Yearly Archives: 2007

This is something you can help with

TR Gregory of Genomicron blog is trying to help his parents as they sell their house and move to Zambia to do good work there, working with the Livingstone Performing Arts Foundation to try to rebuild the old Livingstone Theater.:

The Livingstone Performing Arts Foundation (LiPAF) mission is to create and perform traditional and original works of music, song and dance which reflect the history, culture, languages and ethnic background of Zambia. Operating as a not for profit organization, LiPAF will enrich the community by providing opportunities for employment, sponsorship of a variety of needy programs and services, and educational programs on topics related to the human condition.

Look around the Foundation site and donate if you can.

The freshest look at the laboratories from the inside

What happens when you invite a bunch of high school students and a bunch of college students to do research over the summer in a bunch of biology labs AND you help them blog about the experience? You get amazing stories and great insights collected at Howard Hughes Precollege Program Summer 2007 and Student Research at Duke. Spend some time on both sites and look around. It is really amazing and eye-opening.

Storm World

stormworld%20cover.jpgUnfortunately, I will still be out of town for this, but if you are in the area on July 12th, you should go to Quail Ridge Books in Raleigh (it is in Ridgewood Shopping Center, 3522 Wade Ave.) at 7pm and meet my SciBling Chris Mooney. He is touring the country reading from his new book Storm World: Hurricanes, Politics, and the Battle Over Global Warming (website).
Last year, when he was touring with the “Republican War On Science” we had a grand time at his reading/signing and afterwards we, of course, had Miller Lite (at least he had, I chose something a little more beer-like). So, mark your calendars now and go and say Hi to Chris on the twelfth.

So many things to do, if I only knew how to get there!

This Tuesday at 7pm, you can come with me and learn everything you want to know about sea urchins at the Ask a Scientist event.
Then, next Friday or two, altough it is in the middle of the workday, I’d still like to go and see the Iron Science Teacher. Jennifer siad that it was great last Friday.
The PEZ museum is supposedly just a small room full of every single PEZ dispenser ever made, but it may be interesting to see if it is not too out of the way. And I’d love to see the Festival of Fire. Who wants to go with me?
I’d like to go to the Monterey Bay Aquarium and Research Institute, the Natural History Museum and the San Francisco Zoo.
I am too far from Giant Sequoias, but Redwoods are almost as big and I’d like to see them if time permits.
And of course, I’d like to meet more local bloggers, in smaller or larger groups, or one-on-one, for meals, meetups, at sciency places in town, or out in the wilderness. Perhaps at Drinking Liberally?
Just e-mail me…

Scienceblogs.com on Wikipedia

Here is the ScienceBlogs page, the embryonic version. Help us make it complete.

Open Access this week

First, I’d like to thank Darksyde for placing the discussion of Open Access science publishing on the front page of DailyKos. If you are a registered user there, go ahead and add your 2 cents to the conversation.
Matt at Behavioral Ecology Blog explains RSS, what it is, how it works and how to use it to get science news. Recommended.
Greg Laden is a Linux advocate. While I am not, I understand that, though Open Source and Open Access are not the same thing, they do go hand in hand in a way. Something to think about…
Bjorn Brembs provides me with some useful advice and ideas.
My SciBlings Josh Rosenau and Alex Palazzo discuss scientific publishing, present and future.
Two interesting articles I will study in detail:
Toward a Post – Academic Science Policy: Scientific Communication and the Collapse of the Mertonian Norms by David Kellogg
Using Social Psychology to Motivate Contributions to Online Communities
Finally, thanks to Mike the Mad Biologist, Anton Zuiker, Gus diZerega, Jacqueline of Element List, Stephen Downes and Melissa McEwen for celebrating my first day at work with me.

Books: “Biased Embryos and Evolution” by Wallace Arthur

Books: 'Biased Embryos and Evolution' by Wallace Arthur
This is a post from June 28, 2005, reviewing one of my favourite new evolution books (reposted here):

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GeneBlogging of the Week

Mendel’s Garden (Genetics Blog Carnival) #16 is up on Eye of DNA.

My picks from ScienceDaily

Life Elsewhere In Solar System Could Be Different From Life As We Know It:

The search for life elsewhere in the solar system and beyond should include efforts to detect what scientists sometimes refer to as “weird” life — that is, life with an alternative biochemistry to that of life on Earth — says a new report from the National Research Council. The committee that wrote the report found that the fundamental requirements for life as we generally know it — a liquid water biosolvent, carbon-based metabolism, molecular system capable of evolution, and the ability to exchange energy with the environment — are not the only ways to support phenomena recognized as life. “Our investigation made clear that life is possible in forms different than those on Earth,” said committee chair John Baross, professor of oceanography at the University of Washington, Seattle.

When Is A Worm Not A Worm? When It’s A Jellyfish…:

One of the world’s strangest creatures has found its long-lost kin. Oxford University scientists have discovered that an extremely rare gutless worm is related to sea anemones and jellyfish, rather than similar-looking animals, reports the journal Science. The finding could cause an evolutionary rethink.

Scientists Find Endangered Monkeys In Vietnam:

A team of scientists from WWF and Conservation International (CI) has discovered the world’s largest known population of grey-shanked doucs (Pygathrix cinerea), increasing chances that the Endangered monkey can be saved from extinction.

Color Is In The Eye Of The Beholder: New Study Examines Unusual Color Properties Of Pumpkin Seed Oil:

The unique makeup of the cells in our retina, as well as the specific physical properties of substances themselves, explain why we occasionally see things change color before our very eyes! Samo and Marko Kreft from the University of Ljubljana in Slovenia investigated this phenomenon using pumpkin seed oil as an example. They have just published their research online in Springer’s journal Naturwissenschaften.

Friday Weird Sex Blogging – Cooling The Balls

Friday Weird Sex Blogging - Cooling The BallsWhat?….

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ClockQuotes

Life is a sleep, love is a dream; and you have lived if you have loved.
– De Musset

Yup, I had the rabbit!

And some other non-descript meats. And great Italian wine. In the great atmosphere of Incanto. In the company of some wonderful people, including, among others, my SciBling Sandra Kiume:

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Did A Virus Make You Smart?

Did A Virus Make You Smart?Not really a review of Greg Bear’s “Darwin’s Radio” and “Darwin’s Children” but musing (practically SF itself) on the topic of these books (from April 20, 2005, also reposted here so you can see the comments):

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Just a few pictures from last night

Jennifer Ouellette has the whole story, but here are a few more pictures (under the fold).
We met at Betelnut restaurant last night – Jennifer, Kristin Abkemaier (formerly of the ‘Radioactive Banana’ blog), Jeff and Curtis of the Jeff’s Bench Science 2.0 site, and my old friends from Chapel Hill, now San Francisco transplants, Justin Watt and Josh Steiger:

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Friday Weird Sex Blogging – The Birds Do It….

Friday Weird Sex Blogging - The Birds Do It....You should check out all of my SiBlings’ Friday Blogging practices, then come back here for a new edition of Friday Weird Sex Blogging. Last week you saw an example of a corkscrew penis. But that is not the only one of a kind. See more under the fold (first posted on July 14, 2006)…

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ClockQuotes

To believe in one’s dreams is to spend all of one’s life asleep.
– Chinese proverb

First day….

PLoS%20first%20day.jpg
Enjoying the computer. Everything works!
More pictures and stuff later – I am exhausted (and a little jet-lagged) so it’s time for bed….

Sleep Schedules in Adolescents

Sleep Schedules in AdolescentsEarlier this year, during the National Sleep Awareness Week, I wrote a series of posts about the changes in sleep schedules in adolescents. Over the next 3-4 hours, I will repost them all, starting with this one from March 26, 2006. Also check my more recent posts on the subject here and here…

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Today’s Carnivals

Scientiae carnival: responsibility is up on Amelie’s Welt.
The Carnival of Education #126 is up on NYC Educator.
Friday Ark #146 is up on The Modulator.
Carnival of Homeschooling: Independence Edition is up on HomeSchoolCafe.

First Day at PloS

I Support the Public Library of ScienceThis post has been written in advance and scheduled for automatic posting. At the time this post shows up, I’ll be sleeping my first night in San Francisco. A few hours later, I’ll be at PLoS offices and will hopefully have online access soon after so I can post my first impressions.
As most of you probably know, I got a job as an Online Community Coordinator at PLoS ONE. Today is my first day at the job! I got the job in an unusual way as well – by posting about it on my blog (and the managing editor posting a comment “Is this a formal application?”). The rest is, as they say, history. To make this post shorter, I have blogged about the job before, about the way I got the job, and some of my thoughts about what I want to do with it, so check out the relevant posts:
I Want This Job!
Update on ‘I Want This Job’
Off to SF
Back from SF
Updates
It’s Official
While my CV and the cover letter were fine, what really got me the job were my blog commenters! That is: YOU! You demonstrated my ability to build an online community better than any Resume can reveal. Although, to be fair, it took me three years to build this community and now I have three months to build one on PLoS! So, I need your help and I am unabashedly begging for it.
So, my #1 goal (and there are other coooool goals I’ll tell you about later) is to dramatically increase the number of comments and annotations on the PLoS ONE papers, without compromising their quality. I have many ideas how to go about it, and so do the other members of the PLoS team, but I am always interested in hearing others (comments section of this post is a perfect place for just such ideas you may have).
For the time being, I will start with raising quantity first, i.e., trying to grow some numbers, e.g., overall traffic, number of return visitors, time spent on site, pageview/visit ratio, etc., building a critical mass until it reaches a threshold at which I will have to also deal with quality (you know the rule on blogs – more comments there are, lower the level of discourse).
Scientists are generally shy about posting stuff online, but a growing number of science bloggers shows that it is possible for them to change their habits! Please help me in that difficult task 😉 After all, you are the ones who are comfortable commenting – so if you set the example and start posting comments, the more reluctant scientists will hopefully follow suit.
As you are aware of, commenting is a positive feedback loop. If you go to a blog post (or a PLoS ONE paper) and see “0 comments” you are unlikely to be the first one to comment (but you are still more likely to do so than a scientist with no experience on blogs whatsoever!). But if you see “3 comments” or “7 comments” or “35 comments” you will be curious and you will click to see what others are saying. By the time you are done reading through the comments, you are already deeply involved and thus much more likely to decide to post a comment of your own (especially if you disagree with some statement there).
While scientists are secretive and shy by training, they are still people. The non-blogging scientists may have very high thresholds, but they do have thresholds! If they see a number of comments there and see something erroneous posted there, they will post a rebuttal, I hope. I need you – the bloggers – to bring the commenting threads up to the threshold levels at which non-blogging scientists will start kicking in. Then, hopefully, there will be a snowball effect and over the long run the growth of commenting will become organic (i.e., I will not need to bug you about this any more).
Here are some broad ideas about Science 2.0 I have (and I will give you particulars on what PLoS-ONE will do in the near future in later posts):
PLoS 500
Science 2.0
Nature Precedings
I will keep using my own blog as part of my toolkit at the job (subscribe/blogroll/bookmark it if you want so you can see the updates here as soon as I post them) and updates will appear here on my blog (and on the PLoS Blog as well). No, this does not mean I will quit blogging about other topics!
What should you expect me to ask/tell you in future job-related posts?
Usually, I will ask you to go to a particular page on PLoS site and do one or more of the following:
– take a look at the visual/psychological effect of the changes we made to the site and give me feedback about it
– test a new application we introduced on the site and let me know how it works and how it can be improved
– post a comment or annotation yourself (on a specific paper, or a paper of your own choice)
– ask the readers of your blog/website/newsgroup/mailing-list to do some of the above.
It’s all voluntary, of course. Do it if you feel like it, and are comfortable doing it, and have time, and are in just the right mood at the time…
Although, heed Orli’s words: “…as we all know, saying no to Bora means courting bad karma…” 😉
In order for you to be able to do this, i.e., to be able to compare the ‘before’ and ‘after’, I’d like you (and your readers) to go over the next few days and familarize yourself with PLoS ONE, its look and feel.
Also, you may want to get more familiar with PLoS as a whole, with all of its journals and with the principle of Open Access.
It will also be helpful if you register for the site, subscribe to RSS feeds of journals, and to e-mail notifications of new articles.
You can also help me if you use some of these ready-made PR materials (cool banners for your sidebars!) and here are some other ideas of the ways you can help.
You can join the PLoS group and PLoS cause on Facebook and invite all your ‘friends’ to join. On another social network? Start a support group yourself there!
One of the first things I am going to do is try to breathe new life into the PLoS Blog and make it a pretty central (and more frequently updated) spot on the site. As Technorati annual reports found out, it is not the age or quality that determines which blogs are popular and highly ranked, but the frequency and regularity of posting. This may also require some re-design. So, it is not a bad idea for you to subscribe to its feed and to check in regularly and post comments. Linking to its posts or placing them on services like digg, delicious, stumbleupon and redditt will also be appreciated.
Finally, go to the Sandbox and try your hand at annotations and comments before you do it on a real paper. Once you are comfortable with the process, find papers in your area of expertise and post a comment – it does not need to be very detailed (or a criticism of the work!). Authors will appreciate it if you tell them that you like the paper in 1-2 nice short sentences as well.
Oh, almost forgot – think about publishing your papers in PLoS-ONE. The average time between submission and publication is 19 days! More than 500 papers have already been published and several are added every week. And you get feedback from colleagues and your paper is likely to be cited more than if it was behind a pay wall. As long as it is good science and well written, it is acceptable. It does not need to be Earth-shaking, revolutionary stuff that goes to Science or Nature (though that is certainly acceptable!). It does not need to be of ‘general interest’ either – a very specialized paper is fine. Also, while currently most of the papers are in the biology/genetics/medicine areas, the journal takes anything from math to archaeology so please help us become more diverse!
Oh, another thing – if you are in Bay Area (San Francisco, California, USA) during July and would like to meet me in person, let me know.
Oh, and tell your friends…

ClockQuotes

When we drink, we get drunk. When we get drunk, we fall asleep. When we fall asleep, we commit no sin. When we commit no sin, we go to heaven. Sooooo, let’s all get drunk and go to heaven!
– Brian O’Rourke

I am in….

…Frisco.
The flights were smooth and uneventful.
I went straight to PLoS, met some people I knew from before and others I knew only over e-mail, did the requisite paperwork, got familiarized with my computer and the beginning of getting familiarized with the ‘behind the scenes’ of the software used by PLoS journals.
My apartment is gorgeous – the owner must be an artist of some kind (probably pottery, as she is spending this month in North Carolina at Pendletonn school) as the place is so artistically and tastefully furnished and decorated.
SF is a very hilly place – I will get fit and develop big leg muscles walking uphill both ways. It took some mountain-climbing this afternoon wondering around the neighborhood and finding a store….
Tomorrow is the first official work day and I’ll probably have something to say about it. I also brought the camera and I’ll try not to forget to take some pictures everywhere I go.

Tangled Skeptics

Tangled Bank #83 is up on Aardvarchaeology
64th Skeptics’ Circle is up on The Sceptical Alchemist.

My Picks From ScienceDaily

Understanding Smooth Eye Pursuit: The Incredible Targeting System Of Human Vision:

Researchers at the University of Pennsylvania have shed new light on how the brain and eye team up to spot an object in motion and follow it, a classic question of human motor control. The study shows that two distinctly different ways of seeing motion are used – one to catch up to a moving object with our eyes, a second to lock on and examine it.

Wolves Of Alaska Became Extinct 12,000 Years Ago, Scientists Report:

The ancient gray wolves of Alaska became extinct some 12,000 years ago, and the wolves in Alaska today are not their descendents but a different subspecies, an international team of scientists reports in the July 3 print edition of the journal Current Biology.

Reap What Your Ancestors Sowed: Cheating Has Long-term Consequences In Evolution Of Cooperation:

Freeloaders can live on the fruits of the cooperation of others, but their selfishness can have long-term consequences, reports an evolutionary biologist from The University of Texas at Austin in a new study.

Altruistic Rats: First Evidence For Generalized Reciprocal Cooperation In Non-humans:

Cooperation in animals has long been a major focus in evolutionary biology. In particular, reciprocal altruism, where helpful acts are contingent upon the likelihood of getting help in return, is especially intriguing because it is open to cheaters. In a new study published this week in the open-access journal PLoS Biology, Claudia Rutte and Michael Taborsky demonstrate the first evidence for generalized reciprocal cooperation in non-humans. The authors show that rats who received help in the past were more likely to help another unknown partner.

Mother-of-pearl: Classic Beauty And Remarkable Strength:

While the shiny material of pearls and abalone shells has long been prized for its iridescence and aesthetic value in jewelry and decorations, scientists admire mother-of-pearl for other physical properties as well.

Friday Weird Sex Blogging – Corkscrewing

Friday Weird Sex Blogging - CorkscrewingYou really think I am going to put this above the fold? No way – you have to click (First posted on July 7, 2006):

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ClockQuotes

Be anchored to some ideal, philosophy or cause that keeps you too excited to sleep.
– Brian Koslow

I’m off…

I am about to go offline now, early to bed, early to rise…travelling to San Fran tomorrow at dawn. Hopefully I’ll be able to get back online by tomorrow afternoon.
I have scheduled a lot of reruns of the old posts (twice a day) and new quotes (once per night), but I will post new stuff as well whenever I find time: the first day at PLoS, pictures from various blogger meetups (excluding the pictures of pseudonymous bloggers), pictures of my strange meal at Incanto…and on Monday morning something you’ll probably find interesting but it is a secret right now.

Liberal Blogging of the Fortnight

The July 4th edition of the Carnival of the Liberals is up on Zaius Nation.

My Picks From ScienceDaily

Stressed-out African Naked Mole-rats May Provide Clues About Human Infertility:

A tiny, blind, hairless subterranean rodent that lives in social colonies in the harsh, semi-arid conditions of Africa could shed light on stress-related infertility in humans, the 23rd annual meeting of the European Society of Human Reproduction and Embryology will hear.

Glimmer Of Hope For Tahitian Tree Snails’ Survival:

Despite the mass extermination of Tahiti’s unique species of tree snails in recent decades, much of their original genetic diversity can still be found in remnant populations that survive on the island, researchers report in the July 3rd issue of Current Biology, a Cell Press publication. The findings offer renewed hope that targeted conservation measures may yet preserve a representative, although impoverished, fraction of Tahiti’s endemic tree snail genetic diversity in the wild–a feat earlier believed to be impossible.

Jellyfish Population Explosion Leads To New Use For Waste Creatures:

Amid growing concern about how to dispose of a booming population of jellyfish — including 6-foot-long monsters weighing more than 400 pounds — scientists in Japan are reporting development of a process for extracting a commercially-valuable biomaterial from the marine animals. Their report is scheduled for the July 27 issue of ACS’ Journal of Natural Products, a monthly publication.

Advancing Research On Interplay Between Biology And Society:

Scientists will find new ways of understanding the interactions of the biological sciences with society, as a result of awards from the National Science Foundation’s (NSF) directorates for biological sciences and for social, behavioral, and economic sciences.

Sex On The Brain (of the science reporters)

Sex On The Brain (of the science reporters)This post was a response to a decent (though not too exciting) study and the horrible media reporting on it. As the blogosphere focused on the press releases, I decided to look at the paper itself and see what it really says. It was first posted on August 09, 2005. Under the fold (reposted on July 12, 2006)…

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ClockQuotes

# Diary, n. A daily record of that part of one’s life, which he can relate to himself without blushing.
– Ambrose Bierce

Happy Fourth of July!

And to my Yugoslav readers: “Srecan Dan Borca!”

New science blogger joins Shakesville

Quixote (who some of you may know from Acid Test) has joined the growing stable of brilliant bloggers at Shakesville – check out the introductiory post.

Obligatory Readings of the Day – Science 2.0

Interview with Timo Hannay, Head of Web Publishing, Nature Publishing Group
Scientific Communications in Web 2.0 Context
Publishing Versus Posting: Nature Magazine Turns to a Conversational Content Model

Why People Write?

I don’t know, but Grrrl and Archy tried to answer that question…

New and Exciting on PLoS-ONE

A bunch of papers just went live on PLoS-ONE and, after a quick scan, these three papers caught my eye:
The Durability of Public Goods Changes the Dynamics and Nature of Social Dilemmas:

An implicit assumption underpins basic models of the evolution of cooperation, mutualism and altruism: The benefits (or pay-offs) of cooperation and defection are defined by the current frequency or distribution of cooperators. In social dilemmas involving durable public goods (group resources that can persist in the environment-ubiquitous from microbes to humans) this assumption is violated. Here, we examine the consequences of relaxing this assumption, allowing pay-offs to depend on both current and past numbers of cooperators. We explicitly trace the dynamic of a public good created by cooperators, and define pay-offs in terms of the current public good. By raising the importance of cooperative history in determining the current fate of cooperators, durable public goods cause novel dynamics (e.g., transient increases in cooperation in Prisoner’s Dilemmas, oscillations in Snowdrift Games, or shifts in invasion thresholds in Stag-hunt Games), while changes in durability can transform one game into another, by moving invasion thresholds for cooperation or conditions for coexistence with defectors. This enlarged view challenges our understanding of social cheats. For instance, groups of cooperators can do worse than groups of defectors, if they inherit fewer public goods, while a rise in defectors no longer entails a loss of social benefits, at least not in the present moment (as highlighted by concerns over environmental lags). Wherever durable public goods have yet to reach a steady state (for instance due to external perturbations), the history of cooperation will define the ongoing dynamics of cooperators.

Leveraging Hierarchical Population Structure in Discrete Association Studies:

Population structure can confound the identification of correlations in biological data. Such confounding has been recognized in multiple biological disciplines, resulting in a disparate collection of proposed solutions. We examine several methods that correct for confounding on discrete data with hierarchical population structure and identify two distinct confounding processes, which we call coevolution and conditional influence. We describe these processes in terms of generative models and show that these generative models can be used to correct for the confounding effects. Finally, we apply the models to three applications: identification of escape mutations in HIV-1 in response to specific HLA-mediated immune pressure, prediction of coevolving residues in an HIV-1 peptide, and a search for genotypes that are associated with bacterial resistance traits in Arabidopsis thaliana. We show that coevolution is a better description of confounding in some applications and conditional influence is better in others. That is, we show that no single method is best for addressing all forms of confounding. Analysis tools based on these models are available on the internet as both web based applications and downloadable source code at http://atom.research.microsoft.com/bio/phylod.aspx.

Super-Genotype: Global Monoclonality Defies the Odds of Nature:

The ability to respond to natural selection under novel conditions is critical for the establishment and persistence of introduced alien species and their ability to become invasive. Here we correlated neutral and quantitative genetic diversity of the weed Pennisetum setaceum Forsk. Chiov. (Poaceae) with differing global (North American and African) patterns of invasiveness and compared this diversity to native range populations. Numerous molecular markers indicate complete monoclonality within and among all of these areas (FST = 0.0) and is supported by extreme low quantitative trait variance (QST = 0.00065-0.00952). The results support the general-purpose-genotype hypothesis that can tolerate all environmental variation. However, a single global genotype and widespread invasiveness under numerous environmental conditions suggests a super-genotype. The super-genotype described here likely evolved high levels of plasticity in response to fluctuating environmental conditions during the Early to Mid Holocene. During the Late Holocene, when environmental conditions were predominantly constant but extremely inclement, strong selection resulted in only a few surviving genotypes.

Blogrolling for Today

Blooking Central


Clear Thinking


History Hunters International


Crappy Graphs


RRRGroup


Average Earthman


Brad Buchsbaum’s Blog

A naturally occuring mutation of the core clock gene timeless in European Drosophila affects photoperiodic response

Surprise, surprise – a paper in Science is up there with a free online access (not the PDF, but the Full Text and that is something!):
A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster:

Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly because it enhances diapause. We show that the mutant allele attenuates the photosensitivity of the circadian clock and causes decreased dimerization of the mutant TIMELESS protein isoform to CRYPTOCHROME, the circadian photoreceptor. This interaction results in a more stable TIMELESS product. These findings reveal a molecular link between diapause and circadian photoreception.
————snip—————
A reduced L-TIM/CRY interaction may explain the differences in the fly’s circadian photoresponsiveness and the enhanced L-TIM stability. The observation that ls-tim females are more prone to diapause at any day length (1) is also consistent with the results presented here. As in the corresponding diapause profiles (1), the transformants conclusively reveal that the circadian photoresponsive phenotypes of natural tim variants are not due to linkage disequilibrium between tim and a nearby locus, but they are attributable to tim itself. Furthermore, the similarity in behavior of natural s-tim variants and P[S-TIM] transformants suggests that the residual putative truncated N-terminal 19-residue TIM product from the s-tim allele does not play any major role in the phenotypes we have studied (2).
It has been argued that the light sensitivity of the circadian clock needs to be abated in temperate zones because of the dramatic increase in summer day lengths in northern latitudes (18, 19). One mechanism for this process involves a reduced sensitivity to light-induced disturbance by having a higher pacemaker amplitude (18, 19). However, the amplitude of TIM cycling in DD was not significantly different between the two variants (fig. S1), nor were there any significant differences in amplitude or phase of the tim mRNA cycle between the s-tim and ls-tim genotypes (fig. S2). Another way to attenuate circadian photoresponsiveness in temperate zones may be by filtering light input into the clock. The molecular changes to the L-TIM protein may buffer the circadian response to light in ls-tim individuals, even in the presence of S-TIM, and may contribute to the positive Darwinian selection observed for ls-tim in the European seasonal environment (1).

So, here is another nice evidence for the connection between the core circadian clock and the photoperiodic response found in a nice evolutionary and ecological context.

Altruism in rats

There is a new paper on PLoS-Biology describing a tit-for-tat-like reciprocal behavior in rats: Generalized Reciprocity in Rats:

The evolution of cooperation is based on four general mechanisms: mutualism, where an action benefits all partners directly; kin selection, where related individuals are supported; “green beard” altruism that is based on a genetic correlation between altruism genes and respective markers; and reciprocal altruism, where helpful acts are contingent upon the likelihood of getting help in return. The latter mechanism is intriguing because it is prone to exploitation. In theory, reciprocal altruism may evolve by direct, indirect, “strong,” and generalized reciprocity. Apart from direct reciprocity, where individuals base their behavior towards a partner on that partner’s previous behavior towards themselves, and which works under only highly restrictive conditions, no other mechanism for reciprocity has been demonstrated among conspecifics in nonhuman animals. Here, we tested the propensity of wild-type Norway rats to help unknown conspecifics in response to help received from other unknown partners in an instrumental cooperative task. Anonymous receipt of help increased their propensity to help by more than 20%, revealing that nonhuman animals may indeed show generalized reciprocity. This mechanism causes altruistic behavior by previous social experience irrespective of partner identity. Generalized reciprocity is hence much simpler and therefore more likely to be important in nature than other reciprocity mechanisms.

Kate wrote a clear and excellent summary of the study.

Free Access or Open Access?

Buyer beware! Not everything in science publishing that calls itself Open Access actually is so.

My Picks From ScienceDaily

Wood Ant Queen Has No Egg-laying Monopoly:

The reproductive monopoly of the ant queen is not as strong as is often thought. Dr. Heikki Helanterä and Prof. Lotta Sundström, biologists working at the University of Helsinki, Finland, investigated worker ovary development and egg laying in nine Northern European wood ant species of the genus Formica, and revealed wide spread reproductive endeavours by workers.

City Site Was Dinosaur Dining Room:

A dinosaur bone bed in southwest Edmonton that served as a feeding area for the direct ancestor of Tyrannosaurus rex has revealed that two dinosaurs, thought to have lived in different eras, actually lived at the same time. Scientists digging for bones at the site this year discovered fossils of Edmontosaurus and Saurolophus this year.

Translating Form Into Function:

In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they’ve been stumped trying to translate the structure into an understanding of function — what the enzyme actually does in the body. This puzzle has hindered drug discovery, since many of the most successful drugs work by blocking enzyme action. Now, in an expedited article in Nature, researchers show that a solution to the puzzle is finally in sight.

Scientists Find Endangered Grey-shanked Doucs In Vietnam:

A team of scientists from WWF and Conservation International (CI) has discovered the world’s largest known population of grey-shanked doucs (Pygathrix cinerea), increasing chances that the Endangered monkey can be saved from extinction.

ClockQuotes

All architecture is great architecture after sunset; perhaps architecture is really a nocturnal art, like the art of fireworks.
– Gilbert Keith Chesterton

Shakesville is back

Yes, Shakesville is online again, but the new dedicated server (that will repel the future Denials of Service) costs money. You can help it survive with a couple of bucks every now and then.

Invertebrates Rule!

Circus of the Spineless #22 is up on Burning Silo.

SB Survey

The Seed Overlords have put up a survey for our blog readers. You can go here or just click on the green box on the right side-bar and tell them all how you use the site, what you like and dislike, etc., so the improvements can be made in the future.
Do we really need more sly sex on our blogs?

Chronic vs. Acute Sleep Deprivation

In all animals, vertebrate and invertebrate alike, one of the defining features of sleep is the “rebound”, i.e., the making up for sleep debt after an acute sleep deprivation event. However, the problem of modern society is a chronic sleep loss in humans – when you loos a couple of hours of needed sleep every day.
Now, a team at Northwestern studied the effects of chronic sleep loss and, lo and behold – bad news! There is no rebound after chronic sleep deprivation.
Chronically sleep deprived? You can’t make up for lost sleep:

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In the study, the researchers kept animals awake for 20 hours per day followed by a four-hour sleep opportunity, over five consecutive days. The team monitored brain wave and muscle activity patterns in order to precisely quantify sleep-wake patterns.
After the first day of sleep loss, animals compensated by increasing their intensity, or depth, of sleep, which is indicative of a homeostatic response. However, on the subsequent days of sleep loss, the animals failed to generate this compensatory response and did not sleep any more deeply or any longer than they did under non-sleep deprived conditions (baseline measurements). At the end of the study, the animals were given three full days to sleep as much as they wanted. Amazingly, they recovered virtually none of the sleep that was lost during the five-day sleep deprivation period.
The findings support what other scientists have discovered in recent experimental studies in humans. Chronic partial sleep loss of even two to three hours per night was found to have detrimental effects on the body, leading to impairments in cognitive performance, as well as cardiovascular, immune and endocrine functions. Sleep-restricted people also reported not feeling sleepy even though their performance on tasks declined.
The Northwestern team s results suggest that animals may undergo a change in their need for sleep, or in their sleep homeostat, in situations where normal sleep time is prohibited or where sleep could be detrimental for survival. An extreme but realistic example of this, says Turek, would be how animals respond to catastrophic environmental conditions, such as Hurricane Katrina. No matter how sleep deprived an animal or human may be, it would not be adaptive for the sleep homeostat to kick in and to make the animal fall sleep when it is in the midst of a flood or forest fire. Therefore, the body undergoes some change that allows it to counter its homeostatic need for sleep and to stay awake to avoid danger.
Turek and his team propose that this change in the sleep regulatory system is reflective of an allostatic response. In the short term, allostatic responses are adaptive, but when sustained on a chronic basis, such as in their study, an allostatic load will develop and lead to negative health outcomes. The allostatic load resulting from the accumulating sleep debt loops back to the sleep regulatory system itself and alters it.
Even though animals and humans may be able to adapt their sleep system to deal with repeated sleep restriction conditions, there could be negative consequences when this pattern is maintained over a long period of time, said Turek. This brings us back to the idea that repeated partial sleep restriction in humans has been linked to metabolic dysfunction and cardiovascular disease.
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Brain Blogging of the Week

Encephalon #26 is up on Neurophilosophy.
Wait! What’s that URL?
Yes, MC is our new SciBling!
He is officially moving (i.e., will be featured on the front page) tomorrow, but he is already all set up with some beautiful banners. So, go say Hello and if by some cosmic mistake you have not been reading his blog before, check his archives on the old address.

World 2.0 at Rainbows End

Books: “Rainbows End” by Vernor Vinge.
It’s 2025 – What happened to science, politics and journalism? Well, you know I’d be intrigued. After all, a person whose taste in science fiction I trust (my brother) told me to read this and particularly to read it just before my interview with PLoS. So, of course I did (I know, it’s been two months, I am slow, but I get there in the end).
‘Rainbows End’ is a novel-length expansion of the short story “Fast Times at Fairmont High” which he finished in August 2001 and first published in “The Collected Stories of Vernor Vinge“. The novel was written in 2005 (published in 2006) and the book happens in 2025, so it is a “near-future SF”, always more difficult to write than another episode of Star Trek.
Checking (after I have read the book) the reviews on Amazon.com, I was really taken aback and it made me think about science fiction, what it is and what people expect from it. So, what follows is simultaneously a book review and my own thoughts about the genre.

Continue reading

EnviroBlogging of the week

Carnival of the Green #84 is up on Bean Sprouts

ClockQuotes

The law, in its majestic equality, forbids the rich as well as the poor to sleep under bridges, to beg in the streets, and to steal bread.
– Anatole France