squid
Comments Off on 27 Best Deep-Sea Species, take two
Posted in Basic Biology, Ecology, Environment, Invertebrates
An Evolutionary Look at Sperm Holds Secrets of Mobility, Fertility:
The fusion of sperm and egg succeeds in mammals because the sperm cells hyperactivate as they swim into the increasingly alkaline female reproductive tract. One fast-moving sperm drives on through the egg’s fertilization barrier.
Mammals have sperm with a tail that reacts when calcium ions enter a microscopic channel in the tail and make the sperm go into overdrive. In fact, four genes are needed to produce the so-called CatSper ion channel in the sperm tail that hypermotivates the sperm. The CatSper genes may someday be targeted in a male contraceptive: no calcium-ion channel gene = no sperm hyperactivity = no fertilization (infertility correlation to the gene blockage has been proven in mice).
The interesting thing is that mammals, reptiles, sea urchins, and even some primitive lower invertebrates, animals without backbones, have all of these four genes, while birds, insects, worms, frogs, and most fish species, do not, says co-author Xingjiang Cai, M.D., Ph.D., of the Duke Department of Cell Biology and the Duke Department of Medicine, in the Division of Cardiology.
The research is reported in: Cai X, Clapham DE (2008) Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex: CatSpers and CatSperβ. PLoS ONE 3(10): e3569. doi:10.1371/journal.pone.0003569
Abstract: The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex, together with an auxiliary subunit, CatSperβ. Here, we report a comprehensive comparative genomics study and evolutionary analysis of CatSpers and CatSperβ, with important correlation to physiological significance of molecular evolution of the CatSper channel complex. The development of the CatSper channel complex with four CatSpers and CatSperβ originated as early as primitive metazoans such as the Cnidarian Nematostella vectensis. Comparative genomics revealed extensive lineage-specific gene loss of all four CatSpers and CatSperβ through metazoan evolution, especially in vertebrates. The CatSper channel complex underwent rapid evolution and functional divergence, while distinct evolutionary constraints appear to have acted on different domains and specific sites of the four CatSper genes. These results reveal unique evolutionary characteristics of sperm-specific Ca2+ channels and their adaptation to sperm biology through metazoan evolution.
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Posted in Basic Biology, Physiology, Reproductive Health
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Posted in Basic Biology
Posted in Basic Biology
Time Lapse Of The Embryonic Development Of Drosophila Melanogast – Watch the top videos of the week here
Posted in Basic Biology
Olivia Judson is back in action on her blog, with a very interesting new post: Braking the Virus:
However — and this is where the opportunity to rewrite genes comes in — there is more than one way to specify most of the amino acids. Glutamine, for example, can also be written as CAA. Arginine can be written in six different ways; proline, in four. The reason for this is that the genetic code has a great deal of redundancy. Although there are 64 possible codons (4 different nucleotides for each of three positions), there are only 20 amino acids to be assigned to them. This means that the particular string of the three amino acids given above could be specified in 48 different ways.
Cells have evolved to take advantage of this by using different codons for different purposes. Genes for proteins that need to be made quickly tend to be composed of “favorite” codons — the ones that the cell has evolved to use frequently. Genes for “slow” proteins tend to be made of disfavored codons — the ones the cell uses rarely. The reason is that if a codon is rare, the cell takes longer to recognize it, so it gets translated more slowly. A protein from a gene made entirely of rare codons, or rare combinations of codons — for the combinations can matter, too — will thus be made with a fraction of the efficiency of the same protein made from favorite codons or codon combinations. (Certain codon combinations can slow down the cell’s reading machinery.)
Of course, as I am interested in biological timing, this got my attention. But, the differences in rates of translation between ‘slow’ and ‘fast’ combinations of codons is so small it is not sufficient to slow down processes all the way to 24 hours. Thus, in circadian clocks, most of the slowing down appears to happen after the protein has been synthetized, using various methods of post-translational modifications. I need to catch up on reading on this – there has been a lot published lately – and perhaps write a post that summarizes it.
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Posted in Basic Biology
Alex, Dan and John Wilkins have wise things to say about metaphors in biology, Big Biology and a recent article by Sir Paul Nurse.
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Posted in Basic Biology, Philosophy
Abbie and PZ chat about the recent discoveries in biology, how exciting those discoveries are, and how annoying it is when Creationists try to put a damper on such excitement:
Posted in Basic Biology, Evolution, Genetics, Science Education
Posted in Basic Biology, Fun, Science Education
A dozen or so years ago, I drove my Biochemistry prof to tears with questions – she had 200 people in front of her and she tried hard to make Biochem interesting enough not to get us all bored to tears, and she was pretty good at that, as much as it is possible not to make people bored to tears with Biochem. But my questions exasperated her mainly because she could not answer them, because, as I learned later, the field of biochemistry was not able to answer those questions yet at the time: questions about dynamics – how fast is a reaction, how long it takes for a pathway to go from beginning to end, how many individual molecules are synthesized per unit of time?, etc.
Well, the field is starting to catch up with my questions lately – adding the temporal dimension to the understanding of what is going on inside the cell. In today’s issue of PLoS Biology, there is a new article that is trying to address exactly this concern: Dynamics and Design Principles of a Basic Regulatory Architecture Controlling Metabolic Pathways:
Single-cell organisms must constantly adjust their gene expression programs to survive in a changing environment. Interactions between different molecules form a regulatory network to mediate these changes. While the network connections are often known, figuring out how the network responds dynamically by looking at a static picture of its structure presents a significant challenge. Measuring the response at a finer time scales could reveal the link between the network’s function and its structure. The architecture of the system we studied in this work–the leucine biosynthesis pathway in yeast–is shared by other metabolic pathways: a metabolic intermediate binds to a transcription factor to activate the pathway genes, creating an intricate feedback structure that links metabolism with gene expression. We measured protein abundance at high temporal resolution for genes in this pathway in response to leucine depletion and studied the effects of various genetic perturbations on gene expression dynamics. Our measurements and theoretical modeling show that only the genes immediately downstream from the intermediate are highly regulated by the metabolite, a feature that is essential to fast recovery from leucine depletion. Since the architecture we studied is common, we believe that our work may lead to general principles governing the dynamics of gene expression in other metabolic pathways.
You should also check out the editorial synopsis for the paper, as it places it nicely into the context – exactly the kind of context I was looking for, in vein, back in my Biochem class: The Fourth Dimension of Biochemical Pathways:
Even on a plain wall chart, the intricacies of a cell’s biochemical pathways can boggle the mind. Hundreds of interweaving routes create and consume thousands of intermediate compounds, which are regulated by a dizzying number of enzymes at every step–a drop in nutrient A turns on pathway B to make intermediate C that is converted to regulator D that stimulates gene E that creates enzyme F to divert intermediate G into pathway H to…whew!…make nutrient A. London’s famously complex subway system is a piker compared to even the simplest cell.
But a static map can’t depict the complexity of a subway system in motion, and a wall chart can’t capture the four-dimensional dynamism of a cell in action, because neither one captures the crucial dimension of time. It matters not only where a train is going, but when it will get there, and it matters not only whether a pathway can produce a nutrient, but how quickly it responds when the nutrient is depleted. In a new study, Chen-Shan Chin, Victor Chubukov, Hao Li, and colleagues begin to address this problem by using a novel method to track the time course of a cell’s response to depletion of the amino acid leucine. They show that the time responses of upstream and downstream segments differ dramatically, and they go on to develop a mathematical model that predicts the response of the pathway to experimental perturbations.
This paper is too fresh for the new carnival, but perhaps in 10 years we’ll look at it and say “it’s a classic!”
Update: The grandmaster himself, Larry, answers my questions. I guess that kinetics were outside of the syllabus for a non-majors class and my questions wasted everyone’s time, and I never had to take any other Biochem afterwards.
Posted in Basic Biology, Science News
Miriam points to this set of pictures of the development of the chicken embryo. As I have written before, I did have to learn how to precisely stage the chick embryos, both the older stages and the early stages, in order to manipulate them at exactly the right time. Cool pics.
Posted in Basic Biology, Birds, Science Education
According to the referrers pages of my Sitemeter, a lot of you are excited by strange penises, strange penises, strange penises and strange penises (or something like it). So, today we have to move to a different topic, traffic-be-damned, for those without phallic fixations. So, read on (first posted on July 21, 2006)….
Posted in Basic Biology
It takes 38 minutes for the E.coli genome to replicate. Yet, E.coli can bo coaxed to divide in a much shorter time: 20 minutes. How is this possible?
Larry poses the riddle and provides the solution.
The key is that complex biochemical processes are taught sequentially, one by one, because that is how we think and process information. Yet, unless there is a need for precise timing (in which case there will be a timer triggering the starts and ends of cellular events), most processes occur all the time, simultaneously, in parallel. How do we teach that?
Posted in Basic Biology, Genetics, Microorganisms, Science Education
When teaching human or animal physiology, it is very easy to come up with examples of ubiqutous negative feedback loops. On the other hand, there are very few physiological processes that can serve as examples of positive feedback. These include opening of the ion channels during the action potential, the blood clotting cascade, emptying of the urinary bladder, copulation, breastfeeding and childbirth. The last two (and perhaps the last three!) involve the hormone oxytocin. The childbirth, at least in humans, is a canonical example and the standard story goes roughly like this:
When the baby is ready to go out (and there’s no stopping it at this point!), it releases a hormone that triggers the first contraction of the uterus. The contraction of the uterus pushes the baby out a little. That movement of the baby stretches the wall of the uterus. The wall of the uterus contains stretch receptors which send signals to the brain. In response to the signal, the brain (actually the posterior portion of the pituitary gland, which is an outgrowth of the brain) releases hormone oxytocin. Oxytocin gets into the bloodstream and reaches the uterus triggering the next contraction which, in turn, moves the baby which further stretches the wall of the uterus, which results in more release of oxytocin…and so on, until the baby is expelled, when everything returns to normal.
As usual, introductory textbook material lags by a few years (or decades) behind the current state of scientific understanding. And a brand new paper just added a new monkeywrench into the story. Oxytocin in the Circadian Timing of Birth by Jeffrey Roizen, Christina E. Luedke, Erik D. Herzog and Louis J. Muglia was published last Tuesday night and I have been poring over it since then. It is a very short paper, yet there is so much there to think about! Oh, and of course I was going to comment on a paper by Erik Herzog – you knew that was coming! Not just that he is my friend, but he also tends to ask all the questions I consider interesting in my field, including questions I wanted to answer myself while I was still in the lab (so I live vicariously though his papers and blog about every one of them).
Unfortunately, I have not found time yet to write a Clock Tutorial on the fascinating topic of embryonic development of the circadian system in mammals and the transfer of circadian time from mother to fetus – a link to it would have worked wonderfully here – so I’ll have to make shortcuts, but I hope that the gist of the paper will be clear anyway.
Learn everything you need to know about protein structure, explained clearly and as simply as the topic allows:
Beta Strands and Beta Sheets
Loops and Turns
Levels of Protein Structure
Examples of Protein Structure
Evolution and Variation in Folded Proteins
I think these should be included into the Basic Concepts collection.
Update: Larry has put together a compilation of all his bog posts on Protein Structure.
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Posted in Basic Biology, Science Education
Get yourself free PDFs of old biology/taxonomy books and papers courtesy of Biodiversity Heritage Library:
Ten major natural history museum libraries, botanical libraries, and research institutions have joined to form the Biodiversity Heritage Library Project. The group is developing a strategy and operational plan to digitize the published literature of biodiversity held in their respective collections. This literature will be available through a global “biodiversity commons.”
Participating institutions:
* American Museum of Natural History (New York, NY)
* The Field Museum (Chicago, IL)
* Harvard University Botany Libraries (Cambridge, MA)
* Harvard University, Ernst Mayr Library of the Museum of Comparative Zoology (Cambridge, MA)
* Marine Biological Laboratory / Woods Hole Oceanographic Institution (Woods Hole, MA)
* Missouri Botanical Garden (St. Louis, MO)
* Natural History Museum (London, UK)
* The New York Botanical Garden (New York, NY)
* Royal Botanic Gardens, Kew (Richmond, UK)
* Smithsonian Institution Libraries (Washington, DC)
The participating libraries have over two million volumes of biodiversity literature collected over 200 years to support the work of scientists, researchers, and students in their home institutions and throughout the world. The 10 member libraries of the Biodiversity Heritage Library (BHL) members now have over 1.124 million pages of key taxonomic literature available on the web.
The BHL will provide basic, important content for immediate research and for multiple bioinformatics initiatives. For the first time in history, the core of our natural history and herbaria library collections will be available to a truly global audience. Web-based access to these collections will provide a substantial benefit to people living and working in the developing world — whether scientists or policymakers.
Hat-tip: Anne-Marie
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Posted in Basic Biology, Open Science
News from SCONC:
Oliver Smithies is the Nobel-Prize winner next door. A professor at UNC for almost 20 years, Smithies got the nod from Stockholm last fall. He will give a seminar at the Friday Center on Thursday March 6 at 6:30 p.m. in a lecture hosted by the Carolinas Chapter of the American Medical Writers Association.
Along with Mario Capecchi and Martin Evans, Smithies was recognized for his research on embryonic stem cells and DNA recombination in mammals. Their work on gene targeting in mice made it possible to study individual genes in health and disease–a fundamental breakthrough that affected all fields of biomedicine. Smithies has used gene targeting to develop mouse models for diseases such as cystic fibrosis, thalassemia, hypertension and atherosclerosis. A reception at 6:00 p.m. will precede the talk. The lecture will be held in the Redbud Room of the Friday Center in Chapel Hill
Posted in Basic Biology, North Carolina, Science Reporting
I tried to understand what DNA barcoding is, as everyone is talking about it. And I tried reading a couple of papers about it – I am a biologist, so I should have understood them, but nope, I was still in the dark.
So, what does one do? Waits for a science blogger to explain it. And so it happens, Karen explained it yesterday. I read it. Slowly and carefully. Only once. And I grokked it all!
Posted in Basic Biology, Evolution, Genetics