Clock Quotes

Cats are smarter than dogs. You can’t get eight cats to pull a sled through snow.
– Jeff Valdez

Happy 100th birthday, Rita Levi Montalcini

Italian scientist, turning 100, still works:

Rita Levi Montalcini, a Nobel Prize-winning scientist, said Saturday that even though she is about to turn 100, her mind is sharper than it was she when she was 20.
Levi Montalcini, who also serves as a senator for life in Italy, celebrates her 100th birthday on Wednesday, and she spoke at a ceremony held in her honor by the European Brain Research Institute.
She shared the 1986 Nobel Prize for Medicine with American Stanley Cohen for discovering mechanisms that regulate the growth of cells and organs.
“At 100, I have a mind that is superior — thanks to experience — than when I was 20,” she told the party, complete with a large cake for her.
The Turin-born Levi Montalcini recounted how the anti-Jewish laws of the 1930s under Benito Mussolini’s Fascist regime forced her to quit university and do research in an improvised laboratory in her bedroom at home.
“Above all, don’t fear difficult moments,” she said. “The best comes from them.”
“I should thank Mussolini for having declared me to be of an inferior race. This led me to the joy of working, not any more unfortunately, in university institutes but in a bedroom,” the scientist said.
Her white hair elegantly coifed and wearing a smart navy blue suit, she raised a glass of sparkling wine in a toast to her long life.

Brilliant! For more details about her and the research she did, read this from Nature.

Happily Ever After

When reading fairy tales as a kid, I always wondered at the end how that ‘happily ever after’ looked like. I never imagined it, in my childhood innocence, that it would be like this:
snowwhite.jpg

Aneesh Paul Chopra will be the first ever CTO of the USA

Today (yes, I know, it was leaked last night), President Obama announced that the first nations’ Chief Technology Officer will be Aneesh Paul Chopra.
The Silicon Valley folks are not pleased. Tim O’Reilly thinks he is an excellent choice. What do you think?

Saving Newspapers: The Musical (funny video)

My picks from ScienceDaily

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Clock Quotes

A man has no more character than he can command in a time of crisis.
– Ralph W. Sockman

The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
Here are the submissions for OpenLab 2009 to date. As we have surpassed 100 entries, all of them, as well as the “submit” buttons and codes, are under the fold. You can buy the 2006, 2007 and 2008 editions at Lulu.com. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):

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Semantic Enhancements of a Research Article

In today’s PLoS Computational Biology: Adventures in Semantic Publishing: Exemplar Semantic Enhancements of a Research Article:

Scientific innovation depends on finding, integrating, and re-using the products of previous research. Here we explore how recent developments in Web technology, particularly those related to the publication of data and metadata, might assist that process by providing semantic enhancements to journal articles within the mainstream process of scholarly journal publishing. We exemplify this by describing semantic enhancements we have made to a recent biomedical research article taken from PLoS Neglected Tropical Diseases, providing enrichment to its content and increased access to datasets within it. These semantic enhancements include provision of live DOIs and hyperlinks; semantic markup of textual terms, with links to relevant third-party information resources; interactive figures; a re-orderable reference list; a document summary containing a study summary, a tag cloud, and a citation analysis; and two novel types of semantic enrichment: the first, a Supporting Claims Tooltip to permit “Citations in Context”, and the second, Tag Trees that bring together semantically related terms. In addition, we have published downloadable spreadsheets containing data from within tables and figures, have enriched these with provenance information, and have demonstrated various types of data fusion (mashups) with results from other research articles and with Google Maps. We have also published machine-readable RDF metadata both about the article and about the references it cites, for which we developed a Citation Typing Ontology, CiTO (http://purl.org/net/cito/). The enhanced article, which is available at http://dx.doi.org/10.1371/journal.pntd.0​000228.x001 , presents a compelling existence proof of the possibilities of semantic publication. We hope the showcase of examples and ideas it contains, described in this paper, will excite the imaginations of researchers and publishers, stimulating them to explore the possibilities of semantic publishing for their own research articles, and thereby break down present barriers to the discovery and re-use of information within traditional modes of scholarly communication.

Related: Creative Re-Use Demonstrates Power of Semantic Enhancement:

A Review article published today in PLoS Computational Biology describes the process of semantically enhancing a research article to enrich content, providing a striking example of how open-access content can be re-used and how scientific articles might take much greater advantage of the online medium in future.
Dr. David Shotton and his team from Oxford University spent about ten weeks enriching the content of an article published in PLoS Neglected Tropical Diseases, the results of which can be seen online here.
The enhanced version includes features like highlighted tagging which you can turn on or off (tagged terms include disease names, organisms, places, people, taxa), citations which include a pop-up containing the relevant quotation from the cited article, document and study summaries, tag clouds and citation analysis…

Statistical myths debunked: ‘Everything is Dangerous’

Stan Young of the National Institute of Statistical Sciences in RTP wants to help you sort junk science from the good stuff. (Remember that observational study that concluded that pregnant women who eat breakfast cereal are more likely to deliver baby boys, for instance?)
Young will give a talk debunking statistical myths entitled “Everything is Dangerous” at the next Sigma Xi Pizza Lunch, at noon Wednesday, April 22.
Pizza Lunch is free and open to science journalists and science communicators of all stripes. Feel free to forward this message to anyone you think might be interested. RSVPs are required (for a reliable slice count) to cclabby@amsci.org.
Directions to Sigma XI:
http://www.sigmaxi.org/about/center/directions.shtml

Today’s carnivals

The Giant’s Shoulders #10 is up on Stochastic Scribbles
I and the Bird #98 is up on Biological Ramblings
Friday Ark #239 is up on Modulator

My picks from ScienceDaily

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Clock Quotes

The better we feel about ourselves, the fewer times we have to knock somebody else down to feel tall.
– Odetta

Is your pilot too sleepy to land you safely?

Ask the pilot:

Ask yourself this: Whom would you prefer at the controls of your plane on a stormy night, a pilot who smoked a joint three days ago, or one who had six hours of sleep prior to a 13-hour workday in which he’s performed half a dozen takeoffs and landings? The first pilot has indulged in a career-ending toke; the second is in full compliance with the rules. I have to assume that the FAA realizes the foolery of such enforcement policies, but it nonetheless chooses to put its resources into drug testing and other politically expedient issues. Meanwhile it procrastinates, performing study after study and poring over data from NASA circadian rhythm experiments in an attempt to answer one of the world’s most perplexing questions: Is exhaustion a detriment to job performance?

Bio-Rad GgggggTtttttttCccccccccAaaaaaaaa – gotta love this video!

[It’s all over the interwebs, but I first saw it posted by Dr.Isis and SciCurious]

New and Exciting in PLoS ONE

Since the last big site upgrade, the Trackbacks on PLoS ONE articles have been invisible. But our system saved them all and today, after another upgrade, they are visible again. So, if you have sent trackbacks from your blog recently, please check if they are on the paper (look under the “Related Content” tab). If not, re-send them (instructions are here). Trackbacks are an important link in the ecosystem of science publishing, connecting the inner world of the paper to the outer world of the commentary, with on-site user feedback tools forming the intermediate layer.
There are 12 new articles published last night and 15 new articles published tonight in PLoS ONE. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
Telephone Triage Service Data for Detection of Influenza-Like Illness:

Surveillance for influenza and influenza-like illness (ILI) is important for guiding public health prevention programs to mitigate the morbidity and mortality caused by influenza, including pandemic influenza. Nontraditional sources of data for influenza and ILI surveillance are of interest to public health authorities if their validity can be established. National telephone triage call data were collected through automated means for purposes of syndromic surveillance. For the 17 states with at least 500,000 inhabitants eligible to use the telephone triage services, call volume for respiratory syndrome was compared to CDC weekly number of influenza isolates and percentage of visits to sentinel providers for ILI. The degree to which the call data were correlated with either CDC viral isolates or sentinel provider percentage ILI data was highly variable among states. Telephone triage data in the U.S. are patchy in coverage and therefore not a reliable source of ILI surveillance data on a national scale. However, in states displaying a higher correlation between the call data and the CDC data, call data may be useful as an adjunct to state-level surveillance data, for example at times when sentinel surveillance is not in operation or in areas where sentinel provider coverage is considered insufficient. Sufficient population coverage, a specific ILI syndrome definition, and the use of a threshold of percentage of calls that are for ILI would likely improve the utility of such data for ILI surveillance purposes.

Antibody-Based Detection and Inhibition of Vaginolysin, the Gardnerella vaginalis Cytolysin:

Bacterial vaginosis (BV) is the most common vaginal infection worldwide and is associated with significant adverse sequelae. We have recently characterized vaginolysin (VLY), the human-specific cytotoxin produced by Gardnerella vaginalis and believed to play a critical role in the pathogenesis of BV and its associated morbidities. We hypothesize that novel antibody-based strategies may be useful for detection of VLY and for inhibition of its toxic effects on human cells. Using purified toxin as an immunogen, we generated polyclonal rabbit immune serum (IS) against VLY. A western blot of G. vaginalis lysate was probed with IS and a single band (57 kD) identified. Immunofluorescence techniques using IS detected VLY production by G. vaginalis. In addition, we have developed a sandwich ELISA assay capable of VLY quantification at ng/ml concentrations in the supernatant of growing G. vaginalis. To investigate the potential inhibitory role of IS on VLY-mediated cell lysis, we exposed human erythrocytes to VLY or VLY pretreated with IS and determined the percent hemolysis. Pretreatment with IS resulted in a significant reduction in VLY-mediated lysis. Similarly, both human cervical carcinoma cells and vaginal epithelial cells exhibited reduced cytolysis following exposure to VLY with IS compared to VLY alone. These results confirm that antibody-based techniques are an effective means of VLY detection. Furthermore, VLY antiserum functions as an inhibitor of VLY-CD59 interaction, mitigating cell lysis. These strategies may have a potential role in the diagnosis and treatment of BV.

PLoS ONE Collections

You may be aware that PLoS ONE has started creating Collections of articles in various areas of research. Two months ago we put together the first such collection – Stress-Induced Depression and Comorbidities: From Bench to Bedside and a month later, we unveiled our second collection – the PLoS ONE Paleontology Collection.
This post overviews what our Collections are all about. It is important to keep in mind that there are two types of Collections at PLoS ONE:
The first type is a one-off, ‘closed’ collection, often associated with a Conference, a Consortium or a Research Center. In this case we ask for, or are offered, a group of manuscripts (in the range 10-40 papers) which are all submitted roughly at the same time, peer-reviewed in the normal fashion, evaluated by the journal according to our normal evaluation process and then, if accepted, published roughly at the same time. The Collection then serves as a Proceedings from the meeting, or a collection of the research output of a Center, Society or Consortium etc.
Papers can still be added over time going forwards (for example, as that research group publishes new content), and so the Collection has the potential to become a ‘living’ Collection of the output from a specific group. Although the closest analogy to a PLoS ONE Collection is a ‘special issue’ of a journal, because of the ability to add new content over time, a PLoS ONE Collection is actually a lot more flexible and powerful than a traditional ‘special issue’. The Stress-Induced Depression and Comorbidities: From Bench to Bedside is an example of this kind of a Collection.
The other kind is different – it is an ‘open’ collection (in the sense that any paper we publish, provided it fits the scope of the Collection, can become part of that Collection). This means that all of our papers to date that deal with the topic (and meet the scope) can be included in the Collection. Furthermore, future articles will be automatically added to the Collection as soon as they are published. The Paleontology Collection is an example of such an open collection and contains all the content we have published in the field of Paleontology.
There may be other types in the future. For instance we may determine (using an expert editor, or using article-level metrics for example) the ‘top’ articles that we have published on a single topic, and highlight them in some sort of ‘best of’ Collection.
The articles in a Collection will always be placed together, prominently displayed and easy to find – just a single click is needed to get there. Each of the articles also prominently displays the link to the Collection it is a part of, so everything is nicely linked together.
It is also important to note that all papers are published as part of the ‘normal’ run of the journal (and so their citation reference is simply the normal citation that any PLoS ONE paper would have). Inclusion in a Collection is simply an attribute of a paper (a ‘tag’ as it were) and so a Collection is simply a way to ‘collect together’ (or ‘aggregate’) published papers on a single topic. Because of this, a single paper can conceivably appear in multiple Collections. It is also worth noting that PLoS ONE Collections can include papers published in other PLoS titles.
We also assume that by placing articles in a topic together, we will highlight to readers the activities (and the broader developments) that are happening in that area. We hope that by seeing this content together in this way, authors and readers will be stimulated to engage in discussions, either using our on-site tools for notes, comments and ratings, or offsite on their personal blogs, sending trackbacks to the articles so they can be easily found there.
If you are organizing a scientific meeting, or are a member of a scientific Society, Consortium or Center, and would be interested in submitting a set of manuscripts for a potential Collection, please contact me at Bora@plos.org.
Cross-posted on everyONE blog.

My picks from ScienceDaily

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Clock Quotes

Good fortune will elevate even petty minds, and give them the appearance of a certain greatness and stateliness, as from their high place they look down upon the world; but the truly noble and resolved spirit raises itself, and becomes more conspicuous in times of disaster and ill fortune.
– Plutarch

Go to minute 17:40 in this video:

My picks from ScienceDaily

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Clock Quotes

That’s what life is like. You have to keep running on the treadmill of evolution or you fall off.
– Bill Nye, The Science Guy

New and Exciting in PLoS ONE

There are 9 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. You can now also easily place articles on various social services (CiteULike, Connotea, Stumbleupon, Facebook and Digg) with just one click. Here are my own picks for the week – you go and look for your own favourites:
Genetic Evidence of Geographical Groups among Neanderthals:

The Neanderthals are a well-distinguished Middle Pleistocene population which inhabited a vast geographical area extending from Europe to western Asia and the Middle East. Since the 1950s paleoanthropological studies have suggested variability in this group. Different sub-groups have been identified in western Europe, in southern Europe and in the Middle East. On the other hand, since 1997, research has been published in paleogenetics, carried out on 15 mtDNA sequences from 12 Neanderthals. In this paper we used a new methodology derived from different bioinformatic models based on data from genetics, demography and paleoanthropology. The adequacy of each model was measured by comparisons between simulated results (obtained by BayesianSSC software) and those estimated from nucleotide sequences (obtained by DNAsp4 software). The conclusions of this study are consistent with existing paleoanthropological research and show that Neanderthals can be divided into at least three groups: one in western Europe, a second in the Southern area and a third in western Asia. Moreover, it seems from our results that the size of the Neanderthal population was not constant and that some migration occurred among the demes.

The Role of Inbreeding in the Extinction of a European Royal Dynasty:

The kings of the Spanish Habsburg dynasty (1516-1700) frequently married close relatives in such a way that uncle-niece, first cousins and other consanguineous unions were prevalent in that dynasty. In the historical literature, it has been suggested that inbreeding was a major cause responsible for the extinction of the dynasty when the king Charles II, physically and mentally disabled, died in 1700 and no children were born from his two marriages, but this hypothesis has not been examined from a genetic perspective. In this article, this hypothesis is checked by computing the inbreeding coefficient (F) of the Spanish Habsburg kings from an extended pedigree up to 16 generations in depth and involving more than 3,000 individuals. The inbreeding coefficient of the Spanish Habsburg kings increased strongly along generations from 0.025 for king Philip I, the founder of the dynasty, to 0.254 for Charles II and several members of the dynasty had inbreeding coefficients higher than 0.20. In addition to inbreeding due to unions between close relatives, ancestral inbreeding from multiple remote ancestors makes a substantial contribution to the inbreeding coefficient of most kings. A statistically significant inbreeding depression for survival to 10 years is detected in the progenies of the Spanish Habsburg kings. The results indicate that inbreeding at the level of first cousin (F = 0.0625) exerted an adverse effect on survival of 17.8%±12.3. It is speculated that the simultaneous occurrence in Charles II (F = 0.254) of two different genetic disorders: combined pituitary hormone deficiency and distal renal tubular acidosis, determined by recessive alleles at two unlinked loci, could explain most of the complex clinical profile of this king, including his impotence/infertility which in last instance led to the extinction of the dynasty.

From Traditional Medicine to Witchcraft: Why Medical Treatments Are Not Always Efficacious:

Complementary medicines, traditional remedies and home cures for medical ailments are used extensively world-wide, representing more than US$60 billion sales in the global market. With serious doubts about the efficacy and safety of many treatments, the industry remains steeped in controversy. Little is known about factors affecting the prevalence of efficacious and non-efficacious self-medicative treatments. Here we develop mathematical models which reveal that the most efficacious treatments are not necessarily those most likely to spread. Indeed, purely superstitious remedies, or even maladaptive practices, spread more readily than efficacious treatments under specified circumstances. Low-efficacy practices sometimes spread because their very ineffectiveness results in longer, more salient demonstration and a larger number of converts, which more than compensates for greater rates of abandonment. These models also illuminate a broader range of phenomena, including the spread of innovations, medical treatment of animals, foraging behaviour, and self-medication in non-human primates.

Today’s carnivals

Encephalon #68 is up at Ouroboros
Grand Rounds Vol. 5 No. 30 are up on Pharmamotion

Hey, You Can’t Say That! Or can you?

I have received, from a friend, a draft of an intra-institutional guideline for employee blogging and online behavior. The employer has been anonymized. The document has been written by non-scientist non-bloggers at the institution and is making the rounds prior to formal review and approval.
We have talked about this at ScienceOnline’09 in the session Hey, You Can’t Say That!. Here are some of the bloggy responses to that session to get you up to speed:
Deep Thoughts and Silliness: Semi-live Blogging Scienceonline09: Day 2
Highly Allochthonous: ScienceOnline Day 2: generalised ramblings
Ideonexus: ScienceOnline09: Hey, You Can’t Say That!
Expression Patterns: ScienceOnline09 – Day 3
Confessions of a Science Librarian: ScienceOnline ’09: Sunday summary and final thoughts
I do not know how many other research institutions (for example universities and research institutes), or other science-related businesses (for example science publishers and biotech), are developing – or have already enacted – similar guidelines, but there’s no time like the present for the science blogging community to plug itself into this discussion and maybe even start taking some active steps (for example recommending a set of guidelines or a template document for circulation and use by scientists and their employers).
What I would like you to do is read these draft guidelines, comment on them on your own blogs, make changes and edits to make it better, or to make it start making sense, make sure that your edits are highly visible (e.g., in bold or red), and then post the URL of your post in the comments of this post. Here is the text as I got it:

Social media guidelines for Big Research Institution (which I will abbreviate as BRI from here on out) staff
These guidelines are intended to cover blogs, where BRI staff discuss their projects or professional work, as well as BRI related pages set up by staff on social networking sites such as Flickr and Facebook. They do not cover any personal use of social media which is primarily about personal matters or hobbies.
We have a long history of BRI staff actively contributing to public discussions. However there are a few simple guidelines for BRI staff to consider when setting up their personal blogs and wikis which are outlined under “Personal social media guidelines” at the end of this document.
Guidelines for a BRI context
BRI can clearly benefit from the use of social media to promote its activities, discuss projects and research, and increase its overall knowledge base. These guidelines are intended to ensure that BRI can have a strategic overview of how we are using social media, use it in an effective way to develop our vision, facilitate its development and cross promote where appropriate.
For the purposes of this document online social media activity by BRI staff and associates falls into two categories:
Public facing – Social media which directly relates to or discusses work or projects at BRI and has a general public audience.
Peer to peer – As above but where the blog, forum, wiki etc is used as a tool for scientists and others to communicate with their peers and is not intended for a general public audience. This includes both social media content hosted by BRI and collaborative projects.
Speak freely, but respect BRI’s confidentiality and values
Whether social media content is public facing or peer to peer, the individual has a duty to:
* behave in a way that is consistent with BRI’s values and policies
* respect the confidentiality of information as outlined in BRI’s staff handbook
Unless there are specific concerns about the nature of the work, BRI staff are free to discuss work and research online. However, staff must not reveal any information which may be confidential. This might include aspects of research, BRI policy or details of internal discussions. Staff should check the BRI IP policy, the staff handbook and/or consult their manager if at all unclear about what might be confidential.
Editorial
The content of peer to peer pages or sites is the responsibility of the relevant department. The content should follow BRI editorial guidelines to ensure usability and accessibility. Content is the responsibility of the individual and their department and would not be edited by BRI editors. Moderation is the responsibility of the relevant department.
Public facing social media is covered by the general editorial guidelines, and should be written for the expected audience and have a moderation plan agreed with BRI.
Intellectual property
All BRI social media output is the intellectual property of BRI.
BRI will operate all of its social media under a creative commons license, which means that content such as images can be reused for educational purposes unless otherwise stated.
It is the responsibility of the author of any social media content to ensure that the copyright is cleared for any material published.
Setting up of new social media and content pages
Whether you are setting up new BRI social media pages within the BRI website or on an existing social media site such as Flickr or Facebook, they need to follow the BRI interactive project process.
In the first instance please discuss with your manager. If they are in agreement then the next step is to complete and submit a concept brief for social media (link here) which outlines:
* the purpose
* the author
* the audience
* the contributors
* moderation plans
* expected duration
* how they fit with department/corporate plans
Concept brief forms are available from your manager.
Existing blogs
Staff who already have a blog, wiki, forum etc. which is related to their work or BRI should discuss it with their manager and the BRI production editor. This will allow for a shared understanding of activity in this area and will help BRI promote and aggregate a body of BRI blogs in the future.
Scientists can link to their blogs from their CV’s on the BRI website but it may also be appropriate to integrate it into other areas of the site and promote it more generally from BRI’s website.
Personal use of social media by BRI staff
If within your blog, wiki or social media pages BRI or work at BRI is highlighted the content should comply with the Code of Conduct outlined in the staff handbook.
Additionally if a personal blog is clearly identifying the staff as a member of BRI it should have a simple and visible disclaimer such as ‘The views expressed on this blog/website are mine alone and do not necessarily reflect the views of BRI.’
Personal social media pages or websites may link to BRI’s website, but should not reproduce material that is available as a result of BRI employment, use any BRI branding, nor should the blog or website purport to represent BRI in any way.
If you wish to use BRI copyrighted material you need to obtain BRI’s permission.
Social media
For the purposes of this document, the term Social Media includes:
* blogs
* forums
* networking sites such as Facebook, Bebo, Linked In
* photo sharing sites such as Flickr
* video sharing sites such as YouTube
* all other sites allowing publishing of opinion and comment where an individual might be viewed as representing BRI
Appendix: BRI’s existing social networking rules
Social networking websites
We provide open access to the internet for business use. However, we do recognize that you might use the internet for personal purposes. This policy sets out your responsibilities in relation to using the internet to access social networking websites such as Facebook, MySpace, Bebo and Friendster.
Personal use of the internet
We allow you to access social networking websites on the internet for personal use during certain times. These times are:
* before and after work hours; and
* during the one-hour break at lunch.
We reserve the right to restrict access to these websites and to bar individuals who abuse our broad approach to open internet access.
Personal conduct
While we respect your right to a private life, we also have a general duty of care for the welfare of all our staff and also a responsibility to ensure that the reputation of BRI as an institution of world standing is protected. We therefore require employees using social networking websites to:
* refrain from identifying yourself as working for BRI;
* ensure that you do not conduct yourself in a way that could be perceived to be of detriment to BRI’s reputation and its role as a public authority; and
* take care not to allow your interaction on these websites to damage working relationships between members of staff and clients of BRI.
Monitoring of internet access at work
We reserve the right to monitor internet usage, but will endeavor to inform you should your usage be under surveillance and the reasons for it. We consider that valid reasons for checking an individual’s internet usage may include suspicions that you have
* been spending an excessive amount of time viewing websites that are not work-related; or
* acted in a way that damages the reputation of BRI and/or breaches commercial confidentiality.
We reserve the right to retain information that it has gathered on an individual’s use of the internet for a period of 12 months.
Access to the web may be withdrawn in any case of misuse of this facility and may result in disciplinary action.
Security and identity theft
You should be aware that social networking websites are a public forum, particularly if you are part of a ‘network’. You should not assume that your entries on any website will remain private. You should never send abusive or defamatory messages.
Please be security conscious and take steps to protect yourself from identity theft, for example by restricting the amount of personal information that you reveal. Social networking websites allow people to post detailed personal information such as date of birth, place of birth and favorite team, which can form the basis of security questions and passwords. In addition, you should:
* ensure that no information is made available that could provide a person with unauthorized access to BRI and/or any confidential information; and
* refrain from recording any confidential information regarding BRI on any network

What do you all think? Go ahead and make your own edits, or de novo drafts on your own blogs, and let me know the permalinks here.

My picks from ScienceDaily

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Clock Quotes

Contentment is for cows; a challenging purpose is for people.
– Denis Waitley

Teaching physiology – Cardiac Arrhythmias: the best video ever!

The Open Laboratory 2009 – the submissions so far

OpenLab logo.jpg
As you may be aware, there was a non-review review of OpenLab 2008 in The New Scientist. I thought about fisking it line-by-line, but Passover interfered, and anyway, Brian, SciCurious, Ed and Blake already did it very, very well, so I can just move on…you can also see a discussion here. Any reputable media outlet out there that would be interested in doing a real review? Contact me.
In the meantime, the reaction to the review brought in some new sales of the book (as well as sales of the previous two anthologies), so it worked out fine in the end. You can buy the 2006, 2007 and 2008 editions at Lulu.com.
Here are the submissions for OpenLab 2009 to date. The “submit” buttons and codes are under the fold. Please use the submission form to add more of your and other people’s posts (remember that we are looking for original poems, art, cartoons and comics, as well as essays):
A Blog Around The Clock: Circadian Rhythm of Aggression in Crayfish
A Blog Around The Clock: Co-Researching spaces for Freelance Scientists?
A Blog Around The Clock: The Shock Value of Science Blogs
A Blog Around The Clock: Defining the Journalism vs. Blogging Debate, with a Science Reporting angle
a k8, a cat, a mission: Moms asking for help
a k8, a cat, a mission: What does good mentorship look like?
a k8, a cat, a mission: Praise and Appreciation
a k8, a cat, a mission: Proximate mechanisms
a k8, a cat, a mission: The lives of women in science
All my faults are stress-related: Scientiae: surviving getting shaked and baked
The Beagle Project Blog: What is the difference between HMS Beagle and RMS Titanic?
Beyond the Short Coat: Hard Conversations: Vaccines and Autism, Part 1
Biochemical Soul: Darwin and the Heart of Evolution
Birds and Science: Caged budgerigars and invasive parakeets
Birds and Science: How do huge bird colonies synchronize?
Birds and Science: Fight and coordination in bird duets
Brontossauros em meu Jardim: Navigation is required*: the incredible case of the desert ant
Coyote Crossing: Spermophilus
Evolutionary Novelties: The glamour of marine biology
Expression Patterns: A Squishy Topic
Expression Patterns: Mr. Darwin, you make me blush
Geófagos: Carbon sequestration by soils
Highly Allochthonous: Is the Earth’s magnetic field about to flip?
The Intersection: Singled Out
Island of Doubt: Sea level rise a red herring?
Island of Doubt: What goes up must come down
Living the Scientific Life: Plumage Color Influences Choice of Mates and Sex of Chicks in Gouldian Finches, Erythrura gouldiae
Living the Scientific Life: Let’s Give Three Bronx Cheers for Bumblebees!
Living the Scientific Life: Dead Birds Do Tell Tales
The MacGuffin: Topiramate Does Not Treat Alcohol Dependnece: Part 1
Made With Molecules: Hey Baby, what’s your AVPR1A like?
Mad Scientist, Junior: Pretty Pictures That Toaster Takes
Malaria, Bedbugs, Sea Lice, and Sunsets: An Interesting Patch of Quicksand
Masks of Eris: Mathematics instruction as a fish
Migrations: What Use is Half a Wing – Evolution of Flight
Mind the Gap: In which I ponder economies of scale
Mind the Gap: In which I tend a strange garden
Mind the Gap: In which I ramp up
Mind the Gap: In which I muster a hypothesis
Mind the Gap: In which I continue to suspend disbelief
Mind the Gap: In which the data back up our habitual suspicions
Mind the Gap: In which I wade through the fringes of textbook fact
Mind the Gap: In which I dally with both sides
Mind the Gap: In which I am given weird treasures
Mind the Gap: In which I confront the aging process
Neurophilosophy: Amnesia in the movies
Neurophilosophy: Brain & behaviour of dinosaurs
Neurophilosophy: Voluntary amputation and extra phantom limbs
Neurotopia: The Value of Stupidity: are we doing it right?
Neurotopia: Why I’m a Scientist
Neurotopia: Korsakoff’s Psychic Disorder in Conjunction with Peripheral Neuritis
New York Minutes: Be afraid, be very afraid…wait, why?
Nothing’s Shocking: Should authors decide whether their revised paper is re-reviewed??
Observations of a Nerd: How big things relate to sex, stress and testosterone
Observations of a Nerd: Why I am not a Darwinist, but we should celebrate Darwin Day
Observations of a Nerd: Darwin’s Degenerates – Evolution’s Finest
Pharyngula: A brief moment in the magnificent history of mankind
Prerogative of Harlots: He Blinded Me With Science
The Primate Diaries: The Nature of Partisan Politics
The Primate Diaries: Introducing a Primate
Reciprocal Space: This is not good enough
The Scientist: On the nature of faith: Part 1
The Scientist: On the last days
The Scientist: On the passing of reprints
The Scientist: On saying goodbye
The Scientist: Ontology
The Scientist: Ontology #2
The Scientist: On winding down
The Scientist: On the weekend
The Scientist: On small victories
The Scientist: On the nature of networking: reprise
The Scientist: Grey Council
The Scientist: On interfaces
The Scientist: Coincidental Chemistry
The Scientist: On the Future
The Scientist: The year of living dangerously–Part 1
The Scientist: The year of living dangerously–Part 2
The Scientist: The year of living dangerously–Finale
The Scientist: What I want to do when I grow up
The Scientist: Inspiration
The Scientist: In which I watch the Watchmen, and land a new job
The Scientist: Ongoing
Skulls in the Stars: Michael Faraday, grand unified theorist? (1851)
Song for jasmine: Charles Darwin’s first theory of evolution
Southern Fried Science: The ecological disaster that is dolphin safe tuna
Stripped Science: The right pairing (comic strip)
Stripped Science: Catfight (cartoon)
Suppertime Sonnets: In Which I Celebrate A Certain Member of the Lycaenidae Family (poem)
Tumors Galore: Tree Tumors
Ways.org: The journal scope in focus — putting scholarly communication in context
White Coat Underground: Journeys
Why is science important?: Richard P. Grant: beautiful and essential
Why is science important?: Jennifer Rohn: severe skepticism, as natural as breathing
Why is science important?: Steffi Suhr: sure it’s pretty, but it’s much more impressive when you know why
xkcd: Correlation (cartoon)

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Triangle Blogger Bash at DPAC

Ah, it takes me so long these days to actually blog about events I attend! This one was last Thursday! But here it is. I went to the Triangle Blogger Bash in Durham, organized by Ginny of 30THREADS (find them on Twitter as well) and hosted by the Durham Performing Arts Center.
I am bad at estimating crowds, but there were at least 50 local bloggers there, some new to me, some old friends like Lenore, Anton, Will, Sheril, Ayse, Wayne and Ginny. There was a nice spread of food and a cash bar. The hosts gave out nice prizes (I never ever win stuff like that). You can see some blog reports here and here.
But the real star of the evening was Rachel (picture under the fold), who is DPAC’s online marketing person. She really gets it, and I am glad that DPAC is forward-looking to hire her and let her do her job properly. She has set up DPAC for all sorts of social networking, so you can follow her (and thus DPAC news and events) on Twitter, Facebook and Flickr, and, as was announced at the Blogger Bash, on their brand new blog. Check it out!
On a more ego-stroking note, Rachel said that the DPAC folks really liked my review of Fiddler on the Roof and sent the link around to various people in the theater business, both locally and in places like New York City. Nice!
Legally Blonde is playing there this week and we’ll be going on Friday. And then it’s time to renew the season’s tickets for the next season, which looks amazing already!

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Waves of Ocean Literacy

Periodic Tables and the Museum of Life and Science Present:
April 14, 2009 | 7:00 P.M.
Waves of Ocean Literacy
Speaker: Cynthia Cudaback, NC State University
If the Earth is a body, the ocean is its blood, circulating over most of the surface, moderating temperature and sustaining life. Cynthia Cudaback provides college and high school students with the tools they need to be informed stewards of the ocean, and its importance to the long-term sustainability of our planet. Her talk will focus on the success of marine education efforts, and opportunities for improvement.
Join us tomorrow night for a discussion about conserving the planet’s liquid resources.
———–
Periodic Tables is a monthly gathering where curious adults can meet in a casual setting to discuss the latest science in plain English. At Periodic Tables, you will chat with your neighbors and local experts about interesting and relevant science happenings right here in the Triangle and beyond. No lengthy PowerPoint presentations, no drawn-out seminars, no confusing jargon. Simply smart and relevant science in a relaxed atmosphere. Eating and drinking is encouraged, and there is no such thing as a stupid question.
Come out and join us on the second Tuesday of every month for a lively conversation at Broad Street Café. Come early to enjoy the fantastic appetizers, wood-fired pizza, burgers and salads that complement their 15 beers on tap and full liquor bar.
Want instant reminders about Periodic Tables? Become our fan on Facebook (http://www.new.facebook.com/pages/Durham-NC/Periodic-Tables-Durhams-Science-Cafe/40756115791)
For more information on Periodic Tables and our future topics please visit our website at http://www.ncmls.org/periodictables

Last call for submissions for ‘Praxis’ and ‘The Giants’ Shoulders’

Since The Lay Scientist had technical problems with the blog, there was no Praxis last month. Martin will thus post it this month (on or close to the 15th). He still has all the entries from last time around, but please also send some fresh submissions as well.
Next edition of The Giant’s Shoulders will be hosted by Stochastic Scribbles on April 16th. So, if you have History Of Science posts (or are just about to write one), please submit.

My picks from ScienceDaily

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Clock Quotes

A good deal happens in a man’s life that he isn’t responsible for. Fortunate openings occur; but it is safe to remember that such breaks are occurring all the time, and other things being equal, the advantage goes to the man who is ready.

– Lawrence Downs

He Said She Said Journalism Dissected

He Said, She Said Journalism: Lame Formula in the Land of the Active User by Jay Rosen. And his new podcast with Dave Winer, mostly about the AP fiasco, has been posted here. Worth a read and a listen.

Why eliminate the peer-review of baseline grants?

ResearchBlogging.orgAbout a week ago, my brother sent me a couple of interesting papers about funding in science, one in Canada, the other in the UK. I barely had time to skim the abstracts at the time, but thought I would put it up for discussion online and come back to it later. So I posted the link, abstract and brief commentary a few days ago to the article: Cost of the NSERC Science Grant Peer Review System Exceeds the Cost of Giving Every Qualified Researcher a Baseline Grant:

Abstract: Using Natural Science and Engineering Research Council Canada (NSERC) statistics, we show that the $40,000 (Canadian) cost of preparation for a grant application and rejection by peer review in 2007 exceeded that of giving every qualified investigator a direct baseline discovery grant of $30,000 (average grant). This means the Canadian Federal Government could institute direct grants for 100% of qualified applicants for the same money. We anticipate that the net result would be more and better research since more research would be conducted at the critical idea or discovery stage. Control of quality is assured through university hiring, promotion and tenure proceedings, journal reviews of submitted work, and the patent process, whose collective scrutiny far exceeds that of grant peer review. The greater efficiency in use of grant funds and increased innovation with baseline funding would provide a means of achieving the goals of the recent Canadian Value for Money and Accountability Review. We suggest that developing countries could leapfrog ahead by adopting from the start science grant systems that encourage innovation.

A long and interesting discussion ensued in the comments, with the author of the paper himself showing up and offering to send reprints to those who are interested. More discussion also happened on FriendFeed here and here.
Several other bloggers also posted about it, and discussions happened on their posts as well. T. Ryan Gregory posted about it both on his Nature Network blog Pyrenaemata and on his indy blog Genomicron.
Larry Moran was largely in agreement with the article, but some commenters were not, including Rosie Redfield whose comment motivated T. Ryan Gregory to post again, just to explain his disagreement with Rosie.
Jonathan Eisen pointed out to a related post of his and Cameron Neylon to a related post of his. Finally, Zen Faulkes used it as a starting point for three posts here,
here and here.
I have finally managed to find time to read the paper myself so I think I can say something semi-intelligent about it. It became obvious that many who commented have not actually read the paper, just the Abstract, and thus were not in the position to respond to it intelligently (the paper actually answers, clearly and in detail, all the questions and complaints voiced by the commenters). The abstract is just, …well, an abstract. The paper is full of thought-provoking ideas and really needs to be read in its entirety.
Finally, my brother showed up in the comments and I would like to use his comment as a starting point today. That is – once you read the actual paper (ask for a reprint if you cannot access it), the linked blog posts and comment threads. I’ll be right here, waiting for you to come back….
I am assuming that the Canadian funding system is not very dissimilar to that in many other countries, including the USA – there is a central governmental body that gets its budget from the government and uses committees of unpaid peer-reviewers to decide how the money will be allocated to the researchers. The paper explains in detail at least a dozen reasons why and how this system is flawed: how it stifles truly innovative science, repels students from entering science, disproportinately pushes women out of science, encumbers students and postdocs with tasks they are not supposed to be doing (e.g., clerical, or technical), introduces an element of uncertainty about one’s livelihood, gives universities excuses to completely get out of research funding, shafts teaching and outreach as criteria for promotion, etc. But the clincher, for politicos at least, is that this system costs more than if a set sum of about $30,000 (Canadian) was given to every academic employed by a Canadian university who asks in any given year.
Yes, giving every Canadian scientist who already has a job and a lab this small amount of money no-questions-asked, geared toward innovative exploratory research, costs the government less than going through the peer-review system that gives money to some and no money to others (not to mention the reinforcement of the Old Boys Club this way).
This does not mean, in their proposal, that all of the Canadian money earmarked for science would be given this way – this is still just a small part of it. If you have a big lab or do expensive research and need to apply for much bigger grants, that would be done by the traditional peer review. But in order to get to the point where you have a good proposal, you need to have some neat stuff done (the “preliminary data”). With the proposed system, that preliminary data can be really exciting or revolutionary, something that, as an initial proposal, would never fly by peers.
Would people send out proposals for crap? Some would, I’m sure, but that doesn’t matter. Most would not. Scientists are curious about nature and would like to test their hunches. Some will flop, some will be amazing – it is the latter that this new system is worth doing for, as they may never be done otherwise. Anyway, how many $5,000,000 grants produced amazing stuff? All? I.Don’t. Think.So.
Where does quality control come from? First, it already came from universities who hired these researchers out of hundreds of applicants for each position. Aren’t they going to trust those best-of-the-best they hired? Second, the research itself will be judged after it is done – at conferences, in journal articles, and in post-publication metrics (citations, downloads, online chatter, etc., including perhaps a Nobel Prize here and there). If it is not up to standards, $30,000 Canadian dollars is not a big price to pay, and even the negative or inconclusive results can be useful to others if the thinking is original. If it is up to standards or more, that person will now have something exciting to base a bigger grant proposal on.
This also goes back to something I like to rant about (oh yes, go read that again!) – the bandwagon of Big Science. Biology, for example, does not equal running gels (hmmm, that’s chemistry, isn’t it?). But many people are given that appearance. “No gels – no grants, no papers, no career” (yup, I was told that a few years ago). Unless you already have a big molecular lab, this small grant will not build you one. Instead, you can do some really cool stuff at other levels – from tissues up to ecosystems and everything in-between, including computer modeling. You can use it to travel to some jungle that has never seen a Westerner and see what species live there – not hypothesis-testing, exploratory and exciting, definitely useful, but not something that is easily funded with a current system. If your proposal includes research on live vertebrates, you first have to get an IACUC proposal, something that will take 6-9 months of extremely frustrating fighting and proposal-modification – getting an IACUC proposal is the toughest peer-review known to science: if they say Yes to your proposal, no other committee of peers can add any more wisdom to it. And if you decide to work on invertebrates – it is much cheaper.
Another paper looks at this from another perspective – four stages of science. The grants, especially the big ones, disproportionately target science in Stage 3. The small baseline grants would target primarily Stage 1, the exciting, innovative stage – and this is a Good Thing. They could also more easily fund research in Stage 2 and Stage 4, also a Good Thing – from the article:

In this article I propose the classification of the evolutionary stages that a scientific discipline evolves through and the type of scientists that are the most productive at each stage. I believe that each scientific discipline evolves sequentially through four stages. Scientists at stage one introduce new objects and phenomena as subject matter for a new scientific discipline. To do this they have to introduce a new language adequately describing the subject matter. At stage two, scientists develop a toolbox of methods and techniques for the new discipline. Owing to this advancement in methodology, the spectrum of objects and phenomena that fall into the realm of the new science are further understood at this stage. Most of the specific knowledge is generated at the third stage, at which the highest number of original research publications is generated. The majority of third-stage investigation is based on the initial application of new research methods to objects and/or phenomena. The purpose of the fourth stage is to maintain and pass on scientific knowledge generated during the first three stages. Groundbreaking new discoveries are not made at this stage. However, new ways to present scientific information are generated, and crucial revisions are often made of the role of the discipline within the constantly evolving scientific environment. The very nature of each stage determines the optimal psychological type and modus operandi of the scientist operating within it. Thus, it is not only the talent and devotion of scientists that determines whether they are capable of contributing substantially but, rather, whether they have the ‘right type’ of talent for the chosen scientific discipline at that time. Understanding the four different evolutionary stages of a scientific discipline might be instrumental for many scientists in optimizing their career path, in addition to being useful in assembling scientific teams, precluding conflicts and maximizing productivity. The proposed model of scientific evolution might also be instrumental for society in organizing and managing the scientific process. No public policy aimed at stimulating the scientific process can be equally beneficial for all four stages. Attempts to apply the same criteria to scientists working on scientific disciplines at different stages of their scientific evolution would be stimulating for one and detrimental for another. In addition, researchers operating at a certain stage of scientific evolution might not possess the mindset adequate to evaluate and stimulate a discipline that is at a different evolutionary stage. This could be the reason for suboptimal implementation of otherwise well-conceived scientific policies.

Now, the proposal in this paper is quite definitive about allowing only researchers employed by universities to apply for such grants. But my mind instantly started thinking about those outside. How about amateur scientists? How about people not affiliated with the academia? How about distributed citizen science projects? Those are usually Stage 1 or Stage 2 projects, attractive to a particular kind of researcher (myself included – don’t try to lure me into a big Stage 3 lab). If I wanted to get some crayfish or spiders (or even birds, if a local IACUC would let me) and do experiments at home, this kind of a small grant would be just ideal. Could I have a local University, or some peers, write a letter in support of my proposal? Would that fly?
The paper also mentions, in a couple of places, similarities and differences between peer-review of grants and peer-review of manuscripts, including the importance of Openness to science. In one place, it mentions new journals “where ideas may be published initially unreviewed, but anyone may append public discussions to each article”. I am hoping this refers to arXiv and Nature Precedings, or even the concept of Open Notebook Science, but it smells too much like one of the pernicious myths spread by the enemies of Open Access about PLoS ONE which is, as readers of this blog are aware, stringently peer-reviewed.
One thing that the article mentions is that the current granting system allows researchers to buy time for research away from their teaching time. They note this as bad for teaching, true, but there is another angle to it. As danah writes in regard to the new proposed NSF funding of qualitative research, this kind of work does not require much in terms of equipment, but much in terms of time. It is essential for people, especially in social sciences, who do qualitative research, to be able to buy the time they need to do their research correctly.
Oh, and I mentioned at the beginning that my brother sent me two papers, yet we talked here only about one of them. The other one, if you are interested in starting a whole new discussion, is this one: Life after death? The Soviet system in British higher education

Recent studies of British higher education (HE) have focused on the application of the principles of the ‘new managerialism’ in the public sector, ostensibly aimed at improving the effectiveness of research and teaching, and also on the increasing commercialisation of HE. This article examines HE management in the light of the historical experience of the Soviet system of economic planning. Analogies with the dysfunctional effects of the Soviet system are elaborated with regard to financial planning and the systems of quality control in academic research and teaching. It is argued that Soviet-style management systems have paradoxically accompanied the growing market orientation of HE, undermining traditional professional values and alternative models of engagement between HE institutions and the wider society.

A FriendFeed discussion has started. Read the entire paper before chiming in, of course – we are scientists here!
Gordon, R., & Poulin, B. (2009). Cost of the NSERC Science Grant Peer Review System Exceeds the Cost of Giving Every Qualified Researcher a Baseline Grant Accountability in Research, 16 (1), 13-40 DOI: 10.1080/08989620802689821

Clock News

Circadian Clock: Scientists Model 3D Structures Of Proteins That Control Human Clock:

Researchers at the Scripps Research Institute say they have taken a leap forward in their quest to understand the proteins that control the human circadian clock — the 24-hour wake-sleep cycle that, when interrupted, can lead to jet lag and other sleep disturbances. Researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surprisingly similar to two cryptochrome proteins that control the “master clock” in humans and other mammals. They have also been able to test how structural changes affect the function of these proteins.

Sleep: Spring Cleaning For The Brain?:

If you’ve ever been sleep-deprived, you know the feeling that your brain is full of wool. Now, a study published in the April 3 edition of the journal Science has molecular and structural evidence of that woolly feeling — proteins that build up in the brains of sleep-deprived fruit flies and drop to lower levels in the brains of the well-rested. The proteins are located in the synapses, those specialized parts of neurons that allow brain cells to communicate with other neurons.

Clock Quotes

There are times when I think that the ideal library is composed solely of reference books. They are like understanding friends-always ready to change the subject when you have had enough of this or that.
– J. Donald Adams

My picks from ScienceDaily

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My picks from ScienceDaily

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Clock Quotes

I couldn’t remember when I had been so disappointed. Except perhaps the time I found out that M&Ms really do melt in your hand …
– Peter Oakley

Friday Weird Sex Blogging – Postscript to Pittendrigh’s Pet Project – Phototaxis, Photoperiodism and Precise Projectile Parabolas of Pilobolus on Pasture Poop

Postscript to Pittendrigh's Pet Project - Phototaxis, Photoperiodism and Precise Projectile Parabolas of Pilobolus on Pasture PoopWe have recently covered interesting reproductive adaptations in mammals, birds, insects, flatworms, plants and protists. For the time being (until I lose inspiration) I’ll try to leave cephalopod sex to the experts and the pretty flower sex to the chimp crew.
In the meantime, I want to cover another Kingdom – the mysterious world of Fungi. And what follows is not just a cute example of a wonderfully evolved reproductive strategy, and not just a way to couple together my two passions – clocks and sex – but also (at the very end), an opportunity to post some of my own hypotheses online.

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Friday Weird Sex Blogging – Sex On The (Dreaming) Brain

Sex On The (Dreaming) Brain (First posted on February 5, 2007) Last week I asked if you would be interested in my take on this paper, since it is in Serbian (and one commenter said Yes, so here it is – I am easy to persuade):

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Friday Weird Sex Blogging – Ladybugs

[First posted here] Since I already posted, earlier in the week, the weirdest and most disgusting animal sex post ever, instead of writing a new one, I’ll just send you to see some cute ladybug sex (scroll down to the middle of the post), which also reminded me of these pictures I discovered a few months ago. Or another one, picked up randomly on the web:
ladybug%20sex.jpg

Friday Weird Sex Blogging – The Giant Stinkin’ Phallus!

{First posted here]. Well, this Friday Weird Sex Blogging is not going to be so unique. After all, Janet and Zuzu have already blogged about it, but who can resist a phallic-looking, rotten-meat smelling, fly-attracting flower! And it is not a B-grade movie on the sci-fi channel. This is real! The Titan Arum (Amorphophallus titanum), in all its 3m tall glory is about to start stinking up the greenhouse at the Brooklyn Botanical Garden (follow the flowering on the blog or watch the flowering web-cam here) :

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Friday Weird Sex Blogging – Losing Your Head For Love

As always, animal porn is under the fold (first posted here):

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Friday Weird Sex Blogging – Penis Fencing

Penis_fencing_insemination.jpgSome flatworms, for instance these pretty Pseudobiceros hancockanus, engage in penis fencing. Both individuals are hermaphrodites, i.e., have both male and female organs. The penis is white, pointed and two-headed. Both individuals are trying to inseminate the other. The one who is inseminated has to bear and lay eggs – a more expensive proposition. The one who “won” the fencing bout and did the insemination can move on and fence some other guys and on and on, “fathering” many progeny until happenning onto a better fencer, getting inseminated, and spending the rest of the life as “mother”.

Friday Weird Sex Blogging – The Birds Do It….

Friday Weird Sex Blogging - The Birds Do It....You should check out all of my SiBlings’ Friday Blogging practices, then come back here for a new edition of Friday Weird Sex Blogging. Last week you saw an example of a corkscrew penis. But that is not the only one of a kind. See more under the fold (first posted on July 14, 2006)…

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Friday Weird Sex Blogging – Cooling The Balls

Friday Weird Sex Blogging - Cooling The BallsWhat?….

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Friday Weird Sex Blogging – Corkscrewing

Friday Weird Sex Blogging - CorkscrewingYou really think I am going to put this above the fold? No way – you have to click (First posted on July 7, 2006):

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