Mananimals in the news again

Not just in the USA. Visceral queeziness coupled with religious sentiment coupled with scientific ignorance appears in other parts of the world as well, as in the UK

The Scottish Council on Human Bioethics, a professional group based in Edinburgh, has published a report on the ethical implications of the practice in the journal Human Reproduction and Genetic Ethics. The report is online at www.schb.org.uk.

The article lists some examples of research:

Later research has spawned human-animal creations, the report said. These usually die at the embryonic stage, but often survive if the mixtures involve only a few cells or genes transferred from one species to another.
The council cited the following examples:
* In 2003, scientists at Cambridge University, U.K. conducted experiments involving fusing the nucleus of a human cell into frog eggs. The stated aim was to produce rejuvenated master cells that could be grown into replacement tissues for treating disease. It was not clear whether fertilization took place, but some kind of development was initiated, the report said.
* In 2005, U.K. scientists transplanted a human chromosome into mouse embryos. The newly born mice carried copies of the chromosome and were able to pass it on to their own young.
* The company Advanced Cell Technologies was reported, in 1999, to have created the first human embryo clone by inserting a human cell nucleus into a cow s egg stripped of chromosomes. The result was an embryo that developed and divided for 12 days before being destroyed.
* Panayiotis Zavos, the operator of a U.S. fertility laboratory, reported in 2003 that he had created around 200 cow-human hybrid embryos that lived for about two weeks and grew to several hundred cells in size, beyond the stage at which cells showed the first signs of developing into tissues and organs.
* In 2003, Hui Zhen Sheng of Shanghai Second Medical University, China, announced that rabbit-human embryos had been created by fusing human cells with rabbit eggs stripped of their chromosomes. The embryos developed to the approximately 100-cell stage that forms after about four days of development.

All of this sounds like useful basic science to me.

Such procedures mix human and animal biological elements to such an extent that it questions the very concept of being entirely human, the report said. This raises grave and complex ethical difficulties.

So? Learn to deal with it. It won’t apply for a passport any time soon.

Some ethicists worry that the experiments might force society to make confounding decisions on whether, say, a human-chimp mix would have human rights. Other concerns are that such a creature could suffer from being outcast as a monster, from having a chimp as its biological father or mother, or from unusual health problems.

That was a quick leap from clumps of cells with mixed genes or cells to walking, talking human-chimp chimeras which, as far as I can tell, no scientists are considering of ever making, except mad scientists in cartoons.

Some inter-species mixtures are powerful research tools, the report said.
This became clear about a decade ago in a series of dramatic experiments in which small sections of brains from developing quails were taken and transplanted into the developing brains of chickens. The resulting chickens exhibited vocal trills and head bobs unique to quails, proving that the transplanted parts of the brain contained the neural circuitry for quail calls. It also offered astonishing proof that complex behaviours could be transferred across species.

Those were realy cool experiments by Evan Balaban, but have nothing to do with mananimals. Those are not genetic chimaeras. Those are surgically transplanted tissues, like you and I getting a pig heart if needed.

While there is revulsion in some quarters that such creations appear to blur the distinction between animals and humans, it could be argued that they are less human than, and therefore pose fewer ethical problems for research than fully human embryos, the committee wrote.

What? What anthropocentric essentialism! And of course, the image accompanying the article is supposed to make you all squeamish:
humandog.JPG
Why didn’t they put this picture instead?
centaur.jpg

ConvergeSouth 2006

The second ConvergeSouth conference on blogging and journalism will be held on the NC A&T University in Greensboro, NC on Saturday, October 14, 2006. Check out the homepage and blog and register soon. It is going to be even more of an Unconference than last year.
Although it is expected that many in attendance will be from the vibrant local blogging community, it is by no means restricted to the South. Last year, we had people coming in from California, New England and abroad, so if you are interested in the blogging/podcasting world, this is a place to be.
I have blogged about the last year’s ConvergeSouth, both as a whole and specific sessions, which you can check out here, here, here, here, here, here, here, here, here, here and here.
If you have any questions, or want to propose a topic for a session, contact Sue or Ed as they are the people “in the know” there.
Technorati Tag: ConvergeSouth

AIDS at 25

Seed ScienceBlogs are liveblogging the 16th International AIDS Conference in Toronto from August 13th-18th.
Two special correspondents on the ground, and our own Tara Smith of Aetiology will post daily commentary on a blog specially dsigned for this occasion – AIDS at 25.
Quite fittingly, the AskTheScienceBlogger question of the week is also about AIDS, and I am sure that a number of my SciBlings will write about the topic in addition to just answering the question, so you will have plenty of opportunity to be informed and educated about AIDS over the next several days. And, if you have not done this yet, this may be a good time to make Scienceblogs.com one of your Technorati favourites.

My picks from ScienceDaily

Teens Who Do Use Condoms Often Don’t Use Them Properly:

A worrying number of young people who do use condoms don’t use them correctly, so risking unwanted pregnancy or infections, reveals research published ahead of print in the journal Sexually Transmitted Infections. But a good relationship with their mothers seemed to be associated with correct condom use, the research showed.

Paleontologist Discovers South American Mammal Fossils:

Fossils of a new hoofed mammal that resembles a cross between a dog and a hare which once roamed the Andes Mountains in southern Bolivia around 13 million years ago was discovered by Darin A. Croft, assistant professor of anatomy at the Case Western Reserve University School of Medicine and a research associate at the Cleveland Museum of Natural History.

Pressure To Be More Muscular May Lead Men To Unhealthy Behaviors:

New research suggests that men feel pressure to have muscular bodies, and that influence can lead some to symptoms of eating disorders, pressure to use steroids, and an unhealthy preoccupation with weightlifting.
—————–snip—————-
“Instead of seeing a decrease in objectification of women in society, there has just been an increase in the objectification of men. And you can see that in the media today,” she said.

Light Guides Flight Of Migratory Birds:

Songbirds use multiple sources of directional cues to guide their seasonal migrations, including the Sun, star patterns, the earth’s magnetic field, and sky polarized light patterns. To avoid navigational errors as cue availability changes with time of day and weather conditions, these “compass” systems must be calibrated to a common reference. Experiments over the last 30 years have failed to resolve the fundamental question of how migratory birds integrate multiple sources of directional information into a coherent navigational system.
Last autumn, Rachel Muheim, a postdoctoral associate in biology professor John Phillips’ lab at Virginia Tech, captured Savannah sparrows in the Yukon before they headed south. She was able to demonstrate that the birds calibrate their magnetic compass based on polarized light patterns at sunset and sunrise.
———————snip———————–
Polarized light is light that oscillates in one plane relative to the direction of propagation. At sunrise and sunset, there is a band of intense polarized light 90 degrees from the sun that passes directly overhead through the zenith and intersects the horizon 90 degrees to the right and left of the sun. Just as the sun location changes with latitude and the time of year, so does the alignment of the band of polarized light.
Muheim and Phillips argue that migratory songbirds average the sunrise and sunset intersections of the polarization band with the horizon to find the north-south meridian (geographic north-south axis), providing a reference that is independent of time of year and latitude. The birds then use this geographic reference to calibrate their other compass systems.
In other words, polarized light, the Sun and stars, and the geomagnetic field are all directional cues for migration, but polarized light appears to provide the primary reference system used to calibrate the other compass systems, said Phillips.
However, previous research had suggested a much more confusing picture.
Migratory birds are born with an innate magnetic compass preference that coincides with their species’ migratory direction. Previous research suggested that before the migration period, songbirds are able to recalibrate the magnetic compass when exposed to a “conflict” between magnetic and celestial (including polarized light) cues, but during migration it appeared that the reverse was true, — the magnetic field was used as the primary reference for calibrating the birds’ other compass systems. But in a few experiments with birds during migration, the birds did recalibrate the magnetic compass.
When Muheim and Phillips did a literature review, they noticed a difference between the experiments of the few scientists who saw migratory birds recalibrate their compass and of those whose birds failed to recalibrate.
“It is important how you do the experiments. It turns out that the part of the sky that matters is just above the horizon,” said Phillips. “In cue conflict experiments carried out before migration, birds were usually housed in outdoor aviaries in a rotated magnetic field, where they had a view of the whole sky, including the horizon. Once migration starts, however, scientists usually exposed birds in “funnel cages”. This is so, after exposure to the cue conflict, the birds’ directional preferences could be recorded; songbirds in migratory condition leave tracks or scratches on the sides of the funnel as they attempt to take flight in the migratory direction. A problem arises, however, because funnels block the lower 20 degrees of the sky. In the only two experiments (out of 30 or so) carried out during migration where birds were exposed to the cue conflict with a view of the horizon, they did recalibrate their magnetic compass — just as was previously observed only in experiments carried out prior to migration.”
Muheim’s experiments proved that seeing polarized light cues near the horizon was the critical factor. “Once the right hypothesis came along, it all fit,” said Phillips.

History of the University

There are several excellent book reviews in the latest American Scientist. Check them out for reviews of Dennett and Collins books, if nothing else, but the one that caught my eye was the review of Academic Charisma and the Origins of the Research University by William Clark, which I will, just because of this review, put on my Amazon wish list. It is a history of academia and how it got to be organized the way it does today.

Rethinking the Fall of Easter Island

An interesting article in the new issue of the American Scientist, challenges the view, made popular by Jared Diamond in Collapse, among others, of the collapse of Easter Island civilization due to overpopulation and cutting down of trees:

“Easter Island has become a case study of human-induced environmental disaster, or “ecocide.” The popular narrative, most famously recounted in Jared Diamond’s book Collapse, depicts native inhabitants triggering the fall of their once-flourishing civilization by cutting down all of the island’s trees. But recent archaeological and paleoenvironmental research point to a very different story. The island may not have been settled until around 1200 A.D., centuries later than previously thought, and it may have been a large rat population, not the human inhabitants, that caused widespread deforestation. This evidence sheds new light on a story that has long fascinated outsiders.”

Say Hi To The New SciBling

The most recent addition to the stable of Seed ScienceBloggers is Molecule Of The Day – better living through chemistry! Go say Hello!

Kevin In China, part 15 – Beijing

Kevin leaves the countryside for a little vacation in the capital.

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Empire, Empiricism, Empowerment: Contributions to Political Cryptozoology

Empire, Empiricism, Empowerment: Contributions to Political Cryptozoology Before the days of Times Select, David Brooks used to provoke long rants twice a week. This post from October 24, 2004 is one of those.

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The mammoth, the knife flake and the possible alternative to Clovis

The find of a knife flake together with a mammoth dated at 16,000 yo, spurs new speculations about pre-Clovis humans in the Americas. This is the clearest description I ever found of a possible alternative hypothesis to Bering-Clovis.

Wearing blue-blocking eyeglasses a few hours before bedtime resets the internal clocks to an earlier hour.

This is an interesting idea:

A novel way to advance the circadian cycle has been proposed as a way to solve the problem associated with the early starting times of middle and high schools. It has been recognized for some time that teen age students do not really wake up until well past the time they physically arrive at school. Researchers at Brown University have found that the student’s blood contains large amounts of the sleep hormone, melatonin. Researchers at the Lighting Innovations Institute of John Carroll University are seeking funding to carry out a study to find out if their method of advancing the melatonin cycle will help.
It is well known that exposing the eyes to light during the evening delays the start of the flow of melatonin until after the person has gone into the darkness of the bedroom. Because the students like to stay up late working on their computers or watching television, their melatonin cycle is delayed. This means that in the morning, the cycle doesn’t end until well after they are in school.
Five years ago it was discovered that not all light causes suppression of melatonin, only blue light. This means that wearing glasses that block blue light is the same as being in darkness as far as melatonin production is concerned. Putting on blue blocking glasses at 9:00 P.M. will move the circadian cycle forward in time so that the melatonin flow is over before the student gets to school.
The blue blocking glasses have been tested as a means to help people with sleeping problems. Putting on the glasses a few hours before bedtime allows melatonin to be present at the time people go to bed. This avoids the delay in falling asleep experienced by many people. Using the glasses also has been reported to help people sleep more soundly.
As a bonus, having melatonin present for a longer time may also reduce the risk of cancer. Melatonin is known to fight cancer in at least three ways. It is a powerful antioxidant, counteracting the damaging effects of free radicals produced by radiation and chemical pollutants. Melatonin also blunts the cancer-promoting nature of estrogen, and it interferes with the metabolism of materials that cancer cells require as food
Wearing the glasses in the late evening results in getting close to the conditions of light and dark experienced before the invention of artificial lighting. Glasses that block the damaging blue light are available at a web site of a spin-off company formed by the John Carroll researchers, http://www.lowbluelights.com. Filters for TV and computer screens as well as safe light bulbs are also available.
The John Carroll University researchers are seeking funding to test the glasses on high schools students to see if moving their circadian cycle forward in time will result in better academic performance in early morning classes.

Well, they are asking funding for research. The underlying science exists, so this is not total hogwash. And they are upfront about the business opportunities for themselves, selling the glasses already even before they did the research.

Daily rhythm in predator-avoidance in tadpoles

A nice new study on ecological aspects of circadian rhythms:

To a tiny tadpole, life boils down to two basic missions: eat, and avoid being eaten. But there’s a trade-off. The more a tadpole eats, the faster it grows big enough to transform into a frog; yet finding food requires being active, which ups the odds of becoming someone else’s dinner.
Scientists have known that prey adjust their activity levels in response to predation risk, but new research by a University of Michigan graduate student shows that internal factors, such as biorhythms, temper their responses.
Michael Fraker, a doctoral student in the laboratory of ecology and evolutionary biology professor Earl Werner, will present his results Aug. 10 at a meeting of the Ecological Society of America in Memphis, Tenn.
Fraker studied tadpoles of the green frog (Rana clamitans), which normally feed more at night, to see whether their responses to predatory dragonfly larvae differed with time of day.
“Green frog tadpoles, like many other aquatic animals, assess predation risk indirectly by sensing chemicals released by their predators into the water,” Fraker said. Typically, the tadpoles respond to such cues by swimming down to the bottom, seeking shelter and remaining still. In his experiments, Fraker exposed tadpoles in a tank to the chemical signatures of dragonfly larvae for one hour during the day and one hour at night. Then he recorded their swimming and feeding activity during and after exposure. Both during the day and at night, the tadpoles initially responded similarly to the chemical cues, showing the typical plunge in activity. But at night they returned to feeding more quickly than during the day.
“My interpretation of these results is that green frog tadpoles behave more conservatively in response to a predator chemical cue during the day because predation risk may still be fairly high and the tadpoles are going to feed very little anyway. That means the growth rate-to-predation risk ratio is low. At night, the ratio is higher because that’s when the tadpoles do most of their feeding. This favors a quicker return to their pre-cue activity levels.”
Considering biorhythmic activity patterns in predator-prey studies is something of a new slant, Fraker said. “The main implication of my results is that prey behavior can be influenced by both external factors—the chemical cues released by the predators—and internal factors such as circadian rhythms. This is important for understanding the mechanisms of prey behavior, which need to be identified in order to make long-term predictions about the effects of prey behavior in ecological communities.”

The work will be presented at a meeting, thus no paper is available yet. Still, one needs to be careful here – different responses during the day and night may be entirely due to effects of light or darkness without modulation by the circadian clock. Thus, they show a diurnal, not circadian, rhythm in this behavior. A real test would be to repeat the experiment in constant light conditions (e.g., constant dim light or constant dark).

Kevin In China, part 14 – The Lure Of The West: McDonalds and Chinese-dubbed Tom Cruise

Getting back to civilization…means having a Big Mac and realizing that watching MI3 dubbed in Chinese does not mean you miss anything of the brilliant plot and dialogue….

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Global Warming disrupts the timing of flowers and pollinators

As the temperatures rise, different organisms respond differently. Some migrate to higher latitudes or altitudes. Others stay put but change the timing of reproduction and other seasonal activities. As a result, ecosystems get remodeled.
So, for instance, insect pollinators and flowers they pollinate may get out of sync.
Animals tend to use photoperiod as a major clue for seasonal timing, with temperature only modulating the response to some extent.
Plants, on the other hand, although they certainly can use photoperiod, are much more strongly influenced by temperature. Non-biologists who have only heard abot vernalization in the context of discussion of Lysenko may not be aware that this process is not bunk pseudoscience, but a target of active research:

Flowers are the reproductive organs of plants and are responsible for forming seeds and fruit. As their name implies, biennials complete their life cycles in two years, germinating, growing and overwintering the first year. The second year, the plants flower in the spring and die back in the fall.
That biennial strategy, Amasino explains, arose as flowering plants, which first evolved some 100 million years ago during the age of the dinosaurs, spread to fill the niches of nature. Spring blooming confers numerous advantages, not the least of which is leafing out and flowering before the competition.
But how do the plants know when to flower?
“If you carve out that niche, you need to get established in the fall, but you need to make darn sure you don’t flower in the fall,” Amasino says. In the case of biennials, “the plants can somehow measure how much cold they’ve been exposed to, and then they can flower rapidly in the spring niche.”
Exposure to the cold triggers a process in plants known as vernalization, where the meristem – a region on the growing point of a plant where rapidly dividing cells differentiate into shoots, roots and flowers – is rendered competent to flower.
In a series of studies of Arabidopsis, a small mustard plant commonly used to study plant genetics, Amasino and his colleagues have found there are certain critical genes that repress flowering.
“The plants we’ve studied, primarily Arabidopsis, don’t flower in the fall season because they possess a gene that blocks flowering,” Amasino explains. “The meristem is where the repressor (gene) is expressed and is where it is shut off.”
The key to initiating flowering, according to the Wisconsin group’s studies, is the ability of plants to switch those flower-blocking genes off, so that they can bloom and complete their pre-ordained life cycles.
But how that gene was turned off was a mystery until Amasino and his group found that exposure to prolonged cold triggered a molecular process that effectively silenced the genes that repress flowering.

So, if the plants respond to temperature by changing the timing of flowering and insect retain the same timing (although they mave migrate away), there will be no flowers around when the insects are looking for them, and no insects buzzing around when the flowers need to be pollinated.
This recently got some experimental support:

“Climate change is already affecting ecological systems and will continue to do so over the coming years, providing a particularly relevant topic for this session,” said Inouye.
For instance, Earthwatch volunteers in the Rocky Mountains helped Inouye document that global warming affects lower altitudes differently than higher ones. As a result, animals exposed to earlier warm weather may exit hibernation earlier and birds responding to earlier spring weather in their wintering grounds may flock north while there are several feet of snow on the ground, risking starvation.
“Already the difference in timing between seasonal events at low and high altitudes has negatively influenced migratory pollinators, such as hummingbirds, which overwinter at lower altitudes and latitudes,” said Inouye. “If climate change disturbs the timing between flowering and pollinators that overwinter in place, such as butterflies, bumblebees, flies, and even mosquitoes, the intimate relationships between plants and pollinators that have co-evolved over the past thousands of years will be irrevocably altered.”

On Horowitz

Apart From Being An Idiot, Horowitz Is Also An Unwiped Anal Orifice With Hemorrhoids This – “Apart From Being An Idiot, Horowitz Is Also An Unwiped Anal Orifice With Hemorrhoids” – is the worst and nastiest blog-post title I ever used. But I was furious. See why…. (first posted here on March 05, 2005, then republished here on December 10, 2005):

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Zebrafish Rules!

I hope PZ will comment on this study:

A humble aquarium fish may be the key to finding therapies capable of preventing the structural birth defects that account for one out of three infant deaths in the United States today.That is one of the implications of a new study published online August 8 in the journal Cell Metabolism. The paper describes a number of striking parallels between a rare but fatal human birth defect called Menkes disease and a lethal mutation in a small tropical fish called the zebrafish that has become an important animal model for studying early development.
————snip—————
In the paper, the researchers describe the discovery of a mutation in the zebrafish that disrupts the distribution of the critical nutrient copper within the fish cells and causes defects that are remarkably similar to those observed in children suffering from Menkes kinky hair disease, which, in its most severe form, causes degeneration and death within two to three years after birth.
“We found this mutation about two and a half years ago,” said Solnica-Krezel. “Because it impairs so many aspects of normal development and causes the embryo to fall apart in two days, we named it ‘Calamity.'” Six months later, she heard a talk that Gitlin gave at a scientific meeting about the results of exposing zebrafish embryos to a chemical agent that disrupts copper metabolism. She was struck by the similarity between his results and those produced by Calamity, so she approached him and they decided to collaborate.

Across the fruited plain

This is interesting:
Landscapes And Human Behavior:

On Arizona State University’s (ASU) Polytechnic campus, graduate student families in the cluster of six houses abutting lush lawns and ornamental bushes spend time together talking while their kids play outside. Meanwhile, the families in a nearby cluster of six homes barely know each other. But that may be in part because their homes sit on native Sonoran desert, not nearly as conducive to recreation as the lush microclimate researchers created in the first neighborhood. Social scientists and biophysical ecologists are finding that environmental surroundings may play a significant role in human social interaction, serving either as a social lubricant as in the first case, or as a barrier.
—————–snip———————
“Experimental approaches are rarely used in studies of human-environment interactions,’ says Casagrande. “By combining research approaches from both the social and biophysical sciences, we can gain new insights into how peoples’ surroundings affect them.”
The study will run until at least 2010, but the results thus far suggest that even those individuals who grew up in the arid environment of Arizona prefer a more lush landscape conducive to recreation and social networking. In addition to the social interactions resulting from the different landscape designs, the researchers are also looking into residents’ level of ecological knowledge, overall environmental values, and perceptions of landscapes. Yabiku and Casagrande hypothesize that residents’ knowledge of flora and fauna will increase more in the mesic than in the native desert cluster.

So, they built several different ‘landscapes’. I’d like to see also some mountains and seashore as well. Any thoughts?

Coturnix on Sex, part II – The Hooters Conundrum

My second guest-blogging post on Echidne Of The Snakes, about the potential to have Hooters fund some breast cancer research. Purposefully written to provoke. Cross-posted under the fold…

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Coturnix on Sex, part I – Blogging in the nude

My first post guest-blogging on Echidne Of The Snakes, cross-posted under the fold.

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Say Hi To Archy

In less than two weeks, Archy (the person – John McKay, not the blog, nor the cockroach) is going to have a biiiiiig birthday party.
He is not asking for presents – he only wants you to come to his place for the party and help him reach a goal.
And while you are there, you are supposed to look around and read – there is a lot of good stuff there!

Nursing and Teaching

Change of Shift, Volume One, Number Four is up on It’s A Nursing Thing
Carnival of Education #79 is up on California LiveWire

Are you a graduate student and a blogger?

If yes, than Carnival of GRADual Progress is for you.

Lamont-Lieberman pick-o-links

Publius
Lance
my wife
Mike Dunford
Ezra, Ezra, Ezra, Ezra
Nicholas Beaudrot , Nicholas Beaudrot
Mike
John
Ed
Jim
Vintage
Mbair
BlueinMo
ChrisinDet
Shar
MGC
Shakespeare’s Sister
Echidne
Lindsay, Lindsay, Lindsay
Pam, Pam
Ed Cone, Ed Cone
Josh
Drum, Drum

Camera

This is what we got yesterday:
agfapd16plenax01.jpg
PD-16 Plenax
Agfa Ansco Corporation, Binghamton, NY.
1930’s
Lens: Hypar Anistigmat f6.3 103mm
T B 25 50 100
616 film
2 1/4 x 4 1/4 in.
One of those was sold on e-bay relatively recently for $85. Is there any possibility that one can find a stash of the old film used in this camera so I can give it try?

I’m Gone Country

Every now and then, especially when the Right Wing comes up with another one of thos silly lists of supposedly conservative rock songs, a lot of people take a look at pop and rock (and hip-hop) songs and do some sociological analysis on them, trying to glean the way society is changing by the way song lyrics have changed.
That is fine, but I think that one needs to focus on the lyrics of country songs instead. Especially if one want to unserstand the mindset of rural/exurban/Southern voter, which seems to be a mystique to some coastal big-city liberals.
I have done that before and occasionaly, others did as well. But Publius made a really, really interesting analysis the other day – THE DIXIE CHICKS – The Most Subversive Band in America .
Do you agree with him?
I have loved the Chicks from the beginning of their stardom, and bought their new CD in advance. It is not ‘Home’, but it is very good.
I thought the closest they were coming to my neck of the woods this Fall is Greensboro, which is but an 1.5 hours away, but it appears they are not (was that on the list, but scratched?). Does anyone have any info if they are coming down to North Carolina any time soon?

My picks from the ScienceDaily

Dominant Meerkats Render Rivals Infertile:

When pregnant, dominant female meerkats subject their subordinates to escalating aggression and temporary eviction causing them to become overly stressed and as a result infertile, a new study finds.

Does Environment Influence Genes? Researcher Gives Hard Thoughts On Soft Inheritance:

Organisms, including humans, all inherit DNA from generation to generation, what biologists call hard inheritance, because the nucleotide sequence of DNA is constant and only changes by rare random mutation as it is passed down the generations.
But there also is evidence, especially in plants, that non-genetic factors modifying the DNA can also be inherited. The modifications of the genetic material take the form of small chemical additions to one of the DNA bases and the alternative packaging of the DNA. These so-called epigenetic modifications are known to be important for turning genes on and off during the course of an organism’s life, but their importance in controlling inheritance has been debated. Many biologists are skeptical of any form of soft inheritance, where the genetic material is not constant, believing that it is only genetic information – DNA — that can be passed onto generations.
———————-snip————————–
“To get to the issue of the more extreme variations of soft inheritance, it has to be determined whether the environment can induce an epigenetic change in an organism that can be inherited in subsequent generations. Certainly, nobody has shown that an epigenetically induced beneficial or adaptive change has been inherited. Mechanistically, there is no reason to discount epigenetic inheritance. The biochemical nuts and bolts are there to support it. The big questions to resolve are how many epigenetic changes are induced by the environment, what types of phenotypes result from these changes, and how many of these epigenetic changes are inherited.”

Kids Need More Time Than Adults Give Them, Study Finds:

Further proof that children require more time comes via a study to be published today in Developmental Science asserting that the fast pace expected by adults–both parents and educators–can be beyond chindren’s perceptual abilities.
——————–snip——————————
“We expect children to be adult-like, because of their proficiency on computers or because they display adult-like speech,” he says, “so we give them instructions and get impatient when they can’t understand what we tell them the first time. Children learn through repetition, at a pace suitable to the child, not to the curriculum. Once upon a time, kids controlled their own pace; now that pace is controlled by adults.”

Scientists Learn How The Brain ‘Boots Up’ To Process Information From The Senses:

The same chemical in the body that is targeted by the drug Viagra® also helps our brains “boot up” in the morning so we can process sights, sound, touch and other sensory information. The discovery could lead to a better understanding of major brain disorders, according to researchers from Wake Forest University School of Medicine.
—————————snip—————————
“We expected to find that signals from the eye would be boosted by nitric oxide,” said Godwin. “Instead, we found that nitric oxide reduced signals from the eyes, and enhanced the feedback from the cortex. The tiny molecule appears to allow the cortex to exert more control on how much information it receives from the thalamus.”

Infants, As Early As Six Months, Do See Errors In Arithmetic:

Using advanced brain sensor technology developed at the University of Oregon, researchers have confirmed often-debated findings from 1992 that showed infants as young as six months know when an arithmetic solution is wrong.

Imaging Study May Help Point Toward More Effective Smoking Cessation Treatments:

Results of a new imaging study, supported in part by the National Institute on Drug Abuse (NIDA), National Institutes of Health, show that the nicotine received in just a few puffs of a cigarette can exert a force powerful enough to drive an individual to continue smoking. Researchers found that the amount of nicotine contained in just one puff of a cigarette can occupy about 30 percent of the brain’s most common type of nicotine receptors, while three puffs of a cigarette can occupy about 70 percent of these receptors. When nearly all of the receptors are occupied (as a result of smoking at least 2 and one-half cigarettes), the smoker becomes satiated, or satisfied, for a time. Soon, however, this level of satiation wears off, driving the smoker to continue smoking throughout the day to satisfy cigarette cravings.

Happy Birthday Avogadro – the Numbers Quotes

From today’s Quotes Of The Day:

As something of a student of history, I need to remember a number of numbers. Few of them remain easily in mind, although I normally can remember 1066, 1492, and 1776. It happens that on this day in 1776, Lorenzo Romano Amedeo Carlo Avogadro was born at Turin, Italy. Amedeo got his law degree at the age of sixteen, and did well, but ten years later began to study science. He made a number of breakthroughs regarding the nature of atoms and molecules, he was the first to realize that oxygen and hydrogen generally occur as molecules of two atoms. When it was possible to actually number the atoms or molecules in one mole (an amount of material, the mass of which in grams is equal to the molecular weight), that number was named Avagadro’s Number. For some reason I have remembered that from ninth grade: 6.022 times ten to the 23rd power. I’ve never actually had a reason to know or use it, but I’ve remembered it.
Beyond a critical point within a finite space, freedom diminishes as numbers increase…. The human question is not how many can possibly survive within the system, but what kind of existence is possible for those who do survive.
– Frank Herbert, 1920 – 1986
Seek not the favor of the multitude; it is seldom got by honest and lawful means. But seek the testimony of the few; and number not voices, but weigh them.
– Immanuel Kant, 1724 – 1804
The rule on staying alive as a forcaster is to give ’em a number or give ’em a date, but never give ’em both at once.
– Jane Bryant Quinn
Every sorrow suggests a thousand songs, and every song recalls a thousand sorrows, and so they are infinite in number, and all the same.
– Marilynne Robinson
One measure of friendship consists not in the number of things friends can discuss, but in the number of things they need no longer mention.
– Clifton Fadiman, 1904 – 1999
Well, if I called the wrong number, then why did you pick up the phone?
– James Grover Thurber

Kevin In China, part 13 – Back To Herping

After getting over his sickness, Kevin moves on with his research…

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What Are Gonads For (Among Else)?

What Are Gonads For (Among Else)?
This post from January 21, 2005, is about insects, parasitoids and the mental approach to science:

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Lamont

Lindsay is liveblogging from the Lamont HQ. My wife, who is not interested in nitty-gritty details of everyday politics and has no idea where Lieberman stands on any issue and has not heard a single word spoken by Liebermann, said that Joe’s loss is totally unsurprising to her. She said that Joe lost today’s race two years ago when the whole nation saw how weak he is – ‘weak’ in every sense of the term, as a person, as a politician, everything. Whoever remembers the pitiful scenes of Joementum from the 2004 primaries, even if completely uninterested in politics since then, cannot possibly vote for him, she said.

Yes, there is a clock in the adrenal gland, so what?

A couple of months ago I wrote about a study in primates, suggesting that there is a circadian clock in the adrenal gland. This was hyped like a big break-through, but, while that was a good and useful study, it did not show anything surprising, e.g., that the adrenal is a pacemaker, only that it is a peripheral clock, which was known for decades, before the whole paradigm of perihperal clocks matured within the field.
Now, there is a new study, this time in mice, on the same question: How the adrenal ‘clock’ keeps the body in synch.
Again, it is touted as something that will fundamentaly change the field:

The circadian network now revealed for the adrenal gland might serve as a “paradigm for the organization of other physiological rhythms,” the researchers said. The findings might also require scientists to do some rethinking, Oster added. Previous studies using organ cultures found that clock gene rhythms can persist for weeks in the absence of external timing signals, leading to the suggestion that peripheral clocks to a large extent operate independently. In marked contrast, the loss of corticosterone rhythm in clock mutant animals with normal adrenals after 2 days in constant darkness indicates a critical dependence of the adrenal on input from the master clock, Oster said.

The study is good, but there is nothing really new and earth-shattering.
We knew there was a peripheral clock in the adrenal.
We knew that peripheral clocks are autonomous in a dish.
We knew that peripheral clocks get entrained/synchronized by neural and/or hormonal inputs from the central pacemaker (e.g., the SCN in mammals).
We knew that peripheral clocks feed back onto the pacamaker.
We knew that every clock has its own rhythm of sensitivity to its entraining agents (e.g., light, food, hormones, neurotransmitters) – that is why we make Phase-Response Curves.
So, we knew that each clock “gates” its own responses to synchronizers – that is the reigning paradigm in the field, not something new that will have to come out of this particular study.

The Five-Day Plan

Do you remember the old Five-Year Plans (‘Petoletka’) in the communist countries? Well, five years is far too long for the ADHD world of the 21st century, not to mention the hyperspeed of the Internet and the Blogosphere. So, I decided to try organizing my blogging in Five-Day Plans. What do you think of that?
First, next five days (Wednesday to Sunday), it will (almost) all politics all the time. The occasion? Guest-blogging on Echidne Of The Snakes. Yes, the Goddess herself has touched me with her bifurkated tongue! After a stint guest-blogging on Eschaton, Echidne is going on a well-deserved vacation for a week and she has lined up a very good list of guest-bloggers, including Blue Lilly, Pseudo-Adrienne, Skylanda, Hybrid and olvlzl.
So, although I have signed up for Thursday, Saturday and Sunday mornings, I may, if inspired, write a few more posts at different days/times. Every post will be cross-posted here, but I urge you to go check out Echidne’s great commenters (and get me out of trouble if I screw up) on each post!
After that, The Second Five-Day Plan (Monday through Friday) will be (almost) all clocks all the time. I will re-post almost all of the remaining Clock Tutorials from Circadiana, plus a few posts pertaining to vertebrates, then write a few more, detailing my research – at least the stuff that is already published, so you’ll know better what I did.
Of course, if something exciting happens in science, politics or whatever, I will make excursions (deviate from the plan! – don’t tell the comissar!), but for the most part I will stick to the plan. After that, I will welcome your feedback – do you like single-focus five-day plans? Did it work for me? I’l ask you again in ten days.

Pictures from Northern Israel, part III

Haifa, more recent

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Pictures from Northern Israel, part II

Under the fold…

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Pictures from Northern Israel, part I

I refuse to write blog posts about the Middle East for a variety of reasons. No matter what I say, there will be a flame war in the comments – if you think that flame-wars in comments are bad when dealing with creationists, animal rightists or Wingnuts, just try tackling Israel! I’ll be acused of being a self-hating Jew and anti-semite and Zionist and anti-Zionist, perhaps simultaneously all of those by the same person in a single sentence.
I do not know enough history of the region and the conflict.
I do not know the specialized terminology – a minefield of seemingly normal English language that is actually full of “code-words” that do not mean what one might think they mean.
If I am biased, it may be because I have heard more Israeli propaganda than the other side.
If I am biased, it is because I have lots of family in Haifa and a kibbutz on Lebanese border and I am nervous every day untiul I get their “We are alive” e-mail.
Some of those relatives may be reading my blog. As it is a huge family, individual members are all over the political spectrum and at least some will not agree with whatever I say.
Not to mention that criticizing actions of the Israeli government does not mean criticizing Israeli people, many of whom criticize their own government a lot, just like many Americans criticize Bush administration and would not like to be equaled with “America”. Those nuances get lost.
One of the relatives from Haifa sent me three PowerPoint slideshows showing some of the damage incurred by Haifa and northern towns. As a blogger, I feel like I should make such documents available. If I had friends in Beirut and they sent me pictures, I’d post them as well, but all my Lebanese friends are here in the States. And, the pictures are excellent and not available on CNN….
So, under the fold is the first of the three slideshows. The other two are in the next two posts. You can use the slider on the right margin or the arrow in the right-top corner to go through the slideshow. E-mail me if you want full size.
Comments closed – this is not a blog-post designed to foster conversation, I treat it as a website where I posted some documents. Israel-related comments posted on other posts will be deleted as irrelevant to the topics of those posts.

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My picks from ScienceDaily

Researcher Studies Sleep Deprivation’s Effect On Decisions:

Everyone needs sleep, but temporary periods with no sleep can be a reality of military operations. To get answers on sleep questions for the military as well as civilians, for nearly four years Dr. Sean Drummond, a Department of Defense-funded researcher, has studied the effects of sleep deprivation on the brain, namely in decision making, as well as how long it takes to recover from periods of no sleep.

Early Exposure To Synthetic Estrogen Puts ‘DES Daughters’ At Higher Risk For Breast Cancer:

So-called “DES daughters,” born to mothers who used the anti-miscarriage drug diethylstilbestrol during pregnancy, are at a substantially greater risk of developing breast cancer compared to women who were not exposed to the drug in utero.

Scientists Solve Sour Taste Proteins:

A team led by Duke University Medical Center researchers has discovered two proteins in the taste buds on the surface of the tongue that are responsible for detecting sour tastes.

Scientists Reverse Evolution: Ancient Gene Reconstructed From Descendants:

University of Utah scientists have shown how evolution works by reversing the process, reconstructing a 530-million-year-old gene by combining key portions of two modern mouse genes that descended from the archaic gene.

I am not sure if “reversing evolution” is the correct term to be applied here, except in making an eye-catching title for this article…
Update: PZ Myers explains the study in detail (and agrees that this is not “evolution in reverse”).
Researchers Find New Learning Strategy:

Central to being human is the ability to adapt: We learn from our mistakes. Previous theories of learning have assumed that the size of learning naturally scales with the size of the mistake. But now biomedical engineers at Washington University in St. Louis have shown that people can use alternative strategies: Learning does not necessarily scale proportionally with error.

Nicotine Found To Protect Against Parkinson’s-like Brain Damage:

New research suggests that nicotine treatment protects against the same type of brain damage that occurs in Parkinson’s disease. The research was conducted in laboratory animals treated with MPTP, an agent that produces a gradual loss of brain function characteristic of Parkinson’s. Experimental animals receiving chronic administration of nicotine over a period of six months had 25 percent less damage from the MPTP treatment than those not receiving nicotine.

Dunno….did smoking help my Dad live a little longer?
http://www.sciencedaily.com/releases/2006/08/060807154944.htm:

No matter how you slice it, the freshwater planarian possesses an amazing ability to regenerate lost body parts. Chop one into pieces, and each piece can grow into a complete planarian. The flatworm relies upon a population of stem cells to accomplish this remarkable feat; recent work sheds light on how planarians maintain these stem cells throughout their lives.

Brain Stimulation That May Boost Vision From The Corner Of Your Eye:

By using simultaneous brain stimulation and activity recording to track the influence of one brain region on another, researchers have developed a new method for boosting brain function that may have implications for treatments of brain disorders and for improving vision. The findings are reported by Christian Ruff, Jon Driver, and their colleagues at University College London and appear in the August 8th issue of Current Biology, published by Cell Press.

Ancient Bison Teeth Provide Window On Past Great Plains Climate, Vegetation:

A University of Washington researcher has devised a way to use the fossil teeth of ancient bison as a tool to reconstruct historic climate and vegetation changes in America’s breadbasket, the Great Plains.

The Shape Of Life: Research Sheds Light On How Cells Take Shape:

How life takes shape is a mystery. Butterfly or baby, cells organize themselves into tissues, tissues form organs, organs become organisms. Over and over, patterns emerge in all living creatures. Spiders get eight legs. Leopards get spots. Every nautilus is encased in an elegant spiral shell.
This phenomenon of pattern formation is critical in developmental biology. But the forces that govern it are far from clear. Alan Turing, father of modern computer science, suggested that the basis for pattern formation was chemical. New research conducted at Brown University and published in the Proceedings of the National Academy of Sciences supplies another surprising answer: Physical, as well as chemical, forces can dictate pattern formation.

Surprising? Since when? D’Arcy Thomspon?

Clockwise or counter-clockwise?

Gray Birds Cover 40,000 Miles Annually:

“Sooty shearwaters may not look like much, but when it comes to travel they put marathoners, cyclists and pretty much everyone else to shame.
These gray, 16-inch birds cover 40,000 miles annually in search of food, the longest migration ever recorded electronically, according to a report in this week’s online edition of Proceedings of the National Academy of Sciences.”

How does that compare to Arctic Terns and their pole-to-pole migration? Or the east-west migration of some ptarmigans from Scandinavia to Kamtchatka and back?

“The birds, which can have a wingspan of 43 inches, followed a figure-eight circuit over the Pacific Ocean. They ranged north to the Bering Sea, south to Antarctica, east to Chile, and west to Japan and New Zealand, covering over 40,000 miles in 200 days, the researchers said.”

Figure of eight? That is an unusual pattern. Is it really a migration in a traditional sense (between summer/breeding and overwintering grounds), or is it more like nomadic flying around in a predictable trajectory?

Recommended reading

Today’s New York Times has a good article about jet-lag: The Science of Zzzzz’s. I am glad to hear that JetBlue is using scientific advice in helping their pilots be fresh and alert, especially now that JetBlue has started flying from RDU.

New studies on Depression

New Depression Findings Could Alter Treatments.
Kids on antidepressants more likely to commit suicide? I have heard about this several times before, but I believe this is a first study directly asking this question:

“The researchers found no link between the antidepressant drugs and suicidal behavior in depressed patients 19 or older. But children and adolescents in the study who were taking antidepressants were about 50 percent more likely than those not on the drugs to try to kill themselves. And they were about 15 times as likely as those not on the medications to complete the act, although the number of suicides was too small to draw definitive conclusions, the authors cautioned.”

Also, a single shot of Ketamine lifts depression for a week in patients for whom no other treatment is effective. Kevin explains how. (snarl) So, in the good old days when IACUC still let me anesthetise my quail with a rompun/ketamine mix, my animals were surely not depressed for a week after surgery. Good to know, even if it is in retrospect (/snark)

Wild, Wild Rounds

Grand Rounds Vol.2, No.46 is up on Mexico Medical Student.
The Wild, Wild West edition of the Carnival of Homeschooling (#32) is up on Spittibee.

Kevin In China, part 12 – Chinese Ebola, or, Getting the Taste of Chinese Medicine

I was wondering why it took Kevin so long to send in another report. Well, he was sick…

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Where Did My Son Get His Smarts?

Where Did My Son Get His Smarts? Do you want to know more about my kids and how we are raising them? If so, this post from March 21, 2005 may be interesting to you.

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The XKCD Day

Today appears to be the day when all ScienceBloggers link to XKCD comics. As a clock person around here, I had to find one that deals with biological oscillations and I quickly found one with Fourier transforms…under the fold:

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Science blogs, rested and refreshed

The Archaean Zone (formerly known as Wolverine Tom), Sporulaand Complex Medium are back in action after longish hiatus.

The changes in the business of science

In the comments to this recent post, Pedro Beltao points out his recent post – Opening up the scientific process – which I would suggest you read.
First reaction will probably be – ah, how idealistic! But it will make you think, I believe. Many elements are already happening, e.g., open-source journals, open comments on online journal articles, as well as blogs and wikis that report research in real time, e.g., Useful Chem Experiments, RRResearch and UsefulChem Wiki.
The world of academic science is slow-moving and resistant to change, but it is already changing nonetheless. And, as each element of Pedro’s model slowly changes, the system as a whole is bound to change, perhaps beyond recognition. If publishing is a public business, the way authority is gained in the field will change. Instead of counting a number of Science/Nature papers, serach committees will be able to take a much deeper look at any individiual’s work and thought. While science will remain intensely competitive, the field where competition occurs will move away from big journals, citation indices and into the public sphere online. Then, teh business of science will stop being “production of manuscrupts” and become, yet again in history, “production of knowledge”.
So, while it will take time, effort and adjusting (and fixing the unforseeable side-effects), and perhaps a change of generation (or two), I do not this that something like this or this or what Pedro is describing is unrealistic.

What a minefield of correlations not being causations!

Sexual Lyrics Prompt Teens to Have Sex:

Teens whose iPods are full of music with raunchy, sexual lyrics start having sex sooner than those who prefer other songs, a study found.
Whether it’s hip-hop, rap, pop or rock, much of popular music aimed at teens contains sexual overtones. Its influence on their behavior appears to depend on how the sex is portrayed, researchers found.

The article does point out skepticism by a couple of other researchers, but the title and the lede suggest that they’d prefer the readers to ignore the skepticism.

Clock Genetics – A Short History

Clock Genetics - A Short HistoryA short post from April 17, 2005 that is a good starting reference for more detailed posts covering recent research in clock genetics (click on spider-clock icon to see the original).

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Bird Magic

My wife and kids went to the beach last week. When they returned they gave me a present. Frankly, I wasn’t expecting a present at all, so I found it funny that they felt apprehensive that I woud not like the present as it was cheap. Then I opened it, and it was….

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Uses Of Blogs

Tim Lambert alerts us that a new book about blogging, Uses Of Blogs, edited by Axel Bruns and Joanne Jacobs, is now out.
Joanne Jacobs, John Quiggin, Mark Bahnisch, Jean Burgess and Melissa Gregg are some of the contributors to the book, looking at various uses of blogs, from personal to political, with quite a heavy emphasis on what I am interested in – the uses in academia and teaching. Unfortunately, there is no chapter about uses of blogs by scientists and/or in science, be it reasearch or teaching or popularization of science.
You can get the more complete information, including the Table of Contents on Axel Burns’ blog, and you can read the Introduction for free (PDF).
I blog about blogging quite often, both about science blogging and political blogging, including specifically about various Uses Of Blogs for scientists.
Unfortunately, I cannot currently afford the book, but I have placed it on my wish list for later purchase. I hope I can get it before the Fall science blogging seminar where I am supposed to persuade local scientists that blogging is good for their health, just like spinach, and I want to give them examples of various uses of blogs in teaching, research, networking, popularization of science, dispelling the myths, critiquing science reporting in the media, fighting against superstition and religious/political attacks on science, documenting nature, online activism (e.g., environmental) and medical information.

Godless Brains

The Synapse vol.1, no.4, is up on Neurotopia.
Carnival of the Godless #46 is up on Love @nd Rage