Did A Virus Make You Smart?

Did A Virus Make You Smart?Not really a review of Greg Bear’s “Darwin’s Radio” and “Darwin’s Children” but musing (practically SF itself) on the topic of these books (from April 20, 2005, also reposted here so you can see the comments):

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Just a few pictures from last night

Jennifer Ouellette has the whole story, but here are a few more pictures (under the fold).
We met at Betelnut restaurant last night – Jennifer, Kristin Abkemaier (formerly of the ‘Radioactive Banana’ blog), Jeff and Curtis of the Jeff’s Bench Science 2.0 site, and my old friends from Chapel Hill, now San Francisco transplants, Justin Watt and Josh Steiger:

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Friday Weird Sex Blogging – The Birds Do It….

Friday Weird Sex Blogging - The Birds Do It....You should check out all of my SiBlings’ Friday Blogging practices, then come back here for a new edition of Friday Weird Sex Blogging. Last week you saw an example of a corkscrew penis. But that is not the only one of a kind. See more under the fold (first posted on July 14, 2006)…

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ClockQuotes

To believe in one’s dreams is to spend all of one’s life asleep.
– Chinese proverb

First day….

PLoS%20first%20day.jpg
Enjoying the computer. Everything works!
More pictures and stuff later – I am exhausted (and a little jet-lagged) so it’s time for bed….

Sleep Schedules in Adolescents

Sleep Schedules in AdolescentsEarlier this year, during the National Sleep Awareness Week, I wrote a series of posts about the changes in sleep schedules in adolescents. Over the next 3-4 hours, I will repost them all, starting with this one from March 26, 2006. Also check my more recent posts on the subject here and here…

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Today’s Carnivals

Scientiae carnival: responsibility is up on Amelie’s Welt.
The Carnival of Education #126 is up on NYC Educator.
Friday Ark #146 is up on The Modulator.
Carnival of Homeschooling: Independence Edition is up on HomeSchoolCafe.

First Day at PloS

I Support the Public Library of ScienceThis post has been written in advance and scheduled for automatic posting. At the time this post shows up, I’ll be sleeping my first night in San Francisco. A few hours later, I’ll be at PLoS offices and will hopefully have online access soon after so I can post my first impressions.
As most of you probably know, I got a job as an Online Community Coordinator at PLoS ONE. Today is my first day at the job! I got the job in an unusual way as well – by posting about it on my blog (and the managing editor posting a comment “Is this a formal application?”). The rest is, as they say, history. To make this post shorter, I have blogged about the job before, about the way I got the job, and some of my thoughts about what I want to do with it, so check out the relevant posts:
I Want This Job!
Update on ‘I Want This Job’
Off to SF
Back from SF
Updates
It’s Official
While my CV and the cover letter were fine, what really got me the job were my blog commenters! That is: YOU! You demonstrated my ability to build an online community better than any Resume can reveal. Although, to be fair, it took me three years to build this community and now I have three months to build one on PLoS! So, I need your help and I am unabashedly begging for it.
So, my #1 goal (and there are other coooool goals I’ll tell you about later) is to dramatically increase the number of comments and annotations on the PLoS ONE papers, without compromising their quality. I have many ideas how to go about it, and so do the other members of the PLoS team, but I am always interested in hearing others (comments section of this post is a perfect place for just such ideas you may have).
For the time being, I will start with raising quantity first, i.e., trying to grow some numbers, e.g., overall traffic, number of return visitors, time spent on site, pageview/visit ratio, etc., building a critical mass until it reaches a threshold at which I will have to also deal with quality (you know the rule on blogs – more comments there are, lower the level of discourse).
Scientists are generally shy about posting stuff online, but a growing number of science bloggers shows that it is possible for them to change their habits! Please help me in that difficult task 😉 After all, you are the ones who are comfortable commenting – so if you set the example and start posting comments, the more reluctant scientists will hopefully follow suit.
As you are aware of, commenting is a positive feedback loop. If you go to a blog post (or a PLoS ONE paper) and see “0 comments” you are unlikely to be the first one to comment (but you are still more likely to do so than a scientist with no experience on blogs whatsoever!). But if you see “3 comments” or “7 comments” or “35 comments” you will be curious and you will click to see what others are saying. By the time you are done reading through the comments, you are already deeply involved and thus much more likely to decide to post a comment of your own (especially if you disagree with some statement there).
While scientists are secretive and shy by training, they are still people. The non-blogging scientists may have very high thresholds, but they do have thresholds! If they see a number of comments there and see something erroneous posted there, they will post a rebuttal, I hope. I need you – the bloggers – to bring the commenting threads up to the threshold levels at which non-blogging scientists will start kicking in. Then, hopefully, there will be a snowball effect and over the long run the growth of commenting will become organic (i.e., I will not need to bug you about this any more).
Here are some broad ideas about Science 2.0 I have (and I will give you particulars on what PLoS-ONE will do in the near future in later posts):
PLoS 500
Science 2.0
Nature Precedings
I will keep using my own blog as part of my toolkit at the job (subscribe/blogroll/bookmark it if you want so you can see the updates here as soon as I post them) and updates will appear here on my blog (and on the PLoS Blog as well). No, this does not mean I will quit blogging about other topics!
What should you expect me to ask/tell you in future job-related posts?
Usually, I will ask you to go to a particular page on PLoS site and do one or more of the following:
– take a look at the visual/psychological effect of the changes we made to the site and give me feedback about it
– test a new application we introduced on the site and let me know how it works and how it can be improved
– post a comment or annotation yourself (on a specific paper, or a paper of your own choice)
– ask the readers of your blog/website/newsgroup/mailing-list to do some of the above.
It’s all voluntary, of course. Do it if you feel like it, and are comfortable doing it, and have time, and are in just the right mood at the time…
Although, heed Orli’s words: “…as we all know, saying no to Bora means courting bad karma…” 😉
In order for you to be able to do this, i.e., to be able to compare the ‘before’ and ‘after’, I’d like you (and your readers) to go over the next few days and familarize yourself with PLoS ONE, its look and feel.
Also, you may want to get more familiar with PLoS as a whole, with all of its journals and with the principle of Open Access.
It will also be helpful if you register for the site, subscribe to RSS feeds of journals, and to e-mail notifications of new articles.
You can also help me if you use some of these ready-made PR materials (cool banners for your sidebars!) and here are some other ideas of the ways you can help.
You can join the PLoS group and PLoS cause on Facebook and invite all your ‘friends’ to join. On another social network? Start a support group yourself there!
One of the first things I am going to do is try to breathe new life into the PLoS Blog and make it a pretty central (and more frequently updated) spot on the site. As Technorati annual reports found out, it is not the age or quality that determines which blogs are popular and highly ranked, but the frequency and regularity of posting. This may also require some re-design. So, it is not a bad idea for you to subscribe to its feed and to check in regularly and post comments. Linking to its posts or placing them on services like digg, delicious, stumbleupon and redditt will also be appreciated.
Finally, go to the Sandbox and try your hand at annotations and comments before you do it on a real paper. Once you are comfortable with the process, find papers in your area of expertise and post a comment – it does not need to be very detailed (or a criticism of the work!). Authors will appreciate it if you tell them that you like the paper in 1-2 nice short sentences as well.
Oh, almost forgot – think about publishing your papers in PLoS-ONE. The average time between submission and publication is 19 days! More than 500 papers have already been published and several are added every week. And you get feedback from colleagues and your paper is likely to be cited more than if it was behind a pay wall. As long as it is good science and well written, it is acceptable. It does not need to be Earth-shaking, revolutionary stuff that goes to Science or Nature (though that is certainly acceptable!). It does not need to be of ‘general interest’ either – a very specialized paper is fine. Also, while currently most of the papers are in the biology/genetics/medicine areas, the journal takes anything from math to archaeology so please help us become more diverse!
Oh, another thing – if you are in Bay Area (San Francisco, California, USA) during July and would like to meet me in person, let me know.
Oh, and tell your friends…

ClockQuotes

When we drink, we get drunk. When we get drunk, we fall asleep. When we fall asleep, we commit no sin. When we commit no sin, we go to heaven. Sooooo, let’s all get drunk and go to heaven!
– Brian O’Rourke

I am in….

…Frisco.
The flights were smooth and uneventful.
I went straight to PLoS, met some people I knew from before and others I knew only over e-mail, did the requisite paperwork, got familiarized with my computer and the beginning of getting familiarized with the ‘behind the scenes’ of the software used by PLoS journals.
My apartment is gorgeous – the owner must be an artist of some kind (probably pottery, as she is spending this month in North Carolina at Pendletonn school) as the place is so artistically and tastefully furnished and decorated.
SF is a very hilly place – I will get fit and develop big leg muscles walking uphill both ways. It took some mountain-climbing this afternoon wondering around the neighborhood and finding a store….
Tomorrow is the first official work day and I’ll probably have something to say about it. I also brought the camera and I’ll try not to forget to take some pictures everywhere I go.

Tangled Skeptics

Tangled Bank #83 is up on Aardvarchaeology
64th Skeptics’ Circle is up on The Sceptical Alchemist.

My Picks From ScienceDaily

Understanding Smooth Eye Pursuit: The Incredible Targeting System Of Human Vision:

Researchers at the University of Pennsylvania have shed new light on how the brain and eye team up to spot an object in motion and follow it, a classic question of human motor control. The study shows that two distinctly different ways of seeing motion are used – one to catch up to a moving object with our eyes, a second to lock on and examine it.

Wolves Of Alaska Became Extinct 12,000 Years Ago, Scientists Report:

The ancient gray wolves of Alaska became extinct some 12,000 years ago, and the wolves in Alaska today are not their descendents but a different subspecies, an international team of scientists reports in the July 3 print edition of the journal Current Biology.

Reap What Your Ancestors Sowed: Cheating Has Long-term Consequences In Evolution Of Cooperation:

Freeloaders can live on the fruits of the cooperation of others, but their selfishness can have long-term consequences, reports an evolutionary biologist from The University of Texas at Austin in a new study.

Altruistic Rats: First Evidence For Generalized Reciprocal Cooperation In Non-humans:

Cooperation in animals has long been a major focus in evolutionary biology. In particular, reciprocal altruism, where helpful acts are contingent upon the likelihood of getting help in return, is especially intriguing because it is open to cheaters. In a new study published this week in the open-access journal PLoS Biology, Claudia Rutte and Michael Taborsky demonstrate the first evidence for generalized reciprocal cooperation in non-humans. The authors show that rats who received help in the past were more likely to help another unknown partner.

Mother-of-pearl: Classic Beauty And Remarkable Strength:

While the shiny material of pearls and abalone shells has long been prized for its iridescence and aesthetic value in jewelry and decorations, scientists admire mother-of-pearl for other physical properties as well.

Friday Weird Sex Blogging – Corkscrewing

Friday Weird Sex Blogging - CorkscrewingYou really think I am going to put this above the fold? No way – you have to click (First posted on July 7, 2006):

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ClockQuotes

Be anchored to some ideal, philosophy or cause that keeps you too excited to sleep.
– Brian Koslow

I’m off…

I am about to go offline now, early to bed, early to rise…travelling to San Fran tomorrow at dawn. Hopefully I’ll be able to get back online by tomorrow afternoon.
I have scheduled a lot of reruns of the old posts (twice a day) and new quotes (once per night), but I will post new stuff as well whenever I find time: the first day at PLoS, pictures from various blogger meetups (excluding the pictures of pseudonymous bloggers), pictures of my strange meal at Incanto…and on Monday morning something you’ll probably find interesting but it is a secret right now.

Liberal Blogging of the Fortnight

The July 4th edition of the Carnival of the Liberals is up on Zaius Nation.

My Picks From ScienceDaily

Stressed-out African Naked Mole-rats May Provide Clues About Human Infertility:

A tiny, blind, hairless subterranean rodent that lives in social colonies in the harsh, semi-arid conditions of Africa could shed light on stress-related infertility in humans, the 23rd annual meeting of the European Society of Human Reproduction and Embryology will hear.

Glimmer Of Hope For Tahitian Tree Snails’ Survival:

Despite the mass extermination of Tahiti’s unique species of tree snails in recent decades, much of their original genetic diversity can still be found in remnant populations that survive on the island, researchers report in the July 3rd issue of Current Biology, a Cell Press publication. The findings offer renewed hope that targeted conservation measures may yet preserve a representative, although impoverished, fraction of Tahiti’s endemic tree snail genetic diversity in the wild–a feat earlier believed to be impossible.

Jellyfish Population Explosion Leads To New Use For Waste Creatures:

Amid growing concern about how to dispose of a booming population of jellyfish — including 6-foot-long monsters weighing more than 400 pounds — scientists in Japan are reporting development of a process for extracting a commercially-valuable biomaterial from the marine animals. Their report is scheduled for the July 27 issue of ACS’ Journal of Natural Products, a monthly publication.

Advancing Research On Interplay Between Biology And Society:

Scientists will find new ways of understanding the interactions of the biological sciences with society, as a result of awards from the National Science Foundation’s (NSF) directorates for biological sciences and for social, behavioral, and economic sciences.

Sex On The Brain (of the science reporters)

Sex On The Brain (of the science reporters)This post was a response to a decent (though not too exciting) study and the horrible media reporting on it. As the blogosphere focused on the press releases, I decided to look at the paper itself and see what it really says. It was first posted on August 09, 2005. Under the fold (reposted on July 12, 2006)…

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ClockQuotes

# Diary, n. A daily record of that part of one’s life, which he can relate to himself without blushing.
– Ambrose Bierce

Happy Fourth of July!

And to my Yugoslav readers: “Srecan Dan Borca!”

New science blogger joins Shakesville

Quixote (who some of you may know from Acid Test) has joined the growing stable of brilliant bloggers at Shakesville – check out the introductiory post.

Obligatory Readings of the Day – Science 2.0

Interview with Timo Hannay, Head of Web Publishing, Nature Publishing Group
Scientific Communications in Web 2.0 Context
Publishing Versus Posting: Nature Magazine Turns to a Conversational Content Model

Why People Write?

I don’t know, but Grrrl and Archy tried to answer that question…

New and Exciting on PLoS-ONE

A bunch of papers just went live on PLoS-ONE and, after a quick scan, these three papers caught my eye:
The Durability of Public Goods Changes the Dynamics and Nature of Social Dilemmas:

An implicit assumption underpins basic models of the evolution of cooperation, mutualism and altruism: The benefits (or pay-offs) of cooperation and defection are defined by the current frequency or distribution of cooperators. In social dilemmas involving durable public goods (group resources that can persist in the environment-ubiquitous from microbes to humans) this assumption is violated. Here, we examine the consequences of relaxing this assumption, allowing pay-offs to depend on both current and past numbers of cooperators. We explicitly trace the dynamic of a public good created by cooperators, and define pay-offs in terms of the current public good. By raising the importance of cooperative history in determining the current fate of cooperators, durable public goods cause novel dynamics (e.g., transient increases in cooperation in Prisoner’s Dilemmas, oscillations in Snowdrift Games, or shifts in invasion thresholds in Stag-hunt Games), while changes in durability can transform one game into another, by moving invasion thresholds for cooperation or conditions for coexistence with defectors. This enlarged view challenges our understanding of social cheats. For instance, groups of cooperators can do worse than groups of defectors, if they inherit fewer public goods, while a rise in defectors no longer entails a loss of social benefits, at least not in the present moment (as highlighted by concerns over environmental lags). Wherever durable public goods have yet to reach a steady state (for instance due to external perturbations), the history of cooperation will define the ongoing dynamics of cooperators.

Leveraging Hierarchical Population Structure in Discrete Association Studies:

Population structure can confound the identification of correlations in biological data. Such confounding has been recognized in multiple biological disciplines, resulting in a disparate collection of proposed solutions. We examine several methods that correct for confounding on discrete data with hierarchical population structure and identify two distinct confounding processes, which we call coevolution and conditional influence. We describe these processes in terms of generative models and show that these generative models can be used to correct for the confounding effects. Finally, we apply the models to three applications: identification of escape mutations in HIV-1 in response to specific HLA-mediated immune pressure, prediction of coevolving residues in an HIV-1 peptide, and a search for genotypes that are associated with bacterial resistance traits in Arabidopsis thaliana. We show that coevolution is a better description of confounding in some applications and conditional influence is better in others. That is, we show that no single method is best for addressing all forms of confounding. Analysis tools based on these models are available on the internet as both web based applications and downloadable source code at http://atom.research.microsoft.com/bio/phylod.aspx.

Super-Genotype: Global Monoclonality Defies the Odds of Nature:

The ability to respond to natural selection under novel conditions is critical for the establishment and persistence of introduced alien species and their ability to become invasive. Here we correlated neutral and quantitative genetic diversity of the weed Pennisetum setaceum Forsk. Chiov. (Poaceae) with differing global (North American and African) patterns of invasiveness and compared this diversity to native range populations. Numerous molecular markers indicate complete monoclonality within and among all of these areas (FST = 0.0) and is supported by extreme low quantitative trait variance (QST = 0.00065-0.00952). The results support the general-purpose-genotype hypothesis that can tolerate all environmental variation. However, a single global genotype and widespread invasiveness under numerous environmental conditions suggests a super-genotype. The super-genotype described here likely evolved high levels of plasticity in response to fluctuating environmental conditions during the Early to Mid Holocene. During the Late Holocene, when environmental conditions were predominantly constant but extremely inclement, strong selection resulted in only a few surviving genotypes.

Blogrolling for Today

Blooking Central


Clear Thinking


History Hunters International


Crappy Graphs


RRRGroup


Average Earthman


Brad Buchsbaum’s Blog

A naturally occuring mutation of the core clock gene timeless in European Drosophila affects photoperiodic response

Surprise, surprise – a paper in Science is up there with a free online access (not the PDF, but the Full Text and that is something!):
A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster:

Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly because it enhances diapause. We show that the mutant allele attenuates the photosensitivity of the circadian clock and causes decreased dimerization of the mutant TIMELESS protein isoform to CRYPTOCHROME, the circadian photoreceptor. This interaction results in a more stable TIMELESS product. These findings reveal a molecular link between diapause and circadian photoreception.
————snip—————
A reduced L-TIM/CRY interaction may explain the differences in the fly’s circadian photoresponsiveness and the enhanced L-TIM stability. The observation that ls-tim females are more prone to diapause at any day length (1) is also consistent with the results presented here. As in the corresponding diapause profiles (1), the transformants conclusively reveal that the circadian photoresponsive phenotypes of natural tim variants are not due to linkage disequilibrium between tim and a nearby locus, but they are attributable to tim itself. Furthermore, the similarity in behavior of natural s-tim variants and P[S-TIM] transformants suggests that the residual putative truncated N-terminal 19-residue TIM product from the s-tim allele does not play any major role in the phenotypes we have studied (2).
It has been argued that the light sensitivity of the circadian clock needs to be abated in temperate zones because of the dramatic increase in summer day lengths in northern latitudes (18, 19). One mechanism for this process involves a reduced sensitivity to light-induced disturbance by having a higher pacemaker amplitude (18, 19). However, the amplitude of TIM cycling in DD was not significantly different between the two variants (fig. S1), nor were there any significant differences in amplitude or phase of the tim mRNA cycle between the s-tim and ls-tim genotypes (fig. S2). Another way to attenuate circadian photoresponsiveness in temperate zones may be by filtering light input into the clock. The molecular changes to the L-TIM protein may buffer the circadian response to light in ls-tim individuals, even in the presence of S-TIM, and may contribute to the positive Darwinian selection observed for ls-tim in the European seasonal environment (1).

So, here is another nice evidence for the connection between the core circadian clock and the photoperiodic response found in a nice evolutionary and ecological context.

Altruism in rats

There is a new paper on PLoS-Biology describing a tit-for-tat-like reciprocal behavior in rats: Generalized Reciprocity in Rats:

The evolution of cooperation is based on four general mechanisms: mutualism, where an action benefits all partners directly; kin selection, where related individuals are supported; “green beard” altruism that is based on a genetic correlation between altruism genes and respective markers; and reciprocal altruism, where helpful acts are contingent upon the likelihood of getting help in return. The latter mechanism is intriguing because it is prone to exploitation. In theory, reciprocal altruism may evolve by direct, indirect, “strong,” and generalized reciprocity. Apart from direct reciprocity, where individuals base their behavior towards a partner on that partner’s previous behavior towards themselves, and which works under only highly restrictive conditions, no other mechanism for reciprocity has been demonstrated among conspecifics in nonhuman animals. Here, we tested the propensity of wild-type Norway rats to help unknown conspecifics in response to help received from other unknown partners in an instrumental cooperative task. Anonymous receipt of help increased their propensity to help by more than 20%, revealing that nonhuman animals may indeed show generalized reciprocity. This mechanism causes altruistic behavior by previous social experience irrespective of partner identity. Generalized reciprocity is hence much simpler and therefore more likely to be important in nature than other reciprocity mechanisms.

Kate wrote a clear and excellent summary of the study.

Free Access or Open Access?

Buyer beware! Not everything in science publishing that calls itself Open Access actually is so.

My Picks From ScienceDaily

Wood Ant Queen Has No Egg-laying Monopoly:

The reproductive monopoly of the ant queen is not as strong as is often thought. Dr. Heikki Helanterä and Prof. Lotta Sundström, biologists working at the University of Helsinki, Finland, investigated worker ovary development and egg laying in nine Northern European wood ant species of the genus Formica, and revealed wide spread reproductive endeavours by workers.

City Site Was Dinosaur Dining Room:

A dinosaur bone bed in southwest Edmonton that served as a feeding area for the direct ancestor of Tyrannosaurus rex has revealed that two dinosaurs, thought to have lived in different eras, actually lived at the same time. Scientists digging for bones at the site this year discovered fossils of Edmontosaurus and Saurolophus this year.

Translating Form Into Function:

In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they’ve been stumped trying to translate the structure into an understanding of function — what the enzyme actually does in the body. This puzzle has hindered drug discovery, since many of the most successful drugs work by blocking enzyme action. Now, in an expedited article in Nature, researchers show that a solution to the puzzle is finally in sight.

Scientists Find Endangered Grey-shanked Doucs In Vietnam:

A team of scientists from WWF and Conservation International (CI) has discovered the world’s largest known population of grey-shanked doucs (Pygathrix cinerea), increasing chances that the Endangered monkey can be saved from extinction.

ClockQuotes

All architecture is great architecture after sunset; perhaps architecture is really a nocturnal art, like the art of fireworks.
– Gilbert Keith Chesterton

Shakesville is back

Yes, Shakesville is online again, but the new dedicated server (that will repel the future Denials of Service) costs money. You can help it survive with a couple of bucks every now and then.

Invertebrates Rule!

Circus of the Spineless #22 is up on Burning Silo.

SB Survey

The Seed Overlords have put up a survey for our blog readers. You can go here or just click on the green box on the right side-bar and tell them all how you use the site, what you like and dislike, etc., so the improvements can be made in the future.
Do we really need more sly sex on our blogs?

Chronic vs. Acute Sleep Deprivation

In all animals, vertebrate and invertebrate alike, one of the defining features of sleep is the “rebound”, i.e., the making up for sleep debt after an acute sleep deprivation event. However, the problem of modern society is a chronic sleep loss in humans – when you loos a couple of hours of needed sleep every day.
Now, a team at Northwestern studied the effects of chronic sleep loss and, lo and behold – bad news! There is no rebound after chronic sleep deprivation.
Chronically sleep deprived? You can’t make up for lost sleep:

———snip————-
In the study, the researchers kept animals awake for 20 hours per day followed by a four-hour sleep opportunity, over five consecutive days. The team monitored brain wave and muscle activity patterns in order to precisely quantify sleep-wake patterns.
After the first day of sleep loss, animals compensated by increasing their intensity, or depth, of sleep, which is indicative of a homeostatic response. However, on the subsequent days of sleep loss, the animals failed to generate this compensatory response and did not sleep any more deeply or any longer than they did under non-sleep deprived conditions (baseline measurements). At the end of the study, the animals were given three full days to sleep as much as they wanted. Amazingly, they recovered virtually none of the sleep that was lost during the five-day sleep deprivation period.
The findings support what other scientists have discovered in recent experimental studies in humans. Chronic partial sleep loss of even two to three hours per night was found to have detrimental effects on the body, leading to impairments in cognitive performance, as well as cardiovascular, immune and endocrine functions. Sleep-restricted people also reported not feeling sleepy even though their performance on tasks declined.
The Northwestern team s results suggest that animals may undergo a change in their need for sleep, or in their sleep homeostat, in situations where normal sleep time is prohibited or where sleep could be detrimental for survival. An extreme but realistic example of this, says Turek, would be how animals respond to catastrophic environmental conditions, such as Hurricane Katrina. No matter how sleep deprived an animal or human may be, it would not be adaptive for the sleep homeostat to kick in and to make the animal fall sleep when it is in the midst of a flood or forest fire. Therefore, the body undergoes some change that allows it to counter its homeostatic need for sleep and to stay awake to avoid danger.
Turek and his team propose that this change in the sleep regulatory system is reflective of an allostatic response. In the short term, allostatic responses are adaptive, but when sustained on a chronic basis, such as in their study, an allostatic load will develop and lead to negative health outcomes. The allostatic load resulting from the accumulating sleep debt loops back to the sleep regulatory system itself and alters it.
Even though animals and humans may be able to adapt their sleep system to deal with repeated sleep restriction conditions, there could be negative consequences when this pattern is maintained over a long period of time, said Turek. This brings us back to the idea that repeated partial sleep restriction in humans has been linked to metabolic dysfunction and cardiovascular disease.
———snip————-

Brain Blogging of the Week

Encephalon #26 is up on Neurophilosophy.
Wait! What’s that URL?
Yes, MC is our new SciBling!
He is officially moving (i.e., will be featured on the front page) tomorrow, but he is already all set up with some beautiful banners. So, go say Hello and if by some cosmic mistake you have not been reading his blog before, check his archives on the old address.

World 2.0 at Rainbows End

Books: “Rainbows End” by Vernor Vinge.
It’s 2025 – What happened to science, politics and journalism? Well, you know I’d be intrigued. After all, a person whose taste in science fiction I trust (my brother) told me to read this and particularly to read it just before my interview with PLoS. So, of course I did (I know, it’s been two months, I am slow, but I get there in the end).
‘Rainbows End’ is a novel-length expansion of the short story “Fast Times at Fairmont High” which he finished in August 2001 and first published in “The Collected Stories of Vernor Vinge“. The novel was written in 2005 (published in 2006) and the book happens in 2025, so it is a “near-future SF”, always more difficult to write than another episode of Star Trek.
Checking (after I have read the book) the reviews on Amazon.com, I was really taken aback and it made me think about science fiction, what it is and what people expect from it. So, what follows is simultaneously a book review and my own thoughts about the genre.

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EnviroBlogging of the week

Carnival of the Green #84 is up on Bean Sprouts

ClockQuotes

The law, in its majestic equality, forbids the rich as well as the poor to sleep under bridges, to beg in the streets, and to steal bread.
– Anatole France

OceanBlogging of the Fortnight

Carnival of the Blue #2 is up on Blogfish.

Kids and their genes

Gene Genie #10 (the peer-reviewed carnival of bioinformatics and computational biology) is up on Genomicron.
Paediatric Grand Rounds 2:6 are up on Breath Spa for Kids.

Net Neutrality?

I am having difficulty understanding what this is about, who is who, what are the institutional affiliations and potential biases, etc. Can someone explain it to me:
Net Neutrality: Undifferentiated Networks Would Require Significant Extra Capacity:

Using computer models, the researchers compared the current “best-effort” approach with a tiered model that separates information into two simple classes — one for most types of information and another for applications requiring service level assurance for high-bandwidth content like video games, telemedicine, and Voice over Internet Protocol (VoIP).
——-snip———
“Clearly, an undifferentiated network in this context is less efficient and more expensive,” said coauthor K.K. Ramakrishnan of AT&T Labs. “We believe understanding the real impacts of the alternative strategies is important as the debate about network architecture unfolds.”

Value of Class-of-Service (CoS) Support in the Internet Backbone:

The user expectation of Internet use has moved from best-effort connectivity to an expectation of reasonable performance & capacity for all types of applications. QoS-sensitive applications like IPTV, gaming, and VoIP could be offered over such a converged IP broadband end-to-end network. Network service providers also would like to support such applications effectively. They need to provision their networks to meet the service level agreements (SLAs). Customer experiences need to be protected and predictable despite network failures and changes in demand as well as application mix.
Currently there is a wide ranging debate on the issue of “network neutrality” which involves both economic and technical aspects. One key aspect of the net neutrality debate is whether best effort application traffic should be carried along with other (so-called “premium”) traffic for which SLA commitments have been made (or are expected, either explicitly or implicitly) without differentiation. An assertion often made in this context is that over-provisioning is an economically viable strategy due to the declining cost of capacity, instead of incurring the complexity and operational costs of running a differentiated-services network. Our study focuses on this specific question within the larger debate. We compare a classless network which is over-provisioned against an engineered network using per-class queuing to offer Class-of-Service (CoS) (i.e., differentiated-service) and meet user expectations and SLAs. In most situations a differentiated network can save significantly over a classless network.

Trees, Trees, I speak for the Trees!

Festival of the Trees #13 – Putting Down Roots – is up on Wrenaissance Reflections.

ClockQuotes

Every closed eye is not sleeping, and every open eye is not seeing.
– Bill Cosby

All Set

OK, I have scheduled to repost automatically some of the best clock-related posts. They will appear every day at 9am and 5pm from July 5th till August 12th. I hope you like them again….
Tomorrow, I’ll schedule a bunch of ClockQuotes for the next month as well, every day at 4am.

Duck testicles, beef tongues and rabbit stew – here I come!

While in San Francisco, I’d like to eat at Incanto (look around the site for their menu and progressive food and water policies, and they also have a blog). It is at 1550 Church Street, on the southwest corner of Church and Duncan Streets in San Francisco’s Noe Valley. Where is that? Anyone game to go with me?

Blogrolling for Today

The Flying Trilobite


Ljubisa Bojic


1420Mhz


Weird Science


Good Tithings


Curious Expeditions


Dandelion Diva


Cabinet of Wonders


Simplistic Art


Mixotrophy


Offal Good

Why a Populist Cannot Win?

Edwards aside, this is an excellent look at the current political landscape in the USA:
John Edwards and Dominant Media’s Selective Skewering of Populist Hypocrisy by Paul Street:

Sicko

Early reviews of the movie are coming out. Definitely read Ezra Klein’s take on it. And Amanda Marcotte’s. Also Mark Hoofnagle. And why Rob does not want to see it.
Perhaps it is my upbringing, but the fact that one has to pay for medical treatment (and/or pay health insurance) was the second most appallingly surprising thing to me when I arrived in the USA (the sincere religiosity of so many natives was the first). After 16 years here, I still cannot really wrap my mind around it. The notion that anyone but doctors, nurses and patients can have a say in medical treatment, or that anyone should make a profit out of people’s sickness is, to my mind, so atrocious, right up there with the notion of slavery. Both are extreme examples of trampling over most basic human rights.
I will go and see the movie as soon as I can.

Good News about the Bosnian “Pyramid”

It’s been a while since I last blogged about the Bosnian Pyramid (I did follow the story superficially, though, but was sick of trolls attracted to the topic), but I have to break the silence for this piece of good news:

The Culture Ministry found the “research” conducted by Osmanagic’s team to be questionable and the collaborators of Osmanagic to lack the credibility needed to allow for continued funding of their “project.” Also criticized by the Bosnian government, according to Javno, is the methods by which Osmanagic et al presented their findings, particularly the fact that they routinely kept their data from experts in relative fields.
The Bosnian Culture Ministry consulted experts including those in the fields of geology, mining, archaeology, and cultural preservation and arrived at the conclusion that Osmanagic’s foundation was not acting in the best interest of Bosnian cultural preservation and that the foundation is in violation of archaeological regulations. The Ministry even concluded that the nature of Osmanagic’s registration with the Bosnia-Herzegovina Justice Ministry may be suspect and should be “looked into.”

They are shutting Osmanagic down. Whew – that took a long time, but at least the story has (so far) a happy ending. In the end, Reason prevailed.

New on PLoS – Genetics and Computational Biology

Lots of new papers just got published in PLoS-Genetics and PLoS-Computational Biology. Here are a couple of papers that caught my eye:
From Morphology to Neural Information: The Electric Sense of the Skate:

The electric sense appears in a variety of animals, from the shark to the platypus, and it facilitates short-range prey detection where environments limit sight. Typically, hundreds or thousands of sensors work in concert. In skates, rays, and sharks, each electrosensor includes a small, innervated bulb, with a thin, gel-filled canal leading to a surface pore. While experiments have mapped single electrosensor activity, the mechanisms that integrate neural input from multiple electrosensors are still largely unknown. Here, we model the response of a precisely mapped subset of electrosensors responding in concert for a skate moving near stationary prey. Just as two ears help locate sound via time and intensity differences, we ask how a bilateral electrosensor array can contribute to electrical scene analysis. Our results show that the sensor array provides rich data for precise prey location, tuned by the morphology to render certain events, like the point of closest approach, “loud and clear.” This proof of principle makes a significant step in understanding the electric sense processing, and we recommend future experiments to compare and assess functions for the diversity of arrays found in other sharks and rays.

Digital Signal Processing Reveals Circadian Baseline Oscillation in Majority of Mammalian Genes which I have already reviewed.
The Effect of Stochasticity on the Lac Operon: An Evolutionary Perspective:

Gene expression is a process that is inherently stochastic because of the low number of molecules that are involved. In recent years it has become possible to measure the amount of stochasticity in gene expression, which has inspired a debate about the importance of stochasticity in gene expression. Little attention, however, has been paid to stochasticity in gene expression from an evolutionary perspective. We studied the evolutionary consequences of stochastic gene expression in one of the best-known systems of genetic regulation, the lac operon of E. coli, which regulates lactose uptake and metabolism. We used a computational approach, in which we let cells evolve their lac operon promoter function in a fluctuating, spatially explicit, environment. Cells can in this way adapt to the environment, but also change the amount of stochasticity in gene expression. We find that cells evolve their repressed transcription rates to higher values in a stochastic model than in a deterministic model. Higher repressed transcription rates means less stochasticity, and, hence, these cells appear to avoid stochastic gene expression in this particular system. We find that this can be explained by the fact that stochastic gene expression causes a larger delay in lactose uptake, compared with deterministic gene expression.

Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish:

Programs of ontogenetic development and regeneration share many components. Differences in genetic requirements between regeneration and development may identify mechanisms specific to the stem cells that maintain cell populations in postembryonic stages, or identify other regeneration-specific functions. Here, we utilize a forward genetic approach that takes advantage of single cell type ablation and regeneration to isolate mechanisms specific to regeneration of the zebrafish melanocyte. Upon chemical ablation of melanocytes, zebrafish larvae reconstitute their larval pigment pattern from undifferentiated precursors or stem cells. We isolated two zebrafish mutants that develop embryonic melanocytes normally but fail to regenerate their melanocytes upon ablation. This phenotype suggests the regeneration-specific roles of the mutated genes. We further identified the mutations in gfpt1 and skiv2l2 and show their stage-specific roles in melanocyte regeneration. Interestingly, these mutants identify regeneration-specific functions not only in early stages of the regeneration process (skiv2l2), but also in late stages of differentiation of the regenerating melanocyte (gfpt1). We suggest that mechanisms of regeneration identified in this mutant screen may reveal fundamental differences between the mechanisms that establish differentiated cells during embryogenesis and those involved in larval or adult growth.