Author Archives: Bora Zivkovic

Poetry in the Open Laboratory 2009

In the first anthology, Open Laboratory 2006, we included a poem by MissPrism, Waterbear Down. In 2007 collection, Much Ado About…The Brain? by Digital Cuttlefish made the cut. In the 2008 edition, the winning poem was The Evolutionary Biology Valentine’s Day Poem, also by Digital Cuttlefish.
So far this year, we have only these four entries in the poetry category:
Horatio Algeranon’s: Jabberbloggy
Neurotopia: Poem of the Day: #4
It’s A Micro World After All: Ode To My Peer Reviews
Suppertime Sonnets: In Which I Celebrate A Certain Member of the Lycaenidae Family
Tom Paine’s Ghost: Beyond Energy
Can we have some more? Just click on the button:

Today’s carnivals

Grand Rounds Vol. 5 No. 49, Old School Style, are up on The Examining Room of Dr. Charles
Carnival of Space #117 is up on Simostronomy
Carnival of the Green #194 is up on Recycle Your Day

Clock Quotes

There are two ways of constructing a software design: One way is to make is so simple that there are obviously no deficiencies, and the other way is to make it so complicated that there are no obvious deficiencies.
– C. A. R. Hoare

New and Exciting in PLoS this week

There are many interesting articles published in PLoS ONE, PLoS Medicine, PLoS Biology and PLoS Neglected Tropical Diseases today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:

Continue reading

Clock Quotes

There is only one way in the world to be distinguished. Follow your instinct! Be yourself, and you’ll be somebody. Be one more blind follower of the blind, and you will have the oblivion you desire.
– Bliss Carman, 1861 – 1929

Microsoft’s New Smart Phone (video)


Does your iPhone have a tape measure? Eh? How can you beat that?
Hat-tip: Science Lush

No more ‘alpha male’!

L. David Mech is a famous wolf researcher (and a blogger about his research). If you have heard of a concept of “alpha-male” it is because of ideas from an old book of his, about social structure of wolf societies.
However, most of the early research on wolves was done on artificially built groups, e.g., wolves caught in various places all put together in a single wolf pen at a zoo. In such rare and unnatural situations, these stranger-wolves do indeed form social hierarchies (or “pecking order” – a term that arose from studies of chickens). But such situations rarely if ever happen out in nature. A pack of wolves is usually composed of Mother, Father and their (sometimes quite grown-up) offspring: closely related individuals who know each other well.
These days, it is L. David Mech himself who is working the hardest to change the way we think about wolf (and dog) packs and to eliminate the term “alpha male” at least from studies of canid behavior if not from metaphors about human societies (hat-tip to Jim Henley). Decades have passed since his book came out, much research was done in the meantime (including by him and his students) and we now know better. That is how science is supposed to work:

The concept of the alpha wolf is well ingrained in the popular wolf literature at least partly because of my book “The Wolf: Ecology and Behavior of an Endangered Species,” written in 1968, published in 1970, republished in paperback in 1981, and currently still in print, despite my numerous pleas to the publisher to stop publishing it. Although most of the book’s info is still accurate, much is outdated. We have learned more about wolves in the last 40 years then in all of previous history.
One of the outdated pieces of information is the concept of the alpha wolf. “Alpha” implies competing with others and becoming top dog by winning a contest or battle. However, most wolves who lead packs achieved their position simply by mating and producing pups, which then became their pack. In other words they are merely breeders, or parents, and that’s all we call them today, the “breeding male,” “breeding female,” or “male parent,” “female parent,” or the “adult male” or “adult female.” In the rare packs that include more than one breeding animal, the “dominant breeder” can be called that, and any breeding daughter can be called a “subordinate breeder.”


Learn more about the wolves here.
Update: Thanks DeLene for alerting me to a recent Mech’s article Whataver Happened to the term Alpha Wolf (PDF)

Student journalists are doing it right – The new The Daily Tar Heel rocks!

I am proud to live in Chapel Hill, the home of UNC and it’s campus newspaper The Daily Tar Heel. As soon as they got elected to their new editorial and managerial positions a couple of months ago, Sara Gregory, Emily Stephenson, Andrew Dunn and the rest of the crew opened up new channels of communication, including a Twitter account and a Facebook page. Did they use those to broadcast how brilliant they are and what great ideas they have in their heads? No, they used them to ask, ask, ask and to listen, listen, listen. Within days they organized an open-door meeting, inviting people from UNC and Chapel Hill communities to come and tell them how they see the campus paper evolve.
The result, a couple of months later, is a brand new newspaper. Last night they unveiled a brand new website. But it’s not just a spiffy website – that would be too cosmetic. It is a very different approach to journalism, much more attuned to the new media ecosystem.
Read their introduction – there are some new ways of doing things there. For example, they understand the ‘Ethic of the Link’:

We started putting links in some of our stories over the summer. This semester we plan to link in all our stories. Our theory with linking is this: We aim to offer you the best news possible. But if someone else does it better, we owe it to you to share with you. Reporters writing for many of our blogs will also be using Publish2 to share links of what they’re reading.

They understand the role of the community and having it involved:

We know we can’t be everywhere, and we want you to share your college experience with us. You can send us photos or story ideas the following ways:
* E-mail Emily Stephenson.
* Post to our Facebook page. You can post photos or write on our wall.
* Tweet to @dailytarheel, @dthbreak or @ewstephe. Include #UNC or #dthcampuspics.
* Post photos to Flickr and tag them with #dthcampuspics.

They are using their new blogs and the social networks very well and I am looking forward to see what they do over the next year:

ScienceOnline2010


We are off to a good start.
We now have a Twitter account I started last night (yes, that is a Saturday night) and already at 35 followers (also follow the #scio10 hashtag).
Our FriendFeed room has 30 subscribers.
On our Facebook Event page, 96 people indicated they are ‘Attending’ and 174 are ‘Maybe Attending’, with majority of both groups (unusual for Facebook) quite serious about trying to really get here.
And the activity on the wiki is already lively – the Program Suggestions page is already full of great ideas – go there and discuss them and add more.

Clock Quotes

What did it matter where you lay once you were dead? In a dirty sump or in a marble tower on top of a high hill? You were dead, you were sleeping the big sleep, you were not bothered by things like that. Oil and water were the same as wind and air to you.
– Raymond Chandler

Cartoons, comic strips and original art for the Open Laboratory 2009

In 2006 we did not include any comic strips in the anthology. In 2007, the Evolgen cartoon, The Lab Fridge was included in the book. In 2008, the winner was an XKCD comic, Purity, while original art by Glendon Mellow was featured on the cover.
Many bloggers make original visual stuff on their blogs – they draw, scan in their kids’ drawings, play with photoshop, do photography or make art. Let’s see some more of that submitted for the next edition. So far, the only submissions in this category are:
Articulate Matter: Proper Lab Technique
The Flying Trilobite: ‘Science-Chess Accommodating Religion’…contest!
Piled Higher & Deeper (PHDComics): Great Tweets of Science
Stripped Science: The right pairing
Stripped Science: Catfight
Science After Sunclipse: Where Does Our Information Come From?
Tessa’s Braces: Exploratorium
xkcd: Correlation
xkcd: Newton and Leibniz
Let’s see some more – just click on the button:

The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
Here are the submissions for OpenLab 2009 to date. As we have surpassed 300 entries, all of them, as well as the “submit” buttons and codes and the bookmarklet, are under the fold. You can buy the 2006, 2007 and 2008 editions at Lulu.com. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):

Continue reading

The Shy Connector

‘How to get strangers to talk to you’ instead of ‘How to talk to strangers’? I find this blog post and slide-show quite interesting. I see how it may apply to introverts – and I sure am not one of them – but I can also see how much of it applies equally well to extroverts like me, almost as a reminder to keep one’s over-extroverted mannerisms under control:

Clock Quotes

At one time my only wish was to be a police official. It seemed to me to be an occupation for my sleepless intriguing mind. I had the idea that there, among criminals, were people to fight: clever, vigorous, crafty fellows. Later I realized that it was good that I did not become one, for most police cases involve misery and wretchedness – not crimes and scandals.
– Soren Aabye Kierkegaard

Introducing PLoS Currents: Influenza

Yesterday PLoS and Google unveiled PLoS Currents: Influenza, a Google Knol hosted collection of rapid communications about the swine flu.
In his blog post A new website for the rapid sharing of influenza research (also posted on the official Google blog), Dr.Harold Varmus explains:

The key goal of PLoS Currents is to accelerate scientific discovery by allowing researchers to share their latest findings and ideas immediately with the world’s scientific and medical communities. Google Knol’s features for community interaction, comment and discussion will enable commentary and conversations to develop around these findings. Given that the contributions to PLoS Currents are not peer-reviewed in detail, however, the results and conclusions must be regarded as preliminary. In time, it is therefore likely that PLoS Currents contributors will submit their work for publication in a formal journal, and the PLoS Journals will welcome these submissions.

The response from the community has been overwhelmingly positive so far. For example, Frederic Lardinois writes, on ReadWriteWeb – Finally a Good Use for Google Knol: Sharing Information About Flu Research:

Overall, we think this is a great project. Knol is a good, easy-to-use platform for these kinds of publications, and given that the articles are also archived on other servers, this project also doesn’t rely on Google to keep Knol’s servers running indefinitely.
PLoS, being a non-profit, is also the right organization to give this project a try. Commercial publishers are still wary of the Internet, and while the open access movement has been gathering some support over the last few years, a lot of research in most scientific fields will still be hidden behind paywalls for a long time.

On Tech Babble: PLOS Currents : Influenza:

PLOS Currents : Influenza is built utilizing Google Knol and a new service from the National Center for Biotechnology Information (NCBI) called Rapid Research Notes. This service allows the user an easy way to follow current research and search for relevant scientific information.
As we approach influenza season, expect greater levels of concern and interest in H1N1.

Steven Salzberg, one of the moderators of PLoS Currents: Influenza, wrote on his blog – Opening up influenza research with a new kind of journal:

What’s the difference between this and a regular journal? Well, first of all, submissions won’t be thoroughly reviewed, which means they don’t “count” as journal papers, but it also means you can publish them later in a peer-reviewed journal. The Public Library of Science has already bought into this model – they’re sponsoring PLoS Currents, after all – and we expect other journals to do so also. So why publish, you might ask? That’s easy: in a highly competitive field such as influenza research, different scientists are often racing to answer the same question. By publishing super-rapidly in PLoS Currents, you will get a citable, time-stamped reference that establishes your discovery, and most importantly, establishes when you made it.
The big win here, we hope, is that scientists will be empowered to announce their results to the world without worrying about being “scooped” – a common fear that leads to many results being kept secret for months while papers are prepared and revised. This in turn will speed up scientific progress overall, which is the real goal behind PLoS Currents.

Eddie Holmes, Chief Moderator of PLoS Currents: Influenza, wrote in a guest-post on the PLoS Blog – Welcome to PLoS Currents: Influenza:

The central idea of PLoS Currents: Influenza is to rapidly disseminate data and ideas in the realm of influenza research, stimulated by the ongoing epidemic of swine-origin influenza virus (H1N1pdm). Given this backdrop, it is no surprise that some of first contributions consider important aspects of the H1N1pdm epidemic.
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Although PLoS Currents: Influenza was inspired by H1N1pdm, it will cover all types of research on all types of influenza virus. Indeed, the emergence of H1N1pdm brings into focus the need for basic research into many fundamental aspects of influenza biology.
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These initial contributions have given PLoS Currents: Influenza an excellent start. The next few months should prove to be very exciting. I therefore encourage all of you working in the area of influenza to send a contribution to PLoS Currents: Influenza, however preliminary, so that your data and ideas are rapidly distributed to a wide audience.

Iddo Friedberg, on ByteSizeBio: PLoS Currents: Influenza. Because knowledge should travel faster than epidemics:

So here we have all chief elements of scientific communication: credibility (by the moderators), timeliness (immediate online publishing) and attribution (by public archiving). PC:I is heavily skewed towards timeliness. The rationale being that in Influenza research and monitoring, time is of essence. After all, a report going through the usual peer review mill can take months: which is exactly the time required for a full-blown pandemic.
Not that other scientific fields are not in need of timeliness. Physicists and mathematicians have known that for almost two decades now. Nature Precedings are also providing an outlet for rapid communication in life sciences. But the combination of speed, accessibility and credibility offered by PC:I is indeed something new and welcome.

Vincent Racaniello on Watching The Watchers: Rapid Sharing of Influenza Research:

Contributions that will be welcome at PLoS Currents: Influenza include research into influenza virology, genetics, immunity, structural biology, genomics, epidemiology, modeling, evolution, policy and control. The manuscripts will not be subject to peer-review, but unsuitable submissions will be screened out by a board of expert moderators. This policy will enable rapid publication of research.
The path to publishing original scientific research is often long and tortuous. A manuscript describing the findings is prepared and submitted to a scientific journal (such as Nature, Cell, Journal of Virology). The manuscript is assigned to two or three expert reviewers, generally scientists involved in the same area of research. If their reviews are favorable, the paper is published. Usually additional experiments are called for, which may require additional time to complete. Many months to a year may pass before the paper is published, although some manuscripts (e.g. those on 2009 pandemic influenza) may be expedited. The point is that PLoS Currents: Influenza will allow everyone – including non-scientists – to read about research soon after the authors have prepared the paper.
PLoS Currents: Influenza is a terrific idea, and I welcome this venture with great enthusiasm. I hope that PLoS Currents will grow to include other areas of science.

David Bruggeman on Pasco Phronesis blog – PLoS Currents – An ArXiv for the Rest of Us?:

Presently in beta, Currents is accepting “new scientific data, analyses, and ideas” and encouraging the discussion and analysis of this information. The material is not peer reviewed as it would be for a regular PLoS publication, but is screened by moderators who are experts in the field at issue. The idea is that the work posted and discussed in Currents would lead to papers in peer reviewed journals at a later date.
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So policy research could find its way into a science journal – excellent.
While the material is hosted by Google, as the PLoS explains on its blog, it is also archived at the National Center for Biotechnology Information. Hopefully the Currents topics will not be simply reactive, but consider a number of different topics that aren’t breathing down our collective neck.
As the ScienceInsider article suggests, this is not the first time a preprint collection has been suggested for biomedical topics. Apparently when PLoS co-founder (and current PCAST co-chair) Harold Varmus tried this when he was leading the National Institutes of Health, some scientific societies raised a ruckus and the effort was discontinued. Hopefully history won’t repeat itself.

Glyn Moody, on his blog ‘Open….’, writes – PLoS Reinvents Publishing and Saves the World:

As someone who has been writing about open access for some years, I find myself returning again and again to the Public Library of Science. That’s because, not content with pioneering open access, PLoS has time and again re-invented the broader world of scientific publishing. Now, it’s done it again.
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The current system of publishing papers is simply too slow to deal with pandemics, where speed is of the essence if we’re to have a chance of nipping them in the bud. It’s good to see PLoS stepping in to help address this major problem.
——————
This is really exciting from many viewpoints. It’s pushing the ideas behind open access even further; it’s reshaping publishing; and it may even save humanity.

So, what do you think?

ScienceOnline’09 – interview with Carlos Hotta

The series of interviews with some of the participants of the 2008 Science Blogging Conference was quite popular, so I decided to do the same thing again this year, posting interviews with some of the people who attended ScienceOnline’09 back in January.
Today, I asked Carlos Hotta from the Brontossauros em meu Jardim blog to answer a few questions.
Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Who are you? What is your (scientific) background?
Carlos Hotta pic.jpgI am the community manager of ScienceBlogs Brasil, the former blog network called Lablogatórios. Lablogatorios started about a year ago as a small project that tried to emulate ScienceBlogs in order to stimulate Science communication using blogs in Brasil. A couple of days after our launch we were contacted by our role models. Now, we are the youngest ScienceBlogs scibling, with 30 blogs.
I also write on my own blog, Brontossauros em meu Jardim (Brontossaurus in my Garden) and, in my spare time, I do some research.
What do you want to do/be when (and if ever) you grow up?
One day I will have my own lab, where I can make people do the experiments for me while I blog and vice-versa. It would not hurt if I could keep making our blog network growing for a while.
What is your Real Life job?
My alter ego is a postdoc fellow at university of São Paulo. I am currently working on sugarcane circadian clocks and helping in the organization of the Brazilian side of the sugarcane genome sequencing project. In my previous incarnations I have done research on the association between the human circadian clock and malaria parasites and on the Arabidopsis circadian clock.
You know I am a big fan of your previous work on clocks and malaria (see references #3 and #4 in this post).
What aspect of science communication and/or particular use of the Web in science interests you the most?

I like the use of blogging as a tool to bridge the gap between scientists and the general public. I am also interested in seeing how scientists will use the Web to work together.
How does (if it does) blogging figure in your work? How about social networks, e.g., Twitter, FriendFeed and Facebook?
My blogging and my researching are still independent entities. However I have started a couple of scientific collaborations with people that contacted me throught the blog. My blog also helped me to be invited to talk about my work a few times. In the next couple of weeks I will talk at a conference both as a blogger and as a researcher and we might see Dr. Jekyll and Mr. Hyde fighting to see who will prevail.
I am a heavy user of Twitter (@carloshotta), weather permitting. People can also find me at Facebook and Orkut, which is very big in Brasil.
When and how did you discover science blogs? What are some of your favourites? Have you discovered any new cool science blogs while at the Conference?
I discovered science blogs when I was told a letter my colleagues and I wrote to Nature (Dodd, A., Hotta, C. and Gardner, M. Harry Potter and the Prisoner of Presumptions. Nature. Vol 437, p 318.) had a lot of resonance in the intertubes. Who would know that Harry Potter genetics could generate a lot of interest? BTW, I still think there is no magic gene in Harry Potter Universe and the magic comes from magic milk people drink when they are children.
My favorite blogger is Ed Yong who does a superb job writing about Science. I also love the way you were able to build a huge community around your blog.
Tell me more about ScienceBlogs Brazil – how it started, how it got to where it is now?
I started my blog in the end of 2007, just after I got my PhD. After a few months I started wondering whether Brazilian science blogs would ever grow to a point that would allow the formation of a site such as ScienceBlogs. This question haunted me for a while when I had an epiphany: we should make a ScienceBlogs-like site IN ORDER TO make Brazilian science blogs grow. And that´s how Atila and I started putting the network together.
Lablogatorios was launched in August 2008 with 15 blogs. It contained a great portion of the Brazilian Science blogging community (yes, we were that small). After a few days we were contacted by SEED, which gave us the opportunity to join the ScienceBlogs community. The new site, ScienceBlogs Brazil launched in March 2009. We had been growing at a very nice pace but the transition gave us a huge boost.
After a year Lablogatorios was launched I can say it was a very sucessful project. Our visits increased more than 5 times in this period (which is still small compared to world-class blogs) but the real success is in the number of science blogs written by Brazilians that were launched in this period.
Is there anything that happened at this Conference – a session, something someone said or did or wrote – that will change the way you think about science communication, or something that you will take with you to your job, blog-reading and blog-writing?
After the conference I wrote a piece about how the blogging community in Brazil still had a lot to grow, in terms of public and maturity, in order to become a fraction of what the blogs written in English were. I would say we are 2 to 3 years behind. Many things that were discussed at the ScienceOnline´09 are just becoming a problem now in Brazil, such as the question of anonimity/pseudonimity or the frequent clash between bloggers and journalists. Our advantage is that we can avoid a lot of pitfalls by observing the history of blogging. Things are easier when you do not have to reinvent the wheel.
It was so nice to meet you and thank you for the interview. I hope to see you again next January.
Bora, I must thank you for all the support you always gave to our project. You are partly responsible for the wild trip we had during this first year.
Carlos Hotta w Anton and Bora pic.jpg
[left to right: Anton Zuiker, Carlos Hotta and myself at the ScienceOnline’09, just minutes after the announcement of ScienceBlogs Brasil]
==========================
See the 2008 interview series and 2009 series for more.

Today’s carnivals

Friday Ark #257 is up on Modulator

Clock Quotes

The sure way of judging whether our first thoughts are judicious, is to sleep on them. If they appear of the same force the next morning as they did over night, and if good nature ratifies what good sense approves, we may be pretty sure we are in the right.
– Horace Walpole

Social Media Revolution (video)

Introducing the Skeptical Blog Anthology 2009 – the best of skeptical blogging

This is exciting! From Young Australian Skeptics: Skeptical Blog Anthology 2009:

Inspired by the annual The Open Laboratory, the Skeptical Blog Anthology is a printed anthology of blog posts voted the very best of 2009, managed by the Young Australian Skeptics in conjunction with the Critical Teaching Education Group (CTEG). The anthology is an attempt to bring a greater awareness of the skeptical content on blog sites and showcase some of the range and diversity in the blogosphere.
With an aim to provide text-based resources to classes and readers who may be interested or intrigued by what skepticism has to offer, entries from January 1st to December 1st 2009 are eligible for submission. Both a print and Portable Document Format (pdf) will be made available for purchase via Lulu.com, with estimated printing early in 2010.
Entries can be self-nominated or proposed by readers of skeptical blog sites. The guidelines proposed by the popular Skeptics’ Circle are a fine indicator of the kind of content suitable for the anthology, including urban legends, the paranormal, quackery, pseudoscience, intelligent design, historical revisionism, critical thinking, skeptical parenting/​educating skeptically, superstitions, etc.
Please use the following form to submit entries, which will continue up to the closing date.

Charles Darwin Lecture Series – Dale Russell: “Islands in the Cosmos: The Evolution of Life on Land”

DARWIN LECTURE SERIES CONTINUES!

How did we come to be here? Answers to this question have preoccupied
humans for millennia. Scientists have sought clues in the genes of
living things, in the physical environments of Earth – from mountaintops
to the depths of the ocean, in the chemistry of this world and those
nearby, in the tiniest particles of matter, and in the deepest reaches
of space. On Tuesday, September 29, Senior Curator of Paleontology Dale
Russell presents a talk based on his new book “Islands in the Cosmos:
The Evolution of Life on Land,” which follows evolution from its origins
to the present day. The talk begins at 6:30 p.m. at the North Carolina
Museum of Natural Sciences in downtown Raleigh and is the fourth
offering of the Museum’s Charles Darwin Lecture Series.
In “Islands of the Cosmos,” Russell traces a path from the dawn of the
universe to speculations about our future on this planet. He centers his
story on the physical and biological processes in evolution, which
interact to favor more successful, and eliminate less successful, forms
of life. It remains to be seen, Russell notes in the book, whether the
human form can survive the dynamic processes that brought it into
existence.
Russell is also author of “A Vanished World: The Dinosaurs of Western
Canada” and “An Odyssey in Time: The Dinosaurs of North America”.
Science author David E. Fastovsky calls Russell “one of the great
creative thinkers of all time in paleontology.” Russell played a key
role in the discovery of the world’s first dinosaur specimen with a
fossilized heart, which became international news when it was reported
in the April 21, 2000 issue of the journal Science. The
66-million-year-old Thescelosaurus, nicknamed Willo, is on display in
the Museum’s Prehistoric North Carolina exhibit hall.
Please RSVP to museum.reservations@ncmail.net. This lecture is free of
charge and seating is on a first come, first served basis. Doors to the
Museum and auditorium will open at 6 p.m. Signed copies of the book will
be available for purchase.
The Museum, in collaboration with the National Evolutionary Synthesis
Center (NESCent) and the W.M. Keck Center for Behavioral Biology at
North Carolina State University, is presenting this lecture series
throughout 2009 to commemorate the bicentennial of Charles Darwin’s
birth and the 150th anniversary of the publication of “The Origin of
Species.” On Tuesday, November 24, Museum paleontologist and Darwin
scholar Paul Brinkman presents the fifth and final lecture in the
series: “Charles Darwin’s Beagle Voyage and the Origin of ‘The Origin’.”

Today’s carnivals

I and the Bird #107 is up on Liza Lee Miller’s blog

Clock Quotes

I have no fear of death, Must be wonderful, like a long sleep. But let’s face it: it’s how you live that really counts.
– Katharine Hepburn

The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
Here are the submissions for OpenLab 2009 to date. As we have surpassed 300 entries, all of them, as well as the “submit” buttons and codes and the bookmarklet, are under the fold. You can buy the 2006, 2007 and 2008 editions at Lulu.com. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):

Continue reading

Today’s carnivals

Change of Shift: Vol. Four, Number 4 is up on Emergiblog
Grand Rounds Vol. 5 No. 48 are up on Invisible Illness Week

Alcoholic Vervet Monkeys! – Weird Nature – BBC animals (video)

New and Exciting in PLoS ONE

There are 15 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
Hippocampal Sharp Wave/Ripples during Sleep for Consolidation of Associative Memory:

The beneficial effect of sleep on memory has been well-established by extensive research on humans, but the neurophysiological mechanisms remain a matter of speculation. This study addresses the hypothesis that the fast oscillations known as ripples recorded in the CA1 region of the hippocampus during slow wave sleep (SWS) may provide a physiological substrate for long term memory consolidation. We trained rats in a spatial discrimination task to retrieve palatable reward in three fixed locations. Hippocampal local field potentials and cortical EEG were recorded for 2 h after each daily training session. There was an increase in ripple density during SWS after early training sessions, in both trained rats and in rats randomly rewarded for exploring the maze. In rats learning the place -reward association, there was a striking further significant increase in ripple density correlated with subsequent improvements in behavioral performance as the rat learned the spatial discrimination aspect of the task. The results corroborate others showing an experience-dependent increase in ripple activity and associated ensemble replay after exploratory activity, but in addition, for the first time, reveal a clear further increase in ripple activity related to associative learning based on spatial discrimination.

Modulatory Communication Signal Performance Is Associated with a Distinct Neurogenomic State in Honey Bees:

Studies of animal communication systems have revealed that the perception of a salient signal can cause large-scale changes in brain gene expression, but little is known about how communication affects the neurogenomic state of the sender. We explored this issue by studying honey bees that produce a vibratory modulatory signal. We chose this system because it represents an extreme case of animal communication; some bees perform this behavior intensively, effectively acting as communication specialists. We show large differences in patterns of brain gene expression between individuals producing vibratory signal as compared with carefully matched non-senders. Some of the differentially regulated genes have previously been implicated in the performance of other motor activities, including courtship behavior in Drosophila melanogaster and Parkinson’s Disease in humans. Our results demonstrate for the first time a neurogenomic brain state associated with sending a communication signal and provide suggestive glimpses of molecular roots for motor control.

The Future of Online (Academic) Publishing

Talk given by Peter Binfield at the ISMTE meeting (slides and audio):

Clock Quotes

If you want your dreams to come true, don’t sleep.
– Yiddish proverb

Not-so-self-correcting science: the hard way, the easy way, and the easiest way

Two recent events put in stark relief the differences between the old way of doing things and the new way of doing things. What am I talking about? The changing world of science publishing, of course.
Let me introduce the two examples first, and make some of my comments at the end.
Example 1. Publishing a Comment about a journal article
My SciBling Steinn brought to our collective attention a horrific case of a scientist who spent a year fighting against the editors of a journal, trying to have a Comment published about a paper that was, in his view, erroneous (for the sake of the argument it does not matter if the author of the original paper or the author of the Comment was right – this is about the way system works, er, does not work). You can read the entire saga as a PDF – it will make you want to laugh and cry and in the end scream with frustration and anger. Do not skip the Addendum at the end.
Thanks to Shirley Wu for putting that very long PDF into a much more manageable and readable form so you can easily read the whole thing right here:
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See? That is the traditional way for science to be ‘self-correcting’….Sure, a particularly egregious example, but it is the system that allows such an example to be a part of that continuum somewhere on its edge – this is not a unique case, just a little bit more extreme than usual.
Janet wrote a brilliant post (hmmm, it’s Janet… was there ever a time I linked to her without noting it was a “brilliant post”? Is it even possible to do?) dissecting the episode and hitting all the right points, including, among others, these two:

Publishing a paper is not supposed to bring that exchange to an end, but rather to bring it to a larger slice of the scientific community with something relevant to add to the exchange. In other words, if you read a published paper in your field and are convinced that there are significant problems with it, you are supposed to communicate those problems to the rest of the scientific community — including the authors of the paper you think has problems. Committed scientists are supposed to want to know if they’ve messed up their calculations or drawn their conclusions on the basis of bad assumptions. This kind of post-publication critique is an important factor in making sure the body of knowledge that a scientific community is working to build is well-tested and reliable — important quality control if the community of science is planning on using that knowledge or building further research upon it.
———-snip———-
The idea that the journal here seems to be missing is that they have a duty to their readers, not just to the authors whose papers they publish. That duty includes transmitting the (peer reviewed) concerns communicated to them about the papers they have published — whether or not the authors of those papers respond to these concerns in a civil manner, or at all. Indeed, if the authors’ response to a Comment on their paper were essentially. “You are a big poopyhead to question our work!” I think there might be a certain value in publishing that Reply. It would, at least, let the scientific community know about the authors’ best responses to the objections other scientists have raised.

Example 2: Instant replication of results
About a month ago, a paper came out in the Journal of the American Chemical Society, which suggested that a reductant acted as an oxidant in a particular chemical reaction.
Paul Docherty, of the Totally Synthetic blog, posted about a different paper from the same issue of the journal the day it came out. The very second comment on that post pointed out that something must be fishy about the reductant-as-oxidant paper. And then all hell broke lose in the comments!
Carmen Drahl, in the August 17 issue of C&EN describes what happened next:

Docherty, a medicinal chemist at Arrow Therapeutics, in London, was sufficiently intrigued to repeat one of the reactions in the paper. He broadcast his observations and posted raw data on his blog for all to read, snapping photos of the reaction with his iPhone as it progressed. Meanwhile, roughly a half-dozen of the blog’s readers did likewise, each with slightly different reaction conditions, each reporting results in the blog’s comment section.

The liveblogging of the experiment by Paul and commenters is here. Every single one of them failed to replicate the findings and they came up with possible reasons why the authors of the paper got an erroneous result. The paper, while remaining on the Web, was not published in the hard-copy version of the journal and the initial authors, the journal and the readers are working on figuring out exactly what happened in the lab – which may actually be quite informative and novel in itself.
Compare and contrast
So, what happened in these two examples?
In both, a paper with presumably erroneous data or conclusions passed peer-review and got published.
In both, someone else in the field noticed it and failed to replicate the experiments.
In both, that someone tried to alert the community that is potentially interested in the result, including the original authors and the journal editors, in order to make sure that people are aware of the possibility that something in that paper is wrong.
In the first example, the authors and editors obstructed the process of feedback. In the second, the authors and editors were not in a position to obstruct the process of feedback.
In the first example, the corrector/replicator tried to go the traditional route and got blocked by gatekeepers. In the second example, the corrector/replicator went the modern route – bypassing the gatekeepers.
If you had no idea about any of this, and you are a researcher in a semi-related field moving in, and you find the original paper via search, what are the chances you will know that the paper is being disputed?
In the first example – zero (until last night). In the second example – large. But in both cases, in order to realize that the paper is contested, one has to use Google! Not just read the paper itself and hope it’s fine. You gotta google it to find out. Most working scientists do not do that yet! Not part of the research culture at this time, unfortunately.
If the Comment was published in the first example, chances that a reader of the paper will then search the later issues of the journal seeking comments and corrections are very small. Thus even if the Comment (and Reply by authors) was published, nobody but a very small inner circle of people currently working on that very problem will ever know.
Back in grad school I was a voracious reader of the literature in my field, including some very old papers. Every now and then I would bump into a paper that seemed really cool. Then I would wonder why nobody ever followed up or even cited it! I’d ask my advisor who would explain to me that people tried to replicate but were not successful, or that this particular author is known to fudge data, etc. That is tacit knowledge – something that is known only by a very small number of people in an Inner Circle. It is a kind of knowledge that is transmitted orally, from advisor to student, or in the hallways at meetings. People who come into the field from outside do not have access to that information. People in the field who live in far-away places and cannot afford to come to conferences do not have access to that information.
Areas of research also go in and out of fashion. A line of research may bump into walls and the community abandons it only to get picked up decades later once the technological advances allow for further studies of the phenomenon. In the meantime, the Inner Circle dispersed, and the tacit knowledge got lost. Yet the papers remain. And nobody knows any more which paper to trust and which one not to. Thus one cannot rely on published literature at all! It all needs to be re-tested all over again! Yikes! How much money, time and effort would have to be put into that!?
Now let’s imagine that lines of research in our two Examples go that way: get abandoned for a while. Let’s assume now that 50 years from now a completely new generation of scientists rediscovers the problem and re-starts studying it. All they have to go with are some ancient papers. No Comment was ever published about the paper in the first Example. Lots of blogging about both afterwards. But in 50 years, will those blogs still exist, or will all the links found on Google (or whatever is used to search stuff online in 50 years) be rotten? What are the chances that the researchers of the future will be able to find all the relevant discussions and refutation of these two papers? Pretty small, methinks.
But what if all the discussions and refutations and author replies are on the paper itself? No problem then – it is all public and all preserved forever. The tacit knowledge of the Inner Circle becomes public knowledge of the entire scientific community. A permanent record available to everyone. That is how science should be, don’t you think?
You probably know that, right now, only BMC, BMJ and PLoS journals have this functionality. You can rate articles, post notes and comments and link/trackback to discussions happening elsewhere online. Even entire Journal Clubs can happen in the comments section of a paper.
Soon, all scientific journals will be online (and probably only online). Next, all the papers – past, present and future – will become freely available online. The limitations of paper will be gone and nothing will prevent publishers from implementing more dynamic approaches to scientific publishing – including on-paper commentary.
If all the journals started implementing comments on their papers tomorrow I would not cry “copycats!” No. Instead, I’d be absolutely delighted. Why?
Let’s say that you read (or at least skim) between a dozen and two dozen papers per day. You found them through search engines (e.g., Google Scholar), or through reference managers (e.g., CiteULike or Mendeley), or as suggestions from your colleagues via social networks (e.g, Twitter, FriendFeed, Facebook). Every day you will land on papers published in many different journals (it really does not matter any more which journal the paper was published in – you have to read all the papers, good or bad, in your narrow domain of interest). Then one day you land on a paper in PLoS and you see the Ratings, Notes and Comments functionality there. You shake your head – “Eh, what’s this weird newfangled thing? What will they come up with next? Not for me!” And you move on.
Now imagine if every single paper in every single journal had those functionalities. You see them between a dozen and two dozen times a day. Some of the papers actually have notes, ratings and comments submitted by others which you – being a naturally curious human being – open and read. Even if you are initially a skeptical curmudgeon, your brain will gradually get trained. The existence of comments becomes the norm. You become primed….and then, one day, you will read a paper that makes you really excited. It has a huge flaw. It is totally crap. Or it is tremendously insightful and revolutionary. Or it is missing an alternative explanation. And you will be compelled to respond. ImmediatelyRightThisMoment!!!11!!!!11!!. In the old days, you’d just mutter to yourself, perhaps tell your students at the next lab meeting. Or even brace yourself for the long and frustrating process (see Example 1) of submitting a formal Comment to the journal. But no, your brain is now primed, so you click on “Add comment”, you write your thoughts and you click “Submit”. And you think to yourself “Hey, this didn’t hurt at all!” And you have just helped thousands of researchers around the world today and in the future have a better understanding of that paper. Permanently. Good job!
That’s how scientific self-correction in real time is supposed to work.

ScienceOnline’09 – interview with Erin Cline Davis

The series of interviews with some of the participants of the 2008 Science Blogging Conference was quite popular, so I decided to do the same thing again this year, posting interviews with some of the people who attended ScienceOnline’09 back in January.
Today, I asked Erin Cline Davis of 23andMe to answer a few questions.
Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Who are you? What is your (scientific) background?
ErinClineDavis pic.jpgI’m Erin Cline Davis. I grew up in southern California, then headed east for college at MIT. I liked it, but those winters are killer, so I returned to sunny CA for grad school at Stanford. I got my PhD in Molecular and Cellular Physiology in 2006. My thesis work was in James Nelson’s lab. In general, the group studies epithelial polarity and adhesion. That’s what I meant to study. But I ended up working on all sorts of random stuff as I tried to understand the role of Par 6, a protein that has been implicated in the establishment of polarity in multiple species, in the nucleus. After finally becoming Dr. Erin, I decided to make a change and become a science writer. Just a few days after my defense I headed down to the L.A. Times as a AAAS Mass Media Fellow. After that, I landed at 23andMe.
What is your Real Life job?
I’m a science writer for 23andMe, a personal genomics service.
How does (if it does) blogging figure in your work? How about social networks, e.g., Twitter, FriendFeed and Facebook?
In addition to creating content for the 23andMe website, I write for our corporate blog, The Spittoon (get it?). It’s really satisfying to be able to help our customers see how their data fits in with the very latest in genetics research. At this point I don’t have my own personal blog, but I would like to in the future if I can ever find the time.
When and how did you discover science blogs? What are some of your favourites? Have you discovered any new cool science blogs while at the Conference?
I started reading science blogs once I became a blogger myself. I read Genetic Future a lot. Everyone at the conference had such cool blogs, but one of my favorite finds was Miriam Goldstein’s The Oyster’s Garter. She is so smart and funny! It’s great that she’s on DoubleX too.
It was so nice to meet you and thank you for the interview. I hope to see you again next January.
==========================
See the 2008 interview series and 2009 series for more.

Clock Quotes

The good people sleep much better at night than the bad people. Of course, the bad people enjoy the waking hours much more.
– Woody Allen

Today’s carnivals

The Giant’s Shoulders #14 is up on The Dispersal of Darwin
Encephalon #74 is up on Neuronarrative
Carnival of the Green #193 is up on The EcoChic

New and Exciting in PLoS this week

Monday – let’s see what’s up in PLoS Biology, PLoS Medicine, PLoS ONE and PLoS Neglected Tropical Diseases. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:

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ScienceOnline’09: Interview with Bjoern Brembs

The series of interviews with some of the participants of the 2008 Science Blogging Conference was quite popular, so I decided to do the same thing again this year, posting interviews with some of the people who attended ScienceOnline’09 back in January.
Today, I asked Bjoern Brembs to answer a few questions.
Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Who are you?What is your (scientific) background?
Bjoern Brembs pic.jpgAs a boy, I was always out and about chasing and catching animals. I’ve been fascinated by watching animals behave and at the time the best way to do this seemed to catch them: frogs, toads, snakes, mice, insects – whatever seemed exciting at the moment was caught, put in a terrarium or other suitable container and observed, only to be released again after some time.
Later, I started reading Konrad Lorenz and other ethologists. I liked their books so much that I started reading other scientists’ books, other biologists like Richard Dawkins, John Eccles or Rupert Riedl, but also physicists like Steven Weinberg or philosophers like Karl Popper or Paul Feyerabend.
I had so much fun with science that it was clear I wanted to study science, in particular biology. Initially, I was fascinated by developmental biology. How can a uniform egg develop into something a lot more complex? Then I attended a lecture by Martin Heisenberg (the youngest son of the uncertainty principle discoverer) on the brain and I was hooked. Heisenberg became also my PhD advisor. Because it makes no sense to try and study behavior without understanding the context in which it is used, I also
specialized in evolution and ecology and have published in both fields before I went into neuroscience full time.
The brain is what makes us who we are. Its main function is to chose from all the different options which behavior to produce next, and nobody knows how it does that. In fact, we know so little about brains that we don’t even know how the brain of a fruit fly works. More astonishing still, we’ve had the ‘connectome’ (all the synaptic connections between all neurons) of the nematode worm C. elegans for over 20 years and still we don’t know what it is that makes a brain out of these 302 neurons and their connections.
When we understand these simpler brains, we’ll have the tools and principles at hand to start and try to understand more
complex brains.
What do you want to do/be when (and if ever) you grow up?
People grow up? I’m not growing up, it’s only that my body doesn’t seem to agree with me. 🙂
One of my life’s goals is to still be doing giant swings on high-bar when I’m over 70, just like my club-mate and multiple German National Champion in his age class Ernst-Jürgen Bever.
What is your Real Life job?
As you may have guessed from my bio, I’m a neurobiologist. As I find the brains of vertebrates to be too complex and daunting for the level of understanding I aim for, I study the brains of invertebrates, which also offer a much richer toolbox for biological study.
My specialization is in learning (and memory), in particular the kind of learning that takes place when animals learn from the consequences of their behavior, i.e. operant learning.
I’ve written a short summary of my most recent research at The Naked Scientists.
My website contains more details about my work than you would ever want to know:
In January, you co-moderated two sessions: one was the introduction to Open Access, and the other imagining a world after Impact Factor. How are the two – growth of Open Access and demise of Impact Factor – related to each other? What has to happen first?
Newly founded OA journals cannot compete with established journals because they don’t have an IF. Scientists are reluctant to publish in journals without the prestige that a high IF brings. In these terms, the IF needs to go before OA journals can strive.
In what aspects can the web change science communication?
The way scientists communicate their findings today is fundamentally broken and I sometimes have the impression it even is FUBAR.
Who or what broke the system? We, the scientists. We multiplied and multiplied until the present day where we publish between one and two million peer-reviewed papers every year in about 25,000 scholarly journals. It is my understanding, even though I haven’t been around at the time, that this became an issue already in the 1960s: the journals had multiplied with the researchers and so had subscription costs – the IF was invented to be able to rank the journals. Libraries, among others, used this rank to help decide which journals to subscribe to. This journal rank has been in place until now, with the added complication that now scientists themselves use the IF to rank other scientists. Today, high IF means prestige, so scientists will often tend to try and publish their best results in journals with a high IF – a self-stabilizing system.
Poof! In comes the internet and all of a sudden one could in principle place all the scholarly articles that have ever been published on a single computer for everybody to read, text-mine, whatever. No more need for journals. Yet, because of the self-stabilization, we’re still essentially stuck with a publication system that we had apparently already outgrown by the 1960s! Given the growth rate of the modern, data-intensive scientific enterprise, it doesn’t take an Einstein to realize that a heavily patched-up communication system that was already outdated 50 years ago isn’t really the most effective way to do business. Thus, the advent of the web questioned our entire way of doing science – it doesn’t get any more fundamental than that.
It’s always easy to criticize – what solutions does the web offer for science communication?
I could paraphrase an infamous politician and say that you don’t communicate in the system you want but in the system you have – but that’s what politicians and publishers say. I have several dreams for how the web can improve scientific communication.
One of my favorite ones at the moment doesn’t have any journals at all in it. It only needs a federated standard for multi-level peer-review. The first level is among cooperating or competing colleagues in the same field. As data is being collected, it is made public to an ever wider audience: first other graduate students, post-docs in the lab, then lab-head, then cooperating colleagues, then other scientists, still within the same field. This is similar to lab meetings and conferences, but online and all the time. Scientists have always self-organized themselves into societies, clubs and other groups, this is the same principle. These interactions make sure that whatever is submitted for formal peer-review has already passed informal peer-review (and there would be a record of it).
Once the data form a large enough body to be communicated with scientists who are not in this field (or the public), a ‘paper’ will be drafted and submitted for formal peer-review. Reviewers will be both experts in the field but also outsiders, to ensure general readability. These ‘papers’ are then ‘published’ in a distributed database, hosted by the institutions’ libraries, according to the
abovementioned federated standard, linking to the record of data collection and peer-review established in the process of the research.
This is only one of many potential ways in which the web could revolutionize scientific communication while ensuring track records, allowing open access to text, data and methods, providing a reputation system for each contribution of each scientist. There are many more, some closer to the current system, some even more utopian than the one I just outlined. The important thing is that as many people as possible realize how good the system could be: then they will be more likely to abandon the current system and support necessary change.
How does (if it does) blogging figure in your work? How about social networks, e.g., Twitter, FriendFeed and Facebook?
Wasn’t blogging invented for opinionated extroverts like me? 🙂
My blog is a way for me to vent, influence others, toy around with ideas, highlight results from colleagues (positively and negatively) and make myself be heard outside the usual circle of physically close colleagues. Science is all about communication – if you have a unique insight and never tell anybody, does it exist?
Friendfeed is of particular value for me, as I both get new ideas, results and information from there but can also influence the topics and discussions. It’s two-way science communication that you usually only get at conferences. At Friendfeed you’re basically at a science conference without a special topic 24/7 – exactly my kind of fix!
When and how did you discover science blogs?
Hmm, I don’t really know. I remember I started mine in 2003 because I thought everybody and their grandmother had one…
What are some of your favourite science blogs?
I don’t really read blogs per se. Most of the people with interesting things to say are on Firendfeed – and if they’re not, someone will link their blog posts there. With Friendfeed there’s hardly a need to read blogs. I would read blogs of colleagues I know personally and/or are in my field, but as of now I don’t know of any who blog but are not already on Friendfeed.
There’s one blog I visit regularly, though. Pharyngula – it’s just so entertaining. Thanks PZ!
Is there anything that happened at this Conference – a session, something someone said or did or wrote – that will change the way you think about science communication, or something that you will take with you to your job, blog-reading and blog-writing?
John Wilbanks‘ presentation on the semantic web was an eye-opener! The potential of this technology is huge and in part because of his presentation I’ve written a grant proposal to develop a web-based science communication system (think informal peer-review above) using semantic web technology – wish me luck!
It was so nice to see see you again and thank you for the interview. I hope to see you again next January.
Thanks for having me there, I had a great time. I would like to come again next year, but I haven’t decided, yet.
==========================
See the 2008 interview series and 2009 series for more.

The Open Laboratory 2009 – the submissions so far

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Clock Quotes

The gent who wakes up and finds himself a success hasn’t been asleep.
– Wilson Mizner

You are all invited to ScienceOnline2010!


It is official – ScienceOnline2010, the fourth annual conference on science and the Web, will be held on January 15-17th, 2010 in the Research Triangle Park area (the exact location to be announced).
Please join us for this three-day event to explore science on the Web. Our goal is to bring together scientists, physicians, patients, educators, students, publishers, editors, bloggers, journalists, writers, web developers, programmers and others to discuss, demonstrate and debate online strategies and tools for doing science, publishing science, teaching science, and promoting the public understanding of science.
* Please take a minute to register (if you were registered last year, use that password) for the wiki.
* Log in and add ideas for the program at this page.
* The registration for the conference itself will open in late Fall 2009. Sign up here to receive advance notice about registration and other conference updates.
(Note: Conference registration is not the same as member registration for editing this wiki, or vice versa – they are two different platforms. To contribute your ideas to this planning wiki, please go to the blue strip on the top of the page and register.)
* If you or your organization are interested in becoming a Sponsor, or helping in other ways, please contact us at info@scienceonline2010.com
* Keep informed about the organization of the conference at the News and Updates page.
* Keep up with the blog and media coverage here.
* This is a collaborative and community conference — we need you to participate now to help us make this a successful, fun and educational event. Please volunteer to help.
* This is a conference to explore new ways in communicating scientific exploration. Our conference addresses a variety of issues and perspectives on science communication, including science literacy, the popularization of science, science in classrooms and in homes, debunking pseudoscience, using blogs as tools for presenting scientific research, writing about science, and health and medicine. In addition to being an internationally known hub of scientific and biomedical research and education, North Carolina has numerous science blogs written by a wide variety of people – see this listing of Science bloggers located in North Carolina (and let me know if there are errors or omissions).
* If twittering, use the hashtag: #scio10 (use the same tag on other services, e.g., Flickr, YouTube, etc.).
* Join the conversation in our FriendFeed room.
* Join the Facebook event (this helps us with estimating the number and composition of potential participants)
* Help us spread the word: in person, by phone or e-mail, on social networks and on blogs and websites. If online, please use our Promo materials:

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A deer, completely unafraid of me, strolling through my backyard

At one point I came as close as 5 yards to it – click on little thumbnails to see bigger pictures:

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Clock Quotes

… We are such stuff
As dreams are made on, and our little life
Is rounded with a sleep.

– William Shakespeare William Shakespeare

Praxis

A run-down of good recent stuff, highly recommended for your weekend reading and bookmarking:
PLoS One: Interview with Peter Binfield:

…In my view PLoS ONE is the most dynamic, innovative and exciting journal in the world, and I am proud to work on it.
In many ways PLoS ONE operates like any other journal however it diverges in several important respects. The founding principle of PLoS ONE was that there are certain aspects of publishing which are best conducted pre-publication and certain aspects which are best conducted post-publication. The advent of online publishing has allowed us to take a step back and re-evaluate these aspects of how we publish research, without the burden of centuries of tradition. In this way, we have been able to experiment with new ways of doing things which may result in dramatic improvements in the entire process of scholarly publication.
The most important thing which has come out of this premise is that unlike almost every other journal in the world, we make no judgment call whatsoever on the ‘impact’ or ‘significance’ or ‘interest level’ of any submission. What this means is that if an article appropriately reports on well-conducted science, and if it passes our peer review process (which determines whether it deserves to join the scientific literature) then we will publish it. In this way, no author should ever receive the message that their article is scientifically sound but ‘not interesting enough’ for our journal, or that their article is ‘only suited to a specialized audience’. As a result, we short circuit the vicious cycle of “submit to a ‘top tier’ journal; get reviewed; get rejected; submit to the next journal down the list; repeat until accepted” and we are therefore able to place good science into the public domain as promptly as possible, with the minimum of burden on the academic community….

The evolution of scientific impact (also a good FriendFeed thread about it):

What is clear to me is this – science and society are much richer and more interconnected now than at any time in history. There are many more people contributing to science in many more ways now than ever before. Science is becoming more broad (we know about more things) and more deep (we know more about these things). At the same time, print publishing is fading, content is exploding, and technology makes it possible to present, share, and analyze information faster and more powerfully.
For these reasons, I believe (as many others do) that the traditional model of peer-reviewed journals should and will necessarily change significantly over the next decade or so.

A threat to scientific communication (read excellent responses by Peter Murray-Rast and Bjoern Brembs and a thread on FriendFeed):

Sulston argues that the use of journal metrics is not only a flimsy guarantee of the best work (his prize-winning discovery was never published in a top journal), but he also believes that the system puts pressure on scientists to act in ways that adversely affect science – from claiming work is more novel than it actually is to over-hyping, over-interpreting and prematurely publishing it, splitting publications to get more credits and, in extreme situations, even committing fraud.
The system also creates what he characterises as an “inefficient treadmill” of resubmissions to the journal hierarchy. The whole process ropes in many more reviewers than necessary, reduces the time available for research, places a heavier burden on peer review and delays the communication of important results.

Why do we still publish scientific papers?:

I agree with the need to filter papers, but I want to be in control of the filter. I don’t want editors to control my filter and I definitely don’t want a monopolist like Thomson to muck up my filter. I don’t care where something is published, if it’s in my direct field I need to read it, no matter how bad it is. If a paper is in my broader field, I’d apply some light filtering, such as rating, comments, downloads, author institute, social bookmarks, or some such. If the paper is in a related field, I’d like to only read reviews of recent advances. If it’s in an unrelated field, but one I’m interested in nonetheless, I’d only want to see the news-and-views article, because I wouldn’t understand anything else anyway. For everything else, titles, headlines or newsreports are good enough for browsing. All of this can be done after publishing and certainly doesn’t require any artificial grouping by pseudo-tags (formerly called journals).

Science Jabberwocky (how to read/understand a scientific paper when you don’t know the technical terms):

I have to confess that in areas outside mine, there seems to be a terrible array of words no more obvious than ‘brillig’ and ‘slithy’. And words that look familiar, like ‘gyre and gimble’, but which don’t look like they are supposed to mean what I’m used to them meaning.

Media tracking:

The theropod behaviour paper that I have been boring you all with this last week or so has been the first time I have had decent control over the media access to my work and by extension the first time I have had a good idea of what happened to the original press release. I know what I sent to whom and when and thus can fairly easily track what happened afterwards to record the spread and exchange of information from that origin. In the past on the Musings I have targeted inaccuracies in news reports of scientific stories but without knowing the exact details of a story (I may have access to the press release but without knowing who it went to). Well, not so this time and as a result the pattern of reporting I can see is both interesting and informative both from understanding how the media works and knowing how to get your own work publicised.

Rapid evolution of rodents: another PLoS ONE study in the media:

Although media attention and coverage is not, and should certainly not be, the only criterion for scientific “quality” (whatever that is!), it is further testimony of the advantage to publish in “Open Acess”-journals in general, and PLoS ONE in particular. This study is also interesting because it shows the value of museum collections as a source for ecological and evolutionary research, a point that Shawn Kuchta has repeatedly emphasized in our lab-meetings (and which I completely agree with, of course).

20 Quick Points from ‘The World Is Open: How Web Technology Is Revolutionizing Education’:

9. Open Access Journals (Opener #5): The publishing world is increasing becoming open access. Open access journals in the healthcare area provide invaluable information to those in the developing world. The Public Library of Science (PLoS) offers free peer-reviewed scientific journals. Scientists who publish in PLoS journals might present their work in SciVee. SciVee allows the user to hear or see the scientist explain his or her research in what is known as pubcasts.

Pedagogy and the Class Blog:

I’ve been using blogs in my teaching for several years now, so I wanted to share a few ideas that have worked for me. I’m no expert and I’m still casting about for solutions to some of the more nagging problems, but after thirteen course blogs spread across seven semesters (I just counted!), I have obtained a small measure of experience. In other words, I keep making mistakes, but at least not the same ones over and over.

Practicing Medicine in the Age of Facebook:

In my second week of medical internship, I received a “friend request” on Facebook, the popular social-networking Web site. The name of the requester was familiar: Erica Baxter. Three years earlier, as a medical student, I had participated in the delivery of Ms. Baxter’s baby. Now, apparently, she wanted to be back in touch…..

Are young people of today Relationally Starved?:

The more I toss it around, I’m not so sure that our students are “relationally starved.” I just think that relationships look much different today than they have in generations past. Their relationships are more fluid and maybe a little more fragile. It is obvious that advances in technology have changed the way relationships are built and maintained (it has for me). This doesn’t mean that children aren’t in need of the same nurturing and love that we might have had, but there are other layers that we need to ask them about. And I think that might be the key, ASK THEM!

The New Yorker vs. the Kindle:

Now, let’s imagine for a moment that we are back in the 15th century, to be precise just shortly after 1439, when Johannes Gensfleisch zur Laden zum Gutenberg invented movable type printing. I can only imagine the complaints that Baker would have uttered in the local paper (which was, of course, copied by hand from the original dictation). What? Only one title on the catalog? (The Bible.) Oh, and the fonts are sooo boring compared to handwriting. And no colors! And the quality of the drawings, simply unacceptable. This movable type printing thing will never ever replace the amanuenses, it will simply die as yet another “modern invention” and things will keep being just the same as they have been throughout what they at the time didn’t yet call the Middle Ages.

The New Yorker & The News Biz:

After many years, I am finally subscribing to the New Yorker again. Not in print, but via their Digital Reader. I’m blogging about it because I like their model: the Digital Reader adds something I wouldn’t get from the library version, and I feel like this new model bears watching as we migrate from print to online.

The psychology of reading for pleasure:

According to a neurological study that Nell performed, processing demands are higher with books than other media (movies, television) but that also means that when you are absorbed in a book, you are more likely to block out distractions. While readers describe being absorbed in a book as “effortless,” their brains are actually intensely active. As one critic said, this is not an escape from thinking, it’s an escape into thinking – intensely, and without distraction.

How Twitter works in theory:

The key to Twitter is that it is phatic – full of social gestures that are like apes grooming each other. Both Google and Twitter have little boxes for you to type into, but on Google you’re looking for information, and expecting a machine response, whereas on Twitter you’re declaring an emotion and expecting a human response. This is what leads to unintentionally ironic newspaper columns bemoaning public banality, because they miss that while you don’t care what random strangers feel about their lunch, you do if its your friend on holiday in Pompeii.
——————–
For those with Habermas’s assumption of a single common public sphere this makes no sense – surely everyone should see everything that anyone says as part of the discussion? In fact this has never made sense, and in the past elaborate systems have been set up to ensure that only a few can speak, and only one person can speak at a time, because a speech-like, real-time discourse has been the foundational assumption.
Too often this worldview has been built into the default assumptions of communications online; we see it now with privileged speakers decrying the use of anonymity in the same tones as 19th century politicians defended hustings in rotten boroughs instead of secret ballots. Thus the tactics of shouting down debate in town halls show up as the baiting and trollery that make YouTube comments a byword for idiocy; when all hear the words of one, the conversation often decays.

Blogging Evolution (PDF):

I describe the general characteristics of blogs, contrasting blogs with other of WWW formats for self-publishing. I describe four categories for blogs about evolutionary biology: “professional,” “amateur,” “apostolic,” and “imaginative.” I also discuss blog networks. I identify paradigms of each category. Throughout, I aim to illuminate blogs about evolutionary biology from the point of view of a
user looking for information about the topic. I conclude that blogs are not the best type of source for systematic and authoritative information about evolution, and that they are best used by the information-seeker as a way of identifying what issues are of interest in the community of evolutionists and for generating research leads or fresh insights on one’s own work.

What Do Mathematicians Need to Know About Blogging?:

Steven Krantz asked me to write an opinion piece about math blogging in the Notices of the American Mathematical Society. I asked if I could talk about this column on my blog, and even have people comment on drafts of it before it comes out in the Notices. He said okay. So, just to get the ball rolling, let me ask: what do you think mathematicians need to know about blogging?

Five Key Reasons Why Newspapers Are Failing and Five Key Reasons Why Newspapers Are Failing, pt. 2:

Journalists are pretty good at working the scene of a disaster. They’ll tell you what happened, who did it, and why.
But when it comes to the disaster engulfing their own profession, their analysis is less rigorous. An uncharacteristic haze characterizes a lot of the reporting and commentary on the current crisis of the industry.
It could have been brought on by delicacy, perhaps romanticism. And since it is not just any crisis, but a definitive one–one that seems to mean an end to the physical papers’ role in American life as we have come to know it–perhaps there’s a little bit of shell-shock in the mix as well.

Online Community Building: Gardening vs Landscaping:

The Gardener creates an ecosystem open to change, available to new groups, and full of fresh opportunities to emerge naturally. The approach is focused on organic collaboration and growth for the entire community. The gardener is simply there to help, cultivate, and clear the weeds if/when they poke up.
The Landscaper creates an ecosystem that matches a preconceived design or pattern. The approach is focused on executing a preconceived environment, regardless of how natural or organic it may be for the larger area. The landscaper is there to ensure that everything stays just as planned.

Don’t Be Such a Scientist: Talking Substance in an Age of Style (book review):

So I end up feeling a bit torn. He’s telling us “Don’t be such a scientist”, and it’s true that there are many occasions when the scientific attitude can generate unnecessary obstacles to accomplishing our goals. At the same time, though, I want to say “Do be such a scientist”, because it’s part of our identity and it makes us stand out as unusual and, like Randy, interesting, even if it sometimes does make us a bit abrasive. But, you know, some of us revel in our abrasiveness; it’s fun.

This has also been in the news a lot last week:
Threats to science-based medicine: Pharma ghostwriting
Wyeth, ‘Ghost-Writing’ and Conflict of Interest
More On Ghostwriting, Wyeth and Hormone Replacement Therapy
Wyeth’s ghostwriting skeletons yanked from the closet
Ghostwriters in the sky
Quickie Must-Read Link … (probably the best commentary of them all).
Several recent posts on the topic dear to my heart – the so-called “civility” in public (including online) discourse:
How Creationism (and Other Idiocies) Are Mainstreamed:

One of the things that has enabled the mainstreaming of various idiocies, from altie woo, to creationism, to global warming denialism is mainstream corporate media’s inability to accurately describe lunacy. For obvious reasons, ‘family-friendly’ newspapers and teevee can’t call creationists, birthers, or deathers batshit lunatic or fucking morons. This is where ‘civility’ (beyond the basic norms of decency when dealing with the mentally ill) and pretensions of ‘balance’ utterly fail.

Weekend Diversion: How to Argue:

You are, of course, free to argue however you like. But if you want to argue on my site, you’re really best off remembering this hierarchy, and staying as high as possible on it. Most of you do pretty well, but this has served me well in general, and I hope it helps you to see things laid out like this. And if not, at least you got a great song out of it!

When an image makes an argument:

Along similar lines to a frequentist interpretation of the strata, maybe this pyramid is conveying something about the ease or difficulty inherent in different types of engagement. It doesn’t take a lot of effort to call someone an asshat, but understanding her argument well enough to raise a good counterexample to it may take some mental labor. If this is the rhetorical work that the pyramidal layout does here, it may also suggest a corresponding hierarchy of people who have the mental skills to engage in each of these ways — making the people at the tippy-top of the pyramid more elite than those using the strategies from lower strata.

How to Argue…:

White men are sufficiently privileged enough to demand that they be treated respectfully while white women, at best, can expect to be presented with contradiction and counterargument. When I saw the category “responding to tone” I thought of the “angry black man” who, although perhaps right, is castigated for his anger and lack of civility for not conforming to the norms of white society. If you’re a non-white woman? Then, the best you can do is hope to not be denied food and shelter if you don’t fuck your husband enough (h/t to Free-Ride for pointing this article out), but you only expect to be part of the discussion if you’re allowed to be.
————————–
The call to civility is a frequent tactic to derail the discussion and is as much of an ad hominem attack as calling someone a cocknozzle. It fails to recognize the perspective of the other party or appreciate why they might be angry.

More on the topic:
Dr. Isis Learns to Argue:

I am lucky to have such thoughtful commenters. When I wrote the previous post I had no idea that bleeding from my vagina was clouding my judgement. Then, just when I thought I had cleared enough of the estrogen from my girl brain to understand, I learned that this was all a carefully planned tactic to teach me a lesson. Damn! I hate when that happens!

Weekend Diversion: How to argue…and actually accomplish something:

Here we arrive at the meat of the matter. Once having accomplished more than about 300 ms worth of consideration of a given topic, people are highly resistant to the idea that their rationale, conclusions and evidence base might actually be wrong. And the wronger the consideration might be, the more resistant to acknowledgment is the individual. We might think of this as the intrapersonal Overton window.

A Tale of Two Nations: the Civil War may have been won by the North, but in truth the South never emotionally conceded.:

The Civil War may have been won by the North, but in truth the South never emotionally conceded.
The Town Hall mobs, the birthers, the teabaggers are all part of that long line of “coded” agitators for the notions of white entitlement and “conservative values.”
Of course, this conservative viewpoint values cheap labor and unabated use of natural resources over technological and economic innovation. It also – and this is its hot molten core – fundamentally believes that white people are born with a divine advantage over people of other skin colors, and are chosen by God to lead the heathen hordes.
That a Town Hall mob is itself a heathen horde would never occur to the economically stressed whites who listen to the lies of the likes of Glenn Beck, Sean Hannity, Rush Limbaugh and Lou Dobbs. Lies that confirm an emotionally reinforcing worldview – however heinous – become truths for those in psychological need of feeling superior and chosen.

I remember an America where black men didn’t grow up to be President.:

And all of them are asking for their America back. I wonder which America that would be?
Would that be the America where the Supreme Court picks your president instead of counting all the votes? Would that be the America where rights to privacy are ignored? Would that be the America where the Vice President shoots his best friend in the face? Or would that be the America where an idiot from Alaska and a college drop-out with a radio show could become the torchbearers for the now illiterate Republican party?
I fear that would not be the America they want back. I fear that the America they want back is the one where black men don’t become President.
I remember that America. In that America people screaming at public gatherings were called out for what they were – an angry mob. Of course, they wore sheets to cover up their bad hair. Let’s be clear about something: if you show up to a town hall meeting with a gun strapped to your leg, the point you are trying to make isn’t a good one. Fear never produced anything worthwhile.

In America, Crazy Is a Preexisting Condition:

The tree of crazy is an ever-present aspect of America’s flora. Only now, it’s being watered by misguided he-said-she-said reporting and taking over the forest. Latest word is that the enlightened and mild provision in the draft legislation to help elderly people who want living wills — the one hysterics turned into the “death panel” canard — is losing favor, according to the Wall Street Journal, because of “complaints over the provision.”

Two oldies but goodies:
Atheists and Anger:

One of the most common criticisms lobbed at the newly-vocal atheist community is, “Why do you have to be so angry?” So I want to talk about:
1. Why atheists are angry;
2. Why our anger is valid, valuable, and necessary;
And 3. Why it’s completely fucked-up to try to take our anger away from us.

Atheists and Anger: A Reply to the Hurricane:

Now my replies to the critics. I suppose I shouldn’t bother, I suppose I should just let it go and focus on the love. But I seem to be constitutionally incapable of letting unfair or inaccurate accusations just slide. So here are my replies to some of the critical comments’ common themes.

The Privilege of Politeness:

One item that comes up over and over in discussions of racism is that of tone/attitude. People of Color (POC) are very often called on their tone when they bring up racism, the idea being that if POC were just more polite about the whole thing the offending person would have listened and apologized right away. This not only derails the discussion but also tries to turn the insults/race issues into the fault of POC and their tone. Many POC have come to the realization that the expectation of politeness when saying something insulting is a form of privilege. At the core of this expectation of politeness is the idea that the POC in question should teach the offender what was wrong with their statement. Because in my experience what is meant by “be polite” is “teach me”, teach me why you’re offended by this, teach me how to be racially sensitive and the bottom line is that it is no one’s responsibility to teach anyone else. And even when POC are as polite as possible there is still hostility read into the words because people are so afraid of being called racist that they would rather go on offending than deal with the hard road of confronting their own prejudices.

Clock Quotes

True silence is the rest of the mind; it is to the spirit what sleep is to the body, nourishment and refreshment.
– William Penn

Science Online London 2009 – now in Second Life

Science Online London is next week. I really wanted to go this year, but hard choices had to be made….eh, well.
For those of you who, like me, cannot be there in person, there are plenty of ways to follow the meeting virtually. Follow @soloconf and the #solo09 hashtag on Twitter. Join the FriendFeed room. Check out the Facebook page. And of course there will be a lot of blogging, including in the Forums at Nature Network.
And for those of you who have computers with enough power and good graphics cards, another option is to follow the conference in Second Life – check that link to see how.

Bring Bing Home

Bing Haubrich has made new friends in Japan, but they want to keep him there. In fact, they have threatened to hold him for ransom unless his American friends and family do two things:
1. Answer questions about Japan/Nippon culture and cuisine.
2. Donate money to help his mother pay the plane fare for his trip.

It’s tempting for a young man to stay in Japan, because so far he has found the food to be awesome and the shopping (even in vending machines) to be, let’s say, “unique.” In fact, the Japanese students think that if he stays long enough he could use his ninja powers to be Emperor someday. I don’t think that this would be a good thing for world peace, as Bing has not worked out his “Megalomania” issues and bad things could happen.

So, test your knowledge and help bring this young man home….

Today’s carnivals

Skeptics Circle #117 is up on Ionian Enchantment
The latest Four Stone Hearth is up on Greg Laden’s blog
Friday Ark #256 is up on Modulator

Making the Web Work for Science (video)

Making the Web Work for Science – Full from Jordan Mendelson on Vimeo.

From left to right: Tim O’Reilly, Jimmy Wales, Stephen Friend and John Wilbanks – via Jonathan (there is also a shorter summary version here)

The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
Here are the submissions for OpenLab 2009 to date. As we have surpassed 280 entries, all of them, as well as the “submit” buttons and codes and the bookmarklet, are under the fold. You can buy the 2006, 2007 and 2008 editions at Lulu.com. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):

Continue reading

Clock Quotes

For me the creative process, first of all, requires a good nine hours of sleep at night. Second, it must not be pushed by the need to produce practical applications.
– William N. Lipscomb, Jr.

Kseniya Simonova – Sand Animation (video)


The winner of Ukraine’s Got Talent.

Clock Interview: John Hogenesch – genes, clocks, Web and ScienceOnline’09

The series of interviews with some of the participants of the 2008 Science Blogging Conference was quite popular, so I decided to do the same thing again this year, posting interviews with some of the people who attended ScienceOnline’09 back in January.
This is also the first in what I hope will be a long series of interviews with researchers in my field of Chronobiology.

Today, I asked John Hogenesch, my chronobiologist colleague who moderated the ‘Community intelligence applied to gene annotation’ session at ScienceOnline’09, to answer a few questions.
Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Who are you? What is your (scientific) background?
I’m an Associate Professor at the University of Pennsylvania in the Department of Pharmacology. Our lab works on clocks, but also on functional genomics in mammals. I did my graduate work in neuroscience at Northwestern University at the Chicago campus with Chris Bradfield. In Chris’s lab, I worked on identifying and characterizing new members of the bHLH-PAS class of transcription factors — several of these orphan PAS domain proteins ended up being Bmal1, its paralog Bmal2, and Npas2, core components of the E-box machinery of the clock. For my postdoctoral training, I joined the lab of Steve Kay at the then developing Genomics Institute of the Novartis Research Foundation. Later , I started my own lab there focusing on functional genomics and became Director of Genomics. These research projects included circadian clock research, but also other areas of biology that were of interest to me or GNF.
How did it happen that you became a scientist? How did you end up in chronobiology?
I’m a second-generation scientist, my dad is professor of chemistry at the University of Southern California. My mom also teaches at USC, and my brother is a political science professor at Cal State Northridge. So, you could say that science/academia is in the family.
I ended up interested in chronobiology largely based on a lecture in the first year graduate school by Joe Takahashi. Joe gave this fabulous lecture covering the progress of the Drosophila clock field in the fall of 1992, and I was hooked.
What is your Real Life job? What do you want to do/be when (and if ever) you grow up?
My real life job is the complicated life of academic science. Teaching, mentoring, sitting on study section, running a research group, being involved in graduate groups, sitting on committees, writing grants, and, time permitting, writing papers. (Oh yeah, I have twin one-year-old boys and a five-year-old to occupy my remaining day and night.)
I’m not sure what I will be when I grow up. I view science as a career of continual development. I started my research career mining genome data for new bHLH-PAS proteins (informatics). Then I cloned and characterized them — molecular and cellular biology. Then I became a genomicist, and learned a lot more about bioinformatics. I’m not really sure what will come next, but I hope to continue to learn how to do new things and apply them to subjects I’m interested in such as the clock.
Can you explain to my lay audience, what your research is all about?
Our research involves learning how the clock works. In humans, the clock is actually your whole body, as clocks are everywhere, not just in your brain. There are really three facets of circadian clock function — synchronizing with your environment, keeping time, and regulating physiology and behavior. We are working on all three of these issues to various extents.
What aspect of science communication and/or particular use of the Web in science interests you the most?
John Hogenesh pic.jpgI call myself a first generation Atari American — I’ve spent most of my life around computers. Because of that, I probably see more opportunities than most people to exploit information technology, bioinformatics, and the Web. I use it to manage my own personal communications — I’m big into Gmail and Google voice. I use tools such as Basecamp, project management software, to keep track of how things are going in the lab and collaborate with other laboratories. We dabble in computational approaches in the lab, occasionally more than dabble.
About 10 years or so ago, I listened to David Botstein when he began advocating for open science and the release of large data sets. It was obvious — if you collect information on 10,000 genes, but only follow up one or a few, it’s really a shame to let the remaining data lie fallow. It occurred to me that a good way to avoid this would be to publish data and make it available. Again pretty obvious. However, depositing data in a database is not enough to ensure that it is used. In 1998, Rusty Thomas, a colleague in the Bradfield lab, and I put together a gene expression database to enable end-users, not card-carrying computational biologists, to explore large toxicology data sets. When I got to GNF and had the resources to do something like this at scale, I jumped at the chance. With an extremely talented graduate student, Andy Su (now director of computational biology at GNF), we built the Gene Atlas/Symatlas, a repository of multiple tissue expression data for human and mouse genes. This resource has been highly used by the research community. I thought, if this works for tissue specific gene expression, which was a peripheral interest of mine, it should work just as well for circadian data. So we built the first circadian expression databases. Now, we’re putting up other large-scale data sets such as siRNA screens. When tens, dozens, or hundreds of labs are using your resources, good things will come of it.
The Web and technology to exploit it have changed, but the basic principle of open science has not. Papers associated with these databases are read more, the data sets are used more, the papers are cited more, it’s win-win.
You are involved in a number of initiatives involving Wikipedia and gene annotation online – can you tell us more about these?
My foray into gene annotation efforts really began with the Gene Atlas. The Web isn’t static, though, and other opportunities emerged. One of these was Wikipedia. We noticed that the canonical gene annotation efforts at NCBI were understaffed — one person ran Locus Link. Andy thought , why not apply community intelligence, which generated a resource to rival Encyclopaedia Britannica, to gene annotation efforts? I agreed. Again, if something like this is going to happen on a genome scale, I’ll do my best to make sure that the circadian clock community benefits first. Now, if you go to Google and search a clock gene such as Bmal1, the first link that comes up is the Arntl entry in Wikipedia. When a clock rookie looks at the circadian gene, they go to its Wikipedia page, an archive and evolving review paper, to learn about it. That’s a fact.
The second recent development is BioGPS, a descendent of the Gene Atlas and SymAtlas. It handles gene synonyms, but more importantly, it allows one to use lightweight methods, URL-based, to aggregate and visualize gene-based data sets. This is the technology we use to build the siRNA screening database. We put our data in there, but also linked this cell based screening data to gene expression data sets (circadian and multiple tissue expression), annotation efforts at NCBI and Wikipedia, and the UCSC genome browser. The really cool aspect of it, though, is that it’s customizable. If you want to add a new data set, you can, or you can link to one of the 100+ plug-in data sets with a couple of mouse clicks. A customized gene portal with your favorite data in a couple of minutes for free.
How does (if it does) blogging figure in your work? How about social networks, e.g., Twitter, FriendFeed and Facebook?
I don’t currently blog. It’s not that I’m opposed to it, it’s just that I have my hands full. I do use Facebook, but mostly to keep up with friends and family.
When and how did you discover science blogs? What are some of your favourites? Have you discovered any new cool science blogs while at the Conference?
Is this a trick question? Yours of course. When I can, I also tune into Mike Eisen, a fellow baseball and genomics enthusiast, and Andy Su.
Is there anything that happened at this Conference – a session, something someone said or did or wrote – that will change the way you think about science communication, or something that you will take with you to your job, blog-reading and blog-writing?
Andy and I had a long discussion with Deepak Singh from Amazon on their Web Services platform (AWS). It’s two things, storage and compute power — you buy what you need when you need it. I came back to Penn and began advocating for testing these platforms out on our own data. Even big institutions such as ours have problems with access to compute clusters. We are already exploiting AWS for proteomics work, and beginning to do the same now for genomic data — Steven Salzberg at the University of Maryland has pioneered some of these ideas.
My summary: at this point, if you use north of 70% of your CPU cycles, you’re probably better off buying your own. If you use less than 50%, AWS already makes sense, and much below that, I would argue it’s a no-brainer. There are some problems — you have to code in a particular way, data transfer costs can add up, but these things can be mitigated and Amazon is working hard to do so. Why buy expensive hardware, maintain and service it, and compete for high-priced IT talent, when Amazon already does that better than academia ever will?
For the molecular biologists in the audience, it’s sort of like buying a polyacrylamide gel rather than pouring one. Until I told people in the lab about eight years ago, no more pouring page gels. It’s time-consuming, which is money consuming, and I would rather have them do something else.
It was so nice to see see you again and thank you for the interview. I hope to see you again next January.
==========================
See the 2008 interview series and 2009 series for more.