Category Archives: History of Science

Happy birthday “Origin of Species”

Or, Happy Evolution Day! It’s time for a party!
It is easy to look up blog coverage – if you search for “Origin of Species” you mostly get good stuff, if you search for “Origin of the Species” you get creationist clap-trap as they cannot even copy and paste correctly (hence they are better known these days as cdesign proponentsists).
Pondering Pikaia and The Beagle Project Blog were first out of the gate this morning with wonderful posts.
Here is a recent book review of the Origin by someone who knows some biology and another one by someone who does not – both are quite nice and eye-opening.
Corpus Callosum, John Wilkins, Shalini, Paul Erland also mark the date.
The first printing of 1250 copies did not fly off the shelves, because they were all already sold to subscribers – yes, amazon.com did not invent pre-ordering of books. The second printing was then rushed immediatelly for public sales in actual physical bookstores.
Upon first reading The Origin, Thomas Henry Huxley famously exclaimed: “How extremely stupid not to have thought of that!”
I first read The Origin (4th edition) when I was about 13 or 14. That was the third serious book I have ever read in English (the first two were Jonathan Livingston Seagull and a biography of Bruce Lee) and it was heavy slogging. I do not remember if I actually finished it (probably not) and mostly remembered the pigeons. Too young.
I read The Origin again (the 1st edition), the whole thing, while taking a “History of Life Science” course with Will Kimler some ten years ago, and then again next semester for his “Darwin In Science And Society” course. As well as a bunch of secondary literature, autobiography, a couple of biographies, some papers…Then the following year, Will and Roger Powell co-taught a graduate seminar “Darwin (Re)visited” where we actually read the entire Origin, entire Voyage of the Beagle, huge chunks of Descent of Man (I read the whole thing), the whole The Expression of the Emotions in Man and Animals, some letters, excerpts from the Orchid book, etc. I also read pieces from the Power Of Movement in Plants and the Earthworm book. I need to re-read all that stuff again (one should, every ten years or so). And you should, too.
More from Dispersal of Darwin, Laelaps, Sandwalk, Afarensis and Yikes!

Triangle Malaria Symposium

The Triangle Malaria Symposium will be on Thursday, November 15, 2007, at 1-7 pm at the Duke University Searle Center. At first I thought it was this week, but now I see it is the week after, so perhaps I can make it to it. Even if I don’t, Anton is going for sure and intends to liveblog it. So far, the speakers include Peter Agre, Margaret Humphreys and Steve Meshnick so the symposium looks VERY promising.

Beagle Project has Swag!

You have seen the button for the Beagle Project on my sidebar – it will stay there forever! But now, I see, they have opened a CafePress store where you can get yourself t-shirts, coffee-mugs and buttons and the proceeds go towards the rebuilding of the ship and its science/education maiden voyage:
Beagle%20mug.jpg

Nothing beats the Hands-On experience!

Just watching someone give a talk is often not enough to remember it later. As they say, a picture is worth a thousand words. And certainly, seeing is believing. But, this presentation is impossible to forget, even if one would rather not remember it so vividly. Oh, and it was absolutely NSFW!
Obligatory Reading of the Day.

Top Five Dead Scientists

James Randerson asks this question, but actually leaving only four slots open as “…If anyone plans not to include Darwin I’m going to have to ask them to step outside.” a sentiment with which Peter McGrath agrees. So – your Top 5?

Bravo, Bravissimo!

John Wilkins just published a paper (…”a review of the centenary festschrift for Mayr…”) and got a book accepted for publication (the book grew out of series of excellent blog posts about species definitions – who says that blogging is bad for your health?)
Congratulations!

The Evolution of What We Think About Who We Are

I may be a little late to this, but better late than never. Laelaps has penned one of those rarities – an exceptionally detailed historical summary of the way people’s understanding of human origins changed over time. Bookmark and read when you have time to really focus.

The hole in your head!

Mo is really spoiling us with exciting, well-researched posts from the history of science and medicine (remember the trepination post from a month ago?). And here he does it again: The rise & fall of the prefrontal lobotomy, the most gripping post on science blogs this week. And a Wicked Stepmother is one of the main characters!

The 7 Most Exciting Moments in Science

Ruchira comments on the article in the Discover Magazine and their choice of seven most magical eureka moments in the history of science.
They are:
* Otto Lowei: discovering the chemical transmission of nerve impulses
* Rene Descartes: developing the Cartesian co-ordinate system of perpendicular lines and planes
* Nikola Tesla: designing the alternate current motor
* Edwin Hubble: discovering the existence of galaxies outside the Milky Way
* Robert Hooke: discovery of the cell as the building block of all living organisms
* Henry Becquerel: discovery of radioactivity
* Alexander Fleming: discovery of penicillin
Agree or disagree?
Didn’t Darwin have an ‘a-ha!’ moment when reading Malthus? How about Kekule’s dream?

Clock News

menaker%26friend.gif
Menaker Awarded Farrell Prize in Sleep Medicine:

Michael Menaker, professor of biology and an international leader in the field of circadian rhythm research, received the Peter C. Farrell Prize in Sleep Medicine from the Harvard Medical School Division of Sleep Medicine during an event there on June 6.
The prize was awarded “in celebration of the life and work of Michael Menaker, trailblazer in circadian biology and prescient illuminator of how Light and Dark, the alternating ancient heritages of our planet, come to govern and synchronize living clocks.”
Menaker was cited as a “ground-breaking investigator of the first circadian genetic mutation in mammals as well as the architect of landmark experiments that elucidate how central and peripheral circadian oscillators are coordinated to each other and with the environment.
Previously Menaker was honored with Virginia’s Outstanding Scientists and Industrialists 2003 Lifetime Achievement Award.

Mike is my academic grandfather, which makes me a very common beast, really! Yes, he has published amazing stuff over the decades and did some really pioneering and revolutionary science. But, his probably greatest contribution to science is the enormous number of students he has advised over the years. He finishes every talk by showing slides (two slides? three these days?) with many, many names of all of his graduate students (typed in a freerunning actograph style) which reads like a who-is-who of Chronobiology. And that is just first generation of his academic offspring – the academic grandkids and great-grandkids are all over the world as well, doing top-notch and exciting science.

Everything You Always Wanted to Know About Pennicillin (and more)

Here is an example of perfect science blogging. It starts seemingly innocuously, with a quiz: Monday’s Molecule #30, where you are supposed to figure out what the compound is.
Then, after a couple of days, there is a post that you may not even realize at first is related to the first one: Bacteria Have Cell Walls
Another day or two, and A and B get connected: How Penicillin Works to Kill Bacteria
But how do we know this? Well, some people figured it out: Nobel Laureates: Sir Alexander Fleming, Ernst Boris Chain, Sir Howard Walter Florey – and now you know how we know.
Finally, putting everything in context of science, society, medicine and history, a two-parter: Penicillin Resistance in Bacteria: Before 1960 and Penecillin Resistance in Bacteria: After 1960
A tour-de-force of science blogging. I wish I could do something like that.

Look! There’s a hole in your head!

The history of trepanation. An utterly amazing post!
And, Bioephemera posted an appropriate illustration to go with it….

Obligatory Reading of the Day – the Experimental Darwin

Darwin did not just sail on the Beagle and then settle down in his armchair and think for the rest of his life. He performed an amazing number of very creative experiments. Afarensis has been writing about them for a while now and I hope you are following his series every week.

So, why did the mammoths REALLY go extinct?

A paper in press in Current Biology (press release here) looks at mitochondrial DNA of mammoths and advances a primarily environmental cause for the mammoth extinction. Razib explains why such a black-and-white dichotomy is unhealthy.
Looking at a different hypothesis, also environmental, for the mammoth extinction (comet impact), Archy places the black-and-white dichotomy in the historical context and tries to figure out why the environmental hypotheses are so popular nowadays, while extinction at the hands of human hunters is not a popular idea any more.

Carolus Linnaeus’ Floral Clocks

When it’s someone’s birthday it is nice to give presents, or a flower. Perhaps a whole boquet of roses. But if the birthday is a really big round number, like 300, and the birthday boy is the one who actually gave names to many of those flowers, it gets a little tougher. Perhaps you may try to do something really difficult and build, actually plant, a Flower Clock. After all, it was Carl von Linne, aka Carolus Linnaeus, today’s birthday celebrator, who invented the flower clock. He drew it like this, but he never actully built one:
flower%20clock%20linnaeus.jpg
The first one to make (and write down) an observation that some plants (in that case, a tropical Tamarind tree) raise their leaves during the day and let them droop down during the night, was Androsthenes, an officer who accompanied Alexander the Great. In the first century, Pliny the Elder made a similar observation, repeated in the thirteenth century by Albertus Magnus.
In 1729, Jean Jacque d’Ortous de Mairan, an astronomer, not a botanist, reported an experiment – considered to be the first true chronobiologial experiment in history – in which he observed the spontaneous daily rise and nightly fall of leaves of Mimosa pudica kept in a closet in the dark. The experiment was repeated with some improvements by Duhamel de Monceau and by Zinn, both in 1759.
Another Swede, Arrhenius argued that a mysterious cosmic Factor X triggered the movements. Charles Darwin published an entire book on the Movement of Plants, arguing that the plant itself generates the daily rhythms. The most famous botanist of the 19th century, Pfeffer, started out favouring the “external hypothesis”, but Darwin’s experiments forced him to change his mind later in his career and accept the “internal” source of such rhythmic movements. In the early 20th century, Erwin Bunning was the first to really thoroughly study circadian rhythms in plants. For the rest of the century, animal research took over and though there has been some progress recently, the understanding of clocks in plants still lags behind that of Drosophila and the mouse.
But it was Carolus Linnaeus back in the 18th century who, fond of personifying plants (mostly in regard to sex) named this phenomenon “sleep” in plants. Soon, he switched his focus from movements of leaves to the daily opening and closing of flowers and performed a broad study of the times of day when each flower species opened and closed:

Linnaeus observed over a number of years that certain plants constantly opened and closed their flowers at particular times of the day, these times varying from species to species. Hence one could deduce the approximate time of day according to which species had opened or closed their flowers. Arranged in sequence of flowering over the day they constituted a kind of floral clock or horologium florae, as Linnaeus called it in his Philosophia Botanica (1751, pages 274-276). A detailed and extended account of this in English will be found in F.W.Oliver’s translation of Anton Kerner’s The Natural History of Plants, 1895, vol.2, pages 215-218. As many of the indicator plants are wildflowers and the opening/closing times depend on latitude, the complexities of planting a floral clock make it an impractical proposition.

While it is not easy to make a functioning flower clock, people have done it. There is one in his hometown of Uppsala, for instance. It has been made in the classroom (pdf) and one can pretty easily find locally useful lists of plants to try to build one.
flowerclocklarge.jpg

Linnaeus; in writings titled Philosophia Botanica wrote about 3 types of flowers:
1. Meteorici, A category which changes their opening and closing times according to the weather conditions.
2. Tropici, Flowers which change their opening and closing specifically to the length of the day.
3. Aequinoctales, Most important here to this story, are the flowers having fixed times for opening and closing, regardless of weather or season.

It is only those last ones that could be used for buildiing Floral Clocks, while the first two groups were important for the studies of vernalization and photoperiodism in plants in the early 20th century.
flower%20clock%20schematic.JPG
You can find some more detail of the flower clock history here. And the idea of a flower clock was also picked up by artists of various kinds:

Linnaeus’s idea for a collection of flowers that opened or closed at a particular time of day was taken up by the French composer Jean Fran aix in his composition L’horloge de flore (The Flower Clock), a concerto for solo oboe and orchestra.
———————
A floral clock features in the fictional city of Quirm, in Soul Music, one of the books in Terry Pratchett’s Discworld series.

Linnaeus Birthday Celebration

As promised, I will gather here (and update a couple of times during the day) some of the most interesting posts from around the blogosphere about the celebrations of the 300th birthday of Carl von Linne aka Carolus Linnaeus, the guy you cussed at when, back in high school, you had to memorize the order of taxonomic categories: Kingdom, Phylum, Class, Order, Family, Genus and Species (and you all know the mnemonic, don’t you?).
So, what’s with the name? Is it Linnaeus or von Linne? Merriam-Webster explains:

But today we come not to praise Linnaeus but to parse his various names. When Linnaeus was born, surnames were not common in Sweden. His father had been known as Nils Ingemarsson (Nils, son of Ingmar) until he attended the University at Lund with the goal of becoming a clergyman. Needing a proper surname, Nils gave himself the Latinized name Linnaeus, after the Linden tree on the family property (which was a warden tree, a very old tree believed to protect the land and people from bad luck).
So when Carl was born, he was given the surname Linnaeus. When he, in turn, enrolled at his father’s alma mater, he registered in full Latin form: Carolus Linnaeus. Then, in 1761, after he had earned some measure of renown for his work Latinizing and simplifying scientific nomenclature, Linnaeus was raised to the rank of nobility and took yet another name: Carl von Linne.

The main webpage for the tricentennial celebration is here. But let’s now move to blogs….
I just have to start with the best essays first! John Wilkins on Linnaeus’ views of classification and species.
A brief biography by Michael Ryan of Paleoblog.
The Dispersal of Darwin looks at the origins of natural history and the associated cultural imperalism. And notes some radio shows.
Bleimanimal of Zooillogix, of course, has to do something different – here is Amphibsaenia
John Lynch tries to rescue old Carl from the threat of Phylocode. And adds a quote.
Annotated Budak at the Biodiversity of Singapore Symposium
After the initial announcement I posted my favourite Linnaeus quote and will post another one later today. OK< here it is, about the sleep in plants and flower clocks.
Listen to the podcast of the NPR story.
Do you know the English names of these species?
Here is the NYTimes article about Linne. If you can’t see NYTimes (or after the article hides behind the subscription wall), the entire birthday article is reprinted here as well as by Matt Dowling.
From a fellow Swede.
Tyra is a fellow gardener.
An article in Wired on Linne, taxonomy and nomenclature.
A Swedish family compares and contrasts Linne and Ken Ham (guess who wins?).
The New Scientist:

He’s more influential than ABBA, more famous than Bjorn Borg and Sweden is celebrating today the 300th birthday of its most illustrious son….

See the wooden statue of Linnaeus in Stockholm (I remember seeing it when I visited in 1990).
Matthew Cob wrote the article for LATimes and kindly reprinted it on his blog.
Bromus tectorum is the Botany Photo of the Day.
An American in Sweden explains it succintly.
A biology teacher uses the opportunity to criticize that awful article in The Economist.
Here is one in Russian, with a nice illustration of Linnaea borealis.
Flatbush Gardener reproduces a portrait of Linne.
A nice biography by Daddicade.
Gardeners love Linne, including Molly Day
A tribute by Leigh Andrew.
Green Chameleon compiled a small linkfest as well.
What is the connection between Linne, apples and Rambo?
A clip from “The Linnaeus Expedition”
Japanese Emperor visits Sweden to celebrate.
Apparently, Linnaeus himself gave an interview yesterday.
This one is bilingual: English and Spanish.
PhiloBiblos
The Independent
A write up on The Writer’s Almanac.
News From The Field on naming plants.
Voltage Gate on sex, God and human origins: Carl Linnaeus, in His Own Words
A photo of a Linnaeus sculpture from the Chicago Botanical Garden taken in 1988.
Skepchick and Linnaeus are obsessed with sex.
Interested in books on taxonomy and systematics?
On ravens and crows, Cheerios and cupcakes for the300th birthday.
So, LINNEAUS NAMED US
For a Swede, he was pretty funny!
Use Linnaeus to learn some Swedish.
And don’t even get me started on the banana.
Linnaeus celebrates his own 300th birthday.
Of course, Carl Brest Van Kempen provides his own original art.
Classification is Art.
Nick Matcke over on Panda’s Thumb compares Carl to Willi Hennig. Yeah, whatever.
Of course the Beagle Project Blog chimes in, with a link to a BBC Frontiers show. And so do the Friends of Darwin.
D. Weinberger links to his article(s) as well.
Cheezy armadillos
ERV has actually built a Linnean flower clock!
Yet Another Unitarian Universalist casually uses binomial nomenclature while going for a walk…
If you have written or seen elsewhere a good contribution, let me know so I can include it here.

Linnaeus Tricentennial tomorrow

Tomorrow is 300th birthday of Carl von Linne (or Carlus Linnaeus) and there will be celebrations in Sweden and around the world. So, tomorrow is a good day for a post about him (and if I find enough time and energy, I may compile the best ones into a mini-carnival).

On this day in history

Oh, no, you are thinking that I was going to write yet another post about my own birthday. Fear not. This is a different kind of voyage that started on this day. On May 11th, 1820, that curiously important litttle ship, HMS ‘Beagle’, was first launched (via Beagle Project blog)

The Greatest Innovation

Spiked and Pfizer are asking:

‘What’s the Greatest Innovation?’ is a survey of key thinkers in science, technology and medicine, conducted by spiked in collaboration with the research-based pharmaceutical company Pfizer. Contributors were asked to identify what they see as the greatest innovation in their field. More than a hundred experts and authorities have responded already, including half-a-dozen Nobel laureates.
The survey will roll through May and June, and the discussion will go live at an event in central London on Wednesday 6 June

What is the difference between innovation and discovery? This is what the press release says:

spiked’s editor-at-large, Mick Hume, said: ‘Some choose “sexy” looking innovations, others apologise for the apparent dullness of their arcane choices. But whatever the appearances, almost all of our respondents exude a sense of certainty about the improvement that innovations in their field are making to our world, and the potential for more of the same.’
Astronomer Stephen W Squyres said ‘rockets capable of reaching space’ were the obvious choice in his field, while developmental biologist Lewis Wolpert pointed out that without the microscope ‘cells would not have been discovered’. Dr David Roblin, vice president of Pfizer Global R&D, hailed the ‘modern clinical trial’ as the greatest innovation in the field of medicine.
Sir Tim Hunt, Nobel laureate and principal scientist at Cancer Research UK, said recombinant DNA technology has made the biggest difference to the way biologists work today. ‘We couldn’t have gotten anywhere without it.’
Howard Garner, professor of cognition and education at Harvard, believes the ‘cognitive revolution’ was a major innovation: ‘Researchers peered inside the black box and, through theoretical models and experimental interventions, attempted to describe the mental structures and processes that are – or give rise to – thoughts as well as behaviours.’
According to science writer Philip Ball, ‘the essence of the molecular sciences is understanding the shape, structure, constitution, location and dynamics of molecules’. Therefore, he says, analytical tools such as nuclear magnetic resonance (NMR) spectroscopy and optical, electron and scanning-probe microscopies ‘are quite simply what makes the discipline possible as a modern science’.
‘”Random search” has revolutionised the checking of facts, the discovering of new information, the gleaning of leads’, said science writer Matt Ridley, while Paul Parsons, editor of BBC Focus magazine, hailed ‘anything that enables us to rub out our mistakes and correct them; to go back and put things right’.
While it is impossible to choose one single innovation mentioned in the spiked/Pfizer survey as the key moment in human history – whether it’s the discovery of nuclear fusion, the invention of eye glasses with arms or text messaging – the survey itself marks some of the triumphs of human ingenuity.
According to Hume, ‘the results of the survey hint at how much more could be achieved if there was a stronger cultural affirmation of the problem-solving potential of scientific experimentation and bold innovation’.

All good examples, but, none of them would be of much use today (or ever) without the computer and, importantly, without the Internet. And those are important innovations in EVERY field. My field would not even exist without continuous, long-term data-collection by computers. And enormity of data produced by computers could not be disseminated without the Internet – publication of summaries as papers is just not enough any more.

Happy Birthday, John James Audubon

John James Audubon was born on his father’s plantation in Haiti on this day in 1780. Despite being born of his father’s mistress, he was raised in France by his father’s wife and educated with other young aristocrats. He took an early interest in drawing birds, when he found himself without an income he proceeded to paint some of the finest images of North America’s avians. The modern Audubon Society approves of his art but would hardly approve of his methods: He got the birds to pose for him by first shooting them.

It is not only fine feathers that make fine birds.
– Aesop
The birds I heard today, which, fortunately, did not come within the scope of my science, sang as freshly as if it had been the first morning of creation.
– Henry David Thoreau, 1817 – 1862
I value my garden more for being full [of] blackbirds than of cherries, and very frankly give them fruit for their songs.
– Joseph Addison, 1672 – 1719
The bird has an honor that man does not have. Man lives in the traps of his abdicated laws and traditions; but the birds live according to the natural law of God who causes the earth to turn around the sun.
– Kahlil Gibran, 1883 – 1931
God loved the birds and invented trees. Man loved the birds and invented cages.
– Jacques Deval, 1895 – 1972
To a man, ornithologists are tall, slender, and bearded so that they can stand motionless for hours, imitating kindly trees, as they watch for birds.
– Gore Vidal

From Quotes of the Day

In Memoriam: Knut Schmidt-Nielsen (September 24, 1915-January 25, 2007)

How did I miss this!?
Knut Schmidt-Nielsen, one of my personal scientific idols, died on January 25th, 2007at the age of 92.
KSN%201.jpgHe has re-invented, or perhaps better to say invented, the field of comparative physiology (now often refered to as ‘evolutionary physiology’). He wrote the standard textbook in the field – Animal Physiology: Adaptation and Environment, that he updated through several editions, from which generations of biologists (including myself) learned to think of physiological mechanisms as adaptations.
He wrote a definitive book on Scaling, as well as a wonderful autobiography – The Camel’s Nose: Memoirs Of A Curious Scientist.
KSN%202.jpgI had a good fortune to meet him a couple of times. He was a Guest Speaker at an NCSU Physiology Graduate Student Research Symposium several years ago where he gave an unusual but fascinating talk. I was his host for the day so I got to spend a lot of time with him one-on-one and try to osmotically draw in some of his genius.
A couple of years later, when his memoir came out, I persuaded Nansy Olson to have a public reading at Quail Ridge Books, which was well attanded and quite fascinating. The very last question from the audience was “Did any of your findings find a practical application?” to which he proudly responded “No!”. The old-style scientist. In it for the curiosity and nothing else.
While Schmidt-Nielsen did research on myriads of different animal species, he will forever be remembered as the Camel Guy. When he arrived at Duke University as a young new professor, he persuaded the Department to let him build an isolation chamber where he could measure the metabolic rate of a camel. They let him do it. He brought in the camel. Fascinating research resulted. He also built an identical, but much smaller, chamber into the wall right next to the camel chamber for the equivalent research in desert mice.
KSN%203.jpgWhen he retired, his position was filled by Steve Nowicki, a birdsong researcher. Duke offered to demolish the camel chamber and turn it into a lab. Steve declined in horror. Instead, he made sure that a plaque was installed at the door (“…this is the camel chamber in which…”) as well as on the little wall-chamber next to it. He turned the inside of the chamber into a grad student office (now, who can beat that – having the office in the ‘camel chamber’?!).
A few years later, Duke University built a monument to Knut Schmidt-Nielsen – a lifesize sculpture of the man and his camel – right outside the Biology building.
For many years after his retirement, Knut Schmidt-Nielsen kept a small office in the Department and came “to work” almost every day. He read the literature, including popular science magazines, and clipped the interesting papers/articles out of them to place in his colleagues’ mailboxes according to their interests. If there was Internet 50 years ago, Knut Schmidt-Nielsen would have been a science blogger for sure!
Always curious, always humble, always learning, always reading, always teaching, always popularizing science, every day of his long life. And that is on top of being truly one of the giants of science of all times.

In Less Than An Hour! ‘Galapagos’ on the National Geographic Channel

I hope you see this on time to tune in.
Hat-tip: The Beagle Project Blog

Happy Birthday, Albert Einstein

Albert Einstein was born at Ulm, Germany on this day in 1879. It’s unlikely you need much background on the author of today’s quotes, so I’ll keep this short. Given how intelligent the man was, it shouldn’t come as a surprise that he had a number of choice comments on the fools around him.

Anger dwells only in the bosom of fools.
Any intelligent fool can make things bigger, more complex, and more violent. It takes a touch of genius – and a lot of courage – to move in the opposite direction.
Before God we are equally wise – and equally foolish.
Common sense is the collection of prejudices acquired by age eighteen.
Only two things are infinite, the universe and human stupidity, and I’m not sure about the former.
The difference between what the most and the least learned people know is inexpressibly trivial in relation to that which is unknown.

– All from Albert Einstein, 1879 – 1955

[From Quotes of the Day]

Beagle Project update

Go here to get the code to put on your sidebar so your visitors can donate to the Beagle Project:

 

In Memoriam: Charles Frederick Ehret, 1924-2007

This news just came in:

Charles F- Ehret died of natural causes on February 24th at his home in Grayslake, Illinois, a suburb of Chicago.

His Wikipedia entry is quote short:

Charles Frederick Ehret is a WWII veteran (Battle of the Bulge/Ardennes along the Siegfried Line) as well as a world renowned molecular biologist who worked at Argonne National Laboratory (ANL) in Lemont, Illinois, USA, for 40 years. Dr. Ehret researched the effects of electromagnetic radiation on bacillus megaterium with Dr. Edward Lawrence (Larry) Powers, as well as the effects of time shifts on paramecia, rats and humans. A graduate of City College of CCNY (College of the City of New York) and the University of Notre Dame, Dr. Ehret formulated the term “circadian dyschronism”, popularized the term “zeitgeber” = “time giver” in the 1980’s while appearing on morning TV news shows, and helped millions of travellers overcome Jet Lag with the Jet Lag Diet, and Overcoming Jet Lag book, both available online. Dr. Ehret once created the worlds largest spectrograph, a rainbow 100 feet long, that was large enough to bathe many petri dishes of tetrahymena in each angstrom of the color spectrum.

While his later interest in human clocks and his book Overcoming Jet Lag made him popular outside of chronobiological circles, within the field he is famous for some ingeniously creative pioneering experiments on circadian clocks in protists, mainly Paramecium and Tetrahymena. Here are the links to a couple of his more popular papers on the topic:
Light synchronization of an endogenous circadian rhythm of cell division in Tetrahymena
Circadian rhythm of pattern formation in populations of a free-swimming organism, Tetrahymena.
Testing the chronon theory of circadian timekeeping (DNA-RNA molecular hybridization testing of chronon theory of circadian timekeeping in protozoa cells)
That last link refers to “the chronon theory” of circadian rhythms, the first serious molecular model for a circadian rhythm generation within a cell, which Ehret proposed back in 1967 when he was only one of a handful of researchers who were actively trying to study the biological clock below the level of the cell. Thus, his longest lasting contribution to science will not be his jet-lag book (which is already a bit aged), but his original Chronon paper:
Ehret, C. F., and Trucco, E., (1967), Molecular models for the circadian clock. I. The chronon concept., J. theor. Biol., 15, 240-262 .
I have mentioned the Chronon Model earlier, when I wrote a quick review of the history of clock genetics and this is what I wrote:

In this model, a series of genes induce each other’s expression, i.e., protein A induces trasncription of gene B, protein B induces expression of gene C and so on until the last protein in the series, about 24 hours later, induces expression of gene A again. This model is, actually, not that far from the currently understood mechanism of interlocking trasncription/translation feedback loops

Pale Blue Dot


A tribute

Aaron Bunsen Lerner, 1920-2007

While Aaron Lerner was not a chronobiologist, his discovery of the hormone melatonin in 1958 was one of the key milestones in the biological rhythm research (just see how much I mention it around here) and the chronobiological community will always regard him as one of its own.
Melatonin.pngYou can learn more about melatonin here (UPI got it wrong – the discovery was not made on human skin but a skin preparation of the frog Rana pipiens).
If you are interested, here are three of the first four Lerner’s papers on the discovery of Melatonin:
ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES (pdf)
Melatonin in Peripheral Nerve
STRUCTURE OF MELATONIN (pdf)
Aaron Lerner was also immortalized in poetry, in the 1998 collection Verse & Universe: Poems About Science and Mathematics (reviewed here):

“til Aaron Lerner, awash in kilos of bovine pineals, extracted melatonin . . a hormone that did bleach tadpoles” (Roald Hoffman)

From the New York Time obituary:
lerner.jpg

Dr. Aaron B. Lerner, a Yale dermatologist and the leader of a team of researchers who discovered melatonin, a powerful hormone regulating human sleep-wake cycles, died on Feb. 3 in New Haven. He was 86.
The cause was complications of Parkinson’s disease, his family said.
In 1958, Dr. Lerner, an expert on skin pigmentation disorders who trained in both chemistry and medicine, led a Yale team that isolated a hormone from the pineal gland within the brain.
In laboratory experiments on frogs, the researchers found that the compound could lighten skin color and theorized that it might have applications in treating human skin disorders. Dr. Lerner named the hormone melatonin, and the team’s findings were announced in The Journal of the American Chemical Society.
Subsequent investigations revealed that melatonin did not hold the key to treating disruptions in skin pigmentation like vitiligo. Research by others has since uncovered the hormone’s importance in maintaining the circadian rhythm of rest and wakefulness, and it is now used to treat sleeplessness and jet lag.
Dr. Lerner later developed a transplantation therapy for vitiligo, a disorder that affects about 1 percent of the population and destroys pigment-making cells. The condition may be disfiguring and leaves light-colored patches around body openings like the mouth and eyes, but does not otherwise affect someone’s health. After removing a postage-stamp-size patch of a patient’s normal skin, he grew the cells in culture, then transplanted them to damaged areas. The result was a more uniform complexion covering the abnormal shades of skin, and it was often accompanied by a reduction in social stigma for the patient. The technique was advanced in the 1980s and remains in use, even as vitiligo is more commonly treated by drugs and exposure to light.
In other work, Dr. Lerner isolated another compound — melanocyte-stimulating hormone, or MSH, which he obtained from the pituitary glands of pigs — and studied its skin-darkening effects. Earlier, while still a graduate student, he and another researcher, G. Robert Greenberg, isolated a protein that appears in the blood at low temperature, a monoclonal antibody known as a cryoglobulin.
Aaron Bunsen Lerner was born in 1920 in Minneapolis. In 1945, he received his medical degree and a doctorate in physiological and physical chemistries from the University of Minnesota. After teaching at the University of Michigan and the University of Oregon, he joined Yale as an associate professor of medicine in 1955. Dr. Lerner became the first chairman of Yale’s dermatology department in 1958. He remained chairman until 1985, and was named a professor emeritus of dermatology in 1991.

The Humongous Darwin Day Linkfest

[Moved to the top of the page. First posted at 1:43am]
Last year, I collected the links to notable posts about Darwin Day and posted them here. That was fun, so I decided to do it again.
I checked the Technorati and Google Blogsearch and took my picks that you can see below. I will update this post several times today and move the post to the top in the evening. If you want your post to appear here, please e-mail me at: Coturnix AT gmail DOT com.
Also, later today, I will update this post with a special announcement (pending the approval by the person in question) – naming the winner of my ten-day Rebuild The Beagle contest. The winner will get a copy of The Open Laboratory.
Update:
The Grand Winner is (drumroll, please…):
Susan Davies
So, the book will be travelling to the UK later today.

If you are new here, check the ten posts about the Beagle contest (Day 1, Day 3, Day 4
Day 5, Day 6, Day 7, Day 8, Day 9 and Day 10) and see what “The Open Laboratory” is all about here.
I decided to split the posts into two groups, the first focusing on yesterday’s Evolution Sunday and the second focusing on today’s Darwin Day.
Here we go (under the fold):

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Darwin Birthday Seminars

Way back when, while I was still an active grad student, I was a student representative on the departmental seminar committee for about four years (going through four faculty members rotating through the position). So, I pushed for a Darwin Day seminar – inviting someone to give a talk that is not all about data, a historian or philosopher, for instance.
So, I managed to get Bob Brandon, from the Philosophy Departament at Duke one year. He talked about multi-level selection, which was great introduction to a couple of more speakers (including David Sloan Wilson himself – that was one of my big scoops) who came later in the semester. Brandon’s talk managed to “soften up” some of the core Dawkinsians in the department to be more receptive to the notion of group selection.
One year, we got Matt Cartmill, from the Biological Anthropology and Anatomy Department at Duke, who explained why Creationism – of any stripe – is bad theology, not just bad science.
And of course, we used our local talent, William Kimler, a biologist turned historian and a Darwinian scholar (student of Will Provine) who gave two lectures while I was there. I can’t wait for his new book to come out. It is “…a book on how Charles Darwin has been used as a symbol of science and the idea of evolution.”
Apparently, Will gave another one this year – I am so glad that the tradition took and that they are continuing with Darwin Day special speakers after all these years.
The first year we did it, we actually had the speaker blow the candles on the cake inscribed (with frosting) with “Happy Birthday, Chuck”.
I wish I could still manage to go to the seminars, but they are at the time of day when I can never go (even when they finally managed to get some speakers that I worked for years, unsuccesffuly, to invite, I had to miss it).
Perhaps next year….

Clock Tutorial #3c – Darwin On Time

Darwin On Time This post is a modification from two papers written for two different classes in History of Science, back in 1995 and 1998. It is a part of a four-post series on Darwin and clocks. I first posted it here on December 02, 2004 and then again here on January 06, 2005:

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Darwinian Method

Darwinian MethodOK, this is really ancient. It started as my written prelims (various answers to various questions by different committeee members) back in November 1999, and even included some graphs I drew. Then I put some of that stuff together (mix and match, copy and paste) and posted (sans graphs) as a four-part post here, here, here and here on December 2004. Then I re-posted it in January 2005 (here, here, here and here). Finally, I reposted two of the four parts here on this blog (Part 2 and Part 3) in July 2006.
This all means that all this is quite out of date. The world has moved on, more research has been done, and I have learned a lot since then. But still, today being Darwin Day, this may be a good opportunity to move the Part I here as well and you decide if it is out of date or not….
Part 2 will be reposted here again in a just a few minutes…..

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Beagle – Day 10

It is midnight, Day 10, so the contest is officially over. The winner will be announced tomorrow. But that does not mean that you should abandon reading the Beagle Project blog or helping the Beagle Project get advertised and funded.

Darwin Day – Essay Contest and Beagle Rebuilding

Alliance For Science is starting the First Darwin Day Essay Contest for high school students. Go to Neurotopia for all the details about it. I am assuming that this is going to become an annual event.
On the other hand, the rebuilding of the HMS Beagle is going to happen only once, for the Darwin Bicentennial in two years. Of course, once the ship is built and is done with its maiden voyage with all the media spotlight on it, the ship will continue to be used for scientific exploraiton and education for many years to come. [Day 9]

Voyage of the (Birds on the) Beagle

I and the Bird #42 is up on Neurophilosophy blog. Beautiful rendition, formatted like Charles Darwin’s diaries from the “Beagle”, which – the ship, I mean – as you know (Day 8), is planned to be rebuilt and sailed again, but only if you help.

Save The World From Bad Poetry…

…by sending a Darwin (or a Lincoln, or more) to the Beagle project. Day six.

Do it for Science!

beagle.jpgDo it for Charles Musters!
Or do it for Charles Darwin.
Or do it for the fun of sailing.
But do it nonetheless:

…send in a Darwin (£10) or a Jackson ($20), spread the word, encourage colleagues to bookmark the site and root through their labcoat pockets for a donation…

Check the website and the blog. Then decide if you think this is a worthy cause.
The donations have started coming in. The biggest so far is $100. If you give more by the end of the tenth day of this drive, you will become a lucky owner of a copy of The Open Laboratory.

As promised, I’ll bug you about this for ten days!

Let’s make sure that this really happens.

How the Giraffe Got Its Neck?

The Icons of Evolution finally tested! Who won? Lamarck or Darwin?
Under the fold:

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If only people read the Bible the way they read their contracts…

If only people read the Bible the way they read their contracts...So, why do Creationists and other quacks try so hard to sound all ‘scienc-y’? (June 15, 2005)

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Sagan Blog-a-thon: Let There Be Light!

Joel is collecting links to all the posts written today in honor of the 10-year anniversary of the death of Carl Sagan.
The phrase “Science as a Candle in the Dark”, the subtitle of Sagan’s magnificient The Demon-Haunted World, evokes such a powerful idea that we are fighting for – the Enlightement.
Coincidentally, today is also another anniversary related to light: on December 20, 1879 Thomas Edison performed the first public demonstration of the electric light. Next year, on the same day – December 20, 1880 – electric street-lights were first swicthed on Broadway. You know I am a Tesla fan, but still, this is a big anniversary of Light, in all the meanings of the word, both literal and metaphorical.
So, here are some quotes about Light, in its various meanings (from Quotes of The Day):
Thousands of candles can be lighted from a single candle, and the life of the candle will not be shortened. Happiness never decreases by being shared.
– Siddhartha Gautama, 563 – 483 BC
Darkness cannot drive out darkness; only light can do that. Hate cannot drive out hate; only love can do that.
– Martin Luther King, Jr, 1929 – 1968
I will love the light for it shows me the way, yet I will endure the darkness because it shows me the stars.
– Og Mandino
The very society of joy redoubles it; so that, while it lights upon my friend it rebounds upon myself, and the brighter his candle burns the more easily will it light mine.
– Robert South
What is to give light must endure burning.
– Viktor Emil Frankl, 1905 – 1997
When in the dark is it better to move or stand still? If still, you won’t bump into anything – but you won’t find the light either.
– Norm Howe

Science Laureate

“A Poet Laureate is a poet officially appointed by a government and often expected to compose poems for state occasions and other government events.” What would be the scientific equivalent, a Science Laureate? A scientist officially appointed by a government and often expected to perform experiments (Mentos and DietCoke?) for state occasions and other government events? If so, Bill Nye should get the title.
But, seriously. In the USA, the poet laureate title is supposedly given only for the quality of the poetry irrespective of the poet’s public persona, social activism, political orientation and telegenicity. If we stick to that criterium for a science laureate and award the title only according to the quality of one’s science then… hey, how about all those Nobel Prize winners?
Yet, there is a popular notion that a poet laureate is SUPPOSED to become a public persona, to advocate for causes and to introduce people to poetry on top of being a fantastic poet. If we take that meaning for science, than Razib, John and Josh‘s idea to nominate E.O.Wilson is right on – a good scientist, a well-known and liked one, author or popular books and public persona. Neil deGrasse Tyson is another good choice. But, I’d go for Stephen Hawking – perhaps the best known scientist in the USA today, as well as, as far as I can tell from a biologist’s perspective, a super-duper-top-star scientist himself.

Happy birthday J.B.S. Haldane

From Quotes of the Day:

John Burdon Sanderson Haldane was born at Edinburgh, Scotland on this day in 1892. He was educated at Eton and Oxford, but possibly most important is the fact that he assisted his scientist father in the lab from age eight. His primary work was in genetics, being the first to provide a mathematical basis for Mendelian genetics and for Darwin’s evolution. He taught at Oxford, Cambridge, and the University of London. In 1957 he became disgusted with policies of the British government and moved to India where he spent the rest of his life.
——————————-
If one could conclude as to the nature of the Creator from a study of his creation it would appear that God has a special fondness for stars and beetles.
This is my prediction for the future – whatever hasn’t happened will happen and no one will be safe from it.
I have never yet met a healthy person who worried very much about his health, or a really good person who worried much about his own soul.
We do not know, in most cases, how far social failure and success are due to heredity, and how far to environment. But environment is the easier of the two to improve.
So many new ideas are at first strange and horrible, though ultimately valuable that a very heavy responsibility rests upon those who would prevent their dissemination.
If human beings could be propagated by cutting, like apple trees, aristocracy would be biologically sound.
– All from J. B. S. Haldane, 1892 – 1964

On Velikovsky

Archy sums it all up in An object lesson in Wiki research. Nice to see a professional historian take a look at history of pseudoscience.

Darwin Online

Yup, I know, many of my sciblings have already posted about this, but curiously, I saw this first outside the Seed’s blogging stable, on Majikthise, several hours before anyone here picked up on it.
Yes, the entire works of Charles Darwin will be placed online for you to browse, search and read for free on this website. Not everything is up yet, but they are working on making it as complete as possible as soon as possible.

Atlantis, lost and found, again

John bemoans the state of science journalism, with some added history of the Atlantis hypothesis.

Chemistry Nobel is really a Biology Nobel

Roger D. Kornberg got a chemistry Nobel Prize this year for figuring out one of the most basic processes in all of biology, stuff we teach in intro classes – DNA transcription, i.e., how the cell “reads” the DNA code and synthesizes messenger RNA molecules that are used as templates for synthesis of proteins. Excellent choice from my perspective of a biologist. But what do the chemists think?
Also, is this the first instance of a parent and the child both getting a Nobel (his father got one four decades ago for DNA replication)?

Nobel Prize for Medicine/Physiology

As you have probably heard already, Andrew Fire and Craig Mello have won the Nobel Prize in Medicine for the discovery of RNA interference.
Jake Young explains what RNAi are and what they do and why is this so revolutionary. Then he explains why those two people got the Nobel for this work instead of some others.
Alex Palazzo (also here), Abel PharmBoy, Carl Zimmer, Nick Anthis and PZ Myers have more and explain it much better than I could ever do. The last time the Nobel was given for work I really understand and like was in 1973 – ah, the good old days when the Nobel did not require molecular biology!
Anyway, this is the first time a Nobel was given for something that was discovered at the time when I was already in the lab and I remember the rumors about it around the molecular labs in the Department. Usually it takes decades for the finding to get a Nobel (and in my field, all the “founders” are dead by now), so this was really fast – indicating how important it is.

Big Teeth and some other Big Organs…

When you are hungry for news about mammoths, you go and visit Archy, of course. But this time, he moves sideways to take a look at mastodons, hippos and Ken Hamm. And the tail, or whatever that is….

The Homunculus

Amanda makes a correct connection between preformationism of old and the anti-abortion ideology of today. The only thing missing is the connection of both to Dawkinsian genocentrism which is just preformationism with modern rhetoric of DNA and genes and “blueprints of life”. The history of the war between epigenetics and preformationism and, within preformationism, between spermists and ovists is masterfully covered in Clara Pinto-Corriea’s book Ovary of Eve.

Clocks in Bacteria V: How about E.coli?

Clocks in Bacteria V: How about E.coli?Fifth in the five-part series on clocks in bacteria, covering more politics than biology (from May 17, 2006):

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