Author Archives: Bora Zivkovic

Clock Quotes

The illiterate of the 21st century will not be those who cannot read and write, but those who cannot learn, unlearn, and relearn
– A. Toffler

New and Exciting in PLoS this week

Hmm, I usually do this on Fridays, but I was busy. So here is a Saturday sampler of papers from all seven PLoS journals published last week. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click.

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We report, you decide

He is the BBC’s latest star – the cab driver who a leading presenter believed was a world expert on the internet music business.
The man stepped unwittingly into the national spotlight when he was interviewed by mistake on the corporation’s News 24 channel.
With the seconds ticking down to a studio discussion about a court case involving Apple Computer and The Beatles’ record label, a floor manager had run to reception and grabbed the man, thinking he was Guy Kewney, editor of Newswireless.net, a specialist internet publication.
Actually, he was a minicab driver who had been waiting to drive Mr Kewney home.
Despite knowing nothing about the case – a judge ruled that the computer company could continue to use the Apple symbol for its iTunes download service – the man gamely attempted to bluff his way through and, speaking in a strong French accent, sustained a (somewhat illogical) form of conversation. Meanwhile, the real Mr Kewney watched indignantly on a monitor in reception.


BBC, just like Bentham publishers, easy to fool.
Follow up here. And there is a
Wikipedia page about the whole incident.

Ethic of the Link

This is an experiment…

…in embedding FriendFeed conversations in a blog post:

Today’s carnivals

The 92nd Edition of Carnival of the Liberals is up on OBAMA ACTION COMICS!
Friday Ark #247 is up on Modulator

My picks from ScienceDaily

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Clock Quotes

There is nothing good about blindly abiding to certain paradigms, simply because you were instructed by authoritative figures from the stages of infancy to do so …
– Vanesh Naidoo

New and Exciting in PLoS ONE

There are 15 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
The Timing of the Shrew: Continuous Melatonin Treatment Maintains Youthful Rhythmic Activity in Aging Crocidura russula:

Laboratory conditions nullify the extrinsic factors that determine the wild expected lifespan and release the intrinsic or potential lifespan. Thus, wild animals reared in a laboratory often show an increased lifespan, and consequently an increased senescence phase. Senescence is associated with a broad suite of physiological changes, including a decreased responsiveness of the circadian system. The time-keeping hormone melatonin, an important chemical player in this system, is suspected to have an anti-aging role. The Greater White-toothed shrew Crocidura russula is an ideal study model to address questions related to aging and associated changes in biological functions: its lifespan is short and is substantially increased in captivity; daily and seasonal rhythms, while very marked the first year of life, are dramatically altered during the senescence process which starts during the second year. Here we report on an investigation of the effects of melatonin administration on locomotor activity of aging shrews.1) The diel fluctuations of melatonin levels in young, adult and aging shrews were quantified in the pineal gland and plasma. In both, a marked diel rhythm (low diurnal concentration; high nocturnal concentration) was present in young animals but then decreased in adults, and, as a result of a loss in the nocturnal production, was absent in old animals. 2) Daily locomotor activity rhythm was monitored in pre-senescent animals that had received either a subcutaneous melatonin implant, an empty implant or no implant at all. In non-implanted and sham-implanted shrews, the rhythm was well marked in adults. A marked degradation in both period and amplitude, however, started after the age of 14-16 months. This pattern was considerably delayed in melatonin-implanted shrews who maintained the daily rhythm for significantly longer. This is the first long term study (>500 days observation of the same individuals) that investigates the effects of continuous melatonin delivery. As such, it sheds new light on the putative anti-aging role of melatonin by demonstrating that continuous melatonin administration delays the onset of senescence. In addition, the shrew appears to be a promising mammalian model for elucidating the precise relationships between melatonin and aging.

Toward the Restoration of Hand Use to a Paralyzed Monkey: Brain-Controlled Functional Electrical Stimulation of Forearm Muscles:

Loss of hand use is considered by many spinal cord injury survivors to be the most devastating consequence of their injury. Functional electrical stimulation (FES) of forearm and hand muscles has been used to provide basic, voluntary hand grasp to hundreds of human patients. Current approaches typically grade pre-programmed patterns of muscle activation using simple control signals, such as those derived from residual movement or muscle activity. However, the use of such fixed stimulation patterns limits hand function to the few tasks programmed into the controller. In contrast, we are developing a system that uses neural signals recorded from a multi-electrode array implanted in the motor cortex; this system has the potential to provide independent control of multiple muscles over a broad range of functional tasks. Two monkeys were able to use this cortically controlled FES system to control the contraction of four forearm muscles despite temporary limb paralysis. The amount of wrist force the monkeys were able to produce in a one-dimensional force tracking task was significantly increased. Furthermore, the monkeys were able to control the magnitude and time course of the force with sufficient accuracy to track visually displayed force targets at speeds reduced by only one-third to one-half of normal. Although these results were achieved by controlling only four muscles, there is no fundamental reason why the same methods could not be scaled up to control a larger number of muscles. We believe these results provide an important proof of concept that brain-controlled FES prostheses could ultimately be of great benefit to paralyzed patients with injuries in the mid-cervical spinal cord.

Scale-Free Music of the Brain:

There is growing interest in the relation between the brain and music. The appealing similarity between brainwaves and the rhythms of music has motivated many scientists to seek a connection between them. A variety of transferring rules has been utilized to convert the brainwaves into music; and most of them are mainly based on spectra feature of EEG. In this study, audibly recognizable scale-free music was deduced from individual Electroencephalogram (EEG) waveforms. The translation rules include the direct mapping from the period of an EEG waveform to the duration of a note, the logarithmic mapping of the change of average power of EEG to music intensity according to the Fechner’s law, and a scale-free based mapping from the amplitude of EEG to music pitch according to the power law. To show the actual effect, we applied the deduced sonification rules to EEG segments recorded during rapid-eye movement sleep (REM) and slow-wave sleep (SWS). The resulting music is vivid and different between the two mental states; the melody during REM sleep sounds fast and lively, whereas that in SWS sleep is slow and tranquil. 60 volunteers evaluated 25 music pieces, 10 from REM, 10 from SWS and 5 from white noise (WN), 74.3% experienced a happy emotion from REM and felt boring and drowsy when listening to SWS, and the average accuracy for all the music pieces identification is 86.8%(κ = 0.800, P<0.001). We also applied the method to the EEG data from eyes closed, eyes open and epileptic EEG, and the results showed these mental states can be identified by listeners. The sonification rules may identify the mental states of the brain, which provide a real-time strategy for monitoring brain activities and are potentially useful to neurofeedback therapy.

Adaptive Response to DNA-Damaging Agents in Natural Saccharomyces cerevisiae Populations from “Evolution Canyon”, Mt. Carmel, Israel:

Natural populations of most organisms, especially unicellular microorganisms, are constantly exposed to harsh environmental factors which affect their growth. UV radiation is one of the most important physical parameters which influences yeast growth in nature. Here we used 46 natural strains of Saccharomyces cerevisiae isolated from several natural populations at the “Evolution Canyon” microsite (Nahal Oren, Mt. Carmel, Israel). The opposing slopes of this canyon share the same geology, soil, and macroclimate, but they differ in microclimatic conditions. The interslope differences in solar radiation (200%-800% more on the “African” slope) caused the development of two distinct biomes. The south-facing slope is sunnier and has xeric, savannoid “African” environment while the north-facing slope is represented by temperate, “European” forested environment. Here we studied the phenotypic response of the S. cerevisiae strains to UVA and UVC radiations and to methyl methanesulfonate (MMS) in order to evaluate the interslope effect on the strains’ ability to withstand DNA-damaging agents. We exposed our strains to the different DNA-damaging agents and measured survival by counting colony forming units. The strains from the “African” slope were more resilient to both UVA and MMS than the strains from the “European” slope. In contrast, we found that there was almost no difference between strains (with similar ploidy) from the opposite slopes, in their sensitivity to UVC radiation. These results suggest that the “African” strains are more adapted to higher solar radiation than the “European” strains. We also found that the tetraploids strains were more tolerant to all DNA-damaging agents than their neighboring diploid strains, which suggest that high ploidy level might be a mechanism of adaptation to high solar radiation. Our results and the results of parallel studies with several other organisms, suggest that natural selection appears to select, at a microscale, for adaptive complexes that can tolerate the higher UV radiation on the “African” slope.

Hello, this is a journalist from the ’80s speaking….

Sorry, could not resist posting this:

The Daily Show With Jon Stewart Mon – Thurs 11p / 10c
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Clock Quotes

Make sure you never, never argue at night. You just lose a good night’s sleep, and you can’t settle anything until morning anyway.
– Rose Fitzgerald Kennedy

New and Exciting in PLoS ONE

There are 16 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
A Standard System to Study Vertebrate Embryos:

Staged embryonic series are important as reference for different kinds of biological studies. I summarise problems that occur when using ‘staging tables’ of ‘model organisms’. Investigations of developmental processes in a broad scope of taxa are becoming commonplace. Beginning in the 1990s, methods were developed to quantify and analyse developmental events in a phylogenetic framework. The algorithms associated with these methods are still under development, mainly due to difficulties of using non-independent characters. Nevertheless, the principle of comparing clearly defined newly occurring morphological features in development (events) in quantifying analyses was a key innovation for comparative embryonic research. Up to date no standard was set for how to define such events in a comparative approach. As a case study I compared the external development of 23 land vertebrate species with a focus on turtles, mainly based on reference staging tables. I excluded all the characters that are only identical for a particular species or general features that were only analysed in a few species. Based on these comparisons I defined 104 developmental characters that are common either for all vertebrates (61 characters), gnathostomes (26), tetrapods (3), amniotes (7), or only for sauropsids (7). Characters concern the neural tube, somite, ear, eye, limb, maxillary and mandibular process, pharyngeal arch, eyelid or carapace development. I present an illustrated guide listing all the defined events. This guide can be used for describing developmental series of any vertebrate species or for documenting specimen variability of a particular species. The guide incorporates drawings and photographs as well as consideration of species identifying developmental features such as colouration. The simple character-code of the guide is extendable to further characters pertaining to external and internal morphological, physiological, genetic or molecular development, and also for other vertebrate groups not examined here, such as Chondrichthyes or Actinopterygii. An online database to type in developmental events for different stages and species could be a basis for further studies in comparative embryology. By documenting developmental events with the standard code, sequence heterochrony studies (i.e. Parsimov) and studies on variability can use this broad comparative data set.

The Effect of the Crosstalk between Photoperiod and Temperature on the Heading-Date in Rice:

Photoperiod and temperature are two important environmental factors that influence the heading-date of rice. Although the influence of the photoperiod on heading has been extensively reported in rice, the molecular mechanism for the temperature control of heading remains unknown. This study reports an early heading mutant derived from tissue culture lines of rice and investigates the heading-date of wild type and mutant in different photoperiod and temperature treatments. The linkage analysis showed that the mutant phenotype cosegregated with the Hd1 locus. Sequencing analysis found that the mutant contained two insertions and several single-base substitutions that caused a dramatic reduction in Hd1mRNA levels compared with wild type. The expression patterns of Hd1 and Hd3a were also analyzed in different photoperiod and temperature conditions, revealing that Hd1 mRNA levels displayed similar expression patterns for different photoperiod and temperature treatments, with high expression levels at night and reduced levels in the daytime. In addition, Hd1 displayed a slightly higher expression level under long-day and low temperature conditions. Hd3a mRNA was present at a very low level under low temperature conditions regardless of the day-length. This result suggests that suppression of Hd3a expression is a principle cause of late heading under low temperature and long-day conditions.

The Role of Dopamine in Drosophila Larval Classical Olfactory Conditioning:

Learning and memory is not an attribute of higher animals. Even Drosophila larvae are able to form and recall an association of a given odor with an aversive or appetitive gustatory reinforcer. As the Drosophila larva has turned into a particularly simple model for studying odor processing, a detailed neuronal and functional map of the olfactory pathway is available up to the third order neurons in the mushroom bodies. At this point, a convergence of olfactory processing and gustatory reinforcement is suggested to underlie associative memory formation. The dopaminergic system was shown to be involved in mammalian and insect olfactory conditioning. To analyze the anatomy and function of the larval dopaminergic system, we first characterize dopaminergic neurons immunohistochemically up to the single cell level and subsequent test for the effects of distortions in the dopamine system upon aversive (odor-salt) as well as appetitive (odor-sugar) associative learning. Single cell analysis suggests that dopaminergic neurons do not directly connect gustatory input in the larval suboesophageal ganglion to olfactory information in the mushroom bodies. However, a number of dopaminergic neurons innervate different regions of the brain, including protocerebra, mushroom bodies and suboesophageal ganglion. We found that dopamine receptors are highly enriched in the mushroom bodies and that aversive and appetitive olfactory learning is strongly impaired in dopamine receptor mutants. Genetically interfering with dopaminergic signaling supports this finding, although our data do not exclude on naïve odor and sugar preferences of the larvae. Our data suggest that dopaminergic neurons provide input to different brain regions including protocerebra, suboesophageal ganglion and mushroom bodies by more than one route. We therefore propose that different types of dopaminergic neurons might be involved in different types of signaling necessary for aversive and appetitive olfactory memory formation respectively, or for the retrieval of these memory traces. Future studies of the dopaminergic system need to take into account such cellular dissociations in function in order to be meaningful.

Ecological Niche Models and Coalescent Analysis of Gene Flow Support Recent Allopatric Isolation of Parasitoid Wasp Populations in the Mediterranean:

The integration of multiple complementary approaches is a powerful way to understand the processes of diversification and speciation. The parasitoid wasp Aphidius transcaspicus Telenga (Hymenoptera: Braconidae) is a parasitoid of Hyalopterus aphids across a wide geographic range. This species shows a remarkable degree of genetic structure among western, central, and eastern Mediterranean population clusters. In this paper we attempt to better characterize this genetic structure. We use a Bayesian coalescent analysis of gene flow under the Isolation with Migration model using mitochondrial and microsatellite markers together with climate-based ecological niche models to better understand the genetic structure of A. transcaspicus in the Mediterranean. The coalescent analysis revealed low levels of migration among western and eastern Mediterranean populations (Nm<1) that were not statistically distinguishable from zero. Niche models showed that localities within population clusters each occupy areas of continuously high environmental suitability, but are separated from each other by large regions of completely unsuitable habitat that could limit dispersal. Overall, environmental characteristics were similar among the population clusters, though significant differences did emerge. These results support contemporary allopatric isolation of Mediterranean populations of A. transcaspicus, which together with previous analyses indicating partial behaviorally mediated reproductive isolation, suggest that the early stages of cryptic speciation may be in progress.

Today’s carnivals

I And The Bird #102 is up on Birder’s Lounge
June edition of Change of Shift is up on Florence dot com
Grand Rounds, Volume 5, Number 38 are up on The Jobbing Doctor
And there are only a couple of days left until the next Giant’s Shoulders, so try to write and send in something appropriate on History Of Science.

My picks from ScienceDaily

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Clock Quotes

If I thought there was some reason to be concerned about them, I wouldn’t be sleeping in this house tonight. (When asked about continued presence of Soviet nuclear submarines along US coastlines)
– Ronald Wilson Reagan

Why or why not cite blog posts in scientific papers?

As the boundaries between formal and informal scientific communication is blurring – think of pre-print sites, Open Notebook Science and blogs, for starters – the issue of what is citable and how it should be cited is becoming more and more prominent.
There is a very interesting discussion on this topic in the comments section at the Sauropod Vertebra Picture of the Week blog, discussing the place of science blogs in the new communication ecosystem and if a blog post can be and should be cited. What counts as a “real publication”? Is the use of the phrase “real publication” in itself misleading?
You may remember that I have touched on this topic several times over the past few years (as two of my blog posts got cited in scientific papers), most recently in the bottom third (after the word “Except…”) of this post, where I wrote:

National Library of Medicine even made some kind of “official rules for citing blogs” which are incredibly misguided and stupid (and were not changed despite some of us, including myself, contacting them and explaining why their rules are stupid – I got a seemingly polite response telling me pretty much that my opinion does not matter). Anyway, how can anyone make such things ‘official’ when each journal has its own reference formatting rules? If you decide to cite a blog post, you can pretty much use your own brain and put together a citation in a format that makes sense.
The thing is, citing blogs is a pretty new thing, and many people are going to be uneasy about it, or ignorant of the ability and appropriateness to cite blogs, or just so unaware of blogs they would not even know that relevant information can be found on them and subsequently cited. So, if you see that a new paper did not cite your paper with relevant information in it, you can get rightfully angry, but if you see that a new paper did not cite your blog post with relevant information in it, you just shrug your shoulders and hope that one day people will learn….
One of the usual reasons given for not citing blog posts is that they are not peer-reviewed. Which is not true. First, if the post contained errors, readers would point them out in the comments. That is the first layer of peer review. Then, the authors of the manuscript found and read a blog post, evaluated its accuracy and relevance and CHOSE to use it as a reference. That is the second layer of peer-review. Then, the people who review the manuscript will also check the references and, if there is a problem with the cited blog post, they will point this out to the editor. This is the third layer of peer-review. How much more peer-review can one ask for?
And all of that ignores that book chapters, books, popular magazine articles and even newspaper articles are regularly cited, not to mention the ubiqutous “personal communication”. But blogs have a bad rep, because dinosaur corporate curmudgeon journalists think that Drudge and Powerline are blogs – the best blogs, actually – and thus write idiotic articles about the bad quality of blogs and other similar nonsense. Well, if you thought Powerline is the best blog (as Time did, quite intentionally, in order to smear all of the blogosphere by equating it with the very worst right-wing blathering idiotic website that happens to use a blogging software), you would have a low of opinion of blogs, too, wouldn’t you?
But what about one’s inability to detect relevant blog posts, as opposed to research papers to cite? Well, Google it. Google loves blogs and puts them high up in searches. If you are doing research, you are likely to regularly search your keywords not just on MedLine or Web Of Science, but also on Google, in which case the relevant blog posts will pop right up. So, there is no excuse there.

But, some will say, still….a blog post is not peer-reviewed!
Remember that the institution of peer review is very recent. It developed gradually in mid-20th century. None of the science published before that was peer reviewed. Yup, only one of Einstein’s papers ever saw peer review.
Much of the science published today is not peer reviewed either as it is done by industry and by the military and, if published at all, is published only internally (or on the other extreme: citizen science which is published on Flickr or Twitter!). But we see and tend to focus only on the academic research that shows up in academic journals – a tip of the iceberg.
If you think that the editorial process is really important, remember that manuscripts, in their final version, need to be submitted by the authors in the form and format ready for publication. It is not the job of editors to rewrite your poorly written manuscript for you. Thus, scientific papers, even those that went through several rounds of peer review on content are, just like blog posts, self-edited on style, grammar and punctuation (and comprehensibility!). What is the difference between peer reviewers and blog commenters? There are more commenters.
Then, think about the way gradual moving away from the Impact Factor erodes the importance of the venue of publication. This kind of GlamorMagz worship is bound to vanish as article-level metrics get more broadly accepted – faster in less competitive areas of research and in bigger countries, slower in biomedical/cancer research and in small countries.
As the form of the scientific paper itself becomes more and more dynamic and individuals get recognized for their contributions regardless of the URL where that contribution happens, why not cite quality blog posts? Or quality comments on papers themselves?

It’s Carrboro

I know, this video is three years old, but it’s cool anyway:

New and Exciting in PLoS ONE

There are 17 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
PER3 Polymorphism Predicts Cumulative Sleep Homeostatic but Not Neurobehavioral Changes to Chronic Partial Sleep Deprivation:

The variable number tandem repeat (VNTR) polymorphism 5-repeat allele of the circadian gene PERIOD3 (PER35/5) has been associated with cognitive decline at a specific circadian phase in response to a night of total sleep deprivation (TSD), relative to the 4-repeat allele (PER34/4). PER35/5 has also been related to higher sleep homeostasis, which is thought to underlie this cognitive vulnerability. To date, no study has used a candidate gene approach to investigate the response to chronic partial sleep deprivation (PSD), a condition distinct from TSD and one commonly experienced by millions of people on a daily and persistent basis. We evaluated whether the PER3 VNTR polymorphism contributed to cumulative neurobehavioral deficits and sleep homeostatic responses during PSD. PER35/5 (n = 14), PER34/5 (n = 63) and PER34/4 (n = 52) healthy adults (aged 22-45 y) demonstrated large, but equivalent cumulative decreases in cognitive performance and physiological alertness, and cumulative increases in sleepiness across 5 nights of sleep restricted to 4 h per night. Such effects were accompanied by increasing daily inter-subject variability in all groups. The PER3 genotypes did not differ significantly at baseline in habitual sleep, physiological sleep structure, circadian phase, physiological sleepiness, cognitive performance, or subjective sleepiness, although during PSD, PER35/5 subjects had slightly but reliably elevated sleep homeostatic pressure as measured physiologically by EEG slow-wave energy in non-rapid eye movement sleep compared with PER34/4 subjects. PER3 genotypic and allelic frequencies did not differ significantly between Caucasians and African Americans. The PER3 VNTR polymorphism was not associated with individual differences in neurobehavioral responses to PSD, although it was related to one marker of sleep homoeostatic response during PSD. The comparability of PER3 genotypes at baseline and their equivalent inter-individual vulnerability to sleep restriction indicate that PER3 does not contribute to the neurobehavioral effects of chronic sleep loss.

Maternal Obesity Induced by Diet in Rats Permanently Influences Central Processes Regulating Food Intake in Offspring:

Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed an obesogenic diet prior to and throughout pregnancy and lactation. We now report that offspring of obese (OffOb) rats display an amplified and prolonged neonatal leptin surge, which is accompanied by elevated leptin mRNA expression in their abdominal white adipose tissue. At postnatal Day 30, before the onset of hyperphagia in these animals, serum leptin is normal, but leptin-induced appetite suppression and phosphorylation of STAT3 in the arcuate nucleus (ARC) are attenuated; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus (PVH), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished. We hypothesise that prolonged release of abnormally high levels of leptin by neonatal OffOb rats leads to leptin resistance and permanently affects hypothalamic functions involving the ARC and PVH. Such effects may underlie the developmental programming of hyperphagia and obesity in these rats.

Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance:

Declining mobility is a major concern, as well as a major source of health care costs, among the elderly population. Lack of mobility is a primary cause of entry into managed care facilities, and a contributing factor to the frequency of damaging falls. Exercise-based therapies have shown great promise in sustaining mobility in elderly patients, as well as in rodent models. However, the genetic basis of the changing physiological responses to exercise during aging is not well understood. Here, we describe the first exercise-training paradigm in an invertebrate genetic model system. Flies are exercised by a mechanized platform, known as the Power Tower, that rapidly, repeatedly, induces their innate instinct for negative geotaxis. When young flies are subjected to a carefully controlled, ramped paradigm of exercise-training, they display significant reduction in age-related decline in mobility and cardiac performance. Fly lines with improved mitochondrial efficiency display some of the phenotypes observed in wild-type exercised flies. The exercise response in flies is influenced by the amount of protein and lipid, but not carbohydrate, in the diet. The development of an exercise-training model in Drosophila melanogaster opens the way to direct testing of single-gene based genetic therapies for improved mobility in aged animals, as well as unbiased genetic screens for loci involved in the changing response to exercise during aging.

Made me laugh…

ROTFL licence plate.jpg
I guess that is it’s purpose. The very first pic I took with the new iPhone. Around the corner here in Chapel Hill.

Science Cafe – Durham: Uncovering the Mysteries of Human Fertility: On Sex, Fertile Days, and Why the Rabbit Dies

From SCONC:

Science Cafe
July 14, 2009 | 7:00 P.M.
Uncovering the Mysteries of Human Fertility: On Sex, Fertile Days, and Why the Rabbit Dies
Speaker: Allen Wilcox, National Institute of Environmental Health Sciences
Everyone knows where babies come from, but few people appreciate the extraordinary and in some cases completely weird processes that have to work right in order for a new life to form.
Dr. Wilcox will discuss the key steps of human conception and early pregnancy including the window of days in which a woman can conceive, some of the factors that affect a couple’s chances of conceiving, and the new options for infertile couples created by modern technology.
Periodic Tables is a monthly gathering where curious adults can meet in a casual setting to discuss the latest science in plain English. At Periodic Tables, you will chat with your neighbors and local experts about interesting and relevant science happenings right here in the Triangle and beyond. No lengthy PowerPoint presentations, no drawn-out seminars, no confusing jargon. Simply smart and relevant science in a relaxed atmosphere. There is no such thing as a stupid question.
Come out and join us for a lively conversation at Broad Street Café at 1116 Broad Street (919.416.9707).

My picks from ScienceDaily

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Clock Quotes

It is vain for you to rise up early, to sit up late, to eat the bread of sorrows: for so he giveth his beloved sleep.
– Psalm 127:2 Bible

SILENCE IS THE ENEMY, part II

Since my post about it is not on the front page any more, I just want to remind you of the groundswell of support for the Silence Is The Enemy initiative.
Join the Facebook group, donate to Doctors Without Borders and write a letter to your representatives. Join the blogger coalition by blogging about this and spreading the word.
Small help is better than no help. And in many cases, growing coverage of an issue in the blogosphere forces the corporate media to break the silence as well, start paying attention and start covering it. Then, once it is in MSM, the elected officials start noticing it and they may actually do something about it. This process may go even faster on this topic, since one of these bloggers is NYTimes op-ed writer Nicholas Kristof.
You can also pitch in by doing nothing but clicking! Blogs donating all June revenue to Doctors Without Borders (income is determined by blog traffic, so you can contribute with each click) are:
Neurotopia
Bioephemera
The Intersection
On Becoming A Domestic And Laboratory Goddess
Aetiology
Sciencewomen
The Questionable Authority
Adventures in Ethics and Science
DrugMonkey
Blog Of The Moderate Left
Seattle Grassroots Examiner
the rugbyologist
And if you can afford more – there are Doctors Without Borders

New and Exciting in PLoS ONE

Today, we unveil a brand new PLoS ONE Collection – the Prokaryotic Genome Collection. The Collection was edited by Niyaz Ahmed, who wrote an introductory Overview.
In other news, there are 17 new articles published last night and another 17 new articles published tonight in PLoS ONE. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:

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Clocks, sleep and non-visual photoreception on Scienceblogs.com

I am not the only one on ScienceBlogs.com to write about circadian rhythms, sleep and (non-visual) photoreception. Over the years, my SciBlings have written about these and related topics as well. Here is a sampler – go and dig for more on their blogs.
Stimulant Improves Sleep
Locked-In Syndrome
Opioids and Sleep Disorders
Home Testing for Sleep Apnea?
Pure Hypomanics: Living Zippedy Doo Dah Lives?
SFN Update: Sleep Deprivation Impacts Memory, Reduces Hippocampal Activity
Data Faker Turns Himself In
Agomelatine: A New Approach For Depression
Casual Fridays: Dave FINALLY finishes analyzing the procrastination data
Just Give ’em Some Nyquil While You’re At It
The Long, Long Sleep
Scientist to Men: Don’t sleep over
Two Stories on Sleep
Why do I feel like I’m falling when I go to sleep?
Power naps work in improving memory performance
Daylight Savings Time Affects Heart Attack Incidence
Don’t Trust an Insomniac
The Perverse Imp
Dolphins stay alert after five straight days of round-the-clock vigilance
The Night-Shift and Naps
Intranasal Orexin/Hypocretin: The Ultimate Uptime Drug?
Sleep behaviour and sleep postures
Sleep loss & false memories
Thinking During Sleep
The value of a good night’s sleep
Sleep, Sex, and Drosophila
Chloral Hydrate (Alkyl halide sleep aid)
Sleep and Heat
Make sure you get some sleep — or at least some caffeine — before that test
The point of sleep, or, Do fruit flies dream of six-legged sheep?
Portable brain activity-recorder shows that sloths aren’t all that sleepy
Lonely people have less efficient sleep
Friday Sprog Blogging: cross-country travel and kid circadian rhythms.
Ask a ScienceBlogger: A Sun Ray a Day….
Drink Your Milk! Go Outside and Play! You Just Might Live Longer
Day Two At SICB
Bears are in on the Hoax, Too
Living Clocks of Arctic Animals
How to evolve a watch
Circadian Clock Neurons
Time-Blind?
Evolution of vertebrate eyes
The eye as a contingent, diverse, complex product of evolutionary processes
Rhabdomeric and ciliary eyes
Medicine and Evolution, part 6: Ivan Schwab on eye evolution
Eyes, Part One: Opening Up the Russian Doll
Eyes, Part Two: Fleas, Fish, and the Careful Art of Deconstruction
Have fun for the rest of the week…

Today’s carnivals

Carnival of the Blue #25 is up on Blogfish
Hourglass X is up on Ouroboros

Open Access panel at Lindau

When I go to the Lindau Nobel meeting in Germany in a few weeks, I will not only report from there as a blogger. I was also asked to participate on a panel about Open Access publishing:

“Beatrice Lugger, German science journalist (and founder of Scienceblogs Germany), will moderate this panel. The panelists are: Nobel Laureates Aaron Ciechanover and Sir Harold Kroto, Bora Zivkovic of PLoS, and Dr Jason Wilde, publisher for the physical sciences at Nature Publishing Group.”

Cognitive Monthly #2 is out

And it is good. Much longer than #1 and interesting to all of us who have kids heavily involved in playing computer games:

Whenever kids are involved in a violent crime, speculation about their upbringing inevitably takes center stage. Were they abused or neglected? Could their parents have prevented the tragedy? Most recently, video games have been targeted as the possible root of the problem. But are video games really to blame for horrific massacres like the shootings at Columbine and Virginia Tech? This month’s report considers the growing role video games play in our kids’ lives–and whether the playing violent games might really cause kids to be violent themselves. We assess the latest research on violent games and how it impacts kids. Researchers have found that playing some violent games does result at least temporarily in aggressive behavior, but it can also be beneficial. Do the benefits of gaming outweigh the many potential harms? We also describe how we’ve managed video games in our family, and offer some guidelines on how parents can approach gaming in their own homes.

Duke Nukem Comes to Dinner: Do Violent Games Make Violent Kids?” can be downloaded for only $2 at Lulu.com and it’s worth the price 😉

Welcome the newest SciBling!

Go say Hello to Walt Crawford at Walt at Random.
Walt is Editorial Director for the Library Leadership Network and also publishes an e-journal Cites & Insights. You can get a taste for his blogging on his old blog, of course.

Do a quiz, help shape research

It will not take more than a couple of minutes. Just go to this Sheril’s post and follow the directions. She will use the results of the quiz to inform experimental design for an interesting project on the neuroscience of kissing. This will then be included in her next book.

Clock Quotes

Finish each day before you begin the next, and interpose a solid wall of sleep between the two. This you cannot do without temperance.
– Ralph Waldo Emerson

My picks from ScienceDaily

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Today’s carnivals

June Scientiae, part II, is up on Sciencewomen
iCephalon, aka, Encephalon #72 is up on Cognitive Daily
Carnival of the Green #183 is up on ooffoo

Clock Quotes

I wouldn’t call it fascism exactly, but a political system nominally controlled by an irresponsible, dumbed down electorate who are manipulated by dishonest, cynical, controlled mass media that dispense the propaganda of a corrupt political establishment can hardly be described as democracy either.
– Edward Zehr

Turtle in front of my house

This one is much bigger than the one I saw last week. At least 12 inches long carapace (more pictures under the fold). What’s the species?
turtle 011.jpg

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The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
Here are the submissions for OpenLab 2009 to date. As we have surpassed 150 entries, all of them, as well as the “submit” buttons and codes and the bookmarklet, are under the fold. You can buy the 2006, 2007 and 2008 editions at Lulu.com. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):

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Clock Quotes

If you lead a country like Britain, a strong country, a country which has taken a lead in world affairs in good times and in bad, a country that is always reliable, then you have to have a touch of iron about you.
– Margaret Thatcher

Mad Avenue Blues – brilliant video

My picks from ScienceDaily

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Clock Quotes

Do not meddle in the affairs of cats, for they are subtle and will piss on your computer.
– Bruce Graham

Video, video, video (video)

Of course the Course description for JOMC 449 – Virtual Communities, Smart Mobs, Citizen Journalism and Participatory Culture is made in video. All the ‘readings’ are viewings of video, all assignments are video-making. So cool!

Fall 2009 MW 3:30 – 4:45, UNC Chapel Hill, Instructor: Paul Jones

In Memoriam: Victor Bruce, 1920-2009

Victor Bruce, a lecturer emeritus in biology at Princeton who conducted advanced studies for more than 25 years on the built-in cycles governing natural rhythms like the sleep-wake cycle, has died. He was 88.
Bruce, who despite a background in engineering became drawn to biological studies, died Friday, May 29, at his home in Princeton after a short struggle with cancer.
“He was an A-1 scientist who did some really neat work,” said John Bonner, Princeton’s George M. Moffett Professor Emeritus of Biology. “He was a wonderful colleague.”
Bruce joined the Department of Biological Sciences in 1956, drawn by the work of Colin Pittendrigh, a noted professor in the department. It was in Pittendrigh’s lab that Bruce began his studies into the circadian rhythms of the one-celled Chlamydomonas, a form of green algae that ultimately became a model organism for scientists.
Plants and animals, Bruce knew, have built-in biological clocks that allow them to flower, sleep or wake at the right time. Without signals from the environment, the clocks keep to 24-hour rotations. Bruce wanted to know what controlled these cycles. In close studies of the algae, he found that some strains varied slightly in the length of their phases. As a result, he conducted some breeding experiments that led to his proving that the periods must be subject to genetic control.
“Victor was really the first person to show that there was a genetic basis to circadian rhythms,” Bonner said. Circadian rhythms and the genetics of that phenomenon are now a burgeoning area of science. Bruce retired from Princeton in 1982….

Read the rest.

A beautiful Mammoth fossil discovered in Serbia

mamut1.jpgAn almost complete and beautifully preserved fossil of the Southern Mammoth, Mammuthus meridionalis was discovered a couple of weeks ago by a team of archaeologists led by Miomir Korać from the Archaeological Institute Belgrade and the Director of the Archaeological park Viminacium in Eastern Serbia.
The fossil, pretty much articulated and all in one place, was discovered at a depth of 27 meters (about 88.5 feet) in sand, which indicates that this area did not experience a serious earthquake for at least a million years or more since the animal died. It was identified as a female. She was about 4.5 meters tall, about 6 meters long, and weighed about 10 tons.
Southern Mammoth is one of the oldest and one of the largest species of mammoths. It is thought to have migrated from Africa into Europe between 1 and 2 million years ago. It was hairy, but not nearly as much as the later Woolly Mammoth, and thus not as adapted for the cold climate of the Ice Ages.
It will probably take only a couple of months to clean up the fossil, analyze it and articulate the skeleton, as it is so well preserved in sand. It will be displayed near the site of discovery, i.e., it will not be shipped to a bigger museum elsewhere.
I will be visiting Belgrade next month for a few days and I am trying to figure out if I could go to Kostolac, see (and photograph) the fossil and interview the researchers. I will let you know how that turns out.

Today’s carnivals

June Scientiae is up on Sciencewomen
Four Stone Hearth #68 is up on remote central
Friday Ark #246 is up on Modulator

Clock Quotes

Perfection of planning is a symptom of decay. During a period of exciting discovery or progress, there is no time to plan the perfect headquarters.
– C. Northcote Parkinson

Science & Technology Parks – what next?

As you may have noticed if you saw this or you follow me on Twitter/FriendFeed/Facebook, I spent half of Tuesday and all of Wednesday at the XXVI International Association of Science Parks World Conference on Science & Technology Parks in Raleigh. The meeting was actually longer (starting on Sunday and ending today), but I was part of a team and we divided up our online coverage the best we could do.
IASP2009 001.jpgChristopher Perrien assembled a team (including his son) to present (and represent) Science In The Triangle, the new local initiative. They manned a booth at which they not only showcased the website, but also had a big screen with TweetDeck showing the livetweeting of the conference by a few of us (e.g., @maninranks, @mistersugar, @IASP2009 and myself), gave out flyers explaining step-by-step how to start using Twitter, and gave hands-on instruction helping people get on Twitter and see what it can do for them.
You can look at the coverage by seaching Twitter for IASP or #IASP or #IASP2009 (in some of my first tweets I misspelled it as IESP). You can search FriendFeed for all the same keywords as well, as most of the tweets got imported there.
IASP2009 002.jpgScience In The Triangle is an online portal for news (and stories about news) about scientific research happening in the Triangle region of North Carolina. This is a way to keep the researchers in the Triangle informed about each other’s work and local science-related events, as well as a way to highlight the local research efforts for the outside audience. It is in its early stages but we’ll work on developing it more. It will be interesting to compare it to other similar portals, like NSF Science Nation and The X-Change Files (neither one of which is regional in character).
Apart from that, what was I doing at this kind of conference? Frankly, I never really thought about science/technology parks much until now. I have spent the last 18 or so years inside the sphere of influence of the Research Triangle Park and was blissfully unaware of the existence of any others. I did not know that there were dozens, perhaps hundreds of such parks around the world (including – and I should have known about it – the Technology Park Ljubljana in Slovenia). I did not know they had an official international association. I did not know that there are specified criteria as to what makes a park a park. Or that, for instance, the NCSU Centennial Campus is considered a science/technology park and is itself a member of the Association, outside of its proximity to RTP. Just learning these things was enlightening in itself, besides the actual susbtance of the talks.
IASP2009 003.jpgThis was also an interesting cultural experience for me. For the past several years, my conference experiences were mainly unconferences or very laid back and friendly science conferences. This was not it. This was a formal, old-style business conference with about a thousands businessmen (and very few women) wearing business suits. Even I felt compelled to wear a coat and tie and uncomfortable shoes to fit in. I also forgot that the program itself was bound to be much more formal. A session called a “panel” does not mean that 3-4 people on the stage will vigorously discuss a topic between themselves and with the vocal audience, but that 3-4 people will give PowerPoint presentations in rapid succession.
But I am not complaining – I know that the business world is even slower to evolve than the science world and that the tech world is light years ahead – as some of those talks were quite interesting and enlightening (see all the Tweets from the various sessions), and some of the people I met (and I knew almost nobody there in the beginning) were interesting as well. For example, Will Hearn prospects the sites for potential corporate (or industrial park) development around the world, from Peru to Macedonia. He runs Site Dynamics and has developed software – SiteXcellerator – that provides important information about the population, education and economics of any place on earth the company may be interested in moving into.
So, what is a science/technology/industrial park? It is a place. Seriously, and importantly, it is a place, in a geographical sense. It is a piece of land which houses a collection of science, technology, business and industrial companies and organizations, all placed together because they can potentially collaborate.
IASP2009 004.jpgThe location of the Park is chosen for being conducive to business (nice tax breaks by the state, for instance) and for containing well-educated and skilled workforce in abundance (thus usually close to a big university). In some cases, the companies go where the skilled potential employees already are. In other cases, the Park members build educational institutions needed to produce skilled workforce out of the local population (so, for example, if biotech moves into a place abandoned by the textile industry, a college needs to be built to re-train the local workers for the new and more high-tech jobs). Some parks are focused on a single industry (e.g., pharmaceutical, or even defense in some places) or even a single product (e.g., solar panels), while other parks are drawing together a variety of different fields.
More than 20 Parks received silver medals last night for existing 25 or more years. So this is not a new fad in any way. Research Triangle Park got a gold medal as it celebrated 50 years of existence this year. It is the largest and the oldest of the science/technology parks in the world, at least among the members of the Association.
But I had a nagging thought in the back of my head. Is RTP really the oldest?
IASP2009 005.jpgSo last night when I got home I went online and started searching for “science cities” or Naukograds of the old Soviet Union. The most famous is Akademgorodok which is possibly a couple of years older than RTP as the Wikipedia page states “in the 1950s” (RTP was founded in 1959) and this NYTimes article from 1996 says “four decades ago” which places its foundation at around 1956.
By the way, that NYTimes article (I actually remember reading it at the time – the heady old days of reading newspapers on paper!) is quite interesting. But take it with a big grain of salt – remember the source and the time: the New York Times in the 1990s was essentially Clinton’s Pravda, especially in the area of foreign politics, so any article about a foreign country is automatically suspicious. I’d love to see a blog post on the topic by a respected Russian blogger, either as an antidote or as a confirmation of that NYTimes article.
I would love to see someone cover the history and evolution of Naukograds, their strengths and weeknesses, ups and downs, during the Soviet era, during Perestroika, and in modern Russia, as well as the science cities that are now located in other countries that gained independence from USSR during the 1990s. That would be quite a teaching moment for everyone involved, I’m sure. If I am reading it correctly, these science cities conform to the criteria of being science/technology parks as the Association of Science Parks defines them. I wonder if any one of them actually became members of the Association since then?
IASP2009 006.jpgBack to the RTP now. Plenary talk by the Duke University President Richard Brodhead confirmed some of the history and some thoughts I had about the importance of RTP in North Carolina history (I missed the talk by Andrew Witty, but Anton blogged it and it appears to have been along similar lines).
UNC-Chapel Hill is the oldest state university in the country. NCSU and Duke are also very old. There are a couple of dozen smaller universities and colleges (and a couple of amazing high schools for kids with math and science talent) in the Triangle. And other science-related organizations. Then, there are many more schools around the state. From what I gather, each one of those schools was on its own, pretty isolated from each other. Researchers at one school were not aware of the researchers at another.
Then, some enlightened people in the state decided that with all those schools churning out all those educated graduates, the jobs for those graduates should also be in North Carolina. Why teach them here, just to see them leave for the greener pastures? And thus the RTP was born.
IASP2009 007.jpgIt took a while for the park to grow, but it attracted or spawned some powerful and creative organizations, from RTI and Glaxo and NIEHS, through IBM and SAS, to Sigma Xi and NESCENT and Lulu.com. Instead of educated people leaving the state in search of jobs, the companies started bringing jobs to where the educated people are – and there was one place to move to: the Research Triangle Park or as close to it as possible.
But that was not the end of the story. All those companies and organizations started collaborating with (or hiring) the researchers from local universities and….this brought people from different Universities together! People from NCSU and Duke and UNC and other schools got introduced to each other this way and started collaborative research with each other. Soon formal and informal collaborations between schools and departments were put in place. As a result, science in the state boomed. Instead of isolated nodes, there was now a network.
And I still think this network is pretty unique in the USA. In other places known for top-level science all of it is concentrated in one big city (e.g., New York City, Boston, Atlanta, or San Francisco) while the countryside of the state has nothing of the sort. And if one adds the historical rivalries between those old Universities in these cities, there is not much network effect there. Much more competitive than collaborative. But in North Carolina there are long-term ongoing collaborations between researchers, departments and schools all across the state, from Wilmington and Greenville, to Triangle, Winston-Salem and Greensboro, to Charlotte, Davidson, Cullowhee, Boone and Asheville (which is why I argued that the Nature Network Triangle Group should be renamed North Carolina Group which you should join if you are in NC and interested in science). Just look at how geographically dispersed the NC science bloggers are, if that is any indication.
IASP2009 008.jpgThus RTP, besides bringing together researchers and industry (which some of us purist scientists may not like that much) also inadvertently spurred on the advancement of pure, basic research. RTP provided the central place that connected all the schools and then people in those schools could make their own connections and do whatever kind of research they liked, even the most basic kind that does not have an obvious and immediate application (of course, long-term, all that basic knowledge ends up being applied to something, it is just impossible to predict at the time what the application could be).
There are other effects of this rise in science and technology in the state. Instead of graduates leaving the state, people from other places started coming in (look at licence plates on cars on I-40, or parked on campuses – you can see everything from Ohio and Michigan and Georgia to New York and California and Alaska), further increasing the concentration of highly educated people. The knowledge and education and expertise are regarded quite highly. Thus, the reality-based party has been in charge of state politics for a long time and last year even the national offices were deemed important enough for locals to vote out the anti-science party.
But that was last 50 years. That is 20th century world. How about today and tomorrow, now that everything about the world is changing: economics, communication, environmental awareness, even the mindset of the new generations?
You know that the rapid changes in the workplace are one of my ‘hot’ topics here. How will the information revolution affect parks (and the domino effect downstream from parks – universities, jobs, infrastructure)?
This is the moment to introduce the most interesting presentation at the meeting, by Anthony Townsend. Anthony is the Research Director at The Institute for the Future, focusing on Science In Action as well as coworking. I tried to get him in touch with Brian Russell of Carrboro Creative Coworking (and if you are in the Triangle area, but Carrboro is too far for you, fill out this survey about the potential need for coworking spaces in other parts of the Triangle), but I am not sure if they found time to meet this week. For this meeting, Anthony wrote a booklet – Future Knowledge Ecosystems: The Next Twenty Years of Technology-Led Economic Development – which you can download as a PDF for free, and I think you should.
His talk was a firehose – I tried live-tweeting it, but even the speed of Twitter was not fast enough for that. I am sure happy that he mentioned PLoS (and showed the homepage of PLoS Genetics on one of his slides) as an example of the new global, instantenuous mechanism of dissemination of scientific information. But I digress…
The main take-home message I got from his talk is that the world has fundamentaly changed over the past decade or so and that science/technology parks, old or new, need to adapt to the new world or die. He provided three possible scenarios. In the first scenario, parks evolve gradually, adapting, with some delay, to fast but predictable changes. In the second scenario, the physical space of the park becomes obsolete as research and connections move online – the park dies. In the third scenario, the parks are forced to adapt quickly and non-incrementally – inventing whole new ways of doing research combining physical and virtual worlds.
A traditional Park is a place where different companies occupy different buildings. The interaction is at the company-to-company level.
A new Park may become a giant coworking space, where the interactions are at the individual-to-individual level. Anthony actually showed a slide of a Park in Finland where a building (or a large floor of a large building) was completely re-done and turned into a coworking space.
As more and more people are turning to telecommuting and coworking, the institution of a physical office is becoming obsolete. What does that mean?
Employees are happy because they can live where they like. They get to collaborate with who they find interesting and useful, not who their corporation also decided to employ. They don’t have to see their bosses or coworkers every day (or ever). Everything else can be done in cyberspace.
What does the company gain from it? Happy productive employees. No echo-chamber effect stemming from employees only talking to each other. Ability to hire employees who are the best in what they do and, knowing that, unwilling to move from the place on Earth they like to live in. Employees who are always up to the latest trends and industry gossip due to constant mingling with the others. Free PR wherever the employees are located – they all meet the locals and answer the inevitable question “What do you do?”
The phenomenon of company loyalty is quickly fading. Most people do not expect to work for a single employer all their lives. They will work several jobs at a time, changing jobs as needed, sometimes jumping from project to project. Getting together with other people in order to get a particular job done, then moving on.
This will actually weaken the corporation – making everyone but controlling CEOs and CFOs happy. Corporations will have to become fluid, somewhat ad hoc, very flexible and adaptable, as their people will be constantly circulating in and out.
In such a world, a sci/tech Park will have to be where the people want to live – a nice place, with nice climate, nice culture, good school systems, safe, etc.
In such a world, single-payer health-care system that is not disbursed via the employer will become a necessity.
Sure, there is the production part of companies that actually produce ‘stuff’ and they will also be in such Parks so their own (and other’s) blue-collar and white-collar employees can routinely interact (Anthony showed a slide of a production line literally weaving through the offices, forcing workers, bureacrats and R&D personel to get to know each other and watch each other at work, thus coming to creative solutions together).
As for science itself, a Park may be something like a Science Motel, a place where both affiliated and freelance scientists can come together, exchange ideas and information, work together, use common facilities and equipment, regardless of who their official employers are and where those are located geographically.
Sounds like something out of science fiction? That kind of future is right around the corner.
The interaction at the organization-to-organization level, the cornerstone of Parks and the local economic growth in the 20th century, has been discussed quite a lot at the meeting, as expected. Especially collaboration between Universities and industry (and sometimes government).
The park-to-park level of interaction, essential in the global economy, and the reason the Association of Science Parks exists, was discussed quite a lot, of course.
IASP2009 009.jpgBut I did not get the vibe that the level of individual-to-individual was on many people’s minds. The idea that the corporation will have to get less coherent and/or hiererchical because the new generations will insist on the individual-to-individual collaboration did not get much air play. The time when people realize that information wants to be free and that, with current technology, it can be set free, is a challenge to corporations, especially for keeping trade secrets. Perhaps there will be less trade secrets as the new mindset sets in – a network can do more and better than competing units.
This was brought splendidly to us all last night, at the end of the Gala (no, not the amazing Tri-chocolate mousse dessert!), by theCarolina Ballet dancers, each bringing his or her own individual skills and talent (and it was visible that they all differ – some are more athletic, some more elegant, the #1 ballerina is top-world-class) and working together to produce a collective piece of beauty.

New and Exciting in PLoS this week

Here are some titles, from all seven PLoS journals, that caught my attention this week. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Mendeley, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:

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Today’s carnivals

Special, one-time carnival “Uncovering Ida” is up on Laelaps
Skeptic’s Circle #112 is up on Cheshire

Caryn Shechtman: A Blogger Success Story (an interview with Yours Truly)

You may have noticed a couple of days ago that Caryn Shechtman posted an interview with me on the New York blog on Nature Network. Then, Caryn and Erin and I thought it might be a good idea to have the entire interview reposted here, for those who missed it. So, proceed under the fold:

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My picks from ScienceDaily

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