Where will the third Nature Network hub be? Why not NC?

Nature Blog Network has two hubs – the Boston one and the London one. They are planning on adding a third one soon but the question is where? So, they will see where the most people are. There are currently only two people signed up as living in the Triangle, but this can change. If you are already in the network, go and change your profile by adding a North Carolina city and add yourself to the Triangle network (if that is actually true, i.e., you really do live in NC) even if you live in a different part of the state. I know there are many NC folks already on, and new people can always join. Let’s try to give Toronto, New York City and Berlin the run for their money.

ClockQuotes

Until you value yourself, you will not value your time. Until you value your time, you will not do anything with it.
– M. Scott Peck

My Picks From ScienceDaily

Gene Mutations In Mice Mimic Human-like Sleep Disorder:

Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and provide an animal model for developing treatments.

Food-related Clock In The Brain Identified:

In investigating the intricacies of the body’s biological rhythms, scientists at Beth Israel Deaconess Medical Center (BIDMC) have discovered the existence of a “food-related clock” which can supersede the “light-based” master clock that serves as the body’s primary timekeeper.

High-school Girls Who Consider Themselves Attractive Are More Likely To Be Targets For Bullying:

University of Alberta Educational Psychology PhD student Lindsey Leenaars has completed a study that assessed what types of high school students are being indirectly victimized. This includes being involved in emotionally damaging scenarios such as receiving hurtful anonymous notes, being socially excluded, or having rumours spread about them, including threats of physical harm.

Estrogen Fuels Female Need For Power And Control:

New University of Michigan psychology research suggests that the sex hormone estrogen may be for women what testosterone is for men: The fuel of power.

Video Games Can Make Us Creative If Spark Is Right:

Video games that energize players and induce a positive mood could also enhance creativity, according to media researchers. However, the study also finds that players who were not highly energized and had a negative mood, registered the highest creativity.

Public Schools As Good As Private Schools In Raising Math Scores, Study Says:

Students in public schools learn as much or more math between kindergarten and fifth grade as similar students in private schools, according to a new University of Illinois study of multi-year, longitudinal data on nearly 10,000 students.

Doing science publicly: Interview with Jean-Claude Bradley

Jean-Claude Bradley and I first met at the First Science Blogging Conference where he led a session on Open Science. We then met at SciFoo and later joined forces on a panel at the ASIS&T meeting and finally met again at the second Science Blogging Conference back in January where Jean-Claude co-moderated a session on Making Data Public. Jean-Claude is famous for being the pioneer of the Open Notebook Science movement. He started posting his daily lab activity and results on his blog Useful Chemistry. Soon, he attracted a lot of feedback and subsequently some excellent collaborators. As the work became more complex, Jean-Claude added more blogs, e.g., UsefulChem Molecules and UsefulChem Experiments, but in the end realized that wiki was a better format for this and started the UsefulChem Wiki where you can see, among else, how one of his students is writing a Masters thesis in real time.
Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Who are you? What is your scientific background? What is your Real Life job?
I am an associate professor of chemistry at Drexel university. I’ve been there since 1996. My Ph.D. is in organic chemistry and I have done postdoctoral work on DNA chips and gene therapy. At Drexel I worked on nanotechnology and scientific knowledge management until 2005 when I started the UsefulChem project, centered on synthesizing new anti-malarial compounds using Open Notebook Science.
What do you want to do/be when (and if ever) you grow up?
I’ve worn many hats in my career and part of the fun is not really being able to predict what makes sense doing several years down the road. I try to concentrate on working on projects that I think will have an important impact and where I am in a unique position to contribute.
When and how did you discover science blogs? What are some of your favourites? Have you discovered any new cool science blogs while at the Conference?
I discovered science blogs just through using various social networking sites and finding like-minded people. Some of the blogs I follow most closely: Cameron Neylon’s Science in the Open, Deepak Singh’s BBGM, Antony William’s ChemSpider, Bill Hooker’s Open Reading Frame, Shirley Wu’s One Big Lab and Peter Murray-Rust’s blog. I don’t like answering these types of questions because I don’t want to leave people out:) There are many others in my blog reader but these are probably my main focus right now because they deal with Open Science issues.
bradleypic.JPGYou are one of the pioneers of Open Notebook Science. Could you, please, explain to my readers what this is?
Open Notebook Science is simply the practice of making one’s laboratory notebook completely public in as close to real time as possible. In organic chemistry this is pretty straightforward – researchers must keep a notebook where they record what they do and observe in an experiment, generally with the intent of making a specific compound. In other fields, records may be kept in different formats but the idea is that the research group doing ONS should strive to do research transparently with as little “insider information” as is reasonable. In organic chemistry this means providing access to all raw data files (spectra for example) so that another researcher can independently verify all observations and conclusions made.
You started your Open Notebook on a blog, but then later moved it to a wiki. Why? What are the advantages and disadvantages of the two platforms?
Yes, initially I started with a blog but realized fairly quickly that it was not sufficient to function as a lab notebook because there is no record of changes made. A wiki is really close to a perfect tool for the actual notebook since all page versions are time-stamped. We use Wikispaces as our hosting service, which has the advantage of providing third-party timestamps on everything recorded or changed.
Doing science is like focusing a lens. At first you have few data points and make some tentative observations. As more data get added and more thinking and talking get done, things become clearer and the notebook is updated accordingly. Sometimes that means errors get fixed and that entire process is tracked by the wiki. I still use the blog as a means of reporting on big picture issues and milestones. I can then link from the blog to the wiki to back up any claims I make.
Very few scientists are doing Open Notebook Science right now – do you see the practice exploding in the near future, with almost everyone doing it? Will this be a generational thing? Or dependent on the scientific discipline?
I don’t see the practice of full ONS becoming used by the majority of researchers very soon, although I do think many more scientist will become more open in some way. For example they may blog more about their current work or make more raw data available after their papers come out. I don’t think the practice should be mandated. Those who choose to do will most likely find it rewarding, if only in meeting new colleagues and collaborators. There may be something to the generational effect – the YouTube generation probably does expect information to be free to consume and share. There is certainly a discipline dependence – where intellectual property is a concern there will be an additional barrier.
When we talk about Science 2.0 and science blogging, we usually discuss science communication, publishing, networking, political action and teaching. But you have performed experiments in Second Life, i.e., Internet is also a tool for actually doing science. Do you see this happening more – people using the Web as a tool in scientific research in the open view of everyone who cares to come by and watch you?
Yes I do see researchers using the web to share their primary research – Gus Rosania and Cameron Neylon are probably the best recent examples. As far as Second Life, it is another tool – with Andrew Lang we are now able to interact with spectra (NMR, IR, etc) simply by “talking” to the display. We can display proteins and molecules in 3D with realistic shapes. Right now, for my work, I view Second Life to be like a website or blog – I can provide basic information about my research and link to the lab notebook on the wiki if people want more information. I have areas on Drexel Island and the American Chemical Society Island to share my lab’s work. My organic chemistry students also do projects for class in Second Life. I think the most useful outcome of using Second Life is meeting new smart people with similar interests. I have met a few wonderful collaborators that way.
Is there anything that happened at this Conference – a session, something someone said or did or wrote – that will change the way you think about science communication, or something that you will take with you to your job, blog-reading and blog-writing?
The most memorable event at the conference was probably meeting Moshe Pritsker from the Journal of Visualized Experiments. He offered to send someone over to my lab to record a protocol – I still have to arrange that….
It was so nice to see you again and thank you for the interview. I hope to see you again in January.
============================
Check out all the interviews in this series.

Social Networking sites for scientists are proliferating….

There is Nature Network, there is Jeff’s Bench, there is Facebook Scibook, Knowble.com is dead, and people are still building new social networking sites aimed at scientists. There is now SciLink (thanks Alex) and now also ResearchGATE (thanks Bertalan). I am joining everything and watching….one of these days, one of these will win. Nobody can guess which one (or perhaps more than one), but perhaps you can tell me which ones you like and dislike and why?

Oldies and Goodies

You have only a week left to submit your entries for the Blog about a classic science paper challenge. The links to early bird posts are already being collected and I hope there will be more soon. If you intend to write about a paper in the field of psychology, SciCurious discovered an awesome website where you can find all the classic articles in the history of psychology. Just yesterday, I saw the website where there will be such a repository of historical papers (and other materials: photos, anecdotes, etc.) in the Chronobiology field. This will be built over the next few months. I’ll try to do my post over the weekend if I can.

Today’s carnivals

Accretionary Wedge #9 is up on Harmonic Tremors
Friday Ark #192 is up on Modulator

Yes, Seasonal Affective Disorder is real

No matter how cutesy the acronim SAD is. Joseph reports on a study that links SAD to serotonin. But serotonin itself may not be necessary to understand how SAD works, though an intimate link between serotonin and melatonin (the former is the biochemical precursor of the latter) suggests that serotonin should be looked at in this context.
Also, if you suffer from SAD you should be very careful preparing for your long-distance travel: getting jet-lagged may trigger a bout of a few days of depression regardless of the time of year.

ClockQuotes

When nobody around you seems to measure up, it’s time to check your yardstick.
– Bill Lemley

New and Exciting in PLoS Genetics and Computational Biology

Inferring Human Colonization History Using a Copying Model:

Humans like to tell stories. Amongst the most captivating is the story of the global spread of modern humans from their original homeland in Africa. Traditionally this has been the preserve of anthropologists, but geneticists are starting to make an important contribution. However, genetic evidence is typically analyzed in the context of anthropological preconceptions. For genetics to provide an accurate and detailed history without reference to anthropology, methods are required that translate DNA sequence data into histories. We introduce a statistical method that has three virtues. First, it is based on a copying model that incorporates the block-by-block inheritance of DNA from one generation to the next. This allows it to capture the rich information provided by patterns of DNA sharing across the whole genome. Second, its parameter space includes an enormous number of possible colonization scenarios, meaning that inferences are correspondingly rich in detail. Third, the inferred colonization scenario is determined algorithmically. We have applied this method to data from 53 human populations and find that while the current consensus is broadly supported, some populations have surprising histories. This scenario can be viewed as a movie, making it transparent where statistical analysis ends and where interpretation begins.

Evolution of Taxis Responses in Virtual Bacteria: Non-Adaptive Dynamics:

Here, we study how signalling networks mediating chemotaxis could have evolved. We simulated the evolution of virtual bacteria, which can explore their environment by alternating between swimming and tumbling. The tumbling frequency is dictated by the output of a signalling network that senses extracellular nutrient levels, while the bacteria’s reproductive success is determined by their ability to find nutrients. Under conditions of abundant food, we find that bacteria quickly evolve signalling networks that enable effective chemotaxis, where increasing nutrient levels increase tumbling frequency. Our findings provide explanation for network dynamics underlying similar behaviour as observed in certain mutant strains of Escherichia coli and in other bacterial species. Conversely, wild-type E. coli respond to increasing nutrient levels by decreasing their tumbling frequency and adapting to constant attractant levels. We observe such adaptive network dynamics when we repeat evolutionary simulations under conditions of scarce food. These findings suggest that (i) adaptation is not necessary for effective chemotaxis, (ii) an ancestral minimal chemotaxis system could have used a simple coupling between the signalling network and the metabolic state, and (iii) environmental conditions are one of the determining factors for the evolution of adaptive responses.

My Picks From ScienceDaily

Some Like It Hot! Structure Of Receptor For Hot Chili Pepper And Pain Revealed:

You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.

Early Life Exposure To Cats May Reduce Risk Of Childhood Allergies And Asthma Symptoms:

A study released by researchers at the Columbia Center for Children’s Environmental Health (CCCEH) at Columbia University’s Mailman School of Public Health, shows that cat ownership may have a protective effect against the development of asthma symptoms in young children at age five. The study, published by the Journal of Allergy and Clinical Immunology, found that children with cats in the home were more likely to have made allergy-related antibodies to cats. At three years of age, children who had made antibodies to cats early in life were more likely to have wheeze, a respiratory symptom associated with asthma. However, by age five, the same children who had grown up with a cat were then found to be less likely to have wheeze.

Kangaroos Threaten One Of Australia’s Last Remaining Original Grasslands, And Endangered Animals:

Australian Department of Defence is currently culling hundreds of kangaroos on the outskirts of the capital Canberra that have produced heated discussions and hit international headlines. Australia’s iconic animal has multiplied so much over recent years that Canberra now has three times as many kangaroos as inhabitants. The situation is particularly critical at two enclosed military sites on the outskirts of the city, which form an ideal refuge for the eastern grey kangaroo (Macropus giganteus).

Ancient Amphibian: Debate Over Origin Of Frogs And Salamanders Settled With Discovery Of Missing Link:

The description of an ancient amphibian that millions of years ago swam in quiet pools and caught mayflies on the surrounding land in Texas has set to rest one of the greatest current controversies in vertebrate evolution. The discovery was made by a research team led by scientists at the University of Calgary.

Unique Adaptive Evolution Found In Snake Proteins Provide New Insight Into Vertebrate Physiology:

Prior to the advent of large sequence datasets, it was assumed that innovation and divergence at the morphological and physiological level would be easily explained at the molecular level. Molecular explanations for physiological adaptations have, however, been rare. Pollock and colleagues now provide evidence that major macroevolutionary changes in snakes (e.g., physiological and metabolic adaptations and venom evolution) have been accompanied by massive functional redesign of core metabolic proteins.

New Family Of Gecko Discovered:

Researchers at the University of Minnesota’s Bell Museum of Natural History and Pennsylvania’s Villanova University have discovered a new family of gecko, the charismatic large-eyed lizard popularized by car insurance commercials.

Reproductive Plasticity Revealed: Neotropical Treefrog Can Choose To Lay Eggs In Water Or On Land:

When frogs reproduce, like all vertebrates, they either lay their eggs in water or on land — with one exception, according to new research by a team of Boston University scientists who discovered a treefrog (Dendropsophus ebraccatus) in Panama that reproduces both ways. The neotropical frog makes a behavioral decision to lay egg masses aquatically in a pond or terrestrially on the overhanging plants above a pond, where the newly-hatched tadpoles simply fall into the water.

Invasion Of Gigantic Burmese Pythons In South Florida Appears To Be Rapidly Expanding:

The invasion of gigantic Burmese pythons in South Florida appears to be rapidly expanding, according to a new report from a University of Florida researcher who’s been chasing the snakes since 2005.

How Can We Measure The Emotional States Of Animals?:

Rats housed in standard conditions show a stronger response to the loss of an expected food reward than those housed in enriched conditions, perhaps indicating a more negative emotional state, according to new research by scientists at Bristol University Veterinary School, published recently in Royal Society Biology Letters.

Lifestyle Evolution Of Wild Marine Bacteria: Free-floating Cells Share With Attached Relatives:

Marine bacteria in the wild organize into professions or lifestyle groups that partition many resources rather than competing for them, so that microbes with one lifestyle, such as free-floating cells, flourish in proximity with closely related microbes that may spend life attached to zooplankton or algae.

Multiple New Species Of Fruit Flies With Overlapping Niches Discovered:

Evidence of physically similar species hidden within plant tissues suggest that diversity of neotropical herbivorous insects may not simply be a function of plant architecture, but may also reflect the great age and area of the neotropics.

First Dinosaur Tracks Discovered On Arabian Peninsula:

Scientists have discovered the first dinosaur tracks on the Arabian Peninsula. They have discovered evidence of a large ornithopod dinosaur, as well as a herd of 11 sauropods walking along a Mesozoic coastal mudflat in what is now the Republic of Yemen.

Today’s carnivals

Grand Rounds Volume 4, No. 35 are up on Musings of a Dinosaur
Carnival of Space #55 is up on Catholic Sensibility
The 87th Skeptics Circle is up on Action Skeptics
Carnival of the Liberals #65 is up on Neural Gourmet
This week’s 172nd edition of the Carnival of Education is up on Teacher in a Strange Land
Carnival of the Green #77 is up on Natural Collection
The 125th Carnival of Homeschooling is up on Po Moyemu–In My Opinion

ScienceOnline’09

The websites/wikis of the first two conferences appear to be down. We will move all of those archives to a new site soon, and very soon the website for the third ScienceOnline conference (formerly known as Science Blogging Conference) will be filled with more information. But for now, you can start using the brand new logo if you want to advertise the event:
scienceonline09.png

The Amplitude Problem

From the Archives

Blogging on Peer-Reviewed Research

If you are one of the few of my readers who actually slogged through my Clock Tutorials, especially the difficult series on Entrainment and Phase Response Curves, you got to appreciate the usefulness of the oscillator theory from physics in its application to the study of biological clocks. Use of physics models in the study of biological rhythms, pioneered by Colin Pittendrigh, is an immensely useful tool in the understanding of the process of entrainment to environmental cycles.
Yet, as I warned several times, a Clock is a metaphor and, as such, has to be treated with thought and caution. Is the physics model always applicable? Is it sometimes deceptive? How much does it oversimplify the behavior out in the natural environment?

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(Non) Adaptive Function of Sleep

(Non) Adaptive Function of SleepFrom November 01, 2005, a review of a review…

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ClockQuotes

People learn something every day, and a lot of times it’s that what they learned the day before was wrong.
– Bill Vaughan

Sex On The (Dreaming) Brain

Sex On The (Dreaming) Brain (First posted on February 5, 2007) Last week I asked if you would be interested in my take on this paper, since it is in Serbian (and one commenter said Yes, so here it is – I am easy to persuade):

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New and Exciting in PLoS ONE

There are 61 articles published in PLoS ONE this week. Here are some of the highlights, look around for more and please comment, rate, and send trackbacks:
Adaptive Evolution and Functional Redesign of Core Metabolic Proteins in Snakes:

Adaptive evolutionary episodes in core metabolic proteins are uncommon, and are even more rarely linked to major macroevolutionary shifts. We conducted extensive molecular evolutionary analyses on snake mitochondrial proteins and discovered multiple lines of evidence suggesting that the proteins at the core of aerobic metabolism in snakes have undergone remarkably large episodic bursts of adaptive change. We show that snake mitochondrial proteins experienced unprecedented levels of positive selection, coevolution, convergence, and reversion at functionally critical residues. We examined Cytochrome C oxidase subunit I (COI) in detail, and show that it experienced extensive modification of normally conserved residues involved in proton transport and delivery of electrons and oxygen. Thus, adaptive changes likely altered the flow of protons and other aspects of function in CO, thereby influencing fundamental characteristics of aerobic metabolism. We refer to these processes as “evolutionary redesign” because of the magnitude of the episodic bursts and the degree to which they affected core functional residues. The evolutionary redesign of snake COI coincided with adaptive bursts in other mitochondrial proteins and substantial changes in mitochondrial genome structure. It also generally coincided with or preceded major shifts in ecological niche and the evolution of extensive physiological adaptations related to lung reduction, large prey consumption, and venom evolution. The parallel timing of these major evolutionary events suggests that evolutionary redesign of metabolic and mitochondrial function may be related to, or underlie, the extreme changes in physiological and metabolic efficiency, flexibility, and innovation observed in snake evolution.

See also this…..
First Dinosaur Tracks from the Arabian Peninsula:

The evolutionary history of Mesozoic terrestrial vertebrates from the Arabian Peninsula is virtually unknown. Despite vast exposures of rocky outcrops, only a handful of fossils have yet been described from the region. Here we report a multi-taxon dinosaur track assemblage near Madar village, 47 km north of Sana’a, Republic of Yemen. This represents the first dinosaur tracksite from the Arabian Peninsula, and the only multi-taxon dinosaur ichnosite in the Middle East. Measurements were taken directly from trackway impressions, following standard ichnological conventions. The presence of bipedal trackmakers is evidenced by a long series of pes imprints preserving smoothly rounded posterior margins, no evidence of a hallux, bluntly rounded digit tips and digital divarication angles characteristic of ornithopod dinosaurs. Nearby, eleven parallel quadrupedal trackways document a sauropod herd that included large and small individuals traveling together. Based on the morphology of manus impressions along with a narrow-gauged stance, the quadrupedal trackways were made by non-titanosauriform neosauropods. Additional isolated tracks and trackways of sauropod and ornithopod dinosaurs are preserved nearby. Taken together, these discoveries present the most evocative window to date into the evolutionary history of dinosaurs of the Arabian Peninsula. Given the limited Mesozoic terrestrial record from the region, this discovery is of both temporal and geographic significance, and massive exposures of similarly-aged outcrops nearby offer great promise for future discoveries.

Anomalous Hypothalamic Responses to Humor in Cataplexy:

Cataplexy is observed in a subset of patients with narcolepsy and affects approximately 1 in 2,000 persons. Cataplexy is most often triggered by strong emotions such as laughter, which can result in transient, yet debilitating, muscle atonia. The objective of this study was to examine the neural systems underlying humor processing in individuals with cataplexy. While undergoing functional Magnetic Resonance Imaging (fMRI), we showed ten narcolepsy-cataplexy patients and ten healthy controls humorous cartoons. In addition, we examined the brain activity of one subject while in a full-blown cataplectic attack. Behavioral results showed that participants with cataplexy rated significantly fewer humorous cartoons as funny compared to controls. Concurrent fMRI showed that patients, when compared to controls and in the absence of overt cataplexy symptoms, showed pronounced activity in the emotional network including the ventral striatum and hypothalamus while viewing humorous versus non-humorous cartoons. Increased activity was also observed in the right inferior frontal gyri -a core component of the inhibitory circuitry. In comparison, the one subject who experienced a cataplectic attack showed dramatic reductions in hypothalamic activity. These findings suggest an overdrive of the emotional circuitry and possible compensatory suppression by cortical inhibitory regions in cataplexy. Moreover, during cataplectic attacks, the hypothalamus is characterized by a marked decrease in activity similar to that observed during sleep. One possible explanation for these findings is an initial overdrive and compensatory shutdown of the hypothalamus resulting in full cataplectic symptoms.

Missing Girls in India: Infanticide, Feticide and Made-to-Order Pregnancies? Insights from Hospital-Based Sex-Ratio-at-Birth over the Last Century:

There are 44 million missing women in India. Gender bias; neglect of girls, infanticides and feticides are responsible. The sex ratio at birth can be used to examine the influence of antenatal sex selection on the sex ratio. Records from 321,991 deliveries at one hospital over 11 decades were utilized. The middle year in each decade was taken as representative of the decade. Data from 33,524 deliveries were then analyzed. Data for each decade was combined with that of previous decades and compared to the data of subsequent decades to look for any change in the trend. Sex ratio in the second children against sex of the first child was studied separately. The mean sex ratio for the 110 years examined was 910 girls to 1000 boys (95% CI; 891 to 930). The sex ratio dropped significantly from 935 (CI: 905 to 967) before 1979, to 892 (CI: 868 to 918) after 1980 (P = 0.04). The sex ratio in the second child was significantly lower if the first child was a girl [716 (CI: 672 to 762] (P<0.001). On the other hand, there was an excess of girls born to mothers whose first child was boy [1140 girls per 1000 boys (CI: 1072 to 1212 P<0.001)]. The sex ratio fell significantly after 1980 when ultra sound machines for antenatal sex determination became available. The sex ratio in second children if the first was a girl was even lower. Sex selective abortions after antenatal sex determination are thus implicated. However data on second children especially the excess of girls born to mothers who have a previous boy seen in the decade before the advent of antenatal ultra sound machines, suggests that other means of sex selection are also used.

Maternal Programming of Sexual Behavior and Hypothalamic-Pituitary-Gonadal Function in the Female Rat:

Variations in parental care predict the age of puberty, sexual activity in adolescence and the age at first pregnancy in humans. These findings parallel descriptions of maternal effects on phenotypic variation in reproductive function in other species. Despite the prevalence of such reports, little is known about potential biological mechanisms and this especially true for effects on female reproductive development. We examined the hypothesis that parental care might alter hypothalamic-pituitary-ovarian function and thus reproductive function in the female offspring of rat mothers that vary pup licking/grooming (LG) over the first week postpartum. As adults, the female offspring of Low LG mothers showed 1) increased sexual receptivity; 2) increased plasma levels of luteinizing hormone (LH) and progesterone at proestrus; 3) an increased positive-feedback effect of estradiol on both plasma LH levels and gonadotropin releasing-hormone (GnRH) expression in the medial preoptic region; and 4) increased estrogen receptor α (ERα) expression in the anterioventral paraventricular nucleus, a system that regulates GnRH. The results of a cross-fostering study provide evidence for a direct effect of postnatal maternal care as well as a possible prenatal influence. Indeed, we found evidence for increased fetal testosterone levels at embryonic day 20 in the female fetuses of High compared to Low LG mothers. Finally, the female offspring of Low LG mothers showed accelerated puberty compared to those of High LG mothers. These data suggest maternal effects in the rat on the development of neuroendocrine systems that regulate female sexual behaviour. Together with studies revealing a maternal effect on the maternal behavior of the female offspring, these findings suggest that maternal care can program alternative reproductive phenotypes in the rat through regionally-specific effects on ERα expression.

The Parallel Worm Tracker: A Platform for Measuring Average Speed and Drug-Induced Paralysis in Nematodes:

Caenorhabditis elegans locomotion is a simple behavior that has been widely used to dissect genetic components of behavior, synaptic transmission, and muscle function. Many of the paradigms that have been created to study C. elegans locomotion rely on qualitative experimenter observation. Here we report the implementation of an automated tracking system developed to quantify the locomotion of multiple individual worms in parallel. Our tracking system generates a consistent measurement of locomotion that allows direct comparison of results across experiments and experimenters and provides a standard method to share data between laboratories. The tracker utilizes a video camera attached to a zoom lens and a software package implemented in MATLAB®. We demonstrate several proof-of-principle applications for the tracker including measuring speed in the absence and presence of food and in the presence of serotonin. We further use the tracker to automatically quantify the time course of paralysis of worms exposed to aldicarb and levamisole and show that tracker performance compares favorably to data generated using a hand-scored metric. Although this is not the first automated tracking system developed to measure C. elegans locomotion, our tracking software package is freely available and provides a simple interface that includes tools for rapid data collection and analysis. By contrast with other tools, it is not dependent on a specific set of hardware. We propose that the tracker may be used for a broad range of additional worm locomotion applications including genetic and chemical screening.

Effects of Gape and Tooth Position on Bite Force and Skull Stress in the Dingo (Canis lupus dingo) Using a 3-Dimensional Finite Element Approach:

Models of the mammalian jaw have predicted that bite force is intimately linked to jaw gape and to tooth position. Despite widespread use, few empirical studies have provided evidence to validate these models in non-human mammals and none have considered the influence of gape angle on the distribution of stress. Here using a multi-property finite element (FE) model of Canis lupus dingo, we examined the influence of gape angle and bite point on both bite force and cranial stress. Bite force data in relation to jaw gape and along the tooth row, are in broad agreement with previously reported results. However stress data showed that the skull of C. l. dingo is mechanically suited to withstand stresses at wide gapes; a result that agreed well with previously held views regarding carnivoran evolution. Stress data, combined with bite force information, suggested that there is an optimal bite angle of between 25° and 35° in C. l. dingo. The function of these rather small bite angles remains unclear.

Imagine Jane and Identify John: Face Identity Aftereffects Induced by Imagined Faces:

It is not known whether prolonged exposure to perceived and imagined complex visual images produces similar shifts in subsequent perception through selective adaptation. This question is important because a positive finding would suggest that perception and imagery of visual stimuli are mediated by shared neural networks. In this study, we used a selective adaptation procedure designed to induce high-level face-identity aftereffects–a phenomenon in which extended exposure to a particular face facilitates recognition of subsequent faces with opposite features while impairing recognition of all other faces. We report here that adaptation to either real or imagined faces produces a similar shift in perception and that identity boundaries represented in real and imagined faces are equivalent. Together, our results show that identity information contained in imagined and real faces produce similar behavioral outcomes. Our findings of high-level visual aftereffects induced by imagined stimuli can be taken as evidence for the involvement of shared neural networks that mediate perception and imagery of complex visual stimuli.

Linking Social and Vocal Brains: Could Social Segregation Prevent a Proper Development of a Central Auditory Area in a Female Songbird?:

Direct social contact and social interaction affect speech development in human infants and are required in order to maintain perceptual abilities; however the processes involved are still poorly known. In the present study, we tested the hypothesis that social segregation during development would prevent the proper development of a central auditory area, using a “classical” animal model of vocal development, a songbird. Based on our knowledge of European starling, we raised young female starlings with peers and only adult male tutors. This ensured that female would show neither social bond with nor vocal copying from males. Electrophysiological recordings performed when these females were adult revealed perceptual abnormalities: they presented a larger auditory area, a lower proportion of specialized neurons and a larger proportion of generalist sites than wild-caught females, whereas these characteristics were similar to those observed in socially deprived (physically separated) females. These results confirmed and added to earlier results for males, suggesting that the degree of perceptual deficiency reflects the degree of social separation. To our knowledge, this report constitutes the first evidence that social segregation can, as much as physical separation, alter the development of a central auditory area.

Tau Mutation in Context

Tau Mutation in Contexthamster.jpgI got several e-mails yesterday about a new study about the molecular mechanism underlying circadian rhythms in mammals (“You gotta blog about this!”), so, thanks to Abel, I got the paper (PDF), printed it out, and, after coming back from the pool, sat down on the porch to read it.
After reading the press releases, I was in a mind-frame of a movie reviewer, looking for holes and weaknesses so I could pounce on it and write a highly critical post, but, even after a whole hour of careful reading of seven pages, I did not find anything deeply disturbing about the paper. Actually, more I read it more I liked it, my mood mellowed, and I am now ready for a long rambling post about it – I have no idea how is it going to end, but let’s go on a journey together….and let me start with a little background – the Big-Picture-kind of background – before I focus on the paper itself.

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ClockQuotes

Sometimes when I look at all my children, I say to myself, Lillian, you should have stayed a virgin.
– Bessie Lillian Gordy Carter (1898-1983)

Development of the human sleep patterns

Development of the human sleep patternsWhat it really means when we are talking about babies “sleeping through the night” (from September 22, 2005)

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Clocks in Bacteria V: How about E.coli?

Clocks in Bacteria V: How about E.coli?Fifth in the five-part series on clocks in bacteria, covering more politics than biology (from May 17, 2006):

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ClockQuotes

The good people sleep much better at night than the bad people. Of course, the bad people enjoy the waking hours much more.
– Woody Allen

New and Exciting in PLoS Biology and PLoS Medicine

Evolution and Creationism in America’s Classrooms: A National Portrait:

We advance this long tradition of surveying teachers with reports from the first nationally representative survey of teachers concerning the teaching of evolution. The survey permits a statistically valid and current portrait of US science teachers that complements US and international surveys of the general public on evolution and scientific literacy [2,24] and on evolution in the classroom [3,25]. Between March 5 and May 1, 2007, 939 teachers participated in the study, either by mail or by completing an identical questionnaire online. Our overall response rate of 48% yielded a sample that may be generalized to the population of all public school teachers who taught a high school-level biology course in the 2006-2007 academic year, with all percentage estimates reported in this essay’s tables and figures having a margin of error of no more than 3.2% at the 95% confidence level. Detailed discussion of the methods of the survey and assessments of non-response can be found in Text S1. Our results confirm wide variance in classroom instruction and indicate a clear need to focus not only on state and federal policy decisions, but on the everyday instruction in American classrooms.

Circadian Transcription Contributes to Core Period Determination in Drosophila:

The existence of circadian clocks, which allow organisms to predict daily changes in their environments, have been recognized for centuries, yet only recently has the molecular machinery responsible for their generation been uncovered. The current model in animals posits that interlocked feedback loops of transcription-translation produce these 24-hour rhythms. In fruit flies, the transcription loop contains a key activator complex, composed of the transcription factors Clock and Cycle. This CLK-CYC complex stimulates the synthesis of repressor proteins like Period and Timeless, which repress the activator complex. The synthesis-repression cycle takes precisely 24 hours under environmental conditions that influence the circadian period. An almost identical process relies on the ortholog proteins CLK-BMAL in mammals. Recent findings have challenged the transcription-translation feedback model and suggest that circadian transcription is an output process and that the post-translational modification of clock proteins is the real central pacemaker mechanism. In the present study, we have manipulated the levels and strength of the CLK-CYC complex. The results demonstrate that its activity is vital for proper period determination and thus indicate that the transcriptional feedback loop is part of the core circadian mechanism.

Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?:

In the last decade or so, we have become familiar with the discovery of new classes of nuclear-encoded regulators (see Glossary) as fundamental controllers of gene expression. Each new discovery has again highlighted the incomplete nature of our understanding of the genome and its regulation. First, small interfering RNAs (siRNAs) demonstrated that RNA molecules are not merely components of the cellular machinery (such as tRNAs and rRNAs) or gene-expression intermediates (mRNAs), but can function as potent trans-acting regulators of specific genes. MicroRNAs (miRNAs) continued this theme and now attract much attention among basic scientists and clinicians alike, both as potential regulators of most human genes and as potential diagnostic tools. In this issue of PLoS Medicine, a research article by Shigetada Teshima-Kondo and colleagues supports the suggestion that another class of regulatory RNAs exists [1]. Furthermore, this class could be the largest to date, since potential members are contained within every mRNA.

The Allure of the Few:

Population ecology–the science of what makes animal and plant populations change, persist, or go extinct–is the most theoretical and mathematical of all ecological disciplines, yet it yields a huge number of practical benefits. When conservation agencies wish to protect a threatened species, but are up against a tight budget and real-world logistical constraints, they use population models to tell them how large an area to reserve and how it should be connected to other habitats, so as to minimise the species’ risk of extinction. In short, population ecology tells us how to get the best “bang for our buck” [1]. Similarly, fishery managers face the perennial issue of determining how heavily they can exploit a fluctuating fish stock without over-harvesting and causing a crash (or extinction). Again, population models, of various complexities, provide guidance in setting fishing quotas and no-take areas [2].

Taz – in the mouse!

funny pictures

PLoS ONE just published a very exciting paper – a regulatory sequence from the genome of a preserved Tasmanian wolf was inserted into a mouse and shown to have the same function:
Resurrection of DNA Function In Vivo from an Extinct Genome:

There is a burgeoning repository of information available from ancient DNA that can be used to understand how genomes have evolved and to determine the genetic features that defined a particular species. To assess the functional consequences of changes to a genome, a variety of methods are needed to examine extinct DNA function. We isolated a transcriptional enhancer element from the genome of an extinct marsupial, the Tasmanian tiger (Thylacinus cynocephalus or thylacine), obtained from 100 year-old ethanol-fixed tissues from museum collections. We then examined the function of the enhancer in vivo. Using a transgenic approach, it was possible to resurrect DNA function in transgenic mice. The results demonstrate that the thylacine Col2A1 enhancer directed chondrocyte-specific expression in this extinct mammalian species in the same way as its orthologue does in mice. While other studies have examined extinct coding DNA function in vitro, this is the first example of the restoration of extinct non-coding DNA and examination of its function in vivo. Our method using transgenesis can be used to explore the function of regulatory and protein-coding sequences obtained from any extinct species in an in vivo model system, providing important insights into gene evolution and diversity.

When Should Schools Start in the morning?

When Should Schools Start in the morning?The fourth part of a four-part series on the topic, this one from April 02, 2006….

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SRBR – Day 2

As you know, I am currently in Florida, at the 20th Anniversary meeting of the Society for Research on Biological Rhythms, that is, my own society. I have not been since 2002, so I am surprised to see how many people remember may face and are happy to see me.
I am also surprised to hear how many people in the field read this blog – some more some less regularly – and even use the ClockTutorials and some other Chronobiology posts in teaching their courses on Biological Clocks. I would have know this before if they would just post comments here!
What I am not surprised, yet am pleased, is how much people are in support of Open Access and love PLoS. I have already talked to dozens of people about the details of PLoS is and what it does and how it does it and why that is good and they should publish with us – and they are very receptive.
I have seen a bunch of interesting talks and posters already. Instead of blogging them myself, I will interview their authors and post the interviews here after I come back home – so look out for a nice series of summer interviews here with various luminaries of the field, ranging from living legends, through currently top researchers, to bright up-and-coming students.
And yes, I am taking pictures, but will post them later. Here, just to make sure everyone knows, is the photographic proof that Professor Steve Steve is having fun:
srbr%20014.jpg

Clocks in Bacteria IV: Clocks in other bacteria

Clocks in Bacteria IV: Clocks in other bacteriaFourth in the five-part series on clocks in bacteria (from April 30, 2006):

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ClockQuotes

The greatest lesson in life is to know that even fools are right sometimes.
– Winston Churchill

More on sleep in adolescents

More on sleep in adolescentsThis is the third part of the series on the topic, from April 01, 2006…

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Clocks in Bacteria III: Evolution of Clocks in Cyanobacteria

Clocks in Bacteria III: Evolution of Clocks in CyanobacteriaThe third installment in the five-part series on clocks in bacteria (from April 19, 2006):

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ClockQuotes

I want a busy life, a just mind, and a timely death.
– Zora Neale Hurston

SRBR – Day 1

I just had nice seafood dinner while watching the sunset over the water with this guy, down in sunny Florida. Readers of this blog have met him before, here and here.
I also saw Erik Herzog, who is familiar to all of you from, e.g., here, here, here and here. I heard him give a presentation about the ways to get an NSF grant in the circadian field.
I am about to see Chris Steele as well.
I attended a Memorial Symposium on Melatonin in honor of Aaron Lerner.
And talked to several people about PLoS already – I am REALLY doing my job.
I am suprised how many people recognize me and are happy to see me – last time I attended SRBR meeting was six years ago.

Sleep Schedules in Adolescents

Blogging on Peer-Reviewed Research
Blogging on Peer-Reviewed Research

Sleep Schedules in AdolescentsEarlier this year, during the National Sleep Awareness Week, I wrote a series of posts about the changes in sleep schedules in adolescents. Over the next 3-4 hours, I will repost them all, starting with this one from March 26, 2006. Also check my more recent posts on the subject here and here…

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Clocks in Bacteria II: Adaptive Function of Clocks in Cyanobacteria

Clocks in Bacteria II: Adaptive Function of Clocks in CyanobacteriaSecond post in a series of five (from April 05, 2006):

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ClockQuotes

Cowards die many times before their deaths;
The valiant never taste of death but once.

– William Shakespeare

My Picks From ScienceDaily

‘Mitochondrial Eve’ Research: Humanity Was Genetically Divided For 100,000 Years:

The human race was divided into two separate groups within Africa for as much as half of its existence, says a Tel Aviv University mathematician. Climate change, reduction in populations and harsh conditions may have caused and maintained the separation.

Simple Artificial Cell Created From Scratch To Study Cell Complexity:

A team of Penn State researchers has developed a simple artificial cell with which to investigate the organization and function of two of the most basic cell components: the cell membrane and the cytoplasm–the gelatinous fluid that surrounds the structures in living cells. The work could lead to the creation of new drugs that take advantage of properties of cell organization to prevent the development of diseases. The team’s findings will be published later this month in the Journal of the American Chemical Society.

Crystal (Eye) Ball: Visual System Equipped With ‘Future Seeing Powers’:

Catching a football. Maneuvering through a room full of people. Jumping out of the way when a golfer yells “fore.” Most would agree these seemingly simple actions require us to perceive and quickly respond to a situation. Assistant Professor of Cognitive Science at Rensselaer Polytechnic Institute Mark Changizi argues they require something more — our ability to foresee the future.

Weather, Waves And Wireless: Super Strength Signalling:

A new study from the University of Leicester has discovered a particular window of time when mobile signals and radio waves are ‘super strength’ — allowing them to be clearer and travel greater distances, potentially interfering with other systems.

Gravity-defying Bird Beak Mystery Solved: Shorebirds Benefit From Surface Tension:

As Charles Darwin showed nearly 150 years ago, bird beaks are exquisitely adapted to the birds’ feeding strategy. A team of MIT mathematicians and engineers has now explained exactly how some shorebirds use their long, thin beaks to defy gravity and transport food into their mouths.

Climbing As Easy As Walking For Smaller Primates:

Smaller primates expend no more energy climbing than they do walking, Duke University researchers have found. This surprising discovery may explain the evolutionary edge that encouraged the tiny ancestors of modern humans, apes and monkeys to climb into the trees about 65 million years ago and stay there.

Parrot Fossil 55 Million Years Old Discovered In Scandinavia:

Palaeontologists have discovered fossil remains in Scandinavia of parrots dating back 55 million years. Reported May 14 in the journal Palaeontology, the fossils indicate that parrots once flew wild over what is now Norway and Denmark.

Success By Learning: Smallest Predator Recognizes Prey By Its Shape:

The Etruscan shrew (Suncus etruscus) is one of the world’s smallest mammals. It is about four centimetres long and weighs merely two grams. Being a nocturnal animal, it hunts predominantly with its sense of touch. Professor Michael Brecht (Bernstein Center for Computional Neuroscience, Berlin) now reported on the particularities of its hunting behaviour at the international conference “Development and function of somatosensation and pain” at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany. “As quick as a flash, the Etruscan shrew scans its prey and adapts, when necessary, its hunting strategy,” explained Brecht in his talk. “Thus, no prey escapes.”

Monkey Studies Important For Brain Science:

Studies with non-human primates have made major contributions to our understanding of the brain and will continue to be an important, if small, part of neuroscience research, according to a recent review published in the British medical journal, The Lancet.

Pain Free Without Numbness — Substance Combination With Chili Peppers:

A dentist’s injection typically causes numbness for several hours. This experience could soon be history. Now, Clifford Woolf, professor at Harvard Medical School and the Massachusetts General Hospital, Boston, USA, and his colleagues have developed a combination of two agents which is able to specifically block pain without producing numbness or motor paralysis. The substance is composed of a normally inactive derivative of the local anesthetic lidocaine, called QX314, and capsaicin, the pain-producing substance in chili peppers.

Culture Affects How Teen Girls See Sexual Harassment:

Teenage girls of all ethnic and socioeconomic backgrounds still experience sexism and sexual harassment — but cultural factors may control whether they perceive sexism as an environmental problem or as evidence of their own shortcomings.

‘The Hairy Beast’ or ‘Super Virgin’?

Ha! Made you look! Which is exactly the point! Go and add your own ideas in the comments there….

Off to Florida….

…no idea what kind of Internet access I will have there, so I scheduled some re-posts and quotes to show up automatically. I’ll add more if I can when I can.

Spider Boat

I’d like to sail on this thing:

Bay Area engineer Ugo Conti has sailed the world, but has always suffered from seasickness. A queasy stomach became his motivation to design “Proteus” – a spider-like sea craft made for smoother sailing. He designed the Wave Adaptive Modular Vessel to cross the ocean while flexing with the movement of the waves. And it may change the way people take to the high seas.

Adolescent Sleep Schedule

From the ArchivesThis kind of ignorant bleating makes me froth at the mouth every time – I guess it is because this is my own blogging “turf”.
One of the recurring themes of my blog is the disdain I have for people who equate sleep with laziness out of their Puritan core of understanding of the world, their “work ethic” which is a smokescreen for power-play, their vicious disrespect for everyone who is not like them, and the nasty feeling of superiority they have towards the teenagers just because they are older, bigger, stronger and more powerful than the kids. Not to forget the idiotic notions that kids need to be “hardened”, or that, just because they managed to survive some hardships when they were teens, all the future generations have to be sentenced to the same types of hardships, just to make it even. This is bullying behavior, and disregarding and/or twisting science in the search for personal triumphalism irks me to no end.

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Clocks in Bacteria I: Synechococcus elongatus

Clocks in Bacteria I: Synechococcus elongatus
First in a series of five posts on clocks in bacteria (from March 08, 2006)…

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ClockQuotes

By the time a man notices that he is no longer young, his youth has long since left him.
– W. Somerset Maugham

My Picks From ScienceDaily

Monarch Butterflies Help Explain Why Parasites Harm Hosts:

It’s a paradox that has confounded evolutionary biologists since Charles Darwin published On the Origin of Species in 1859: Since parasites depend on their hosts for survival, why do they harm them? A new University of Georgia and Emory University study of monarch butterflies and the microscopic parasites that hitch a ride on them finds that the parasites strike a middle ground between the benefits gained by reproducing rapidly and the costs to their hosts. The study, published in the early online edition of the journal Proceedings of the National Academy of Sciences, provides the first empirical evidence in a natural system of what’s called the “trade-off hypothesis.”

Recipe For Energy Saving Unravelled In Migratory Birds:

Pointed wings together with carrying less weight per wing area and avoidance of high winds and atmospheric turbulence save a bird loads of energy during migration. This has been shown for the first time in free-flying wild birds by researchers at Princeton University, the University of Montana, and the German Max Planck Institute for Ornithology. They state that climate change might have a critical impact on small migrants’ energy budgets if it causes higher winds and atmospheric instability as predicted.

Warming Climate Is Changing Life On Global Scale, Says New Study:

A vast array of physical and biological systems across the earth are being affected by warming temperatures caused by humans, says a new analysis of information not previously assembled all in one spot. The effects on living things include earlier leafing of trees and plants over many regions; movements of species to higher latitudes and altitudes in the northern hemisphere; changes in bird migrations in Europe, North America and Australia; and shifting of the oceans’ plankton and fish from cold- to warm-adapted communities.

New Insights Into The Dynamics Of The Brain’s Cortex:

Using mathematics and a computer model of brain activity, Roberto Fernández Galán, Ph.D., an assistant professor of neurosciences at Case Western Reserve University School of Medicine, has shown a direct link between activity in the cortex and the microscopic structure of this neuronal network.

Endocrine Disruptors In Common Plastics Linked To Obesity Risk:

Exposure during development either in the womb or during infancy to chemicals used to make products such as baby bottles, the lining of food tins and some plastic food wraps and containers, may contribute to the development of obesity, according to new research presented at the European Congress on Obesity.

Female Sex Offenders Often Have Mental Problems:

Women who commit sexual offences are just as likely to have mental problems or drug addictions as other violent female criminals. This according to the largest study ever conducted of women convicted of sexual offences in Sweden.

Girls, Young Women Can Cut Risk Of Early Breast Cancer Through Regular Exercise:

Mothers, here’s another reason to encourage your daughters to be physically active: Girls and young women who exercise regularly between the ages of 12 and 35 have a substantially lower risk of breast cancer before menopause compared to those who are less active, new research shows.

Bears And Hibernation: New Insights Into Metabolism In Extreme Conditions:

Due to their ability to produce a potent inhibitor of protein degradation, hibernating bears do not lose muscle mass after long periods of hibernation. This is the main conclusion of the study directed by Professor Josep M. Argilés and co-written by Francisco J. López-Soriano, Gemma Fuster, Sílvia Busquets and Vanessa Almendro of the Cancer Research Group at the Biochemistry and Molecular Biology Department of the University of Barcelona (UB).

Rapid, Dramatic ‘Reverse Evolution’ Documented In Tiny Fish Species:

Evolution is supposed to inch forward over eons, but sometimes, at least in the case of a little fish called the threespine stickleback, the process can go in relative warp-speed reverse, according to a study led by researchers at Fred Hutchinson Cancer Research Center and published online ahead of print in the May 20 issue of Current Biology.

Mice Can Do Without Humans’ Most Treasured Genes:

The mouse is a stalwart stand-in for humans in medical research, thanks to genomes that are 85 percent identical. But identical genes may behave differently in mouse and man, a study by University of Michigan evolutionary biologists Ben-Yang Liao and Jianzhi Zhang reveals.

Sciencewoman at ISEF 2008

Sciencewoman is in Atlanta, judging this year’s International Science and Engineering Fair and liveblogging the whole thing:
Going to Atlanta….
First Taste of the International Science and Engineering Fair
ISEF 2008: Nobel Laureates Panel
ISEF 2008: Day 1 by the numbers
ISEF 2008: Full disclosure
ISEF 2008: Impressive science by high school students
ISEF 2008: Cool science and practical applications
ISEF 2008: Special awards and scenes from around the fair
Update: Here are the winners:
ISEF 2008: The best of the best! And they’re girls!

Books: “Snooze…Or Lose! – 10 “No-War” Ways To Improve Your Teen’s Sleep Habits” by Helene A. Emsellem, MD

Snooze%20or%20Lose.jpgMy regular readers are probably aware that the topic of adolescent sleep and the issue of starting times of schools are some of my favourite subjects for a variety of reasons: I am a chronobiologist, I am an extreme “owl” (hence the name of this blog), I am a parent of developing extreme “owls”, I have a particular distaste for Puritanical equation of sleep with laziness which always raises its ugly head in discussions of adolescent sleep, and much of my own research is somewhat related to this topic (see the bottom of this post for Related Posts).
So, I was particularly pleased when Jessica of the excellent Bee Policy blog informed me of the recent publication of a book devoted entirely to this topic. Snooze…or Lose! by Helen Emsellem was published by National Academies and Jessica managed to get me an Advanced Reading Copy to review.

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Columbia Book Sale

I got an interesting e-mail yesterday:

Columbia White Sale goes through May 31st. For more information, please visit: http://cup.columbia.edu/sale/23. We are offering up to 80% off on more than 1,000 titles in all subjects. (There are some really great deals). I hope this will be of interest to you and your readers. Please feel free to pass the word to friends and colleagues.

Hmmmmm, shiny!

Museum Night

The fifth annual Museum Night in Belgrade and other Serbian cities will be held this Saturday, May 17th:

More than 130 museums and galleries in 23 towns in Serbia will be open just for you, so the only decision you have to make is to choose a good company. We hope you are in good shape because there will be so many interesting exhibitions, concerts and performances that you will literally have the whole Belgrade under your feet!

What a great idea – pick a day, have special exhibits, events and concerts, all for free, and get the entire town to come out and enjoy.

How YOU can help with malaria research

Social networking meets social conscience:

As reported today in the science journal Nature, MalariaEngage.org aims to help in the stuggle against malaria. Rather than throwing buckets of money at big name Western research institutes, the new website aims to give smaller locally-based African projects a bigger profile.
Relying on grass-roots support from people who are concerned about poverty and disease, the website hopes to fund in-country research that would otherwise be overlooked by the big funders such as the Gates Foundation or NIH.
The site provides profiles of projects that individuals (that’s you and me!) can evaluate and choose to support.

EuroVision 2008

I am kinda glad I went to Belgrade earlier and escaped the craziness of the EuroVision contest. The tickets have been sold out for a long time now. At least the European visitors will see how pretty Belgrade is now and how nicely it has recovered from a decade of wars, sanctions, hyperinflation, mismanagement and bombing.